Regulation of pluripotency and differentiation by deubiquitinating enzymes

Ubiquitin chain diversity at a glance

(2016) Masato Akutsu et al.   JOURNAL OF CELL SCIENCE

The role of deubiquitinating enzymes in spermatogenesis

(2015) Bharathi Suresh et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Deubiquitinases (DUBs) and DUB inhibitors: a patent review

(2015) Pershang Farshi et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Deubiquitinating enzymes regulate Hes1 stability and neuronal differentiation

(2015) Taeko Kobayashi et al.   FEBS Journal

Direct conversion of human fibroblasts into functional osteoblasts by defined factors

(2015) Kenta Yamamoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deubiquitinases in cancer

(2015) Rongbin Wei et al.   Oncotarget

RNF168 Promotes Noncanonical K27 Ubiquitination to Signal DNA Damage

(2015) Marco Gatti et al.   Cell Reports

Direct Conversion of Fibroblasts into Functional Astrocytes by Defined Transcription Factors

(2015) Massimiliano Caiazzo et al.   Stem Cell Reports

Clinically used antirheumatic agent auranofin is a proteasomal deubiquitinase inhibitor and inhibits tumor growth

(2015) Ningning Liu et al.   Oncotarget

Lys11- and Lys48-linked ubiquitin chains interact with p97 during endoplasmic-reticulum-associated degradation

(2014) Matthew Locke et al.   BIOCHEMICAL JOURNAL

Posttranslational Modifications of Defined Embryonic Reprogramming Transcription Factors

(2014) Suresh Ramakrishna et al.   Cellular Reprogramming

Direct Conversion of Adult Skin Fibroblasts to Endothelial Cells by Defined Factors

(2014) Jung-Kyu Han et al.   CIRCULATION

USP15 stabilizes MDM2 to mediate cancer-cell survival and inhibit antitumor T cell responses

(2014) Qiang Zou et al.   NATURE IMMUNOLOGY

Direct conversion of mouse and human fibroblasts to functional melanocytes by defined factors

(2014) Ruifeng Yang et al.   Nature Communications

MicroRNA-124 protects against focal cerebral ischemia via mechanisms involving Usp14-dependent REST degradation

(2013) Thorsten R. Doeppner et al.   ACTA NEUROPATHOLOGICA

The deubiquitylase USP15 stabilizes newly synthesized REST and rescues its expression at mitotic exit

(2013) Monica Faronato et al.   CELL CYCLE

Deubiquitinating Enzymes as Therapeutic Targets in Cancer

(2013) Key-Hwan Lim et al.   CURRENT PHARMACEUTICAL DESIGN

Molecular mechanisms and functions of cytokine-inducible deubiquitinating enzymes

(2013) Key-Hwan Lim et al.   CYTOKINE & GROWTH FACTOR REVIEWS

USP10 inhibits genotoxic NF-κB activation by MCPIP1-facilitated deubiquitination of NEMO

(2013) Jixiao Niu et al.   EMBO JOURNAL

The Epigenetic Modifier Ubiquitin-specific Protease 22 (USP22) Regulates Embryonic Stem Cell Differentiation via Transcriptional Repression of Sex-determining Region Y-box 2 (SOX2)

(2013) Robyn T. Sussman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deubiquitylases From Genes to Organism

(2013) Michael J. Clague et al.   PHYSIOLOGICAL REVIEWS

The SOX2-Interactome in Brain Cancer Cells Identifies the Requirement of MSI2 and USP9X for the Growth of Brain Tumor Cells

(2013) Jesse L. Cox et al.   PLoS One

Loss of Usp9x Disrupts Cortical Architecture, Hippocampal Development and TGFβ-Mediated Axonogenesis

(2013) Shane Stegeman et al.   PLoS One

Oscillatory Control of Factors Determining Multipotency and Fate in Mouse Neural Progenitors

(2013) I. Imayoshi et al.   SCIENCE

The Lysine48-Based Polyubiquitin Chain Proteasomal Signal: Not a Single Child Anymore

