The form and function of channelrhodopsin

Gamma oscillations organize top-down signalling to hypothalamus and enable food seeking

(2017) Marta Carus-Cadavieco et al.   NATURE

Thalamic amplification of cortical connectivity sustains attentional control

(2017) L. Ian Schmitt et al.   NATURE

Manipulating fear associations via optogenetic modulation of amygdala inputs to prefrontal cortex

(2017) Oded Klavir et al.   NATURE NEUROSCIENCE

Integration of optogenetics with complementary methodologies in systems neuroscience

(2017) Christina K. Kim et al.   NATURE REVIEWS NEUROSCIENCE

Bidirectional Control of Generalized Epilepsy Networks via Rapid Real-Time Switching of Firing Mode

(2017) Jordan M. Sorokin et al.   NEURON

Prefrontal Parvalbumin Neurons in Control of Attention

(2016) Hoseok Kim et al.   CELL

Warm-Sensitive Neurons that Control Body Temperature

(2016) Chan Lek Tan et al.   CELL

Identification of a Natural Green Light Absorbing Chloride Conducting Channelrhodopsin fromProteomonas sulcata

(2016) Jonas Wietek et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The antiepileptic and ictogenic effects of optogenetic neurostimulation of PV-expressing interneurons

(2016) Fadi Assaf et al.   JOURNAL OF NEUROPHYSIOLOGY

Structure of a CLC chloride ion channel by cryo-electron microscopy

(2016) Eunyong Park et al.   NATURE

Simultaneous fast measurement of circuit dynamics at multiple sites across the mammalian brain

(2016) Christina K Kim et al.   NATURE METHODS

Imprinting and recalling cortical ensembles

(2016) L. Carrillo-Reid et al.   SCIENCE

Active cortical dendrites modulate perception

(2016) Naoya Takahashi et al.   SCIENCE

A three-dimensional movie of structural changes in bacteriorhodopsin

(2016) Eriko Nango et al.   SCIENCE

Active site structure and absorption spectrum of channelrhodopsin-2 wild-type and C128T mutant

(2016) Yanan Guo et al.   Chemical Science

Anion channelrhodopsins for inhibitory cardiac optogenetics

(2016) Elena G. Govorunova et al.   Scientific Reports

Optogenetic and chemogenetic strategies for sustained inhibition of pain

(2016) Shrivats M. Iyer et al.   Scientific Reports

Biophysics of Channelrhodopsin

(2015) Franziska Schneider et al.   Annual Review of Biophysics

Light–Dark Adaptation of Channelrhodopsin Involves Photoconversion between the all-trans and 13-cis Retinal Isomers

(2015) Sara Bruun et al.   BIOCHEMISTRY

Projections from neocortex mediate top-down control of memory retrieval

(2015) Priyamvada Rajasethupathy et al.   NATURE

Learning enhances the relative impact of top-down processing in the visual cortex

(2015) Hiroshi Makino et al.   NATURE NEUROSCIENCE

Optogenetics: 10 years of microbial opsins in neuroscience

(2015) Karl Deisseroth   NATURE NEUROSCIENCE

Closed-Loop and Activity-Guided Optogenetic Control

(2015) Logan Grosenick et al.   NEURON

Temporal evolution of helix hydration in a light-gated ion channel correlates with ion conductance

(2015) Víctor A. Lórenz-Fonfría et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural foundations of optogenetics: Determinants of channelrhodopsin ion selectivity

(2015) Andre Berndt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prefrontal cortical regulation of brainwide circuit dynamics and reward-related behavior

(2015) E. A. Ferenczi et al.   SCIENCE

Expanding the optogenetics toolkit

(2015) A. Berndt et al.   SCIENCE

Natural light-gated anion channels: A family of microbial rhodopsins for advanced optogenetics

(2015) E. G. Govorunova et al.   SCIENCE

Atomistic design of microbial opsin-based blue-shifted optogenetics tools

(2015) Hideaki E. Kato et al.   Nature Communications

An improved chloride-conducting channelrhodopsin for light-induced inhibition of neuronal activity in vivo

(2015) Jonas Wietek et al.   Scientific Reports

Native architecture of the Chlamydomonas chloroplast revealed by in situ cryo-electron tomography

(2015) Benjamin D Engel et al.   eLife

Early Formation of the Ion-Conducting Pore in Channelrhodopsin-2

(2014) Jens Kuhne et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Lag, lock, sync, slip: the many 'phases' of coupled flagella

(2014) K. Y. Wan et al.   Journal of the Royal Society Interface

Independent optical excitation of distinct neural populations

(2014) Nathan C Klapoetke et al.   NATURE METHODS

Simultaneous cellular-resolution optical perturbation and imaging of place cell firing fields

(2014) John Peter Rickgauer et al.   NATURE NEUROSCIENCE

Structure-Guided Transformation of Channelrhodopsin into a Light-Activated Chloride Channel

(2014) A. Berndt et al.   SCIENCE

Conversion of Channelrhodopsin into a Light-Gated Chloride Channel

(2014) J. Wietek et al.   SCIENCE

Ion Selectivity and Competition in Channelrhodopsins

(2013) Franziska Schneider et al.   BIOPHYSICAL JOURNAL

Microbial and Animal Rhodopsins: Structures, Functions, and Molecular Mechanisms

(2013) Oliver P. Ernst et al.   CHEMICAL REVIEWS

Characterization of a Highly Efficient Blue-shifted Channelrhodopsin from the Marine AlgaPlatymonas subcordiformis

(2013) Elena G. Govorunova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Towards an Understanding of Channelrhodopsin Function: Simulations Lead to Novel Insights of the Channel Mechanism

(2013) Hiroshi C. Watanabe et al.   JOURNAL OF MOLECULAR BIOLOGY

Optogenetic Control of Fly Optomotor Responses

(2013) V. Haikala et al.   JOURNAL OF NEUROSCIENCE

Optogenetic identification of a rapid eye movement sleep modulatory circuit in the hypothalamus

(2013) Sonia Jego et al.   NATURE NEUROSCIENCE

ReaChR: a red-shifted variant of channelrhodopsin enables deep transcranial optogenetic excitation

(2013) John Y Lin et al.   NATURE NEUROSCIENCE

Crystal structure of the channelrhodopsin light-gated cation channel

(2012) Hideaki E. Kato et al.   NATURE

Two-photon optogenetic toolbox for fast inhibition, excitation and bistable modulation

(2012) Rohit Prakash et al.   NATURE METHODS

Tuning the Electronic Absorption of Protein-Embedded All-trans-Retinal

(2012) W. Wang et al.   SCIENCE

Glutamate residue 90 in the predicted transmembrane domain 2 is crucial for cation flux through channelrhodopsin 2

(2011) Karelia Ruffert et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Microbial Opsin Family of Optogenetic Tools

(2011) Feng Zhang et al.   CELL

Bioinformatic and Mutational Analysis of Channelrhodopsin-2 Protein Cation-conducting Pathway

(2011) Anna Pia Plazzo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Asymmetric properties of theChlamydomonas reinhardtiicytoskeleton direct rhodopsin photoreceptor localization

(2011) Telsa M. Mittelmeier et al.   JOURNAL OF CELL BIOLOGY

Projection Structure of Channelrhodopsin-2 at 6 Å Resolution by Electron Crystallography

(2011) Maria Müller et al.   JOURNAL OF MOLECULAR BIOLOGY

Neocortical excitation/inhibition balance in information processing and social dysfunction

(2011) Ofer Yizhar et al.   NATURE

Principles for applying optogenetic tools derived from direct comparative analysis of microbial opsins

(2011) Joanna Mattis et al.   NATURE METHODS

High-efficiency channelrhodopsins for fast neuronal stimulation at low light levels

(2011) A. Berndt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

New Channelrhodopsin with a Red-Shifted Spectrum and Rapid Kinetics from Mesostigma viride

(2011) E. G. Govorunova et al.   mBio

Molecular and Cellular Approaches for Diversifying and Extending Optogenetics

(2010) Viviana Gradinaru et al.   CELL

Ultrafast optogenetic control

(2010) Lisa A Gunaydin et al.   NATURE NEUROSCIENCE

Structural Guidance of the Photocycle of Channelrhodopsin-2 by an Interhelical Hydrogen Bond

(2009) Christian Bamann et al.   BIOCHEMISTRY

Characterization of Engineered Channelrhodopsin Variants with Improved Properties and Kinetics

(2009) John Y. Lin et al.   BIOPHYSICAL JOURNAL

Bi-stable neural state switches

(2009) André Berndt et al.   NATURE NEUROSCIENCE

Glu 87 of Channelrhodopsin-1 Causes pH-dependent Color Tuning and Fast Photocurrent Inactivation

(2009) Satoshi P. Tsunoda et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Optical Deconstruction of Parkinsonian Neural Circuitry

(2009) V. Gradinaru et al.   SCIENCE

Phasic Firing in Dopaminergic Neurons Is Sufficient for Behavioral Conditioning

(2009) H.-C. Tsai et al.   SCIENCE

Molecular Determinants Differentiating Photocurrent Properties of Two Channelrhodopsins fromChlamydomonas

(2008) Hongxia Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Red-shifted optogenetic excitation: a tool for fast neural control derived from Volvox carteri

(2008) Feng Zhang et al.   NATURE NEUROSCIENCE

Channelrhodopsin-1 Initiates Phototaxis and Photophobic Responses in Chlamydomonas by Immediate Light-Induced Depolarization

(2008) P. Berthold et al.   PLANT CELL