Conformational States of Exchange Protein Directly Activated by cAMP (EPAC1) Revealed by Ensemble Modeling and Integrative Structural Biology

Evolving SAXS versatility: solution X-ray scattering for macromolecular architecture, functional landscapes, and integrative structural biology

(2019) Chris A Brosey et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

SASBDB: Towards an automatically curated and validated repository for biological scattering data

(2019) Alexey G. Kikhney et al.   PROTEIN SCIENCE

Small angle X‐ray scattering‐assisted protein structure prediction in CASP13 and emergence of solution structure differences

(2019) Greg L. Hura et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Mechanism of Selective Enzyme Inhibition through Uncompetitive Regulation of an Allosteric Agonist

(2018) Stephen Boulton et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Intracellular cAMP Sensor EPAC: Physiology, Pathophysiology, and Therapeutics Development

(2018) William G. Robichaux et al.   PHYSIOLOGICAL REVIEWS

2017 publication guidelines for structural modelling of small-angle scattering data from biomolecules in solution: an update

(2017) Jill Trewhella et al.   Acta Crystallographica Section D-Structural Biology

The role of Epac in the heart

(2016) Takayuki Fujita et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Cyclic AMP Sensor EPAC Proteins and Their Role in Cardiovascular Function and Disease

(2016) Frank Lezoualc’h et al.   CIRCULATION RESEARCH

Role of Exchange Protein Directly Activated by Cyclic AMP Isoform 1 in Energy Homeostasis: Regulation of Leptin Expression and Secretion in White Adipose Tissue

(2016) Yaohua Hu et al.   MOLECULAR AND CELLULAR BIOLOGY

ConSurf 2016: an improved methodology to estimate and visualize evolutionary conservation in macromolecules

(2016) Haim Ashkenazy et al.   NUCLEIC ACIDS RESEARCH

Critical role for Epac1 in inflammatory pain controlled by GRK2-mediated phosphorylation of Epac1

(2016) Pooja Singhmar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Resolution ofab initioshapes determined from small-angle scattering

(2016) Anne T. Tuukkanen et al.   IUCrJ

Inhibition of Epac1 suppresses mitochondrial fission and reduces neointima formation induced by vascular injury

(2016) Hui Wang et al.   Scientific Reports

Exchange protein directly activated by cAMP encoded by the mammalian rapgef3 gene: Structure, function and therapeutics

(2015) Upasana Banerjee et al.   GENE

Advanced ensemble modelling of flexible macromolecules using X-ray solution scattering

(2015) Giancarlo Tria et al.   IUCrJ

McSAS: software for the retrieval of model parameter distributions from scattering patterns

(2015) I. Bressler et al.   JOURNAL OF APPLIED CRYSTALLOGRAPHY

Epac1-dependent phospholamban phosphorylation mediates the cardiac response to stresses

(2014) Satoshi Okumura et al.   JOURNAL OF CLINICAL INVESTIGATION

SASBDB, a repository for biological small-angle scattering data

(2014) Erica Valentini et al.   NUCLEIC ACIDS RESEARCH

Epac2 Mediates Cardiac β1-Adrenergic–Dependent Sarcoplasmic Reticulum Ca 2+ Leak and Arrhythmia

(2013) Laëtitia Pereira et al.   CIRCULATION

Pancreatic β-Cell Response to Increased Metabolic Demand and to Pharmacologic Secretagogues Requires EPAC2A

(2013) Woo-Jin Song et al.   DIABETES

Exchange protein activated by cAMP 1 (Epac1)-deficient mice develop β-cell dysfunction and metabolic syndrome

(2013) Alan K. L. Kai et al.   FASEB JOURNAL

Balancing GRK2 and EPAC1 levels prevents and relieves chronic pain

(2013) Huijing Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

Increased sugar uptake promotes oncogenesis via EPAC/RAP1 and O-GlcNAc pathways

(2013) Yasuhito Onodera et al.   JOURNAL OF CLINICAL INVESTIGATION

Accurate assessment of mass, models and resolution by small-angle scattering

(2013) Robert P. Rambo et al.   NATURE

GLP-1 receptor activation and Epac2 link atrial natriuretic peptide secretion to control of blood pressure

(2013) Minsuk Kim et al.   NATURE MEDICINE

Exchange protein directly activated by cAMP plays a critical role in bacterial invasion during fatal rickettsioses

(2013) B. Gong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cyclic AMP sensor EPAC proteins and energy homeostasis

(2013) Muayad Almahariq et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Publication guidelines for structural modelling of small-angle scattering data from biomolecules in solution

(2012) David A. Jacques et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Applications of small-angle X-ray scattering to biomacromolecular solutions

(2012) Maxim V. Petoukhov et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

BayesApp: a web site for indirect transformation of small-angle scattering data

(2012) Steen Hansen   JOURNAL OF APPLIED CRYSTALLOGRAPHY

New developments in theATSASprogram package for small-angle scattering data analysis

(2012) Maxim V. Petoukhov et al.   JOURNAL OF APPLIED CRYSTALLOGRAPHY

Enhanced Leptin Sensitivity, Reduced Adiposity, and Improved Glucose Homeostasis in Mice Lacking Exchange Protein Directly Activated by Cyclic AMP Isoform 1

(2012) J. Yan et al.   MOLECULAR AND CELLULAR BIOLOGY

A Fluorescence-Based High-Throughput Assay for the Discovery of Exchange Protein Directly Activated by Cyclic AMP (EPAC) Antagonists

(2012) Tamara Tsalkova et al.   PLoS One

Structural Analyses of a Constitutively Active Mutant of Exchange Protein Directly Activated by cAMP

(2012) Mark A. White et al.   PLoS One

cAMP regulates DEP domain-mediated binding of the guanine nucleotide exchange factor Epac1 to phosphatidic acid at the plasma membrane

(2012) S. V. Consonni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Isoform-specific antagonists of exchange proteins directly activated by cAMP

(2012) T. Tsalkova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of Dynamics in the Autoinhibition and Activation of the Exchange Protein Directly Activated by Cyclic AMP (EPAC)

(2011) Bryan VanSchouwen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanism of Intracellular cAMP Sensor Epac2 Activation

(2011) Sheng Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural analysis of intrinsically disordered proteins by small-angle X-ray scattering

(2011) Pau Bernadó et al.   Molecular BioSystems

Mapping allostery through the covariance analysis of NMR chemical shifts

(2011) R. Selvaratnam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Radixin Assembles cAMP Effectors Epac and PKA into a Functional cAMP Compartment

(2010) Daniel Hochbaum et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Spatial Regulation of Cyclic AMP-Epac1 Signaling in Cell Adhesion by ERM Proteins

(2010) M. Gloerich et al.   MOLECULAR AND CELLULAR BIOLOGY

Small-angle scattering for structural biology-Expanding the frontier while avoiding the pitfalls

(2010) David A. Jacques et al.   PROTEIN SCIENCE

DAMMIF, a program for rapidab-initioshape determination in small-angle scattering

(2009) Daniel Franke et al.   JOURNAL OF APPLIED CRYSTALLOGRAPHY

Determination of the molecular weight of proteins in solution from a single small-angle X-ray scattering measurement on a relative scale

(2009) H. Fischer et al.   JOURNAL OF APPLIED CRYSTALLOGRAPHY

Mechanism of Epac Activation

(2009) Tamara Tsalkova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Critical role of the N-terminal cyclic AMP-binding domain of Epac2 in its subcellular localization and function

(2009) Manabu Niimura et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Epac and PKA: a tale of two intracellular cAMP receptors

(2008) Xiaodong Cheng et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Entropy-driven cAMP-dependent Allosteric Control of Inhibitory Interactions in Exchange Proteins Directly Activated by cAMP

(2008) Rahul Das et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of Epac2 in complex with a cyclic AMP analogue and RAP1B

(2008) Holger Rehmann et al.   NATURE

The SWISS-MODEL Repository and associated resources

(2008) F. Kiefer et al.   NUCLEIC ACIDS RESEARCH