Review
Biochemistry & Molecular Biology
Xipo Zhao, Jinchao Liu, Juncheng Li, Xinyu Liang, Weiyi Zhou, Shaoxian Peng
Summary: This paper summarizes the structural factors affecting the heat resistance of PLA and systematically summarizes methods to improve its heat resistance. It discusses the crystallization behavior of PLA and the effects of nucleating agents, cross-linking, grafting, and annealing processes on its heat resistance. The research on combining PLA with reinforcements to improve its mechanical properties and heat resistance is also described. Improving the heat resistance of PLA is crucial for promoting the application of biodegradable materials.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Polymer Science
Luana C. Llanes, Samuel H. Clasen, Alfredo T. N. Pires, Idejan P. Gross
Summary: This study evaluated the plasticizing effect of dibutyl maleate and dibutyl fumarate on poly(lactic acid), showing that specimens plasticized with dibutyl fumarate exhibited lower glass transition temperature, lower Young's modulus, and higher elongation at break compared to those plasticized with dibutyl maleate.
EUROPEAN POLYMER JOURNAL
(2021)
Article
Polymer Science
B. Hermenegildo, R. M. Meira, D. M. Correia, A. G. Diez, S. Ribeiro, C. Ribeiro, L. Perez-Alvarez, J. L. Vilas-Vilela, S. Lanceros-Mendez
Summary: Polymer scaffolds are widely used in tissue engineering, but their biomimicry needs improvement for better tissue regeneration. This study combines poly(lactic-co-glycolide) with an ionic liquid or iron oxide nanoparticles to create biodegradable scaffolds with electroactive or magnetoactive response. The inclusion of the ionic liquid or nanoparticles alters the mechanical properties and surface morphology of the polymer, and the biocompatibility of the materials depends on the type and content of the fillers.
EUROPEAN POLYMER JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Georg Lutter, Thomas Puehler, Lukas Cyganek, Jette Seiler, Anita Rogler, Tanja Herberth, Philipp Knueppel, Stanislav N. Gorb, Janarthanan Sathananthan, Stephanie Sellers, Oliver J. Mueller, Derk Frank, Irma Haben
Summary: In this study, biodegradable PCL nanofiber scaffolds were used as a matrix for the generation of tissue-engineered heart valves with human ECFCs and iMSCs. Results showed good cell adhesion and distribution on PCL fibers, with coated fibers increasing cell numbers only at early stages. Mechanical properties of seeded PCL scaffolds were comparable to native heart valves, indicating successful tissue engineering of heart valves with human cells on a biodegradable scaffold.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Environmental
Rahele Mahtabi, Soheila Zamanlui Benisi, Vahabodin Goodarzi, Shahrokh Shojaei
Summary: A novel nanocomposites based on Polylactic acid (PLA) and Poly(glycerol succinic acid) (PGSU) containing hydroxyapatite nanoparticles was prepared. Various analyses were conducted to evaluate the molecular structures, possible interactions, crystallinity, microstructure, nanoparticle dispersion, thermal stability, mechanical properties, hydrophobicity, cell behavior, and gene expressions of the samples. The results showed that PGSU and n-HA had significant effects on the properties and behavior of the nanocomposites, indicating their potential for various applications in tissue engineering.
JOURNAL OF POLYMERS AND THE ENVIRONMENT
(2023)
Article
Biochemistry & Molecular Biology
Muhammad Sohail Sarwar, Abdul Ghaffar, Qingrong Huang, Meraj Khalid, Aneela Anwar, Abdulfatah M. Alayoubi, Muhammad Latif
Summary: Blending natural polysaccharides with synthetic polymers to create composite films for drug delivery systems has received much attention due to their biodegradability and biocompatibility. This study focuses on the easy preparation of Starch/Poly(allylamine hydrochloride) (ST/PAH) blend films and their potential as a sustained-release DDS for various biomedical applications. The films exhibited intermolecular H-bonding and hydrophobic characteristics.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Polymer Science
Shuo Chen, Yihan Wang, Lei Yang, Chengzhen Chu, Shichun Cao, Zhao Wang, Jiajia Xue, Zhengwei You
Summary: In this review, the recent progress in synthesis, process technologies, and biomedical applications of biodegradable elastomers is summarized. The emphasis is on the molecular design and processing strategies of biodegradable polyesters and polyurethanes, as well as the newly developed functionalities in biomedical applications. Future research directions, challenges, and potential solutions are discussed.
PROGRESS IN POLYMER SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Rong Wang, Xiaojie Sun, Lanlan Chen, Wenbin Liang
Summary: In this study, biodegradable blends of PGA and PBAT with in situ compatibilization using MDI were prepared. The addition of PBAT was found to increase the complex viscosity and storage modulus of the blends, leading to improved compatibility and impact strength. The morphology of the dispersed phase evolved from spherical structure to in situ microfiber, enhancing interfacial adhesion and improving toughness.
Review
Biochemical Research Methods
Samanta Castaneda-Rodriguez, Maykel Gonzalez-Torres, Rosa Maria Ribas-Aparicio, Maria Luisa Del Prado-Audelo, Gerardo Leyva-Gomez, Eda Soenmez Gurer, Javad Sharifi-Rad
Summary: Tissue engineering and regenerative medicine aim to develop materials that can replace, restore, or enhance organs or tissues, and improve cellular capacity for proliferation, migration, and differentiation. Renewable resources have been utilized to produce environmentally friendly biomaterials, including the biodegradable polymer poly(lactic acid) (PLA). In combination with other polymers, PLA can be modified to create biomaterials with suitable properties for tissue engineering applications. This review focuses on the advancements in modified PLA as tissue engineering materials, highlighting efforts to overcome limitations such as biological inertness, low cell adhesion, and slow degradation rate, and develop enhanced alternative biomaterials.
JOURNAL OF BIOLOGICAL ENGINEERING
(2023)
Review
Polymer Science
Maria Laura Di Lorenzo
Summary: PLLA and PBS are biodegradable, compostable, and biocompatible polymers that have complementary properties, making blending them an opportunity to exploit their favorable characteristics. However, research on the properties of PLLA/PBS blends has yielded contradictory results, creating complexity in their utilization.
Article
Polymer Science
Yulia Victorovna Tertyshnaya, Maria Victorovna Podzorova, Ivetta Aramovna Varyan, Victor Victorovich Tcherdyntsev, Mikhail Yurievich Zadorozhnyy, Elena Valerievna Medvedeva
Summary: Electrospun fabrics were used as substrates for the growth of winter wheat seeds, and their effects on seed germination and plant growth were studied. The structure and properties of nonwoven agromaterials were controlled and analyzed using differential scanning calorimetry, IR-spectroscopy, and optical microscopy.
Article
Materials Science, Multidisciplinary
Gutian Zhao, Xin Li, Yuan Tian, Gensheng Wu, Yi Zhang, Wei Jiang, Juekuan Yang, Zhonghua Ni
Summary: This study investigates the use of PLLA monofilaments for braided carotid stents, characterizing the properties of the monofilaments and demonstrating that the braided PLLA stents have good mechanical properties and can provide adequate support.
JOURNAL OF MATERIALS SCIENCE
(2021)
Article
Nanoscience & Nanotechnology
Lv Ke, Ting Yang, Chenyu Liang, Xin Guan, Tian Li, Yang Jiao, Daoyuan Tang, Donghui Huang, Shihang Li, Shenghui Zhang, Xinjian He, Huan Xu
Summary: In this study, electroactive and antibacterial poly(lactic acid) nanofibrous membranes (NFMs) were fabricated using a facile method. Microwave-assisted doping was employed to produce zinc-doped titanium dioxide nanoparticles, which greatly improved the properties of the PLA nanofibers. The composite NFMs showed enhanced filtration performance and antibacterial activity compared to pure PLA, making them promising for healthcare applications.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Engineering, Environmental
Matias Menossi, Florencia Salcedo, Nazarena Rivilli, Andres Torres Nicolini, Vera A. Alvarez, Leandro N. Luduena
Summary: Novel formulations based on corn starch, thermoplastic starch, poly (lactic acid), and poly (epsilon-caprolactone) were developed for agricultural mulch films. The addition of poly (epsilon-caprolactone) had slight effects on the properties of PLA/CS and PLA/TPS blends. Bioassays showed that the use of these biodegradable mulch films based on PLA/CS and PLA/TPS had positive effects on the growth of tomato plants, comparable to low-density polyethylene.
JOURNAL OF POLYMERS AND THE ENVIRONMENT
(2023)
Article
Biochemistry & Molecular Biology
Lokesh Agrawal, Sunil Kumar Vimal, Paolo Barzaghi, Takashi Shiga, Marco Terenzio
Summary: A biomaterial formulation consisting of melanin and PHB has been developed, which exhibits physio-chemical, electrical, and biological compatibility with neural tissues. The blended scaffolds improve cell adhesion and growth of motor and sensory neurons, making it a potential regenerative modality for neural tissue injuries.
MACROMOLECULAR BIOSCIENCE
(2022)
Article
Oncology
Sebastian Burbano De Lara, Doan Duy Hai Tran, Aldrige Bernardus Allister, Mareike Polenkowski, Bjoern Nashan, Martina Koch, Teruko Tamura
Summary: This study identifies C20orf204-189AA as a cancer type-specific fine tuner in HCC, enhancing cell proliferation and ribosomal RNA transcription, and interacting with ribosomal RNA and nucleolin. The expression of C20orf204-189AA correlates with tumor differentiation grade and patient survival in HCC.
Article
Gastroenterology & Hepatology
Bjorn Nashan, Peter Schemmer, Felix Braun, Hans J. Schlitt, Andreas Pascher, Christian G. Klein, Ulf P. Neumann, Irena Kroeger, Peter Wimmer
Summary: The study demonstrated that the use of everolimus in combination with rTAC after liver transplantation may be more advantageous for renal function preservation compared to standard therapy with sTAC. While no significant difference was observed in the full analysis set, renal function was significantly enhanced in the compliance set.
LIVER TRANSPLANTATION
(2022)
Article
Immunology
Zebin Zhu, Yang Liu, Wei Wu, Dehao Huang, Yafei Guo, Hao Zheng, Ning Wang, Zhijun Xu, Xuefeng Li, Jiwei Qin, Lianxin Liu, Bjorn Nashan
Summary: Severe neurologic complications greatly affect the quality of life of patients with chronic liver disease. Hepatic myelopathy is a rare but devastating disease, characterized by progressive symmetrical spastic paralysis in the limbs. Timely and effective clinical intervention is required for the management of this severe neurologic complication, although liver transplantation is an effective treatment, the prognosis remains poor.
TRANSPLANTATION PROCEEDINGS
(2022)
Article
Multidisciplinary Sciences
Haibo Wu, Peiqi He, Yong Ren, Shiqi Xiao, Wei Wang, Zhenbang Liu, Heng Li, Zhe Wang, Dingyu Zhang, Jun Cai, Xiangdong Zhou, Dongpo Jiang, Xiaochun Fei, Lei Zhao, Heng Zhang, Zhenhua Liu, Rong Chen, Weiqing Li, Chaofu Wang, Shuyang Zhang, Jiwei Qin, Bjorn Nashan, Cheng Sun
Summary: In this study, comprehensive transcriptional and histological analyses were performed on deceased severe COVID-19 patients. The researchers found correlations between the presence of viral antigens and lymphocyte suppression yet myeloid activation, suggesting distinct functions of these cells during pathogenesis. These findings provide valuable insights for understanding the etiology of COVID-19 and developing targeted therapies.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Xinhao Hou, Chengming Zhu, Mingjing Xu, Xiangyang Chen, Cheng Sun, Bjorn Nashan, Shouhong Guang, Xuezhu Feng
Summary: Starvation enhances trans-splicing of translation-related genes in adult C. elegans by promoting SL1 trans-splicing through the action of SNAPc and TOFU-5. Knocking down these factors extends worm survival under starvation conditions, indicating the importance of SL trans-splicing in nutritional response and survival regulation.
JOURNAL OF GENETICS AND GENOMICS
(2022)
Article
Oncology
Min Li, Tianjiao Zhang, Jing Zhu, Yuebo Li, Wenying Chen, Yanhu Xie, Wei Zhang, Rongzhu Chen, Wei Wei, Guihong Wang, Jiwei Qin, Weidong Zhao, Dabao Wu, Zhen Shen, Bjorn Nashan, Ying Zhou
Summary: The present study evaluated postoperative complications and the impact of an enhanced recovery programme in patients with epithelial ovarian carcinoma. The study found that applying an enhanced recovery programme is feasible in patients undergoing extensive upper abdominal surgery, and certain clinical factors are associated with adverse postoperative outcomes.
Article
Oncology
Mohamed Moustafa, Katarzyna-Krystyna Daehling, Armin Guenther, Leonie Riebandt, Daniel J. Smit, Kristoffer Riecken, Carina Schroeder, Ruimeng Zhuang, Till Krech, Malte Kriegs, Boris Fehse, Jakob R. Izbicki, Lutz Fischer, Bjorn Nashan, Jun Li, Manfred Juecker
Summary: This study verifies the impact of targeting CD90 and EpCAM markers in HCC cells with a combination therapy of AKT and mTOR inhibitors. The results demonstrate that combined targeting of AKT and mTOR effectively reduces the proliferation of CD90 and EpCAM positive HCC cells in vitro, but resistance to the treatment occurs in vivo.
Article
Oncology
Huan Liu, Ronghua Zhao, Rongrong Qin, Haoyu Sun, Qiang Huang, Lianxin Liu, Zhigang Tian, Bjorn Nashan, Cheng Sun, Rui Sun
Summary: This study revealed specific subsets of NK cells in healthy human liver tissues, but only some subsets were present in HCC and peritumor tissues. Cytotoxic NK cell subsets were absent in HCC tissues. The study also identified potential non-invasive prognostic biomarkers in patients with HCC.
CANCER BIOLOGY & MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Wanqing Hou, Bernard Nsengimana, Chuyun Yan, Bjorn Nashan, Shuxin Han
Summary: This article reviews the functional characteristics of endoplasmic reticulum stress and its potentially pathogenic role in liver injury caused by rifampicin.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Yong-Shuai Wang, Wei Wang, Sai Zhang, Shen-Yu Zhang, Ai-Zong Shen, Hua-Chuan Song, Huan-Zhang Yao, Rui-Peng Song, Fan-Zheng Meng, Lei Li, Bjoern Nashan, Ji-Zhou Wang, Lian-Xin Liu
Summary: This study compared the clinical efficacy of avatrombopag and rh-TPO in the treatment of severe TCP associated with CLD. The results showed that avatrombopag demonstrated better clinical efficacy and fewer side effects, particularly in patients with Child-Pugh Class A.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Gastroenterology & Hepatology
Rongrong Qin, Jiwei Qin, Xuefeng Li, Zhijun Xu, Peiqi He, Xiaodong Yuan, Cheng Sun, Bjoern Nashan
Summary: This study analyzed the number and phenotypes of NK cells in liver transplant recipients and simulated the immunosuppressive microenvironment in vitro. It found that cyclosporine A, sirolimus/everolimus, and tacrolimus significantly impaired NK cell cytolytic activity and cytokine secretion. The MMF-containing regimen increased the expression of suppressive genes, while mTOR inhibitors had less impact on NK cell function.
HEPATOBILIARY SURGERY AND NUTRITION
(2023)
Meeting Abstract
Immunology
Rongrong Qin, Cheng Sun, Bjorn Nashan
Meeting Abstract
Immunology
M. B. Krueger, A. Bonifacius, P. Mausberg, R. Taubert, B. Nashan, B. Maecker-Kolhoff, R. Blasczyk, B. Eiz-Vesper
EUROPEAN JOURNAL OF IMMUNOLOGY
(2022)
Meeting Abstract
Surgery
R. R. Qin, C. Sun, B. Nashan
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Meeting Abstract
Surgery
R. Qin, J. Qin, C. Sun, B. Nashan
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)