Review
Immunology
Takuma Okawa, Motoyoshi Nagai, Koji Hase
Summary: Nutrient metabolism is closely associated with immune cell differentiation and function, with interventions like intermittent fasting potentially manipulating immune cell functions. Nutritional status also influences immune cell subset dynamics, offering new therapeutic strategies for immunological disorders.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Geriatrics & Gerontology
Elangbam Tomtheelnganbee, Puja Sah, R. Sharma
Summary: Ageing is a complex process influenced by the environment and controlled by interactions between nutrient sensors and mitochondrial physiology. Calorie restriction has been proven as the most successful intervention for achieving longevity and healthspan.
Article
Biochemistry & Molecular Biology
Anuradha Rachakatla, Rajender Rao Kalashikam
Summary: Properly planned calorie restriction (CR) with regular exercise can lead to healthy weight loss and have beneficial effects on lifespan and age-associated diseases. The pathways regulated by CR include AMP-activated protein kinase (AMPK), Forkhead box transcription factor, mammalian target of rapamycin (mTOR), insulin-like growth factor-1 (IGF-1) pathway, nuclear factor kappa B pathway, and stress response pathways. CR can have both acute and chronic effects on mental health and brain function. It can also affect the health and development of offspring through epigenetic modifications. CR at middle and old age has a significant preventive impact against age-associated diseases.
DNA AND CELL BIOLOGY
(2022)
Review
Physiology
Nadezda V. Andrianova, Marina I. Buyan, Anastasia K. Bolikhova, Dmitry B. Zorov, Egor Y. Plotnikov
Summary: Dietary restriction (DR) has been shown to improve kidney diseases, but its beneficial effects may decrease with age. Aging is associated with impairments in organ function, which could affect the protective potential of DR.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Cell Biology
Armen Yerevanian, Luke M. Murphy, Sinclair Emans, Yifei Zhou, Fasih M. Ahsan, Daniel Baker, Sainan Li, Adebanjo Adedoja, Lucydalila Cedillo, Nicole L. Stuhr, Einstein Gnanatheepam, Khoi Dao, Mohit Jain, Sean P. Curran, Irene Georgakoudi, Alexander A. Soukas
Summary: Partial depletion of riboflavin promotes metabolic health and extends lifespan in C. elegans by reducing intracellular flavin concentrations.
Article
Cell Biology
Iqra Hussain, Harini K. Sureshkumar, Michael Bauer, Ignacio Rubio
Summary: This study investigates the role of caloric restriction in the resilience of hepatocytes to inflammatory cell damage and reveals that caloric restriction can reliably protect hepatocytes from cellular damage caused by pro-inflammatory cytokines. The activation of mTORC1 in starved hepatocytes is crucial for sustaining protein synthesis in resistant cells and is uncoupled from the regulation of autophagy.
Article
Endocrinology & Metabolism
Zhijun Zhao, Jing Cao, Chaoqun Niu, Menghuan Bao, Jiaqi Xu, Daliang Huo, Shasha Liao, Wei Liu, John R. Speakman
Summary: The study reveals that exposure to a temperature of 32.5 degrees C leads to a reduced lifespan in both mice and hamsters, coinciding with lowered metabolic rate and elevated body temperature. This demonstrates the significant impact of body temperature and metabolic rate on lifespan.
Review
Geriatrics & Gerontology
Augusto Schneider, Tatiana D. Saccon, Driele N. Garcia, Bianka M. Zanini, Jose V. V. Isola, Jessica D. Hense, Joao A. Alvarado-Rincon, Marcelo B. Cavalcante, Jeffrey B. Mason, Michael B. Stout, Andrzej Bartke, Michal M. Masternak
Summary: Female mammals are born with a limited ovarian reserve of primordial follicles, which are gradually activated throughout the reproductive lifecycle to determine its length; before exhaustion of the ovarian reserve, females experience declines in fertility and health; research on long-living murine models has shown that strategies for extending lifespan can also delay ovarian aging.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Article
Biology
Kengo Watanabe, Tomasz Wilmanski, Priyanka Baloni, Max Robinson, Gonzalo G. Garcia, Michael R. Hoopmann, Mukul K. Midha, David H. Baxter, Michal Maes, Seamus R. Morrone, Kelly M. Crebs, Charu Kapil, Ulrike Kusebauch, Jack Wiedrick, Jodi Lapidus, Lance Pflieger, Christopher Lausted, Jared C. Roach, Gwenlyn Glusman, Steven R. Cummings, Nicholas J. Schork, Nathan D. Price, Leroy Hood, Richard A. Miller, Robert L. Moritz, Noa Rappaport
Summary: Aging is characterized by progressive deterioration in homeostasis, which requires a systems-level perspective to investigate the molecular dysregulation of underlying biological processes. This study examines the systemic changes in molecular regulation of biological processes under different lifespan-extending interventions. The findings suggest that these interventions generally tighten the regulation of biological modules, particularly in processes such as fatty acid oxidation, immune response, and stress response.
