Combination of Ruthenium Complex and Doxorubicin Synergistically Inhibits Cancer Cell Growth by Down-Regulating PI3K/AKT Signaling Pathway

Dinuclear Organoruthenium Complexes Exhibiting Antiproliferative Activity through DNA Damage and a Reactive-Oxygen-Species-Mediated Endoplasmic Reticulum Stress Pathway

(2019) Jian Zhao et al.   INORGANIC CHEMISTRY

A Ru II Polypyridyl Alkyne Complex Based Metal–Organic Frameworks for Combined Photodynamic/Photothermal/Chemotherapy

(2019) Xiaochun Hu et al.   CHEMISTRY-A EUROPEAN JOURNAL

Cancer-Targeting Functionalization of Selenium-Containing Ruthenium Conjugate with Tumor Microenvironment-Responsive Property to Enhance Theranostic Effects

(2018) Zhennan Zhao et al.   CHEMISTRY-A EUROPEAN JOURNAL

Ru(II) Compounds: Next-Generation Anticancer Metallotherapeutics?

(2018) Sreekanth Thota et al.   JOURNAL OF MEDICINAL CHEMISTRY

P53 enhances apoptosis induced by doxorubicin only under conditions of severe DNA damage

(2018) Ru-Wei Lin et al.   CELL CYCLE

Transition Metal Complexes and Photodynamic Therapy from a Tumor-Centered Approach: Challenges, Opportunities, and Highlights from the Development of TLD1433

(2018) Susan Monro et al.   CHEMICAL REVIEWS

Stimuli-Responsive Therapeutic Metallodrugs

(2018) Xiaohui Wang et al.   CHEMICAL REVIEWS

Designing luminescent ruthenium prodrug for precise cancer therapy and rapid clinical diagnosis

(2018) Zhennan Zhao et al.   BIOMATERIALS

Synthesis and anticancer properties of ruthenium (II) complexes as potent apoptosis inducers through mitochondrial disruption

(2017) Dan Wan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Ruthenium(II) polypyridyl complexes: Synthesis, characterization and anticancer activity studies on BEL-7402 cells

(2017) Dan Wan et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Mitochondria Targeted Protein-Ruthenium Photosensitizer for Efficient Photodynamic Applications

(2017) Sabyasachi Chakrabortty et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

10H-3,6-Diazaphenothiazine induces G2/M phase cell cycle arrest and caspase-dependent apoptosis and inhibits cell invasion of A2780 ovarian carcinoma cells through the regulation of NF-κB and (BIRC6-XIAP) complexes

(2017) Jianxin Zhang et al.   Drug Design Development and Therapy

Patching of Lipid Rafts by Molecular Self-Assembled Nanofibrils Suppresses Cancer Cell Migration

(2017) Guanying Li et al.   Chem

Mechanistic clues to the protective effect of chrysin against doxorubicin-induced cardiomyopathy: Plausible roles of p53, MAPK and AKT pathways

(2017) Eman M. Mantawy et al.   Scientific Reports

X-ray-responsive selenium nanoparticles for enhanced cancer chemo-radiotherapy

(2016) Bo Yu et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Down-regulation of hTERT and Cyclin D1 transcription via PI3K/Akt and TGF-β pathways in MCF-7 Cancer cells with PX-866 and Raloxifene

(2016) Gregory W. Peek et al.   EXPERIMENTAL CELL RESEARCH

Endoplasmic Reticulum Stress and Associated ROS

(2016) Hafiz Zeeshan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Regorafenib induces extrinsic and intrinsic apoptosis through inhibition of ERK/NF-κB activation in hepatocellular carcinoma cells

(2016) Jai-Jen Tsai et al.   ONCOLOGY REPORTS

Functionalization of Platinum Complexes for Biomedical Applications

(2015) Xiaoyong Wang et al.   ACCOUNTS OF CHEMICAL RESEARCH

Improving the Anticancer Efficacy of Laminin Receptor-Specific Therapeutic Ruthenium Nanoparticles (RuBB-Loaded EGCG-RuNPs) via ROS-Dependent Apoptosis in SMMC-7721 Cells

(2015) Yanhui Zhou et al.   ACS Applied Materials & Interfaces

Noncovalent Ruthenium(II) Complexes–Single-Walled Carbon Nanotube Composites for Bimodal Photothermal and Photodynamic Therapy with Near-Infrared Irradiation

(2015) Pingyu Zhang et al.   ACS Applied Materials & Interfaces

Ruthenium(II) polypyridyl complexes as mitochondria-targeted two-photon photodynamic anticancer agents

(2015) Jiangping Liu et al.   BIOMATERIALS

The Inositol Polyphosphate 5-Phosphatase PIPP Regulates AKT1-Dependent Breast Cancer Growth and Metastasis

