A human monoclonal antibody 264RAD targeting αvβ6 integrin reduces tumour growth and metastasis and modulates key biomarkers in vivo

Tumor grafts derived from women with breast cancer authentically reflect tumor pathology, growth, metastasis and disease outcomes

(2011) Yoko S DeRose et al.   NATURE MEDICINE

Anti-Transforming Growth Factor   Receptor II Antibody Has Therapeutic Efficacy against Primary Tumor Growth and Metastasis through Multieffects on Cancer, Stroma, and Immune Cells

(2010) Z. Zhong et al.   CLINICAL CANCER RESEARCH

Epigenetic downregulation of human disabled homolog 2 switches TGF-β from a tumor suppressor to a tumor promoter

(2010) Adèle Hannigan et al.   JOURNAL OF CLINICAL INVESTIGATION

Psoriasin (S100A7) associates with integrin β6 subunit and is required for αvβ6-dependent carcinoma cell invasion

(2010) M R Morgan et al.   ONCOGENE

MicroRNA miR-93 promotes tumor growth and angiogenesis by targeting integrin-β8

(2010) L Fang et al.   ONCOGENE

Reduced Expression of Integrin αvβ8 Is Associated with Brain Arteriovenous Malformation Pathogenesis

(2009) Hua Su et al.   AMERICAN JOURNAL OF PATHOLOGY

Confounding Effects in "A Six-Gene Signature Predicting Breast Cancer Lung Metastasis"

(2009) A. C. Culhane et al.   CANCER RESEARCH

Mice that lack activity of  v 6- and  v 8-integrins reproduce the abnormalities of Tgfb1- and Tgfb3-null mice

(2009) P. Aluwihare et al.   JOURNAL OF CELL SCIENCE

Antibody-Mediated Blockade of Integrin  v 6 Inhibits Tumor Progression In vivo by a Transforming Growth Factor- Regulated Mechanism

(2008) L. A. Koopman Van Aarsen et al.   CANCER RESEARCH

 v 6 Integrin Promotes the Invasion of Morphoeic Basal Cell Carcinoma through Stromal Modulation

(2008) D. Marsh et al.   CANCER RESEARCH

Integrin αvβ6 is a marker of the progression of biliary and portal liver fibrosis and a novel target for antifibrotic therapies

(2008) Yury Popov et al.   JOURNAL OF HEPATOLOGY

Engineering a Single-Chain Fv Antibody to αvβ6 Integrin Using the Specificity-Determining Loop of a Foot-and-Mouth Disease Virus

(2008) Heide Kogelberg et al.   JOURNAL OF MOLECULAR BIOLOGY

TGF-β-mediated activation of RhoA signalling is required for efficient V12HaRas and V600EBRAF transformation

(2008) Y M Fleming et al.   ONCOGENE

Inhibition of Integrin αvβ6, an Activator of Latent Transforming Growth Factor-β, Prevents Radiation-induced Lung Fibrosis

(2007) Khalid Puthawala et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Partial Inhibition of Integrin αvβ6 Prevents Pulmonary Fibrosis without Exacerbating Inflammation

(2007) Gerald S. Horan et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE