A Hepatic Scaffold from Decellularized Liver Tissue: Food for Thought

The role of extracellular matrix on liver stem cell fate: A dynamic relationship in health and disease

(2019) Natalia Sánchez-Romero et al.   DIFFERENTIATION

Technological advancements for the development of stem cell-based models for hepatotoxicity testing

(2019) Alessandra Natale et al.   ARCHIVES OF TOXICOLOGY

Decellularized ECM-derived bioinks: Prospects for the future

(2019) Fatemeh Kabirian et al.   METHODS

3D Bioprinting of cardiac tissue and cardiac stem cell therapy

(2019) Matthew Alonzo et al.   Translational Research

A decade of progress in liver regenerative medicine

(2018) Jingwei Zhang et al.   BIOMATERIALS

Three-dimensional hydrogel culture conditions promote the differentiation of human induced pluripotent stem cells into hepatocytes

(2018) Ying Luo et al.   CYTOTHERAPY

Skin tissue engineering using 3D bioprinting: An evolving research field

(2018) Sam P. Tarassoli et al.   Journal of Plastic Reconstructive and Aesthetic Surgery

Decellularized human liver extracellular matrix (hDLM)-mediated hepatic differentiation of human induced pluripotent stem cells (hIPSCs)

(2018) Maria Jaramillo et al.   Journal of Tissue Engineering and Regenerative Medicine

Organ-Derived Decellularized Extracellular Matrix: A Game Changer for Bioink Manufacturing?

(2018) Deepak Choudhury et al.   TRENDS IN BIOTECHNOLOGY

Decellularized Wharton's jelly extracellular matrix as a promising scaffold for promoting hepatic differentiation of human induced pluripotent stem cells

(2018) Mousa Kehtari et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Comparative evaluation of decellularized porcine liver matrices crosslinked with different chemical and natural crosslinking agents

(2018) Mengyu Gao et al.   XENOTRANSPLANTATION

Long-term liver-specific functions of hepatocytes in electrospun chitosan nanofiber scaffolds coated with fibronectin

(2017) Divya Rajendran et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Decellularized caprine liver extracellular matrix as a 2D substrate coating and 3D hydrogel platform for vascularized liver tissue engineering

(2017) Tarun Agarwal et al.   Journal of Tissue Engineering and Regenerative Medicine

Liver transplantation for colorectal liver metastasis: Survival without recurrence can be achieved

(2017) Christian Toso et al.   LIVER TRANSPLANTATION

Sofosbuvir, Velpatasvir, and Voxilaprevir for Previously Treated HCV Infection

(2017) Marc Bourlière et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mouse decellularised liver scaffold improves human embryonic and induced pluripotent stem cells differentiation into hepatocyte-like cells

(2017) Maëlle Lorvellec et al.   PLoS One

In situ expansion of engineered human liver tissue in a mouse model of chronic liver disease

(2017) Kelly R. Stevens et al.   Science Translational Medicine

Decellularization of Whole Human Liver Grafts Using Controlled Perfusion for Transplantable Organ Bioscaffolds

(2017) Monique M.A. Verstegen et al.   STEM CELLS AND DEVELOPMENT

A Drug-Induced Hybrid Electrospun Poly-Capro-Lactone: Cell-Derived Extracellular Matrix Scaffold for Liver Tissue Engineering

(2017) Rhiannon Grant et al.   TISSUE ENGINEERING PART A

Construction of bioengineered hepatic tissue derived from human umbilical cord mesenchymal stem cells via aggregation culture in porcine decellularized liver scaffolds

(2017) Yi Li et al.   XENOTRANSPLANTATION

Three‑dimensional cell culture: A powerful tool in tumor research and drug discovery (Review)

(2017) Donglai Lv et al.   Oncology Letters

Rapid production of human liver scaffolds for functional tissue engineering by high shear stress oscillation-decellularization

(2017) Giuseppe Mazza et al.   Scientific Reports

Heparin-gelatin mixture improves vascular reconstruction efficiency and hepatic function in bioengineered livers

(2016) Kamal Hany Hussein et al.   Acta Biomaterialia

Tailoring mechanical properties of decellularized extracellular matrix bioink by vitamin B2-induced photo-crosslinking

