Network integration of multi-tumour omics data suggests novel targeting strategies

Architecture of the human interactome defines protein communities and disease networks

(2017) Edward L. Huttlin et al.   NATURE

Proteome-Scale Human Interactomics

(2017) Katja Luck et al.   TRENDS IN BIOCHEMICAL SCIENCES

Methods for the integration of multi-omics data: mathematical aspects

(2016) Matteo Bersanelli et al.   BMC BIOINFORMATICS

Effect of AKT3 expression on MYC- and caspase-8-dependent apoptosis caused by polo-like kinase inhibitors in HCT 116 cells

(2016) Yuma Nonomiya et al.   CANCER SCIENCE

Network-based in silico drug efficacy screening

(2016) Emre Guney et al.   Nature Communications

Direct Transcriptional Consequences of Somatic Mutation in Breast Cancer

(2016) Adam Shlien et al.   Cell Reports

Efficacy of low dose temozolomide in combination with bortezomib in U87 glioma cells: a flow cytometric analysis

(2015) Panagiotis J. Vlachostergios et al.   Archives of Medical Science

Systems medicine of inflammaging

(2015) Gastone C. Castellani et al.   BRIEFINGS IN BIOINFORMATICS

The BioPlex Network: A Systematic Exploration of the Human Interactome

(2015) Edward L. Huttlin et al.   CELL

The proteasome inhibitor Bortezomib (Velcade) as potential inhibitor of estrogen receptor-positive breast cancer

(2015) Sonja Thaler et al.   INTERNATIONAL JOURNAL OF CANCER

Pathway and network analysis of cancer genomes

(2015)   NATURE METHODS

DGIdb 2.0: mining clinically relevant drug–gene interactions

(2015) Alex H. Wagner et al.   NUCLEIC ACIDS RESEARCH

Uncovering disease-disease relationships through the incomplete interactome

(2015) J. Menche et al.   SCIENCE

Mitotic centromere-associated kinesin (MCAK): a potential cancer drug target

(2015) Mourad Sanhaji et al.   Oncotarget

Chk1 Inhibition as a novel therapeutic strategy for treating triple-negative breast and ovarian cancers

(2014) Christopher Bryant et al.   BMC CANCER

Kinome-wide Functional Screen Identifies Role of PLK1 in Hormone-Independent, ER-Positive Breast Cancer

(2014) N. E. Bhola et al.   CANCER RESEARCH

A Proteome-Scale Map of the Human Interactome Network

(2014) Thomas Rolland et al.   CELL

Multiplatform Analysis of 12 Cancer Types Reveals Molecular Classification within and across Tissues of Origin

(2014) Katherine A. Hoadley et al.   CELL

The Mechanistic Links Between Proteasome Activity, Aging and Agerelated Diseases

(2014) Isabel Saez et al.   CURRENT GENOMICS

Role of the ubiquitin proteasome system in hematologic malignancies

(2014) Anagh A. Sahasrabuddhe et al.   IMMUNOLOGICAL REVIEWS

IKKβ inhibitor in combination with bortezomib induces cytotoxicity in breast cancer cells

(2014) HIROMASA HIDESHIMA et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Probabilistic Networks of Blood Metabolites in Healthy Subjects As Indicators of Latent Cardiovascular Risk

(2014) Edoardo Saccenti et al.   JOURNAL OF PROTEOME RESEARCH

Comprehensive molecular profiling of lung adenocarcinoma

(2014) Eric A. Collisson et al.   NATURE

Pan-cancer network analysis identifies combinations of rare somatic mutations across pathways and protein complexes

(2014) Mark D M Leiserson et al.   NATURE GENETICS

COSMIC: exploring the world's knowledge of somatic mutations in human cancer

(2014) Simon A. Forbes et al.   NUCLEIC ACIDS RESEARCH

Comparison of gene expression patterns across 12 tumor types identifies a cancer supercluster characterized by TP53 mutations and cell cycle defects

(2014) E Martínez et al.   ONCOGENE

Exome Sequencing Links Corticospinal Motor Neuron Disease to Common Neurodegenerative Disorders

(2014) G. Novarino et al.   SCIENCE

Inhibition of Polo-Like Kinase 1 Induces Cell Cycle Arrest and Sensitizes Glioblastoma Cells to Ionizing Radiation

(2013) Julia Alejandra Pezuk et al.   CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS

The complexity of NF-κB signaling in inflammation and cancer

(2013) Bastian Hoesel et al.   Molecular Cancer

Comprehensive molecular characterization of clear cell renal cell carcinoma

(2013)   NATURE

Integrated genomic characterization of endometrial carcinoma

(2013) Gad Getz et al.   NATURE

Mutational landscape and significance across 12 major cancer types

(2013) Cyriac Kandoth et al.   NATURE

Emerging landscape of oncogenic signatures across human cancers

(2013) Giovanni Ciriello et al.   NATURE GENETICS

The Cancer Genome Atlas Pan-Cancer analysis project

(2013) John N Weinstein et al.   NATURE GENETICS

Structure and dynamics of molecular networks: A novel paradigm of drug discovery

(2013) Peter Csermely et al.   PHARMACOLOGY & THERAPEUTICS

Pathway-based personalized analysis of cancer

(2013) Y. Drier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enhancing CHK1 inhibitor lethality in glioblastoma

(2012) Yong Tang et al.   CANCER BIOLOGY & THERAPY

The Chk1 inhibitor AZD7762 sensitises p53 mutant breast cancer cells to radiation in vitro and in vivo

(2012) ZHIKUN MA et al.   Molecular Medicine Reports

Systematic identification of genomic markers of drug sensitivity in cancer cells

(2012) Mathew J. Garnett et al.   NATURE

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

(2012) Jordi Barretina et al.   NATURE

Comprehensive molecular portraits of human breast tumours

(2012) Daniel C. Koboldt et al.   NATURE

Genomics of Drug Sensitivity in Cancer (GDSC): a resource for therapeutic biomarker discovery in cancer cells

(2012) Wanjuan Yang et al.   NUCLEIC ACIDS RESEARCH

Measures of centrality based on the spectrum of the Laplacian

(2012) Scott D. Pauls et al.   PHYSICAL REVIEW E

Polo-Like Kinase 1 Inhibition Kills Glioblastoma Multiforme Brain Tumor Cells in Part Through Loss of SOX2 and Delays Tumor Progression in Mice

(2012) Cathy Lee et al.   STEM CELLS

Proteasome-based mechanisms of intrinsic and acquired bortezomib resistance in non-small cell lung cancer

(2011) Leonie H.A.M. de Wilt et al.   BIOCHEMICAL PHARMACOLOGY

The PathOlogist: an automated tool for pathway-centric analysis

(2011) Sharon I Greenblum et al.   BMC BIOINFORMATICS

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Kinesin family member 2C (KIF2C/MCAK) is a novel marker for prognosis in human gliomas

(2011) Li Bie et al.   CLINICAL NEUROLOGY AND NEUROSURGERY

Impaired bortezomib binding to mutant β5 subunit of the proteasome is the underlying basis for bortezomib resistance in leukemia cells

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ResponseNet: revealing signaling and regulatory networks linking genetic and transcriptomic screening data

(2011) A. Lan et al.   NUCLEIC ACIDS RESEARCH

The Accuracy of Survival Time Prediction for Patients with Glioma Is Improved by Measuring Mitotic Spindle Checkpoint Gene Expression

(2011) Li Bie et al.   PLoS One

Subtype and pathway specific responses to anticancer compounds in breast cancer

(2011) L. M. Heiser et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Directed Protein Interaction Network for Investigating Intracellular Signal Transduction

(2011) A. Vinayagam et al.   Science Signaling

Most Random Gene Expression Signatures Are Significantly Associated with Breast Cancer Outcome

(2011) David Venet et al.   PLoS Computational Biology

Bortezomib-resistant myeloma cell lines: a role for mutated PSMB5 in preventing the accumulation of unfolded proteins and fatal ER stress

(2010) M Ri et al.   LEUKEMIA

An Epigenetic Switch Involving NF-κB, Lin28, Let-7 MicroRNA, and IL6 Links Inflammation to Cell Transformation

(2009) Dimitrios Iliopoulos et al.   CELL

Characterization of the ubiquitin–proteasome system in bortezomib-adapted cells

(2009) T Rückrich et al.   LEUKEMIA

Sixteen-Kinase Gene Expression Identifies Luminal Breast Cancers with Poor Prognosis

(2008) P. Finetti et al.   CANCER RESEARCH

Protein networks in disease

(2008) T. Ideker et al.   GENOME RESEARCH