COMMUNICATIONS BIOLOGY
(2023)
Article
Biology
Kengo Watanabe, Tomasz Wilmanski, Priyanka Baloni, Max Robinson, Gonzalo G. Garcia, Michael R. Hoopmann, Mukul K. Midha, David H. Baxter, Michal Maes, Seamus R. Morrone, Kelly M. Crebs, Charu Kapil, Ulrike Kusebauch, Jack Wiedrick, Jodi Lapidus, Lance Pflieger, Christopher Lausted, Jared C. Roach, Gwenlyn Glusman, Steven R. Cummings, Nicholas J. Schork, Nathan D. Price, Leroy Hood, Richard A. Miller, Robert L. Moritz, Noa Rappaport
Summary: This study investigates the molecular regulation of biological processes in the liver under different lifespan-extending interventions. The results show that these interventions generally tighten the regulation of biological modules, particularly in fatty acid oxidation, immune response, and stress response. Differences between proteins and transcripts suggest a mechanism involving cap-independent translation. Integrated analysis also supports systemic shifts in fatty acid metabolism.
COMMUNICATIONS BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Aleksandra Mladenovic Djordjevic, Natasa Loncarevic-Vasiljkovic, Efstathios S. Gonos
Summary: It is well established that lifestyle and dietary habits have a significant impact on life span, aging rate, and age-related diseases. Dietary restriction and healthy dietary patterns have been linked to increased survival and longevity, with the ability to modify oxidative stress levels. However, the debate regarding the role of dietary restriction as a golden standard for prolonging life span and ameliorating aging effects continues.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Review
Cardiac & Cardiovascular Systems
Yuqin Wang, Yongnan Li, Hong Ding, Dan Li, Wanxi Shen, Xiaowei Zhang
Summary: In this article, the research advancements and molecular mechanisms regulating autophagy related to Sirtuins are summarized. The biological function of Sirtuins across various cardiovascular diseases are elucidated, and the development of novel drugs that regulate Sirtuin-mediated autophagy is discussed.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Richard Campion, Leanne Bloxam, Kimberley Burrow, Philip J. Brownridge, Daniel R. Pentland, Patricia Thomas, Campbell W. Gourlay, Claire E. Eyers, Jeff W. Barclay, Alan Morgan
Summary: Dietary restriction (DR) can increase replicative lifespan in yeast by enhancing mitochondrial respiration and affecting the expression of certain proteins, while also inhibiting mating in yeast. These changes may be related to proteins associated with the heat shock protein (HSP) family.
BIOCHEMICAL JOURNAL
(2021)
Article
Cell Biology
David G. Le Couteur, Samantha M. Solon-Biet, Benjamin L. Parker, Tamara Pulpitel, Amanda E. Brandon, Nicholas J. Hunt, Jibran A. Wali, Rahul Gokarn, Alistair M. Senior, Gregory J. Cooney, David Raubenheimer, Victoria C. Cogger, David E. James, Stephen J. Simpson
Summary: Diet composition has a significant impact on the hepatic proteome, influencing not only metabolic pathways but also fundamental processes like mitochondrial function and RNA splicing.
Review
Peripheral Vascular Disease
Cydne A. Perry, Kishore M. Gadde
Summary: The review examines the role of calorie restriction (CR) in preventing cardiovascular disease, focusing on the reduction of cardiometabolic risk factors and promotion of atherosclerotic stability. The findings suggest that CR may be effective in reducing the development of atherosclerosis and improving cardiometabolic risk profiles, particularly in nonobese young and middle-aged adults. However, more controlled trials with larger sample sizes and longer follow-ups are needed to fully understand the long-term therapeutic effects.
CURRENT ATHEROSCLEROSIS REPORTS
(2022)
Review
Biochemistry & Molecular Biology
Haitao Wang, Jiangping Xu, Philip Lazarovici, Wenhua Zheng
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2017)
Article
Biochemistry & Molecular Biology
Galit Gincberg, Esther Shohami, Philip Lazarovici, Uriel Elchalal
JOURNAL OF MOLECULAR NEUROSCIENCE
(2018)
Article
Cell & Tissue Engineering
Galit Gincberg, Esther Shohami, Victoria Trembovler, Alexander G. Alexandrovich, Philip Lazarovici, Uriel Elchalal
Article
Biochemistry & Molecular Biology
Galia Tiram, Shiran Ferber, Paula Ofek, Anat Eldar-Boock, Dikla Ben-Shushan, Eilam Yeini, Adva Krivitsky, Roni Blatt, Nava Almog, Jack Henkin, Orit Amsalem, Eylon Yavin, Gadi Cohen, Philip Lazarovici, Joo Sang Lee, Eytan Ruppin, Michael Milyavsky, Rachel Grossman, Zvi Ram, Marcelo Calderon, Rainer Haag, Ronit Satchi-Fainaro
Review
Neurosciences
Haitao Wang, Jiangping Xu, Philip Lazarovici, Remi Quirion, Wenhua Zheng
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2018)
Review
Food Science & Technology
Philip Lazarovici, Cezary Marcinkiewicz, Peter I. Lelkes
Article
Biochemistry & Molecular Biology
Chaim Gilon, Agata Gitlin-Domagalska, Adi Lahiani, Shiran Yehoshua-Alshanski, Adi Shumacher-Klinger, Dan Gilon, Mahmoud Taha, Israel Sekler, Amnon Hoffman, Philip Lazarovici
Review
Biochemistry & Molecular Biology
Limor Rubin, Collin T. Stabler, Adi Schumacher-Klinger, Cezary Marcinkiewicz, Peter Lelkes, Philip Lazarovici
Summary: This review explores the role of neurotrophins in neurogenesis, vasculogenesis, and embryonic development of the respiratory system, as well as their implications for respiratory diseases.
CYTOKINE & GROWTH FACTOR REVIEWS
(2021)
Article
Cell Biology
Lijun Ge, Shuyuan Liu, Limor Rubin, Philip Lazarovici, Wenhua Zheng
Summary: Insulin-like growth factor-1 (IGF-1) and its binding proteins and receptors are expressed in the central nervous system (CNS), playing a neurotrophic role in normal growth and development. Recent research suggests that IGF-1 may also have neuroprotective effects in neurological disorders such as stroke, brain trauma, Alzheimer's disease, and epilepsy, by modulating glutamate-mediated excitotoxic signaling pathways. Animal studies and clinical trials have demonstrated the potential therapeutic value of IGF-1 in CNS diseases. This review focuses on the relationship between IGF-1-induced neuroprotection and glutamate-induced excitatory neurotoxicity, providing a basis for the clinical application of IGF-I as a neuroprotective therapy for neurological diseases associated with glutamate excitotoxicity.
Article
Materials Science, Multidisciplinary
Majdi Saleem Naamneh, Philip Lazarovici, Jehoshua Katzhendler
Summary: This study investigated the activity of different organocatalysts and initiators in the ring-opening polymerization of OCAs derived from phenylalanine. It found that dimethylaminoethyl amine and dimethylaminopropyl amine were highly active catalysts for controlled polymerization, while 4-(Hydroxymethyl)-1H-imidazole was the most effective catalyst for uncontrolled polymerization in the presence of 4-DMAP. The study highlights the potential application of Phe-OCA polymers in biomedical materials and provides important implications for the synthesis of polymeric polyesters in translational medicine.
ACS APPLIED POLYMER MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Michal Klazas, Majdi Saleem Naamneh, Wenhua Zheng, Philip Lazarovici
Summary: The study aimed to investigate the protective effect of gabapentin on Taxol-induced peripheral neuropathy and its impact on intra-epidermal nerve fibers density.
Article
Biochemistry & Molecular Biology
David Lankri, Dikla Haham, Adi Lahiani, Philip Lazarovici, Dmitry Tsvelikhovsky
ACS CHEMICAL NEUROSCIENCE
(2018)
Review
Neurosciences
Adi Lahiani, Annette Brand-Yavin, Ephraim Yavin, Philip Lazarovici
Article
Biochemistry & Molecular Biology
Matan Geron, Rakesh Kumar, Henry Matzner, Adi Lahiani, Galit Gincberg, Gadi Cohen, Philip Lazarovici, Avi Priel
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2017)