The constitutive androstane receptor and pregnane X receptor in the brain

High-content analysis of constitutive androstane receptor (CAR) translocation identifies mosapride citrate as a CAR agonist that represses gluconeogenesis

(2019) Bryan Mackowiak et al.   BIOCHEMICAL PHARMACOLOGY

THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Transporters

(2019) Stephen P H Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Nuclear hormone receptors

(2019) Stephen P H Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Enzymes

(2019) Stephen P H Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

CITCO Directly Binds to and Activates Human Pregnane X Receptor

(2019) Wenwei Lin et al.   MOLECULAR PHARMACOLOGY

CINPA1 binds directly to constitutive androstane receptor and inhibits its activity

(2018) Milu T. Cherian et al.   BIOCHEMICAL PHARMACOLOGY

Activation of nuclear receptor PXR impairs glucose tolerance and dysregulates GLUT2 expression and subcellular localization in liver

(2018) Fatemeh Hassani-Nezhad-Gashti et al.   BIOCHEMICAL PHARMACOLOGY

Effect of Pregnenolone 16α-Carbonitrile on the Expression of P-Glycoprotein in the Intestine, Brain and Liver of Mice

(2018) Yuki Yamasaki et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Atrazine Triggers Mitochondrial Dysfunction and Oxidative Stress in Quail (Coturnix C. coturnix) Cerebrum via Activating Xenobiotic-Sensing Nuclear Receptors and Modulating Cytochrome P450 Systems

(2018) Jia Lin et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Pregnane X Receptor Deletion Modifies Recognition Memory and Electroencephalographic Activity

(2018) Badreddine Boussadia et al.   NEUROSCIENCE

Comparison of the effects of sodium phenobarbital in wild type and humanized constitutive androstane receptor (CAR)/pregnane X receptor (PXR) mice and in cultured mouse, rat and human hepatocytes

(2018) Corinne Haines et al.   TOXICOLOGY

Triclocarban Disrupts the Epigenetic Status of Neuronal Cells and Induces AHR/CAR-Mediated Apoptosis

(2018) M. Kajta et al.   MOLECULAR NEUROBIOLOGY

A novel nuclear xenobiotic receptors (AhR/PXR/CAR)-mediated mechanism of DEHP-induced cerebellar toxicity in quails ( Coturnix japonica ) via disrupting CYP enzyme system homeostasis

(2017) Zheng-Hai Du et al.   ENVIRONMENTAL POLLUTION

Hepatic and hippocampal cytochrome P450 enzyme overexpression during spontaneous recurrent seizures

(2017) Leonie Runtz et al.   EPILEPSIA

Overexpression of pregnane X and glucocorticoid receptors and the regulation of cytochrome P450 in human epileptic brain endothelial cells

(2017) Chaitali Ghosh et al.   EPILEPSIA

Xenobiotic Nuclear Receptors Pregnane X Receptor and Constitutive Androstane Receptor Regulate Antiretroviral Drug Efflux Transporters at the Blood-Testis Barrier

(2017) Sana-Kay Whyte-Allman et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

PXR: More Than Just a Master Xenobiotic Receptor

(2017) Peter O. Oladimeji et al.   MOLECULAR PHARMACOLOGY

The IUPHAR/BPS Guide to PHARMACOLOGY in 2018: updates and expansion to encompass the new guide to IMMUNOPHARMACOLOGY

(2017) Simon D Harding et al.   NUCLEIC ACIDS RESEARCH

SPA70 is a potent antagonist of human pregnane X receptor

(2017) Wenwei Lin et al.   Nature Communications

Mechanisms of xenobiotic receptor activation: Direct vs. indirect

(2016) Bryan Mackowiak et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Regulation of hepatic energy metabolism by the nuclear receptor PXR

(2016) Jukka Hakkola et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Visualizing the Architectures and Interactions of Nuclear Receptors