(2012) Yelena Kravtsova-Ivantsiv et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Ubiquitin Code

(2012) David Komander et al.   Annual Review of Biochemistry

UPS Delivers Pluripotency

(2012) Yasutaka Okita et al.   Cell Stem Cell

Regulation of Pluripotency and Cellular Reprogramming by the Ubiquitin-Proteasome System

(2012) Shannon M. Buckley et al.   Cell Stem Cell

Proteasome Inhibitors: An Expanding Army Attacking a Unique Target

(2012) Alexei F. Kisselev et al.   CHEMISTRY & BIOLOGY

Ubiquitin-specific Peptidase 9, X-linked (USP9X) Modulates Activity of Mammalian Target of Rapamycin (mTOR)

(2012) Pooja Agrawal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deubiquitinase FAM/USP9X Interacts with the E3 Ubiquitin Ligase SMURF1 Protein and Protects It from Ligase Activity-dependent Self-degradation

(2012) Yang Xie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RNF20 and USP44 Regulate Stem Cell Differentiation by Modulating H2B Monoubiquitylation

(2012) Gilad Fuchs et al.   MOLECULAR CELL

Distinct Regulatory Mechanisms and Functions for p53-Activated and p53-Repressed DNA Damage Response Genes in Embryonic Stem Cells

(2012) Mangmang Li et al.   MOLECULAR CELL

USP22 Antagonizes p53 Transcriptional Activation by Deubiquitinating Sirt1 to Suppress Cell Apoptosis and Is Required for Mouse Embryonic Development

(2012) Zhenghong Lin et al.   MOLECULAR CELL

Stromal control of cystine metabolism promotes cancer cell survival in chronic lymphocytic leukaemia

(2012) Wan Zhang et al.   NATURE CELL BIOLOGY

USP15 stabilizes TGF-β receptor I and promotes oncogenesis through the activation of TGF-β signaling in glioblastoma

(2012) Pieter J A Eichhorn et al.   NATURE MEDICINE

USP22 Is Useful as a Novel Molecular Marker for Predicting Disease Progression and Patient Prognosis of Oral Squamous Cell Carcinoma

(2012) Songlin Piao et al.   PLoS One

Post-translational modulation of pluripotency

(2012) Ning Cai et al.   Journal of Molecular Cell Biology

USP11 augments TGF  signalling by deubiquitylating ALK5

(2012) M. A. Al-Salihi et al.   Open Biology

USP22 Acts as an Oncogene by the Activation of BMI-1-Mediated INK4a/ARF Pathway and Akt Pathway

(2011) Yan-Long Liu et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

The Multifaceted Roles of USP7: New Therapeutic Opportunities

(2011) Benjamin Nicholson et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

A role of HAUSP in tumor suppression in a human colon carcinoma xenograft model

(2011) Kerstin Becker et al.   CELL CYCLE

USP22, an hSAGA subunit and potential cancer stem cell marker, reverses the polycomb-catalyzed ubiquitylation of histone H2A

(2011) Xiao-yong Zhang et al.   CELL CYCLE

Cellular strategies for making monoubiquitin signals

(2011) Harish N. Ramanathan et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

USP22 regulates cell proliferation by deubiquitinating the transcriptional regulator FBP1

(2011) Boyko S Atanassov et al.   EMBO REPORTS

Pharmacological targets in the ubiquitin system offer new ways of treating cancer, neurodegenerative disorders and infectious diseases

(2011) Mariola J. Edelmann et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Protein monoubiquitination and polyubiquitination generate structural diversity to control distinct biological processes

(2011) Martin Sadowski et al.   IUBMB LIFE

Direct conversion of mouse fibroblasts to hepatocyte-like cells by defined factors

(2011) Sayaka Sekiya et al.   NATURE

Deubiquitylase HAUSP stabilizes REST and promotes maintenance of neural progenitor cells

(2011) Zhi Huang et al.   NATURE CELL BIOLOGY

Overexpression of Ubiquitin Specific Protease 44 (USP44) Induces Chromosomal Instability and Is Frequently Observed in Human T-Cell Leukemia

(2011) Ying Zhang et al.   PLoS One

The therapeutic potential of deubiquitinating enzyme inhibitors

(2010) Frédéric Colland   BIOCHEMICAL SOCIETY TRANSACTIONS

Structural Basis for Assembly and Activation of the Heterotetrameric SAGA Histone H2B Deubiquitinase Module

(2010) Alwin Köhler et al.   CELL

USP10 Regulates p53 Localization and Stability by Deubiquitinating p53

(2010) Jian Yuan et al.   CELL

K48- and K63-linked polyubiquitination of deubiquitinating enzyme USP44

(2010) Bharathi Suresh et al.   CELL BIOLOGY INTERNATIONAL

The role of deubiquitinating enzymes in apoptosis

(2010) Suresh Ramakrishna et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

K11-Linked Polyubiquitination in Cell Cycle Control Revealed by a K11 Linkage-Specific Antibody

(2010) Marissa L. Matsumoto et al.   MOLECULAR CELL

Direct conversion of fibroblasts to functional neurons by defined factors

(2010) Thomas Vierbuchen et al.   NATURE

Regulation and Cellular Roles of Ubiquitin-Specific Deubiquitinating Enzymes

(2009) Francisca E. Reyes-Turcu et al.   Annual Review of Biochemistry

The emerging complexity of protein ubiquitination

(2009) David Komander   BIOCHEMICAL SOCIETY TRANSACTIONS

FAM/USP9x, a Deubiquitinating Enzyme Essential for TGFβ Signaling, Controls Smad4 Monoubiquitination

(2009) Sirio Dupont et al.   CELL

Role of the Murine Reprogramming Factors in the Induction of Pluripotency

(2009) Rupa Sridharan et al.   CELL

Quantitative Proteomics Reveals the Function of Unconventional Ubiquitin Chains in Proteasomal Degradation

(2009) Ping Xu et al.   CELL

USP9X Enhances the Polarity and Self-Renewal of Embryonic Stem Cell-derived Neural Progenitors

(2009) Lachlan A. Jolly et al.   MOLECULAR BIOLOGY OF THE CELL

Ubiquitin-like Sequence in ASK1 Plays Critical Roles in the Recognition and Stabilization by USP9X and Oxidative Stress-Induced Cell Death

(2009) Hiroaki Nagai et al.   MOLECULAR CELL

Linkage-Specific Avidity Defines the Lysine 63-Linked Polyubiquitin-Binding Preference of Rap80

(2009) Joshua J. Sims et al.   MOLECULAR CELL

Linking the p53 tumour suppressor pathway to somatic cell reprogramming

(2009) Teruhisa Kawamura et al.   NATURE

Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival

(2009) Martin Schwickart et al.   NATURE

Involvement of linear polyubiquitylation of NEMO in NF-κB activation

(2009) Fuminori Tokunaga et al.   NATURE CELL BIOLOGY

Breaking the chains: structure and function of the deubiquitinases

(2009) David Komander et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Control of AMPK-related kinases by USP9X and atypical Lys29/Lys33-linked polyubiquitin chains

(2008) Abdallah K. Al-Hakim et al.   BIOCHEMICAL JOURNAL

The Putative Cancer Stem Cell Marker USP22 Is a Subunit of the Human SAGA Complex Required for Activated Transcription and Cell-Cycle Progression

(2008) Xiao-Yong Zhang et al.   MOLECULAR CELL

A TFTC/STAGA Module Mediates Histone H2A and H2B Deubiquitination, Coactivates Nuclear Receptors, and Counteracts Heterochromatin Silencing

(2008) Yue Zhao et al.   MOLECULAR CELL

The deubiquitinylation and localization of PTEN are regulated by a HAUSP–PML network

(2008) Min Sup Song et al.   NATURE

Targeting ubiquitin specific proteases for drug discovery

(2007) Laurent Daviet et al.   BIOCHIMIE