Polyphyllin VII Induces an Autophagic Cell Death by Activation of the JNK Pathway and Inhibition of PI3K/AKT/mTOR Pathway in HepG2 Cells

Dual Role of JNK1-mediated phosphorylation of Bcl-2 in autophagy and apoptosis regulation

(2014) Yongjie Wei et al.   Autophagy

Paris saponin VII inhibits growth of colorectal cancer cells through Ras signaling pathway

(2014) Yuhua Li et al.   BIOCHEMICAL PHARMACOLOGY

Paris saponin VII from trillium tschonoskii reverses multidrug resistance of adriamycin-resistant MCF-7/ADR cells via P-glycoprotein inhibition and apoptosis augmentation

(2014) Yuhua Li et al.   JOURNAL OF ETHNOPHARMACOLOGY

A Novel Herbal Medicine, KIOM-C, Induces Autophagic and Apoptotic Cell Death Mediated by Activation of JNK and Reactive Oxygen Species in HT1080 Human Fibrosarcoma Cells

(2014) Aeyung Kim et al.   PLoS One

U12, a UDCA Derivative, Acts as an Anti-Hepatoma Drug Lead and Inhibits the mTOR/S6K1 and Cyclin/CDK Complex Pathways

(2014) Yang Xu et al.   PLoS One

Growth inhibition by pennogenyl saponins from Rhizoma paridis on hepatoma xenografts in nude mice

(2014) Ya-Shu Chen et al.   STEROIDS

Inhibition of cathepsin S induces autophagy and apoptosis in human glioblastoma cell lines through ROS-mediated PI3K/AKT/mTOR/p70S6K and JNK signaling pathways

(2014) Li Zhang et al.   TOXICOLOGY LETTERS

Functions of autophagy in normal and diseased liver

(2013) Mark J. Czaja et al.   Autophagy

p38 and JNK MAPK pathways control the balance of apoptosis and autophagy in response to chemotherapeutic agents

(2013) Xinbing Sui et al.   CANCER LETTERS

Autophagy and human diseases

(2013) Peidu Jiang et al.   CELL RESEARCH

Akebia saponin PA induces autophagic and apoptotic cell death in AGS human gastric cancer cells

(2013) Mei-Ying Xu et al.   FOOD AND CHEMICAL TOXICOLOGY

Steroidal saponin of Trillium tschonoskii. Reverses multidrug resistance of hepatocellular carcinoma

(2013) Hui Wang et al.   PHYTOMEDICINE

A ginseng metabolite, compound K, induces autophagy and apoptosis via generation of reactive oxygen species and activation of JNK in human colon cancer cells

(2013) A D Kim et al.   Cell Death & Disease

Guidelines for the use and interpretation of assays for monitoring autophagy

(2012) Daniel J. Klionsky et al.   Autophagy

Histone deacetylase 6 functions as a tumor suppressor by activating c-Jun NH2-terminal kinase-mediated beclin 1-dependent autophagic cell death in liver cancer

(2012) Kwang Hwa Jung et al.   HEPATOLOGY

Steroidal saponins with antimicrobial activity from stems and leaves of Paris polyphylla var. yunnanensis

(2012) Xu-Jie Qin et al.   STEROIDS

Targeting autophagic pathways for cancer drug discovery

(2012) Bo Liu et al.   Chinese Journal of Cancer

Silibinin Activated p53 and Induced Autophagic Death in Human Fibrosarcoma HT1080 Cells via Reactive Oxygen Species-p38 and c-Jun N-Terminal Kinase Pathways

(2011) Wen-Jun Duan et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Targeting cancer cells through autophagy for anticancer therapy

(2010) Sandra Turcotte et al.   CURRENT OPINION IN CELL BIOLOGY

Involvement of JNK in the regulation of autophagic cell death

(2010) S Shimizu et al.   ONCOGENE

Upregulation of Beclin-1 expression and phosphorylation of Bcl-2 and p53 are involved in the JNK-mediated autophagic cell death

(2009) Kyung-Jin Park et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Polygonatum cyrtonema lectin induces apoptosis and autophagy in human melanoma A375 cells through a mitochondria-mediated ROS–p38–p53 pathway

(2008) Bo Liu et al.   CANCER LETTERS

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL

Expansion and evolution of cell death programmes

(2008) Alexei Degterev et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The pivotal role of c-Jun NH2-terminal kinase-mediated Beclin 1 expression during anticancer agents-induced autophagy in cancer cells

(2008) D-D Li et al.   ONCOGENE