(2016) Sepideh Khorasanizadeh et al.   ENDOCRINOLOGY

Lack of CAR impacts neuronal function and cerebrovascular integrity in vivo

(2016) Baddreddine Boussadia et al.   EXPERIMENTAL NEUROLOGY

Regulation of PXR and CAR by protein-protein interaction and signaling crosstalk

(2016) Peter Oladimeji et al.   Expert Opinion on Drug Metabolism & Toxicology

RXRα, PXR and CAR xenobiotic receptors mediate the apoptotic and neurotoxic actions of nonylphenol in mouse hippocampal cells

(2016) E. Litwa et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Monocrotophos Induces the Expression of Xenobiotic Metabolizing Cytochrome P450s (CYP2C8 and CYP3A4) and Neurotoxicity in Human Brain Cells

(2016) Vinay Kumar Tripathi et al.   MOLECULAR NEUROBIOLOGY

Activation of the Constitutive Androstane Receptor induces hepatic lipogenesis and regulates Pnpla3 gene expression in a LXR-independent way

(2016) Alice Marmugi et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

PXR interaction with p53: a meeting of two masters

(2016) D Robbins et al.   Cell Death & Disease

Regulation of ABC efflux transporters at blood-brain barrier in health and neurological disorders

(2015) Hisham Qosa et al.   BRAIN RESEARCH

Targeting xenobiotic receptors PXR and CAR in human diseases

(2015) Monimoy Banerjee et al.   DRUG DISCOVERY TODAY

Statin-activated nuclear receptor PXR promotes SGK2 dephosphorylation by scaffolding PP2C to induce hepatic gluconeogenesis

(2015) Saki Gotoh et al.   Scientific Reports

Pregnane X receptor activation and silencing promote steatosis of human hepatic cells by distinct lipogenic mechanisms

(2014) Andreas Bitter et al.   ARCHIVES OF TOXICOLOGY

Symbiotic Bacterial Metabolites Regulate Gastrointestinal Barrier Function via the Xenobiotic Sensor PXR and Toll-like Receptor 4

(2014) Madhukumar Venkatesh et al.   IMMUNITY

Rifaximin: beyond the traditional antibiotic activity

(2014) Fiorella Calanni et al.   JOURNAL OF ANTIBIOTICS

Role of pregnane xenobiotic receptor in the midbrain ventral tegmental area for estradiol- and 3α,5α-THP-facilitated lordosis of female rats

(2014) C. A. Frye et al.   PSYCHOPHARMACOLOGY

Involvement of pregnane xenobiotic receptor in mating-induced allopregnanolone formation in the midbrain and hippocampus and brain-derived neurotrophic factor in the hippocampus among female rats

(2014) C. A. Frye et al.   PSYCHOPHARMACOLOGY

Novel receptor targets for production and action of allopregnanolone in the central nervous system: a focus on pregnane xenobiotic receptor

(2014) Cheryl A. Frye et al.   Frontiers in Cellular Neuroscience

Constitutive androstane receptor upregulates Abcb1 and Abcg2 at the blood–brain barrier after CITCO activation

(2013) Julia Lemmen et al.   BRAIN RESEARCH

PXR Ablation Alleviates Diet-Induced and Genetic Obesity and Insulin Resistance in Mice

(2013) J. He et al.   DIABETES

Nuclear receptors PXR and CAR: implications for drug metabolism regulation, pharmacogenomics and beyond

(2013) Xiaojuan Chai et al.   Expert Opinion on Drug Metabolism & Toxicology

The orphan nuclear receptors at their 25-year reunion

(2013) Shannon E Mullican et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

In vivoinduction of P-glycoprotein expression at the mouse blood-brain barrier: an intracerebral microdialysis study

(2013) Gary N. Y. Chan et al.   JOURNAL OF NEUROCHEMISTRY

Motivated Behaviors and Levels of 3α,5α-THP in the Midbrain Are Attenuated by Knocking Down Expression of Pregnane Xenobiotic Receptor in the Midbrain Ventral Tegmental Area of Proestrous Rats

(2013) Cheryl Anne Frye et al.   Journal of Sexual Medicine

Activation of Human Stearoyl-Coenzyme A Desaturase 1 Contributes to the Lipogenic Effect of PXR in HepG2 Cells

(2013) Jun Zhang et al.   PLoS One

Signaling by Nuclear Receptors

(2013) R. Sever et al.   Cold Spring Harbor Perspectives in Biology

Pregnane X receptor upregulates ABC-transporter Abcg2 and Abcb1 at the blood-brain barrier

(2012) Julia Lemmen et al.   BRAIN RESEARCH

PXR and NF-κB correlate with the inducing effects of IL-1β and TNF-α on ABCG2 expression in breast cancer cell lines

(2012) Obeid M. Malekshah et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Role of CAR and PXR in xenobiotic sensing and metabolism

(2012) Yue-Ming Wang et al.   Expert Opinion on Drug Metabolism & Toxicology

Expression and Inducibility of Cytochrome P450s (CYP1A1, 2B6, 2E1, 3A4) in Human Cord Blood CD34+ Stem Cell–Derived Differentiating Neuronal Cells

(2012) Abhishek K. Singh et al.   TOXICOLOGICAL SCIENCES

Characterization of human cytochrome P450 induction by pesticides

(2012) Khaled Abass et al.   TOXICOLOGY

Nuclear receptor PXR, transcriptional circuits and metabolic relevance

(2011) Chibueze A. Ihunnah et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Inhibition of NF-κB by a PXR-dependent pathway mediates counter-regulatory activities of rifaximin on innate immunity in intestinal epithelial cells

(2011) Andrea Mencarelli et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Regulation of P-glycoprotein by orphan nuclear receptors in human brain microvessel endothelial cells

(2011) Gary N. Y. Chan et al.   JOURNAL OF NEUROCHEMISTRY

Transcriptomic and Quantitative Proteomic Analysis of Transporters and Drug Metabolizing Enzymes in Freshly Isolated Human Brain Microvessels

(2011) Ramzi Shawahna et al.   MOLECULAR PHARMACEUTICS

Post-translational modification of pregnane x receptor

(2011) Jeff L. Staudinger et al.   PHARMACOLOGICAL RESEARCH

Regulation of drug-metabolizing enzymes by xenobiotic receptors: PXR and CAR

(2010) Antonia H. Tolson et al.   ADVANCED DRUG DELIVERY REVIEWS

Structural Overview of the Nuclear Receptor Superfamily: Insights into Physiology and Therapeutics

(2010) Pengxiang Huang et al.   Annual Review of Physiology

Flavonoids activate pregnane × receptor-mediated CYP3A4 gene expression by inhibiting cyclin-dependent kinases in HepG2 liver carcinoma cells

(2010) Hanqing Dong et al.   BMC BIOCHEMISTRY

Pregnane X receptor suppresses proliferation and tumourigenicity of colon cancer cells

(2010) N Ouyang et al.   BRITISH JOURNAL OF CANCER

Characterization of porcine pregnane X receptor, farnesoid X receptor and their splice variants

(2010) Matthew A Gray et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Evolution of promiscuous nuclear hormone receptors: LXR, FXR, VDR, PXR, and CAR

(2010) Matthew D. Krasowski et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Constitutive Androstane Receptor-Mediated Up-Regulation of ATP-Driven Xenobiotic Efflux Transporters at the Blood-Brain Barrier

(2010) X. Wang et al.   MOLECULAR PHARMACOLOGY

Xenobiotic, Bile Acid, and Cholesterol Transporters: Function and Regulation

(2010) C. D. Klaassen et al.   PHARMACOLOGICAL REVIEWS

Nuclear Receptor CAR Represses TNFα-Induced Cell Death by Interacting with the Anti-Apoptotic GADD45B

(2010) Yukio Yamamoto et al.   PLoS One

Genetic and Epigenetic Regulation and Expression Signatures of Glutathione S-Transferases in Developing Mouse Liver

(2010) Julia Yue Cui et al.   TOXICOLOGICAL SCIENCES

Retinoids activate RXR/CAR-mediated pathway and induce CYP3A

(2009) Shiyong Chen et al.   BIOCHEMICAL PHARMACOLOGY

Constitutive androstane receptor transcriptionally activates human CYP1A1 and CYP1A2 genes through a common regulatory element in the 5′-flanking region

(2009) Kouichi Yoshinari et al.   BIOCHEMICAL PHARMACOLOGY

Regulation of Tissue-Specific Carboxylesterase Expression by Pregnane X Receptor and Constitutive Androstane Receptor

(2009) C. Xu et al.   DRUG METABOLISM AND DISPOSITION

A novel pregnane X receptor and S14-mediated lipogenic pathway in human hepatocyte

(2009) Amélie Moreau et al.   HEPATOLOGY

The Constitutive Androstane Receptor Is an Anti-obesity Nuclear Receptor That Improves Insulin Sensitivity

(2009) Jie Gao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pregnane X Receptor (PXR) Regulates P-Glycoprotein at the Blood-Brain Barrier: Functional Similarities between Pig and Human PXR

(2009) M. Ott et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Expression and distribution of CYP3A genes, CYP2B22, and MDR1, MRP1, MRP2, LRP efflux transporters in brain of control and rifampicin-treated pigs

(2009) Annalisa Nannelli et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Activation of nuclear receptor CAR ameliorates diabetes and fatty liver disease

(2009) B. Dong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expression and inducibility of CYP1A1, 1A2, 1B1 by β-naphthoflavone and CYP2B22, 3A22, 3A29, 3A46 by rifampicin in the respiratory and olfactory mucosa of pig

(2009) A. Messina et al.   TOXICOLOGY

Effect of β-naphthoflavone on AhR-regulated genes (CYP1A1, 1A2, 1B1, 2S1, Nrf2, and GST) and antioxidant enzymes in various brain regions of pig

(2009) Annalisa Nannelli et al.   TOXICOLOGY

Characterization of the porcine constitutive androstane receptor (CAR) and its splice variants

(2009) M. A. Gray et al.   XENOBIOTICA

Dexamethasone increases expression and activity of multidrug resistance transporters at the rat blood-brain barrier

(2008) Vishal S. Narang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Expression and transcriptional regulation of ABC transporters and cytochromes P450 in hCMEC/D3 human cerebral microvascular endothelial cells

(2008) Sandrine Dauchy et al.   BIOCHEMICAL PHARMACOLOGY

Interplay between the Nuclear Receptor Pregnane X Receptor and the Uptake Transporter Organic Anion Transporter Polypeptide 1A2 Selectively Enhances Estrogen Effects in Breast Cancer

(2008) H. E. Meyer zu Schwabedissen et al.   CANCER RESEARCH

Identification of Ginkgo biloba as a Novel Activator of Pregnane X Receptor

(2008) E. Y. H. Yeung et al.   DRUG METABOLISM AND DISPOSITION

Cyclin-dependent Kinase 2 Negatively Regulates Human Pregnane X Receptor-mediatedCYP3A4Gene Expression in HepG2 Liver Carcinoma Cells

(2008) Wenwei Lin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Coordinated Nuclear Receptor Regulation of the Efflux Transporter, Mrp2, and the Phase-Ii Metabolizing Enzyme, GSTπ, at the Blood—Brain Barrier

(2008) Björn Bauer et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Induction of Hepatic Glutathione S-Transferases in Male Mice by Prototypes of Various Classes of Microsomal Enzyme Inducers

(2008) Tamara R. Knight et al.   TOXICOLOGICAL SCIENCES

Comparison of the induction profile for drug disposition proteins by typical nuclear receptor activators in human hepatic and intestinal cells

(2007) P Martin et al.   BRITISH JOURNAL OF PHARMACOLOGY

Hepatic Fatty Acid Transporter Cd36 Is a Common Target of LXR, PXR, and PPARγ in Promoting Steatosis

(2007) Jie Zhou et al.   GASTROENTEROLOGY

The Phytoestrogen Coumestrol Is a Naturally Occurring Antagonist of the Human Pregnane X Receptor

(2007) Hongwei Wang et al.   MOLECULAR ENDOCRINOLOGY