Transcription factor C/EBP-β induces tumor-suppressor phosphatase PHLPP2 through repression of the miR-17–92 cluster in differentiating AML cells

Contemporary Treatment of APL

(2014) Elizabeth H. Cull et al.   Current Hematologic Malignancy Reports

MicroRNA-19a/b regulates multidrug resistance in human gastric cancer cells by targeting PTEN

(2013) Fang Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

miR-205 Targets PTEN and PHLPP2 to Augment AKT Signaling and Drive Malignant Phenotypes in Non-Small Cell Lung Cancer

(2013) J. Cai et al.   CANCER RESEARCH

The miR-17/92 cluster: a comprehensive update on its genomics, genetics, functions and increasingly important and numerous roles in health and disease

(2013) E Mogilyansky et al.   CELL DEATH AND DIFFERENTIATION

microRNA-224 Promotes Cell Proliferation and Tumor Growth in Human Colorectal Cancer by Repressing PHLPP1 and PHLPP2

(2013) W.-T. Liao et al.   CLINICAL CANCER RESEARCH

mir-17-92: a polycistronic oncomir with pleiotropic functions

(2013) Virginie Olive et al.   IMMUNOLOGICAL REVIEWS

Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

(2013) J. Gao et al.   Science Signaling

Regulation of C/EBPβ and resulting functions in cells of the monocytic lineage

(2012) René Huber et al.   CELLULAR SIGNALLING

MicroRNAs

(2012) Mir Farshid Alemdehy et al.   CURRENT OPINION IN HEMATOLOGY

Suppression of survival signalling pathways by the phosphatase PHLPP

(2012) Audrey K. O’Neill et al.   FEBS Journal

Negative regulation of miR-145 by C/EBP-β through the Akt pathway in cancer cells

(2012) Mohit Sachdeva et al.   NUCLEIC ACIDS RESEARCH

The deubiquitination enzyme USP46 functions as a tumor suppressor by controlling PHLPP-dependent attenuation of Akt signaling in colon cancer

(2012) X Li et al.   ONCOGENE

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

microRNAs: Master Regulators as Potential Therapeutics in Cancer

(2011) Michela Garofalo et al.   Annual Review of Pharmacology and Toxicology

Pleckstrin Homology Domain Leucine-rich Repeat Protein Phosphatase (PHLPP): A New Player in Cell Signaling

(2011) Noel A. Warfel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The miRNA-17∼92 cluster mediates chemoresistance and enhances tumor growth in mantle cell lymphoma via PI3K/AKT pathway activation

(2011) E Rao et al.   LEUKEMIA

PHLPP-Mediated Dephosphorylation of S6K1 Inhibits Protein Translation and Cell Growth

(2011) J. Liu et al.   MOLECULAR AND CELLULAR BIOLOGY

c-Myc dependent expression of pro-apoptotic Bim renders HER2-overexpressing breast cancer cells dependent on anti-apoptotic Mcl-1

(2011) Mario Campone et al.   Molecular Cancer

mTOR-Dependent Regulation of PHLPP Expression Controls the Rapamycin Sensitivity in Cancer Cells

(2010) Jianyu Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Proapoptotic Function of Noxa in Human Leukemia Cells Is Regulated by the Kinase Cdk5 and by Glucose

(2010) Xazmin H. Lowman et al.   MOLECULAR CELL

Mst1 Is an Interacting Protein that Mediates PHLPPs' Induced Apoptosis

(2010) Meng Qiao et al.   MOLECULAR CELL

Structure and activity of putative intronic miRNA promoters

(2010) A. M. Monteys et al.   RNA

Inhibition of Class I Phosphoinositide 3-Kinase Activity Impairs Proliferation and Triggers Apoptosis in Acute Promyelocytic Leukemia without Affecting Atra-Induced Differentiation

(2009) C. Billottet et al.   CANCER RESEARCH

Repression of the miR-17-92 cluster by p53 has an important function in hypoxia-induced apoptosis

(2009) Hong-li Yan et al.   EMBO JOURNAL

Activation of miR-17-92 by NK-like homeodomain proteins suppresses apoptosis via reduction of E2F1 in T-cell acute lymphoblastic leukemia

(2009) Stefan Nagel et al.   LEUKEMIA & LYMPHOMA

Targeting Protein Serine/Threonine Phosphatases for Drug Development

(2009) J. L. McConnell et al.   MOLECULAR PHARMACOLOGY

MicroRNA-17-92 down-regulates expression of distinct targets in different B-cell lymphoma subtypes

(2008) M. Inomata et al.   BLOOD

Targeted Deletion Reveals Essential and Overlapping Functions of the miR-17∼92 Family of miRNA Clusters

(2008) Andrea Ventura et al.   CELL

Translationally regulated C/EBPβ isoform expression upregulates metastatic genes in hormone-independent prostate cancer cells

(2008) Myoung H. Kim et al.   PROSTATE

PHLiPPing the switch on Akt and protein kinase C signaling

(2008) John Brognard et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM