USP22 Acts as an Oncogene by the Activation of BMI-1-Mediated INK4a/ARF Pathway and Akt Pathway

USP22, an hSAGA subunit and potential cancer stem cell marker, reverses the polycomb-catalyzed ubiquitylation of histone H2A

(2011) Xiao-yong Zhang et al.   CELL CYCLE

The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelial-mesenchymal transition in human nasopharyngeal epithelial cells

(2009) Li-Bing Song et al.   JOURNAL OF CLINICAL INVESTIGATION

PTEN inhibits BMI1 function independently of its phosphatase activity

(2009) Catherine Fan et al.   Molecular Cancer

“Stemness” Genomics Law Governs Clinical Behavior of Human Cancer: Implications for Decision Making in Disease Management

(2008) Gennadi V. Glinsky   JOURNAL OF CLINICAL ONCOLOGY

Dubbing SAGA Unveils New Epigenetic Crosstalk

(2008) W.W.M. Pim Pijnappel et al.   MOLECULAR CELL

The Putative Cancer Stem Cell Marker USP22 Is a Subunit of the Human SAGA Complex Required for Activated Transcription and Cell-Cycle Progression

(2008) Xiao-Yong Zhang et al.   MOLECULAR CELL

A TFTC/STAGA Module Mediates Histone H2A and H2B Deubiquitination, Coactivates Nuclear Receptors, and Counteracts Heterochromatin Silencing

(2008) Yue Zhao et al.   MOLECULAR CELL