(2015) Lisa M. Ooms et al.   CANCER CELL

Drug Combination Studies and Their Synergy Quantification Using the Chou–Talalay Method—Letter

(2015) John C. Ashton   CANCER RESEARCH

Receptor selective ruthenium-somatostatin photosensitizer for cancer targeted photodynamic applications

(2015) Tao Wang et al.   CHEMICAL COMMUNICATIONS

Pin1-Induced Proline Isomerization in Cytosolic p53 Mediates BAX Activation and Apoptosis

(2015) Ariele Viacava Follis et al.   MOLECULAR CELL

Spherical Cancer Models in Tumor Biology

(2015) Louis-Bastien Weiswald et al.   NEOPLASIA

Signalling specificity in the Akt pathway in breast cancer

(2014) Abbe R. Clark et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

RuNH2@AuNPs as two-photon luminescent probes for thiols in living cells and tissues

(2014) Pingyu Zhang et al.   BIOMATERIALS

Mixed-ligand ruthenium polypyridyl complexes as apoptosis inducers in cancer cells, the cellular translocation and the important role of ROS-mediated signaling

(2014) Zhennan Zhao et al.   DALTON TRANSACTIONS

Preclinical combination therapy of the investigational drug NAMI-A+ with doxorubicin for mammary cancer

(2014) Alberta Bergamo et al.   INVESTIGATIONAL NEW DRUGS

Simultaneous observation of the metabolism of cisplatin and NAMI-A in human plasma in vitro by SEC-ICP-AES

(2014) Melani Sooriyaarachchi et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Targeting Nucleus DNA with a Cyclometalated Dipyridophenazineruthenium(II) Complex

(2014) Huaiyi Huang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Doxorubicin delivery to 3D multicellular spheroids and tumors based on boronic acid-rich chitosan nanoparticles

(2013) Xin Wang et al.   BIOMATERIALS

The ruthenium compound KP1339 potentiates the anticancer activity of sorafenib in vitro and in vivo

(2013) Petra Heffeter et al.   EUROPEAN JOURNAL OF CANCER

Mitochondria are the primary target in the induction of apoptosis by chiral ruthenium(II) polypyridyl complexes in cancer cells

(2013) Jin-Quan Wang et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

The induction of mitochondria-mediated apoptosis in cancer cells by ruthenium(ii) asymmetric complexes

(2013) Chen Qian et al.   Metallomics

Molecular and Cellular Characterization of the Biological Effects of Ruthenium(II) Complexes Incorporating 2-Pyridyl-2-pyrimidine-4-carboxylic Acid

(2012) Vanessa Pierroz et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ruthenium anticancer compounds: myths and realities of the emerging metal-based drugs

(2011) Alberta Bergamo et al.   DALTON TRANSACTIONS

The mass-action law based algorithms for quantitative econo-green bio-research

(2011) Ting-Chao Chou   Integrative Biology

Approaching tumour therapy beyond platinum drugs

(2011) A. Bergamo et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Combinations Go on Trial

(2011)   Cancer Discovery

Drug Combination Studies and Their Synergy Quantification Using the Chou-Talalay Method

(2010) T.-C. Chou   CANCER RESEARCH

Ruthenium Polypyridyl Complexes That Induce Mitochondria-Mediated Apoptosis in Cancer Cells

(2010) Tianfeng Chen et al.   INORGANIC CHEMISTRY

Intracellular protein binding patterns of the anticancer ruthenium drugs KP1019 and KP1339

(2010) Petra Heffeter et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Nuclear Permeable Ruthenium(II) β-Carboline Complexes Induce Autophagy To Antagonize Mitochondrial-Mediated Apoptosis

(2010) Caiping Tan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Simultaneous activation of p53 and inhibition of XIAP enhance the activation of apoptosis signaling pathways in AML

(2009) B. Z. Carter et al.   BLOOD

A Ruthenium-Containing Organometallic Compound Reduces Tumor Growth through Induction of the Endoplasmic Reticulum Stress Gene CHOP

(2009) Xiangjun Meng et al.   CANCER RESEARCH

The cell death machinery governed by the p53 tumor suppressor in response to DNA damage

(2009) Kiyotsugu Yoshida et al.   CANCER SCIENCE

XIAP as a ubiquitin ligase in cellular signaling

(2009) S Galbán et al.   CELL DEATH AND DIFFERENTIATION

XIAP discriminates between type I and type II FAS-induced apoptosis

(2009) Philipp J. Jost et al.   NATURE

KP1019, A New Redox-Active Anticancer Agent - Preclinical Development and Results of a Clinical Phase I Study in Tumor Patients

(2008) Christian G. Hartinger et al.   CHEMISTRY & BIODIVERSITY

The Biological Behavior of Prostate Cancer Cells in 3D Culture Systems

(2008) Masatoshi WATANABE et al.   YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN