Impairment of Membrane Lipid Homeostasis by Bichalcone Analog TSWU-BR4 Attenuates Function of GRP78 in Regulation of the Oxidative Balance and Invasion of Cancer Cells

ER stress sensor, glucose regulatory protein 78 (GRP78) regulates redox status in pancreatic cancer thereby maintaining “stemness”

(2019) Patricia Dauer et al.   Cell Death & Disease

Downregulation of miR-144 by triptolide enhanced p85α−PTEN complex formation causing S phase arrest of human nasopharyngeal carcinoma cells

(2019) Chien-Wei Wu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Compartmentalisation of RAC1 signalling

(2018) Aishwarya Payapilly et al.   CURRENT OPINION IN CELL BIOLOGY

Nitric oxide reduces oxidative stress in cancer cells by forming dinitrosyliron complexes

(2018) Sumit Sahni et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Natural products targeting ER stress pathway for the treatment of cardiovascular diseases

(2018) Ker Woon Choy et al.   PHARMACOLOGICAL RESEARCH

Perturbing the Dynamics and Organization of Cell Membrane Components: A New Paradigm for Cancer-Targeted Therapies

(2018) Nuno Bernardes et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

PI3K-p110α mediates the oncogenic activity induced by loss of the novel tumor suppressor PI3K-p85α

(2017) Lauren M. Thorpe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ROS-independent Nrf2 activation in prostate cancer

(2017) Ilaria Bellezza et al.   Oncotarget

Impact of high cholesterol and endoplasmic reticulum stress on metabolic diseases: An updated mini-review

(2017) Erdi Sozen et al.   Redox Biology

Endoplasmic Reticulum Stress Protein GRP78 Modulates Lipid Metabolism to Control Drug Sensitivity and Antitumor Immunity in Breast Cancer

(2016) Katherine L. Cook et al.   CANCER RESEARCH

The role of ER stress in lipid metabolism and lipotoxicity

(2016) Jaeseok Han et al.   JOURNAL OF LIPID RESEARCH

Suppression of phospho-p85α-GTP-Rac1 lipid raft interaction by bichalcone analog attenuates cancer cell invasion

(2016) Hui-Li Lu et al.   MOLECULAR CARCINOGENESIS

Lipid metabolic reprogramming in cancer cells

(2016) S Beloribi-Djefaflia et al.   Oncogenesis

Role of acid sphingomyelinase bioactivity in human CD4+ T-cell activation and immune responses

(2015) A Bai et al.   Cell Death & Disease

Regulation of the PI3K pathway through a p85α monomer–homodimer equilibrium

(2015) Lydia WT Cheung et al.   eLife

Cholesteryl Ester Accumulation Induced by PTEN Loss and PI3K/AKT Activation Underlies Human Prostate Cancer Aggressiveness

(2014) Shuhua Yue et al.   Cell Metabolism

Acid sphingomyelinase activity is regulated by membrane lipids and facilitates cholesterol transfer by NPC2

(2014) Vincent O. Oninla et al.   JOURNAL OF LIPID RESEARCH

GRP78 Suppresses Lipid Peroxidation and Promotes Cellular Antioxidant Levels in Glial Cells following Hydrogen Peroxide Exposure

(2014) Kaori Suyama et al.   PLoS One

Subcellular Fractionation and Localization Studies Reveal a Direct Interaction of the Fragile X Mental Retardation Protein (FMRP) with Nucleolin

(2014) Mohamed S. Taha et al.   PLoS One

Nitric oxide is a positive regulator of the Warburg effect in ovarian cancer cells

(2014) C A Caneba et al.   Cell Death & Disease

Alteration of Endoplasmic Reticulum Lipid Rafts Contributes to Lipotoxicity in Pancreatic β-Cells

(2013) Ebru Boslem et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cancer Cells Resistant to Therapy Promote Cell Surface Relocalization of GRP78 Which Complexes with PI3K and Enhances PI(3,4,5)P3 Production

(2013) Yi Zhang et al.   PLoS One

MicroRNA-144 promotes cell proliferation, migration and invasion in nasopharyngeal carcinoma through repression of PTEN

(2012) Li-Yi Zhang et al.   CARCINOGENESIS

Suppressing the formation of lipid raft-associated Rac1/PI3K/Akt signaling complexes by curcumin inhibits SDF-1α-induced invasion of human esophageal carcinoma cells

(2012) Meng-Liang Lin et al.   MOLECULAR CARCINOGENESIS

New bichalcone analogs as NF-κB inhibitors and as cytotoxic agents inducing Fas/CD95-dependent apoptosis

(2011) M. Vijaya Bhaskar Reddy et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Destabilization of CARP mRNAs by aloe-emodin contributes to caspase-8-mediated p53-independent apoptosis of human carcinoma cells

(2011) Meng-Liang Lin et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

PI3K/Akt signaling requires spatial compartmentalization in plasma membrane microdomains

(2011) X. Gao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct positive regulation of PTEN by the p85 subunit of phosphatidylinositol 3-kinase

(2010) R. B. Chagpar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aloe-emodin induces apoptosis of human nasopharyngeal carcinoma cells via caspase-8-mediated activation of the mitochondrial death pathway

(2009) Meng-Liang Lin et al.   CANCER LETTERS