Mixed-ligand ruthenium polypyridyl complexes as apoptosis inducers in cancer cells, the cellular translocation and the important role of ROS-mediated signaling

Subcellular Localization and Transport Kinetics of Ruthenium Organometallic Anticancer Compounds in Living Cells: A Dose-Dependent Role for Amino Acid and Iron Transporters

(2014) M. Klajner et al.   INORGANIC CHEMISTRY

Synergistic Induction of Apoptosis by Methylseleninic Acid and Cisplatin, The Role of ROS-ERK/AKT-p53 Pathway

(2014) Yibo Zhang et al.   MOLECULAR PHARMACEUTICS

Selective cellular uptake and induction of apoptosis of cancer-targeted selenium nanoparticles

(2013) Yanyu Huang et al.   BIOMATERIALS

Peptide directed transmembrane transport and nuclear localization of Ru(ii) polypyridyl complexes in mammalian cells

(2013) Lorraine Blackmore et al.   CHEMICAL COMMUNICATIONS

Increasing the Bioavailability of RuIIIAnticancer Complexes through Hydrophobic Albumin Interactions

(2013) Michael I. Webb et al.   CHEMISTRY-A EUROPEAN JOURNAL

Protein binding by dinuclear polypyridyl ruthenium(ii) complexes and the effect of cucurbit[10]uril encapsulation

(2013) Fangfei Li et al.   DALTON TRANSACTIONS

Differential effects of amino acid surface decoration on the anticancer efficacy of selenium nanoparticles

(2013) Yanxian Feng et al.   DALTON TRANSACTIONS

Microwave-assisted synthesis of arene ruthenium(II) complexes that induce S-phase arrest in cancer cells by DNA damage-mediated p53 phosphorylation

(2013) Qiong Wu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Selenocystine potentiates cancer cell apoptosis induced by 5-fluorouracil by triggering reactive oxygen species-mediated DNA damage and inactivation of the ERK pathway

(2013) Cundong Fan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Transferrin Serves As a Mediator to Deliver Organometallic Ruthenium(II) Anticancer Complexes into Cells

(2013) Wei Guo et al.   INORGANIC CHEMISTRY

Structural Studies on Dinuclear Ruthenium(II) Complexes That Bind Diastereoselectively to an Antiparallel Folded Human Telomere Sequence

(2013) Tom Wilson et al.   JOURNAL OF MEDICINAL CHEMISTRY

Membrane Localized Iridium(III) Complex Induces Endoplasmic Reticulum Stress and Mitochondria-Mediated Apoptosis in Human Cancer Cells

(2013) Rui Cao et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Contrasting Activity of Iodido versus Chlorido Ruthenium and Osmium Arene Azo- and Imino-pyridine Anticancer Complexes: Control of Cell Selectivity, Cross-Resistance, p53 Dependence, and Apoptosis Pathway

(2013) Isolda Romero-Canelón et al.   JOURNAL OF MEDICINAL CHEMISTRY

Quantitative visualization of DNA G-quadruplex structures in human cells

(2013) Giulia Biffi et al.   Nature Chemistry

Enhancement of Auranofin-Induced Apoptosis in MCF-7 Human Breast Cells by Selenocystine, a Synergistic Inhibitor of Thioredoxin Reductase

(2013) Chaoran Liu et al.   PLoS One

Visual specific luminescent probing of hybrid G-quadruplex DNA by a ruthenium polypyridyl complex

(2012) Guo-Liang Liao et al.   CHEMICAL COMMUNICATIONS

Ruthenium(ii) polypyridyl complexes and DNA—from structural probes to cellular imaging and therapeutics

(2012) Martin R. Gill et al.   CHEMICAL SOCIETY REVIEWS

Stabilization of G-Quadruplex DNA, Inhibition of Telomerase Activity and Live Cell Imaging Studies of Chiral Ruthenium(II) Complexes

(2012) Dongdong Sun et al.   CHEMISTRY-A EUROPEAN JOURNAL

The potential of organometallic complexes in medicinal chemistry

(2012) Gilles Gasser et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Ruthenium complexes containing 2,6-bis(benzimidazolyl)pyridine derivatives induce cancer cell apoptosis by triggering DNA damage-mediated p53 phosphorylation

(2012) Linlin Li et al.   DALTON TRANSACTIONS

SUMOylation of hnRNP-K is required for p53-mediated cell-cycle arrest in response to DNA damage

(2012) Seong Won Lee et al.   EMBO JOURNAL

New Ruthenium(II)–Letrozole Complexes as Anticancer Therapeutics

(2012) Annie Castonguay et al.   JOURNAL OF MEDICINAL CHEMISTRY

Molecular and Cellular Characterization of the Biological Effects of Ruthenium(II) Complexes Incorporating 2-Pyridyl-2-pyrimidine-4-carboxylic Acid

(2012) Vanessa Pierroz et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enhancement of cell permeabilization apoptosis-inducing activity of selenium nanoparticles by ATP surface decoration

(2012) Yibo Zhang et al.   Nanomedicine-Nanotechnology Biology and Medicine

β-Caryophyllene oxide inhibits growth and induces apoptosis through the suppression of PI3K/AKT/mTOR/S6K1 pathways and ROS-mediated MAPKs activation

(2011) Kyung-Ran Park et al.   CANCER LETTERS

Antitumor Activity of Metal-Chelating Compound Dp44mT Is Mediated by Formation of a Redox-Active Copper Complex That Accumulates in Lysosomes

(2011) D. B. Lovejoy et al.   CANCER RESEARCH

Mechanism of Cytotoxicity and Cellular Uptake of Lipophilic Inert Dinuclear Polypyridylruthenium(II) Complexes

(2011) Michelle J. Pisani et al.   ChemMedChem

Ruthenium complexes containing bis-benzimidazole derivatives as a new class of apoptosis inducers

(2011) Linlin Li et al.   DALTON TRANSACTIONS

Chiral ruthenium(II) anthraquinone complexes as dual inhibitors of topoisomerases I and II

(2011) Jun-Feng Kou et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Sensing Amyloid-β Aggregation Using Luminescent Dipyridophenazine Ruthenium(II) Complexes

(2011) Nathan P. Cook et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Differences in the Cellular Response and Signaling Pathways between Cisplatin and Monodentate Organometallic Ru(II) Antitumor Complexes Containing a Terphenyl Ligand

(2011) Anna Kisova et al.   MOLECULAR PHARMACEUTICS

Responsive and mitochondria-specific ruthenium(ii) complex for dual in vitro applications: two-photon (near-infrared) induced imaging and regioselective cell killing

(2010) Hanzhong Ke et al.   CHEMICAL COMMUNICATIONS

Fascinating variability in the chemistry and properties of 2,6-bis-(benzimidazol-2-yl)-pyridine and 2,6-bis-(benzthiazol-2-yl)-pyridine and their complexes

(2010) Miroslav Boča et al.   COORDINATION CHEMISTRY REVIEWS

Ruthenium Polypyridyl Complexes That Induce Mitochondria-Mediated Apoptosis in Cancer Cells

(2010) Tianfeng Chen et al.   INORGANIC CHEMISTRY

Turning off Transcription of thebcl-2Gene by Stabilizing thebcl-2Promoter Quadruplex with Quindoline Derivatives

(2010) Xiao-Dong Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Nuclear Permeable Ruthenium(II) β-Carboline Complexes Induce Autophagy To Antagonize Mitochondrial-Mediated Apoptosis

(2010) Caiping Tan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Selective Targeting of Gold Nanorods at the Mitochondria of Cancer Cells: Implications for Cancer Therapy

(2010) Liming Wang et al.   NANO LETTERS

Exploring the cellular accumulation of metal complexes

(2009) Cindy A. Puckett et al.   DALTON TRANSACTIONS

Synthesis, Characterization, and in vitro Antimalarial and Antitumor Activity of New Ruthenium(II) Complexes of Chloroquine

(2009) Chandima S. K. Rajapakse et al.   INORGANIC CHEMISTRY

The Importance of Negative Superhelicity in Inducing the Formation of G-Quadruplex and i-Motif Structures in the c-Myc Promoter: Implications for Drug Targeting and Control of Gene Expression

(2009) Daekyu Sun et al.   JOURNAL OF MEDICINAL CHEMISTRY

A ruthenium(II) polypyridyl complex for direct imaging of DNA structure in living cells

(2009) Martin R. Gill et al.   Nature Chemistry

Mechanism of Cellular Uptake of a Ruthenium Polypyridyl Complex†

(2008) Cindy A. Puckett et al.   BIOCHEMISTRY

Selenocystine induces apoptosis of A375 human melanoma cells by activating ROS-mediated mitochondrial pathway and p53 phosphorylation

(2008) T. Chen et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Bis(benzimidazole)pyridine derivative as a new class of G-quadruplex inducing and stabilizing ligand

(2008) Guorui Li et al.   CHEMICAL COMMUNICATIONS

KP1019, A New Redox-Active Anticancer Agent - Preclinical Development and Results of a Clinical Phase I Study in Tumor Patients

(2008) Christian G. Hartinger et al.   CHEMISTRY & BIODIVERSITY

DNA binding by Ru(II)–bis(bipyridine)–pteridinyl complexes

(2008) Shannon R. Dalton et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Diarylethynyl Amides That Recognize the Parallel Conformation of Genomic Promoter DNA G-Quadruplexes

(2008) Jyotirmayee Dash et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY