Single Spheroid Metabolomics: Optimizing Sample Preparation of Three-Dimensional Multicellular Tumor Spheroids

MetaboAnalystR: an R package for flexible and reproducible analysis of metabolomics data

(2018) Jasmine Chong et al.   BIOINFORMATICS

13 C-labelled yeast as internal standard for LC–MS/MS and LC high resolution MS based amino acid quantification in human plasma

(2018) G. Hermann et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Challenges and emergent solutions for LC-MS/MS based untargeted metabolomics in diseases

(2018) Liang Cui et al.   MASS SPECTROMETRY REVIEWS

Guidelines and considerations for the use of system suitability and quality control samples in mass spectrometry assays applied in untargeted clinical metabolomic studies

(2018) David Broadhurst et al.   Metabolomics

Interest is high in improving quality control for clinical metabolomics: setting the path forward for community harmonization of quality control standards

(2018) Richard D. Beger   Metabolomics

3D growth of cancer cells elicits sensitivity to kinase inhibitors but not lipid metabolism modifiers.

(2018) Dylan Trefor Jones et al.   MOLECULAR CANCER THERAPEUTICS

Network integration of multi-tumour omics data suggests novel targeting strategies

(2018) Ítalo Faria do Valle et al.   Nature Communications

Endogenous and xenobiotic metabolic stability of primary human hepatocytes in long-term 3D spheroid cultures revealed by a combination of targeted and untargeted metabolomics

(2017) Sabine U. Vorrink et al.   FASEB JOURNAL

Quality assurance and quality control processes: summary of a metabolomics community questionnaire

(2017) Warwick B. Dunn et al.   Metabolomics

A subset of platinum-containing chemotherapeutic agents kills cells by inducing ribosome biogenesis stress

(2017) Peter M Bruno et al.   NATURE MEDICINE

3D tumor spheroids: an overview on the tools and techniques used for their analysis

(2016) Elisabete C. Costa et al.   BIOTECHNOLOGY ADVANCES

Differential Glutamate Metabolism in Proliferating and Quiescent Mammary Epithelial Cells

(2016) Jonathan L. Coloff et al.   Cell Metabolism

The Next Generation of Platinum Drugs: Targeted Pt(II) Agents, Nanoparticle Delivery, and Pt(IV) Prodrugs

(2016) Timothy C. Johnstone et al.   CHEMICAL REVIEWS

In vivo synthesized 34S enriched amino acid standards for species specific isotope dilution of proteins

(2016) Gerrit Hermann et al.   JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY

Anticancer metal drugs and immunogenic cell death

(2016) Alessio Terenzi et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Monitoring cancer prognosis, diagnosis and treatment efficacy using metabolomics and lipidomics

(2016) Emily G. Armitage et al.   Metabolomics

Expression of GRP78, Master Regulator of the Unfolded Protein Response, Increases Chemoresistance in Pancreatic Ductal Adenocarcinoma

(2016) J. B. Gifford et al.   MOLECULAR CANCER THERAPEUTICS

The Interplay of Reactive Oxygen Species, Hypoxia, Inflammation, and Sirtuins in Cancer Initiation and Progression

(2016) Marco Tafani et al.   Oxidative Medicine and Cellular Longevity

Spheroid cancer stem cells display reprogrammed metabolism and obtain energy by actively running the tricarboxylic acid (TCA) cycle

(2016) Masakazu Sato et al.   Oncotarget

Capturing tumor complexity in vitro: Comparative analysis of 2D and 3D tumor models for drug discovery

(2016) Kristin Stock et al.   Scientific Reports

Recommendations for the Generation, Quantification, Storage, and Handling of Peptides Used for Mass Spectrometry-Based Assays

(2015) A. N. Hoofnagle et al.   CLINICAL CHEMISTRY

Three-Dimensional Cell Culture Systems and Their Applications in Drug Discovery and Cell-Based Biosensors

(2014) Rasheena Edmondson et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Metallodrugs in Medicinal Inorganic Chemistry

(2014) Katja Dralle Mjos et al.   CHEMICAL REVIEWS

Mechanisms of cell uptake and toxicity of the anticancer drug cisplatin

(2014) Nasma D. Eljack et al.   Metallomics

Consensus guidelines for the detection of immunogenic cell death

(2014) Oliver Kepp et al.   OncoImmunology

Mammalian cell metabolomics: Experimental design and sample preparation

(2013) Zacarías León et al.   ELECTROPHORESIS

Metabolomics in cancer biomarker discovery: Current trends and future perspectives

(2013) Emily G. Armitage et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Identification of Cisplatin-Regulated Metabolic Pathways in Pluripotent Stem Cells

(2013) Louise von Stechow et al.   PLoS One

Hypoxia-Induced Reactive Oxygen Species Cause Chromosomal Abnormalities in Endothelial Cells in the Tumor Microenvironment

(2013) Miyako Kondoh et al.   PLoS One

Sulfur containing amino acids – challenge of accurate quantification

(2012) Evelyn Rampler et al.   JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY

Opportunities and challenges for use of tumor spheroids as models to test drug delivery and efficacy

(2012) Geeta Mehta et al.   JOURNAL OF CONTROLLED RELEASE

Diagnosing the decline in pharmaceutical R&D efficiency

(2012) Jack W. Scannell et al.   NATURE REVIEWS DRUG DISCOVERY

Metabolomics: the apogee of the omics trilogy

(2012) Gary J. Patti et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Oxaliplatin: a review in the era of molecularly targeted therapy

(2011) T. Alcindor et al.   Current Oncology

Consensus-Phenotype Integration of Transcriptomic and Metabolomic Data Implies a Role for Metabolism in the Chemosensitivity of Tumour Cells

(2011) Rachel Cavill et al.   PLoS Computational Biology

Metabolite extraction from adherently growing mammalian cells for metabolomics studies: optimization of harvesting and extraction protocols

(2010) Katja Dettmer et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Multicellular tumor spheroids: An underestimated tool is catching up again

(2010) Franziska Hirschhaeuser et al.   JOURNAL OF BIOTECHNOLOGY

Quantitative Evaluation of Intracellular Metabolite Extraction Techniques for Yeast Metabolomics

(2009) André B. Canelas et al.   ANALYTICAL CHEMISTRY

The mechanism of action of platinum anticancer agents—what do we really know about it?

(2009) Dan Gibson   DALTON TRANSACTIONS