Perturbing the Dynamics and Organization of Cell Membrane Components: A New Paradigm for Cancer-Targeted Therapies

Azurin interaction with the lipid raft components ganglioside GM-1 and caveolin-1 increases membrane fluidity and sensitivity to anti-cancer drugs

(2018) Nuno Bernardes et al.   CELL CYCLE

High cholesterol in lipid rafts reduces the sensitivity to EGFR-TKI therapy in non-small cell lung cancer

(2018) Qiufang Chen et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Interacting Cancer Machineries: Cell Signaling, Lipid Metabolism, and Epigenetics

(2018) Thomas W. Grunt   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Nitric Oxide Generated by Tumor-Associated Macrophages Is Responsible for Cancer Resistance to Cisplatin and Correlated With Syntaxin 4 and Acid Sphingomyelinase Inhibition

(2018) Cristiana Perrotta et al.   Frontiers in Immunology

Aberrant lipid metabolism in cancer cells - the role of oncolipid-activated signaling

(2017) Upasana Ray et al.   FEBS Journal

Influence of doxorubicin on model cell membrane properties: insights from in vitro and in silico studies

(2017) Ana Catarina Alves et al.   Scientific Reports

Understanding the accumulation of P-glycoprotein substrates within cells: The effect of cholesterol on membrane partitioning

(2016) Nandhitha Subramanian et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Biophysics in cancer: The relevance of drug-membrane interaction studies

(2016) Ana Catarina Alves et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

p28-Mediated Activation of p53 in G 2 –M Phase of the Cell Cycle Enhances the Efficacy of DNA Damaging and Antimitotic Chemotherapy

(2016) Tohru Yamada et al.   CANCER RESEARCH

Modulation of membrane properties of lung cancer cells by azurin enhances the sensitivity to EGFR-targeted therapy and decreased β1 integrin-mediated adhesion

(2016) Nuno Bernardes et al.   CELL CYCLE

Phase I trial of p28 (NSC745104), a non-HDM2-mediated peptide inhibitor of p53 ubiquitination in pediatric patients with recurrent or progressive central nervous system tumors: A Pediatric Brain Tumor Consortium Study

(2016) Rishi R. Lulla et al.   NEURO-ONCOLOGY

High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities

(2015) Traver Hart et al.   CELL

27LBA Evidence of activity of a new mechanism of action (MoA): A first-in-human study of the first-in-class fatty acid synthase (FASN) inhibitor, TVB-2640, as monotherapy or in combination

(2015) H.T. Arkenau et al.   EUROPEAN JOURNAL OF CANCER

Membrane lipid therapy: Modulation of the cell membrane composition and structure as a molecular base for drug discovery and new disease treatment

(2015) Pablo V. Escribá et al.   PROGRESS IN LIPID RESEARCH

P-cadherin signals through the laminin receptor α6β4 integrin to induce stem cell and invasive properties in basal-like breast cancer cells

(2015) André Filipe Vieira et al.   Oncotarget

Increased Exposure of Phosphatidylethanolamine on the Surface of Tumor Vascular Endothelium

(2015) Jason H. Stafford et al.   NEOPLASIA

Regulation of the cancer cell membrane lipid composition by NaCHOleate

(2014) Victoria Lladó et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The basic structure and dynamics of cell membranes: An update of the Singer–Nicolson model

(2014) Félix M. Goñi   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Membrane rafts as a novel target in cancer therapy

(2014) Anita Hryniewicz-Jankowska et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

High-throughput molecular profiling of a P-cadherin overexpressing breast cancer model reveals new targets for the anti-cancer bacterial protein azurin

(2014) Nuno Bernardes et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Complex Interplay between the P-Glycoprotein Multidrug Efflux Pump and the Membrane: Its Role in Modulating Protein Function

(2014) Frances Jane Sharom   Frontiers in Oncology

Biophysics of cell membrane lipids in cancer drug resistance: Implications for drug transport and drug delivery with nanoparticles

(2013) Chiranjeevi Peetla et al.   ADVANCED DRUG DELIVERY REVIEWS

Importance of lipid microdomains, rafts, in absorption, delivery, and biological effects of resveratrol

(2013) Dominique Delmas et al.   Annals of the New York Academy of Sciences

Disrupting membrane raft domains by alkylphospholipids

(2013) A.B. Gomide et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Interaction of membrane/lipid rafts with the cytoskeleton: Impact on signaling and function

(2013) Brian P. Head et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The Fluid—Mosaic Model of Membrane Structure: Still relevant to understanding the structure, function and dynamics of biological membranes after more than 40years

(2013) Garth L. Nicolson   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

A first-in-class, first-in-human, phase I trial of p28, a non-HDM2-mediated peptide inhibitor of p53 ubiquitination in patients with advanced solid tumours

(2013) M A Warso et al.   BRITISH JOURNAL OF CANCER

Caveolae as plasma membrane sensors, protectors and organizers

(2013) Robert G. Parton et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Bacterial Protein Azurin Impairs Invasion and FAK/Src Signaling in P-Cadherin-Overexpressing Breast Cancer Cell Models

