Biophysical Control of Bile Duct Epithelial Morphogenesis in Natural and Synthetic Scaffolds

Pathobiology of biliary epithelia

(2018) Angela C. Cheung et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Determinants of fibrosis progression and regression in NASH

(2018) Detlef Schuppan et al.   JOURNAL OF HEPATOLOGY

Efficient functional cyst formation of biliary epithelial cells using microwells for potential bile duct organisation in vitro

(2018) Astia Rizki-Safitri et al.   Scientific Reports

Growth of Epithelial Organoids in a Defined Hydrogel

(2018) Nicolas Broguiere et al.   ADVANCED MATERIALS

Development and characterization of cholangioids from normal and diseased human cholangiocytes as an in vitro model to study primary sclerosing cholangitis

(2017) Lorena Loarca et al.   LABORATORY INVESTIGATION

Regenerative Medicine and the Biliary Tree

(2017) Thiago De Assuncao et al.   SEMINARS IN LIVER DISEASE

Laminin 411 and 511 promote the cholangiocyte differentiation of human induced pluripotent stem cells

(2016) Kazuo Takayama et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Substrate stiffness and matrix composition coordinately control the differentiation of liver progenitor cells

(2016) Andreas P. Kourouklis et al.   BIOMATERIALS

Designer matrices for intestinal stem cell and organoid culture

(2016) Nikolce Gjorevski et al.   NATURE

Culture and establishment of self-renewing human and mouse adult liver and pancreas 3D organoids and their genetic manipulation

(2016) Laura Broutier et al.   Nature Protocols

Neural tube morphogenesis in synthetic 3D microenvironments

(2016) Adrian Ranga et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Cues Guiding Matrix Stiffness in Liver Fibrosis

(2016) Takaoki Saneyasu et al.   Biomed Research International

Epithelial polarity – Generating and integrating signals from the ECM with integrins

(2015) Aki Manninen   EXPERIMENTAL CELL RESEARCH

Synthetic matrices reveal contributions of ECM biophysical and biochemical properties to epithelial morphogenesis

(2015) Nduka O. Enemchukwu et al.   JOURNAL OF CELL BIOLOGY

Development and characterization of human-induced pluripotent stem cell-derived cholangiocytes

(2015) Thiago M De Assuncao et al.   LABORATORY INVESTIGATION

Directed differentiation of cholangiocytes from human pluripotent stem cells

(2015) Mina Ogawa et al.   NATURE BIOTECHNOLOGY

Cholangiocytes derived from human induced pluripotent stem cells for disease modeling and drug validation

(2015) Fotios Sampaziotis et al.   NATURE BIOTECHNOLOGY

Small airway-on-a-chip enables analysis of human lung inflammation and drug responses in vitro

(2015) Kambez H Benam et al.   NATURE METHODS

CPM Is a Useful Cell Surface Marker to Isolate Expandable Bi-Potential Liver Progenitor Cells Derived from Human iPS Cells

(2015) Taketomo Kido et al.   Stem Cell Reports

Generation of functional cholangiocyte-like cells from human pluripotent stem cells and HepaRG cells

(2014) Noushin Dianat et al.   HEPATOLOGY

Generation of a vascularized and functional human liver from an iPSC-derived organ bud transplant

(2014) Takanori Takebe et al.   Nature Protocols

3D niche microarrays for systems-level analyses of cell fate

(2014) A. Ranga et al.   Nature Communications

The influence of matrix properties on growth and morphogenesis of human pancreatic ductal epithelial cells in 3D

(2013) Asad Raza et al.   BIOMATERIALS

In situ cell manipulation through enzymatic hydrogel photopatterning

(2013) Katarzyna A. Mosiewicz et al.   NATURE MATERIALS

Microfabrication of human organs-on-chips

(2013) Dongeun Huh et al.   Nature Protocols

A Synthetic Matrix with Independently Tunable Biochemistry and Mechanical Properties to Study Epithelial Morphogenesis and EMT in a Lung Adenocarcinoma Model

(2012) B. J. Gill et al.   CANCER RESEARCH

Epithelial organization and cyst lumen expansion require efficient Sec13-Sec31-driven secretion

(2012) A. K. Townley et al.   JOURNAL OF CELL SCIENCE

Pak1 Regulates the Orientation of Apical Polarization and Lumen Formation by Distinct Pathways

(2012) Orlando deLeon et al.   PLoS One

Artificial niche microarrays for probing single stem cell fate in high throughput

(2011) Samy Gobaa et al.   NATURE METHODS

An algorithm-based topographical biomaterials library to instruct cell fate

(2011) H. V. Unadkat et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enhanced proteolytic degradation of molecularly engineered PEG hydrogels in response to MMP-1 and MMP-2

(2010) J. Patterson et al.   BIOMATERIALS

Biliary differentiation and bile duct morphogenesis in development and disease

(2009) Peggy Raynaud et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Ductular Network Formation by Rat Biliary Epithelial Cells in the Dynamical Culture with Collagen Gel and Dimethylsulfoxide Stimulation

(2008) Wataru Hashimoto et al.   AMERICAN JOURNAL OF PATHOLOGY

Cell-Polarity Dynamics Controls the Mechanism of Lumen Formation in Epithelial Morphogenesis

(2008) Fernando Martín-Belmonte et al.   CURRENT BIOLOGY

The role of matrix stiffness in regulating cell behavior

(2008) Rebecca G. Wells   HEPATOLOGY

Depletion of apical transport proteins perturbs epithelial cyst formation and ciliogenesis

(2008) J. M. Torkko et al.   JOURNAL OF CELL SCIENCE