Combination of Ruthenium Complex and Doxorubicin Synergistically Inhibits Cancer Cell Growth by Down-Regulating PI3K/AKT Signaling Pathway
出版年份 2020 全文链接
标题
Combination of Ruthenium Complex and Doxorubicin Synergistically Inhibits Cancer Cell Growth by Down-Regulating PI3K/AKT Signaling Pathway
作者
关键词
-
出版物
Frontiers in Oncology
Volume 10, Issue -, Pages -
出版商
Frontiers Media SA
发表日期
2020-02-19
DOI
10.3389/fonc.2020.00141
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- Dinuclear Organoruthenium Complexes Exhibiting Antiproliferative Activity through DNA Damage and a Reactive-Oxygen-Species-Mediated Endoplasmic Reticulum Stress Pathway
- (2019) Jian Zhao et al. INORGANIC CHEMISTRY
- A Ru II Polypyridyl Alkyne Complex Based Metal–Organic Frameworks for Combined Photodynamic/Photothermal/Chemotherapy
- (2019) Xiaochun Hu et al. CHEMISTRY-A EUROPEAN JOURNAL
- Cancer-Targeting Functionalization of Selenium-Containing Ruthenium Conjugate with Tumor Microenvironment-Responsive Property to Enhance Theranostic Effects
- (2018) Zhennan Zhao et al. CHEMISTRY-A EUROPEAN JOURNAL
- Ru(II) Compounds: Next-Generation Anticancer Metallotherapeutics?
- (2018) Sreekanth Thota et al. JOURNAL OF MEDICINAL CHEMISTRY
- P53 enhances apoptosis induced by doxorubicin only under conditions of severe DNA damage
- (2018) Ru-Wei Lin et al. CELL CYCLE
- Transition Metal Complexes and Photodynamic Therapy from a Tumor-Centered Approach: Challenges, Opportunities, and Highlights from the Development of TLD1433
- (2018) Susan Monro et al. CHEMICAL REVIEWS
- Stimuli-Responsive Therapeutic Metallodrugs
- (2018) Xiaohui Wang et al. CHEMICAL REVIEWS
- Designing luminescent ruthenium prodrug for precise cancer therapy and rapid clinical diagnosis
- (2018) Zhennan Zhao et al. BIOMATERIALS
- Synthesis and anticancer properties of ruthenium (II) complexes as potent apoptosis inducers through mitochondrial disruption
- (2017) Dan Wan et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Ruthenium(II) polypyridyl complexes: Synthesis, characterization and anticancer activity studies on BEL-7402 cells
- (2017) Dan Wan et al. JOURNAL OF INORGANIC BIOCHEMISTRY
- Mitochondria Targeted Protein-Ruthenium Photosensitizer for Efficient Photodynamic Applications
- (2017) Sabyasachi Chakrabortty et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- 10H-3,6-Diazaphenothiazine induces G2/M phase cell cycle arrest and caspase-dependent apoptosis and inhibits cell invasion of A2780 ovarian carcinoma cells through the regulation of NF-κB and (BIRC6-XIAP) complexes
- (2017) Jianxin Zhang et al. Drug Design Development and Therapy
- Patching of Lipid Rafts by Molecular Self-Assembled Nanofibrils Suppresses Cancer Cell Migration
- (2017) Guanying Li et al. Chem
- Mechanistic clues to the protective effect of chrysin against doxorubicin-induced cardiomyopathy: Plausible roles of p53, MAPK and AKT pathways
- (2017) Eman M. Mantawy et al. Scientific Reports
- X-ray-responsive selenium nanoparticles for enhanced cancer chemo-radiotherapy
- (2016) Bo Yu et al. COLLOIDS AND SURFACES B-BIOINTERFACES
- Down-regulation of hTERT and Cyclin D1 transcription via PI3K/Akt and TGF-β pathways in MCF-7 Cancer cells with PX-866 and Raloxifene
- (2016) Gregory W. Peek et al. EXPERIMENTAL CELL RESEARCH
- Endoplasmic Reticulum Stress and Associated ROS
- (2016) Hafiz Zeeshan et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Regorafenib induces extrinsic and intrinsic apoptosis through inhibition of ERK/NF-κB activation in hepatocellular carcinoma cells
- (2016) Jai-Jen Tsai et al. ONCOLOGY REPORTS
- Functionalization of Platinum Complexes for Biomedical Applications
- (2015) Xiaoyong Wang et al. ACCOUNTS OF CHEMICAL RESEARCH
- Improving the Anticancer Efficacy of Laminin Receptor-Specific Therapeutic Ruthenium Nanoparticles (RuBB-Loaded EGCG-RuNPs) via ROS-Dependent Apoptosis in SMMC-7721 Cells
- (2015) Yanhui Zhou et al. ACS Applied Materials & Interfaces
- Noncovalent Ruthenium(II) Complexes–Single-Walled Carbon Nanotube Composites for Bimodal Photothermal and Photodynamic Therapy with Near-Infrared Irradiation
- (2015) Pingyu Zhang et al. ACS Applied Materials & Interfaces
- Ruthenium(II) polypyridyl complexes as mitochondria-targeted two-photon photodynamic anticancer agents
- (2015) Jiangping Liu et al. BIOMATERIALS
- The Inositol Polyphosphate 5-Phosphatase PIPP Regulates AKT1-Dependent Breast Cancer Growth and Metastasis
- (2015) Lisa M. Ooms et al. CANCER CELL
- Drug Combination Studies and Their Synergy Quantification Using the Chou–Talalay Method—Letter
- (2015) John C. Ashton CANCER RESEARCH
- Receptor selective ruthenium-somatostatin photosensitizer for cancer targeted photodynamic applications
- (2015) Tao Wang et al. CHEMICAL COMMUNICATIONS
- Pin1-Induced Proline Isomerization in Cytosolic p53 Mediates BAX Activation and Apoptosis
- (2015) Ariele Viacava Follis et al. MOLECULAR CELL
- Spherical Cancer Models in Tumor Biology
- (2015) Louis-Bastien Weiswald et al. NEOPLASIA
- Signalling specificity in the Akt pathway in breast cancer
- (2014) Abbe R. Clark et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- RuNH2@AuNPs as two-photon luminescent probes for thiols in living cells and tissues
- (2014) Pingyu Zhang et al. BIOMATERIALS
- Mixed-ligand ruthenium polypyridyl complexes as apoptosis inducers in cancer cells, the cellular translocation and the important role of ROS-mediated signaling
- (2014) Zhennan Zhao et al. DALTON TRANSACTIONS
- Preclinical combination therapy of the investigational drug NAMI-A+ with doxorubicin for mammary cancer
- (2014) Alberta Bergamo et al. INVESTIGATIONAL NEW DRUGS
- Simultaneous observation of the metabolism of cisplatin and NAMI-A in human plasma in vitro by SEC-ICP-AES
- (2014) Melani Sooriyaarachchi et al. JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
- Targeting Nucleus DNA with a Cyclometalated Dipyridophenazineruthenium(II) Complex
- (2014) Huaiyi Huang et al. JOURNAL OF MEDICINAL CHEMISTRY
- Doxorubicin delivery to 3D multicellular spheroids and tumors based on boronic acid-rich chitosan nanoparticles
- (2013) Xin Wang et al. BIOMATERIALS
- The ruthenium compound KP1339 potentiates the anticancer activity of sorafenib in vitro and in vivo
- (2013) Petra Heffeter et al. EUROPEAN JOURNAL OF CANCER
- Mitochondria are the primary target in the induction of apoptosis by chiral ruthenium(II) polypyridyl complexes in cancer cells
- (2013) Jin-Quan Wang et al. JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
- The induction of mitochondria-mediated apoptosis in cancer cells by ruthenium(ii) asymmetric complexes
- (2013) Chen Qian et al. Metallomics
- Molecular and Cellular Characterization of the Biological Effects of Ruthenium(II) Complexes Incorporating 2-Pyridyl-2-pyrimidine-4-carboxylic Acid
- (2012) Vanessa Pierroz et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Ruthenium anticancer compounds: myths and realities of the emerging metal-based drugs
- (2011) Alberta Bergamo et al. DALTON TRANSACTIONS
- The mass-action law based algorithms for quantitative econo-green bio-research
- (2011) Ting-Chao Chou Integrative Biology
- Approaching tumour therapy beyond platinum drugs
- (2011) A. Bergamo et al. JOURNAL OF INORGANIC BIOCHEMISTRY
- Combinations Go on Trial
- (2011) Cancer Discovery
- Drug Combination Studies and Their Synergy Quantification Using the Chou-Talalay Method
- (2010) T.-C. Chou CANCER RESEARCH
- Ruthenium Polypyridyl Complexes That Induce Mitochondria-Mediated Apoptosis in Cancer Cells
- (2010) Tianfeng Chen et al. INORGANIC CHEMISTRY
- Intracellular protein binding patterns of the anticancer ruthenium drugs KP1019 and KP1339
- (2010) Petra Heffeter et al. JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
- Nuclear Permeable Ruthenium(II) β-Carboline Complexes Induce Autophagy To Antagonize Mitochondrial-Mediated Apoptosis
- (2010) Caiping Tan et al. JOURNAL OF MEDICINAL CHEMISTRY
- Simultaneous activation of p53 and inhibition of XIAP enhance the activation of apoptosis signaling pathways in AML
- (2009) B. Z. Carter et al. BLOOD
- A Ruthenium-Containing Organometallic Compound Reduces Tumor Growth through Induction of the Endoplasmic Reticulum Stress Gene CHOP
- (2009) Xiangjun Meng et al. CANCER RESEARCH
- The cell death machinery governed by the p53 tumor suppressor in response to DNA damage
- (2009) Kiyotsugu Yoshida et al. CANCER SCIENCE
- XIAP as a ubiquitin ligase in cellular signaling
- (2009) S Galbán et al. CELL DEATH AND DIFFERENTIATION
- XIAP discriminates between type I and type II FAS-induced apoptosis
- (2009) Philipp J. Jost et al. NATURE
- KP1019, A New Redox-Active Anticancer Agent - Preclinical Development and Results of a Clinical Phase I Study in Tumor Patients
- (2008) Christian G. Hartinger et al. CHEMISTRY & BIODIVERSITY
- The Biological Behavior of Prostate Cancer Cells in 3D Culture Systems
- (2008) Masatoshi WATANABE et al. YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN
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