(2013) Nuno Bernardes et al.   PLoS One

Role for membrane remodeling in cell death: Implication for health and disease

(2013) Xavier Tekpli et al.   TOXICOLOGY

“Iron-saturated” bovine lactoferrin improves the chemotherapeutic effects of tamoxifen in the treatment of basal-like breast cancer in mice

(2012) Xueying Sun et al.   BMC CANCER

Therapeutic potential of targeting ceramide/glucosylceramide pathway in cancer

(2012) Melis Kartal Yandım et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Lipid metabolism in cancer

(2012) Claudio R. Santos et al.   FEBS Journal

The six amino acid antimicrobial peptide bLFcin6penetrates cells and delivers siRNA

(2012) Bing Fang et al.   FEBS Journal

Emodin inhibits invasion and migration of prostate and lung cancer cells by downregulating the expression of chemokine receptor CXCR4

(2012) Sooho Ok et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Atorvastatin sensitizes human non-small cell lung carcinomas to carboplatin via suppression of AKT activation and upregulation of TIMP-1

(2012) Jie Chen et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Linker for Activation of T-cell Family Member2 (LAT2) a Lipid Raft Adaptor Protein for AKT Signaling, Is an Early Mediator of Alkylphospholipid Anti-leukemic Activity

(2012) Carolina H. Thomé et al.   MOLECULAR & CELLULAR PROTEOMICS

Carcinogenesis alters fatty acid profile in breast tissue

(2012) Nazila Azordegan et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Lipid–lipid interactions in bilayer membranes: Married couples and casual liaisons

(2012) Peter J. Quinn   PROGRESS IN LIPID RESEARCH

A cell penetrating peptide derived from azurin inhibits angiogenesis and tumor growth by inhibiting phosphorylation of VEGFR-2, FAK and Akt

(2011) Rajeshwari R. Mehta et al.   ANGIOGENESIS

P-cadherin role in normal breast development and cancer

(2011) André Albergaria et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

In vitro and in vivo efficacy of edelfosine-loaded lipid nanoparticles against glioma

(2011) Ander Estella-Hermoso de Mendoza et al.   JOURNAL OF CONTROLLED RELEASE

Lipid Rafts and Fas/CD95 Signaling in Cancer Chemotherapy

(2011) Consuelo Gajate et al.   Recent Patents on Anti-Cancer Drug Discovery

Chemoprevention of Head and Neck Cancer by Green Tea Extract: EGCG—The Role of EGFR Signaling and “Lipid Raft”

(2011) Muneyuki Masuda et al.   Journal of Oncology

Lovastatin induces apoptosis of ovarian cancer cells and synergizes with doxorubicin: potential therapeutic relevance

(2010) Anna Martirosyan et al.   BMC CANCER

Preclinical pharmacokinetics, metabolism, and toxicity of azurin-p28 (NSC745104) a peptide inhibitor of p53 ubiquitination

(2010) Lee Jia et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

A 28-Amino-Acid Peptide Fragment of the Cupredoxin Azurin Prevents Carcinogen-Induced Mouse Mammary Lesions

(2010) R. R. Mehta et al.   Cancer Prevention Research

Caveolin-1 interacts with a lipid raft-associated population of fatty acid synthase

(2010) Dolores Di Vizio et al.   CELL CYCLE

Perifosine induces cell cycle arrest and apoptosis in human hepatocellular carcinoma cell lines by blockade of Akt phosphorylation

(2010) Hong-rong Fei et al.   CYTOTECHNOLOGY

Lipid map of the mammalian cell

(2010) G. van Meer et al.   JOURNAL OF CELL SCIENCE

Drug Resistance in Breast Cancer Cells: Biophysical Characterization of and Doxorubicin Interactions with Membrane Lipids

(2010) Chiranjeevi Peetla et al.   MOLECULAR PHARMACEUTICS

Lipidomics: coming to grips with lipid diversity

(2010) Andrej Shevchenko et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Lipid raft-targeted therapy in multiple myeloma

(2010) F Mollinedo et al.   ONCOGENE

Lipid Rafts As a Membrane-Organizing Principle

(2010) D. Lingwood et al.   SCIENCE

Noncationic Peptides Obtained From Azurin Preferentially Enter Cancer Cells

(2009) B. N. Taylor et al.   CANCER RESEARCH

Modeling the interaction between the N-terminal domain of the tumor suppressor p53 and azurin

(2009) Monia Taranta et al.   JOURNAL OF MOLECULAR RECOGNITION

A peptide fragment of azurin induces a p53-mediated cell cycle arrest in human breast cancer cells

(2009) T. Yamada et al.   MOLECULAR CANCER THERAPEUTICS

The liquid-ordered phase in membranes

(2008) Peter J. Quinn et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Synergistic inhibition of head and neck tumor growth by green tea (−)‐epigallocatechin‐3‐gallate and EGFR tyrosine kinase inhibitor

(2008) Xin Zhang et al.   INTERNATIONAL JOURNAL OF CANCER

Probing the interaction between p53 and the bacterial protein azurin by single molecule force spectroscopy

(2008) Monia Taranta et al.   JOURNAL OF MOLECULAR RECOGNITION

Principles of bioactive lipid signalling: lessons from sphingolipids

(2008) Yusuf A. Hannun et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Dissecting lipid raft facilitated cell signaling pathways in cancer

(2007) Samir Kumar Patra   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER