Structural basis for loading and inhibition of a bacterial T6 SS phospholipase effector by the VgrG spike

In situ and high‐resolution cryo‐EM structure of a bacterial type VI secretion system membrane complex

(2019) Chiara Rapisarda et al.   EMBO JOURNAL

Delivery of the Pseudomonas aeruginosa Phospholipase Effectors PldA and PldB in a VgrG- and H2-T6SS-Dependent Manner

(2019) Sarah Wettstadt et al.   Frontiers in Microbiology

PAAR proteins act as the ‘sorting hat’ of the type VI secretion system

(2019) Thomas E. Wood et al.   MICROBIOLOGY-SGM

Automated map sharpening by maximization of detail and connectivity

(2018) Thomas C. Terwilliger et al.   Acta Crystallographica Section D-Structural Biology

Real-space refinement in PHENIX for cryo-EM and crystallography

(2018) Pavel V. Afonine et al.   Acta Crystallographica Section D-Structural Biology

Mechanism of loading and translocation of type VI secretion system effector Tse6

(2018) Dennis Quentin et al.   Nature Microbiology

A fully automatic method yielding initial models from high-resolution cryo-electron microscopy maps

(2018) Thomas C. Terwilliger et al.   NATURE METHODS

A Bayesian approach to beam-induced motion correction in cryo-EM single-particle analysis

(2018) Jasenko Zivanov et al.   IUCrJ

Biogenesis and structure of a type VI secretion baseplate

(2018) Yassine Cherrak et al.   Nature Microbiology

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination

(2017) Ali Punjani et al.   NATURE METHODS

UCSF ChimeraX: Meeting modern challenges in visualization and analysis

(2017) Thomas D. Goddard et al.   PROTEIN SCIENCE

The Hcp proteins fused with diverse extended-toxin domains represent a novel pattern of antibacterial effectors in type VI secretion systems

(2017) Jiale Ma et al.   Virulence

Type VI secretion TssK baseplate protein exhibits structural similarity with phage receptor-binding proteins and evolved to bind the membrane complex

(2017) Van Son Nguyen et al.   Nature Microbiology

Type VI secretion and anti-host effectors

(2016) Abderrahman Hachani et al.   CURRENT OPINION IN MICROBIOLOGY

Molecular Dissection of the Interface between the Type VI Secretion TssM Cytoplasmic Domain and the TssG Baseplate Component

(2016) Laureen Logger et al.   JOURNAL OF MOLECULAR BIOLOGY

Gctf: Real-time CTF determination and correction

(2016) Kai Zhang   JOURNAL OF STRUCTURAL BIOLOGY

High Sensitivity Crosslink Detection Coupled With Integrative Structure Modeling in the Mass Spec Studio

(2016) Vladimir Sarpe et al.   MOLECULAR & CELLULAR PROTEOMICS

A phospholipase A1 antibacterial Type VI secretion effector interacts directly with the C-terminal domain of the VgrG spike protein for delivery

(2016) Nicolas Flaugnatti et al.   MOLECULAR MICROBIOLOGY

Priming and polymerization of a bacterial contractile tail structure

(2016) Abdelrahim Zoued et al.   NATURE

Structure of the T4 baseplate and its function in triggering sheath contraction

(2016) Nicholas M. I. Taylor et al.   NATURE

KEGG: new perspectives on genomes, pathways, diseases and drugs

(2016) Minoru Kanehisa et al.   NUCLEIC ACIDS RESEARCH

VgrG C terminus confers the type VI effector transport specificity and is required for binding with PAAR and adaptor–effector complex

(2016) Devanand D. Bondage et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aim, Load, Fire: The Type VI Secretion System, a Bacterial Nanoweapon

(2016) Francesca R. Cianfanelli et al.   TRENDS IN MICROBIOLOGY

The structure of VgrG1 fromPseudomonas aeruginosa, the needle tip of the bacterial type VI secretion system

(2016) Mercedes Spínola-Amilibia et al.   Acta Crystallographica Section D-Structural Biology

A Novel Bio-Orthogonal Cross-Linker for Improved Protein/Protein Interaction Analysis

(2015) Catherine Nury et al.   ANALYTICAL CHEMISTRY

An Interbacterial NAD(P)+ Glycohydrolase Toxin Requires Elongation Factor Tu for Delivery to Target Cells

(2015) John C. Whitney et al.   CELL

Chimeric adaptor proteins translocate diverse type VI secretion system effectors in Vibrio cholerae

(2015) D. Unterweger et al.   EMBO JOURNAL

Intraspecies Competition in Serratia marcescens Is Mediated by Type VI-Secreted Rhs Effectors and a Conserved Effector-Associated Accessory Protein

(2015) Juliana Alcoforado Diniz et al.   JOURNAL OF BACTERIOLOGY

Biogenesis and structure of a type VI secretion membrane core complex

(2015) Eric Durand et al.   NATURE

The Phyre2 web portal for protein modeling, prediction and analysis

(2015) Lawrence A Kelley et al.   Nature Protocols

Identification of divergent type VI secretion effectors using a conserved chaperone domain

(2015) Xiaoye Liang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Type VI Secretion TssEFGK-VgrG Phage-Like Baseplate Is Recruited to the TssJLM Membrane Complex via Multiple Contacts and Serves As Assembly Platform for Tail Tube/Sheath Polymerization

(2015) Yannick R. Brunet et al.   PLoS Genetics

Architecture and assembly of the Type VI secretion system

(2014) Abdelrahim Zoued et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Type VI secretion system effectors: poisons with a purpose

(2014) Alistair B. Russell et al.   NATURE REVIEWS MICROBIOLOGY

Deciphering key features in protein structures with the new ENDscript server

(2014) Xavier Robert et al.   NUCLEIC ACIDS RESEARCH

VgrG, Tae, Tle, and beyond: the versatile arsenal of Type VI secretion effectors

(2014) Eric Durand et al.   TRENDS IN MICROBIOLOGY

Structure of the type VI secretion phospholipase effector Tle1 provides insight into its hydrolysis and membrane targeting

(2014) Haidai Hu et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

A View to a Kill: The Bacterial Type VI Secretion System

(2013) Brian T. Ho et al.   Cell Host & Microbe

Structure and properties of the C-terminal β-helical domain of VgrG protein from Escherichia coli O157

(2013) Kazuya Uchida et al.   JOURNAL OF BIOCHEMISTRY

Lytic Activity of theVibrio choleraeType VI Secretion Toxin VgrG-3 Is Inhibited by the Antitoxin TsaB

(2013) Teresa M. Brooks et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Haemolysin Coregulated Protein Is an Exported Receptor and Chaperone of Type VI Secretion Substrates

(2013) Julie M. Silverman et al.   MOLECULAR CELL

PAAR-repeat proteins sharpen and diversify the type VI secretion system spike

(2013) Mikhail M. Shneider et al.   NATURE

Identification of T6SS-dependent effector and immunity proteins by Tn-seq in Vibrio cholerae

(2013) T. G. Dong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Type VI secretion requires a dynamic contractile phage tail-like structure

(2012) M. Basler et al.   NATURE

Template-based protein structure modeling using the RaptorX web server

(2012) Morten Källberg et al.   Nature Protocols

MOLEonline 2.0: interactive web-based analysis of biomacromolecular channels

(2012) K. Berka et al.   NUCLEIC ACIDS RESEARCH

REFMAC5 for the refinement of macromolecular crystal structures

(2011) Garib N. Murshudov et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

An Epigenetic Switch Involving Overlapping Fur and DNA Methylation Optimizes Expression of a Type VI Secretion Gene Cluster

(2011) Yannick R. Brunet et al.   PLoS Genetics

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

A novel fluorogenic substrate for the measurement of endothelial lipase activity

(2010) Andrew L. Darrow et al.   JOURNAL OF LIPID RESEARCH

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Comparative genomic analysis uncovers 3 novel loci encoding type six secretion systems differentially distributed in Salmonella serotypes

(2009) Carlos J Blondel et al.   BMC GENOMICS

Dissecting the bacterial type VI secretion system by a genome wide in silico analysis: what can be learned from available microbial genomic resources?

(2009) Frédéric Boyer et al.   BMC GENOMICS

A Type VI Secretion System Effector Protein, VgrG1, from Aeromonas hydrophila That Induces Host Cell Toxicity by ADP Ribosylation of Actin

(2009) G. Suarez et al.   JOURNAL OF BACTERIOLOGY

Type VI secretion apparatus and phage tail-associated protein complexes share a common evolutionary origin

(2009) P. G. Leiman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA