CITCO Directly Binds to and Activates Human Pregnane X Receptor

Drug discovery technologies to identify and characterize modulators of the pregnane X receptor and the constitutive androstane receptor

(2019) Sergio C. Chai et al.   DRUG DISCOVERY TODAY

Activation of Pregnane X Receptor Sensitizes Mice to Hemorrhagic Shock Induced Liver Injury

(2019) Yang Xie et al.   HEPATOLOGY

Mechanistic Insights of Phenobarbital-Mediated Activation of Human but Not Mouse Pregnane X Receptor

(2019) Linhao Li et al.   MOLECULAR PHARMACOLOGY

Indirect activation of constitutive androstane receptor in three-dimensionally cultured HepG2 cells

(2019) Kosuke Yokobori et al.   BIOCHEMICAL PHARMACOLOGY

Reverse pharmacophore mapping and molecular docking studies for discovery of GTPase HRas as promising drug target for bis-pyrimidine derivatives

(2018) Sanjiv Kumar et al.   Chemistry Central Journal

PXR: More Than Just a Master Xenobiotic Receptor

(2017) Peter O. Oladimeji et al.   MOLECULAR PHARMACOLOGY

SPA70 is a potent antagonist of human pregnane X receptor

(2017) Wenwei Lin et al.   Nature Communications

Tryptophan 299 is a conserved residue of human pregnane X receptor critical for the functional consequence of ligand binding

(2016) Monimoy Banerjee et al.   BIOCHEMICAL PHARMACOLOGY

Small-molecule modulators of PXR and CAR

(2016) Sergio C. Chai et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Regulation of PXR and CAR by protein-protein interaction and signaling crosstalk

(2016) Peter Oladimeji et al.   Expert Opinion on Drug Metabolism & Toxicology

Development of BODIPY FL Vindoline as a Novel and High-Affinity Pregnane X Receptor Fluorescent Probe

(2014) Wenwei Lin et al.   BIOCONJUGATE CHEMISTRY

Protein and ligand preparation: parameters, protocols, and influence on virtual screening enrichments

(2013) G. Madhavi Sastry et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Phenobarbital Indirectly Activates the Constitutive Active Androstane Receptor (CAR) by Inhibition of Epidermal Growth Factor Receptor Signaling

(2013) S. Mutoh et al.   Science Signaling

Piperine activates human pregnane X receptor to induce the expression of cytochrome P450 3A4 and multidrug resistance protein 1

(2013) Yue-Ming Wang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Role of CAR and PXR in xenobiotic sensing and metabolism

(2012) Yue-Ming Wang et al.   Expert Opinion on Drug Metabolism & Toxicology

The Use of HepaRG and Human Hepatocyte Data in Predicting CYP Induction Drug-Drug Interactions via Static Equation and Dynamic Mechanistic Modelling Approaches

(2011) Ken Grime et al.   CURRENT DRUG METABOLISM

Pregnane X receptor- andCYP3A4-humanized mouse models and their applications

(2010) Jie Cheng et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cyclin-dependent Kinase 2 Negatively Regulates Human Pregnane X Receptor-mediatedCYP3A4Gene Expression in HepG2 Liver Carcinoma Cells

(2008) Wenwei Lin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulatory Cross-Talk between Drug Metabolism and Lipid Homeostasis: Constitutive Androstane Receptor and Pregnane X Receptor Increase Insig-1 Expression

(2008) A. Roth et al.   MOLECULAR PHARMACOLOGY