(2016) Jinah Jang et al.   Acta Biomaterialia

Modeling Development and Disease with Organoids

(2016) Hans Clevers   CELL

Instant Blood-Mediated Inflammatory Reaction in Hepatocyte Transplantation: Current Status and Future Perspectives

(2016) Charlotte A. Lee et al.   CELL TRANSPLANTATION

Organoids from adult liver and pancreas: Stem cell biology and biomedical utility

(2016) Christopher J. Hindley et al.   DEVELOPMENTAL BIOLOGY

Bioengineered Livers: A New Tool for Drug Testing and a Promising Solution to Meet the Growing Demand for Donor Organs

(2016) Franziska Mußbach et al.   EUROPEAN SURGICAL RESEARCH

Induced pluripotent stem cell technology: a decade of progress

(2016) Yanhong Shi et al.   NATURE REVIEWS DRUG DISCOVERY

Acute-on-chronic liver failure: terminology, mechanisms and management

(2016) Shiv K. Sarin et al.   Nature Reviews Gastroenterology & Hepatology

Decellularized Liver Extracellular Matrix as Promising Tools for Transplantable Bioengineered Liver Promotes Hepatic Lineage Commitments of Induced Pluripotent Stem Cells

(2016) Kyung-Mee Park et al.   TISSUE ENGINEERING PART A

Recellularization via the bile duct supports functional allogenic and xenogenic cell growth on a decellularized rat liver scaffold

(2016) Wessam Hassanein et al.   Organogenesis

Functional Maturation of Induced Pluripotent Stem Cell Hepatocytes in Extracellular Matrix-A Comparative Analysis of Bioartificial Liver Microenvironments

(2016) Bo Wang et al.   Stem Cells Translational Medicine

Concise Review: Organoids Are a Powerful Tool for the Study of Liver Disease and Personalized Treatment Design in Humans and Animals

(2016) Sathidpak Nantasanti et al.   Stem Cells Translational Medicine

Efficient recellularisation of decellularised whole-liver grafts using biliary tree and foetal hepatocytes

(2016) Satoshi Ogiso et al.   Scientific Reports

Decellularization and Recellularization of Rat Livers With Hepatocytes and Endothelial Progenitor Cells

(2015) Pengcheng Zhou et al.   ARTIFICIAL ORGANS

Bioengineered transplantable porcine livers with re-endothelialized vasculature

(2015) In Kap Ko et al.   BIOMATERIALS

Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver

(2015) Meritxell Huch et al.   CELL

Modeling mouse and human development using organoid cultures

(2015) M. Huch et al.   DEVELOPMENT

Degradable hydrogels derived from PEG-diacrylamide for hepatic tissue engineering

(2015) Kelly R. Stevens et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Injectable shear-thinning hydrogels used to deliver endothelial progenitor cells, enhance cell engraftment, and improve ischemic myocardium

(2015) Ann C. Gaffey et al.   JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY

Pivotal role of liver sinusoidal endothelial cells in NAFLD/NASH progression

(2015) Masashi Miyao et al.   LABORATORY INVESTIGATION

Micropatterned coculture of primary human hepatocytes and supportive cells for the study of hepatotropic pathogens

(2015) Sandra March et al.   Nature Protocols

Recellularization of Rat Liver Scaffolds by Human Liver Stem Cells

(2015) Victor Navarro-Tableros et al.   TISSUE ENGINEERING PART A

Porcine Liver Decellularization Under Oscillating Pressure Conditions: A Technical Refinement to Improve the Homogeneity of the Decellularization Process

(2015) Benjamin Struecker et al.   TISSUE ENGINEERING PART C-METHODS

Decellularized human liver as a natural 3D-scaffold for liver bioengineering and transplantation

(2015) Giuseppe Mazza et al.   Scientific Reports

Hemocompatibility improvement of perfusion-decellularized clinical-scale liver scaffold through heparin immobilization

(2015) Ji Bao et al.   Scientific Reports

Current achievements and future perspectives in whole-organ bioengineering

(2015) Andrea Peloso et al.   Stem Cell Research & Therapy

Three-Dimensional Printing of the Skin

(2015) Haitham Algzlan et al.   JAMA Dermatology

Cryo-chemical decellularization of the whole liver for mesenchymal stem cells-based functional hepatic tissue engineering

(2014) Wei-Cheng Jiang et al.   BIOMATERIALS

Decellularized scaffolds as a platform for bioengineered organs

(2014) Luis F. Tapias et al.   Current Opinion in Organ Transplantation

Improved rat liver decellularization by arterial perfusion under oscillating pressure conditions

(2014) Benjamin Struecker et al.   Journal of Tissue Engineering and Regenerative Medicine

Stem cells with decellularized liver scaffolds in liver regeneration and their potential clinical applications

(2014) Qian Zhou et al.   LIVER INTERNATIONAL

Microfluidic organs-on-chips

(2014) Sangeeta N Bhatia et al.   NATURE BIOTECHNOLOGY

Liver regeneration

(2014) Shennen A. Mao et al.   Translational Research

Mesenchymal stem cells support hepatocyte function in engineered liver grafts

(2014) Yoshie Kadota et al.   Organogenesis

The effect of detergents on the basement membrane complex of a biologic scaffold material

(2013) D.M. Faulk et al.   Acta Biomaterialia

Immunogenicity of Decellularized Porcine Liver for Bioengineered Hepatic Tissue

(2013) Sayed-Hadi Mirmalek-Sani et al.   AMERICAN JOURNAL OF PATHOLOGY

Organ Bioengineering and Regeneration as the New Holy Grail for Organ Transplantation

(2013) Giuseppe Orlando et al.   ANNALS OF SURGERY

Decellularization for whole organ bioengineering

(2013) J E Arenas-Herrera et al.   Biomedical Materials

Sisyphus, the Giffen's paradox and the Holy Grail: time for organ transplantation to transition toward a regenerative medicine-focused type of research

(2013) Andrea Peloso et al.   Expert Review of Clinical Immunology

Decellularized liver scaffolds effectively support the proliferation and differentiation of mouse fetal hepatic progenitors

(2013) Xiaojun Wang et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Differentiation of progenitors in the liver: a matter of local choice

(2013) Luke Boulter et al.   JOURNAL OF CLINICAL INVESTIGATION

Vascularized and functional human liver from an iPSC-derived organ bud transplant

(2013) Takanori Takebe et al.   NATURE

Role of the extracellular matrix in regulating stem cell fate

(2013) Fiona M. Watt et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Spheroid Culture for Enhanced Differentiation of Human Embryonic Stem Cells to Hepatocyte-Like Cells

(2013) Kartik Subramanian et al.   STEM CELLS AND DEVELOPMENT

Thinking outside the liver: Induced pluripotent stem cells for hepatic applications

(2013) Mekala Subba Rao   WORLD JOURNAL OF GASTROENTEROLOGY

Biofabrication and testing of a fully cellular nerve graft

(2013) Christopher M Owens et al.   Biofabrication

The differentiation of MSCs into functional hepatocyte-like cells in a liver biomatrix scaffold and their transplantation into liver-fibrotic mice

(2012) Ru Ji et al.   BIOMATERIALS

3D spheroid culture of hESC/hiPSC-derived hepatocyte-like cells for drug toxicity testing

(2012) Kazuo Takayama et al.   BIOMATERIALS

Scale-dependent mechanical properties of native and decellularized liver tissue

(2012) Douglas W. Evans et al.   Biomechanics and Modeling in Mechanobiology

Human-Scale Whole-Organ Bioengineering for Liver Transplantation: A Regenerative Medicine Approach

(2012) Hiroshi Yagi et al.   CELL TRANSPLANTATION

Clinical applications of mesenchymal stem cells

(2012) Shihua Wang et al.   Journal of Hematology & Oncology

Evaluation of two decellularization methods in the development of a whole-organ decellularized rat liver scaffold

(2012) Haozhen Ren et al.   LIVER INTERNATIONAL

Rotating Microgravity-Bioreactor Cultivation Enhances the Hepatic Differentiation of Mouse Embryonic Stem Cells on Biodegradable Polymer Scaffolds

(2012) Yingjie Wang et al.   TISSUE ENGINEERING PART A

Application of Three-Dimensional Culture Conditions to Human Embryonic Stem Cell-Derived Definitive Endoderm Cells Enhances Hepatocyte Differentiation and Functionality

(2012) Thamil Selvee Ramasamy et al.   TISSUE ENGINEERING PART A

Three-dimensional culture of hepatocytes on porcine liver tissue-derived extracellular matrix

(2011) Ren Lang et al.   BIOMATERIALS

An overview of tissue and whole organ decellularization processes

(2011) Peter M. Crapo et al.   BIOMATERIALS

Modeling and therapy of human liver diseases using induced pluripotent stem cells: How far have we come?

(2011) Alejandro Soto-Gutierrez et al.   HEPATOLOGY

Efficient generation of functional hepatocyte-like cells from human fetal hepatic progenitor cells in vitro

(2011) Weitao Zhang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Use of Decellularized Porcine Liver for Engineering Humanized Liver Organ

(2011) Omar Barakat et al.   JOURNAL OF SURGICAL RESEARCH

Decellularized liver matrix as a carrier for the transplantation of human fetal and primary hepatocytes in mice

(2011) Ping Zhou et al.   LIVER TRANSPLANTATION

Humanized mice with ectopic artificial liver tissues

(2011) A. A. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Whole-Organ Regenerative Medicine Approach for Liver Replacement

(2011) Alejandro Soto-Gutierrez et al.   TISSUE ENGINEERING PART C-METHODS

From 3D cell culture to organs-on-chips

(2011) Dongeun Huh et al.   TRENDS IN CELL BIOLOGY

Method for the decellularization of intact rat liver

(2011) Thomas Shupe et al.   Organogenesis

Construction of a Portal Implantable Functional Tissue-Engineered Liver Using Perfusion-Decellularized Matrix and Hepatocytes in Rats

(2010) Ji Bao et al.   CELL TRANSPLANTATION

In Vitro Differentiated Adult Human Liver Progenitor Cells Display Mature Hepatic Metabolic Functions: A Potential Tool for in Vitro Pharmacotoxicological Testing

(2010) Dung Ngoc Khuu et al.   CELL TRANSPLANTATION

The generation of hepatocytes from mesenchymal stem cells and engraftment into the liver

(2010) Bruno Christ et al.   Current Opinion in Organ Transplantation

Lineage restriction of human hepatic stem cells to mature fates is made efficient by tissue-specific biomatrix scaffolds

(2010) Yunfang Wang et al.   HEPATOLOGY

The use of whole organ decellularization for the generation of a vascularized liver organoid

(2010) Pedro M. Baptista et al.   HEPATOLOGY

Acute liver failure

(2010) William Bernal et al.   LANCET

Primary human hepatocytes on biodegradable poly(l-lactic acid) matrices: A promising model for improving transplantation efficiency with tissue engineering

(2010) Eva Török et al.   LIVER TRANSPLANTATION

Nuclear reprogramming to a pluripotent state by three approaches

(2010) Shinya Yamanaka et al.   NATURE

Organ reengineering through development of a transplantable recellularized liver graft using decellularized liver matrix

(2010) Basak E Uygun et al.   NATURE MEDICINE

A nonviral minicircle vector for deriving human iPS cells

(2010) Fangjun Jia et al.   NATURE METHODS

Human hepatocyte transplantation: current experience and future challenges

(2010) Anil Dhawan et al.   Nature Reviews Gastroenterology & Hepatology

3D PLGA Scaffolds Improve Differentiation and Function of Bone Marrow Mesenchymal Stem Cell–Derived Hepatocytes

(2010) Jun Li et al.   STEM CELLS AND DEVELOPMENT

Mesenchymal stem cell-based therapy: a new paradigm in regenerative medicine

(2009) Neeraj Kumar Satija et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Human hepatocyte transplantation: state of the art

(2009) E. Fitzpatrick et al.   JOURNAL OF INTERNAL MEDICINE

The Extracellular Matrix: Not Just Pretty Fibrils

(2009) R. O. Hynes   SCIENCE

Stem and progenitor cells for liver repopulation: can we standardise the process from bench to bedside?

(2008) P Sancho-Bru et al.   GUT

Perfusion-decellularized matrix: using nature's platform to engineer a bioartificial heart

(2008) Harald C Ott et al.   NATURE MEDICINE

A brief definition of regenerative medicine

(2007) Chris Mason et al.   Regenerative Medicine