Oncogenic MCT-1 activation promotes YY1-EGFR-MnSOD signaling and tumor progression

Manganese Superoxide Dismutase Expression Regulates the Switch Between an Epithelial and a Mesenchymal-Like Phenotype in Breast Carcinoma

(2016) Ser Yue Loo et al.   ANTIOXIDANTS & REDOX SIGNALING

GON4L Drives Cancer Growth through a YY1-Androgen Receptor-CD24 Axis

(2016) N. Agarwal et al.   CANCER RESEARCH

Yin Yang 1 is associated with cancer stem cell transcription factors (SOX2, OCT4, BMI1) and clinical implication

(2016) Samantha Kaufhold et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

EF4 disengages the peptidyl-tRNA CCA end and facilitates back-translocation on the 70S ribosome

(2016) Dejiu Zhang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

EF4 disengages the peptidyl-tRNA CCA end and facilitates back-translocation on the 70S ribosome

(2016) Dejiu Zhang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

EGFR over-expression in non-small cell lung cancers harboring EGFR mutations is associated with marked down-regulation of CD82

(2015) Chi-Hwa Yang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Apoptosis, autophagy, necroptosis, and cancer metastasis

(2015) Zhenyi Su et al.   Molecular Cancer

Designing a broad-spectrum integrative approach for cancer prevention and treatment

(2015) Keith I. Block et al.   SEMINARS IN CANCER BIOLOGY

MnSOD upregulation sustains the Warburg effect via mitochondrial ROS and AMPK-dependent signalling in cancer

(2015) Peter C. Hart et al.   Nature Communications

Using the MCF10A/MCF10CA1a Breast Cancer Progression Cell Line Model to Investigate the Effect of Active, Mutant Forms of EGFR in Breast Cancer Development and Treatment Using Gefitinib

(2015) Darrell C. Bessette et al.   PLoS One

Targeting MCT-1 oncogene inhibits Shc pathway and xenograft tumorigenicity

(2015) Hung-Ju Shih et al.   Oncotarget

Yin Yang 1 is a target of microRNA-34 family and contributes to gastric carcinogenesis

(2015) An-Ming Wang et al.   Oncotarget

DENR–MCT-1 promotes translation re-initiation downstream of uORFs to control tissue growth

(2014) Sibylle Schleich et al.   NATURE

MCT-1 expression and PTEN deficiency synergistically promote neoplastic multinucleation through the Src/p190B signaling activation

(2014) M-H Wu et al.   ONCOGENE

YY1 is indispensable for Lgr5+ intestinal stem cell renewal

(2014) A. O. Perekatt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of reactive oxygen species and metabolism on cancer cells and their microenvironment

(2014) Ana Costa et al.   SEMINARS IN CANCER BIOLOGY

Constitutive and ligand-induced EGFR signalling triggers distinct and mutually exclusive downstream signalling networks

(2014) Sharmistha Chakraborty et al.   Nature Communications

Mir-34: A New Weapon Against Cancer?

(2014) Gabriella Misso et al.   Molecular Therapy-Nucleic Acids

Oxidative stress and cancer: An overview

(2012) Venus Sosa et al.   AGEING RESEARCH REVIEWS

Reactive Oxygen Species in Cancer Stem Cells

(2012) Xiaoke Shi et al.   ANTIOXIDANTS & REDOX SIGNALING

Mutation profiling identifies numerous rare drug targets and distinct mutation patterns in different clinical subtypes of breast cancers

(2012) Libero Santarpia et al.   BREAST CANCER RESEARCH AND TREATMENT

The involvement of MCT-1 oncoprotein in inducing mitotic catastrophe and nuclear abnormalities

(2012) Hung-Ju Shih et al.   CELL CYCLE

Bcl-w promotes cell invasion by blocking the invasion-suppressing action of Bax

(2012) Eun Mi Kim et al.   CELLULAR SIGNALLING

An investigation of the affinities, specificity and kinetics involved in the interaction between the Yin Yang 1 transcription factor and DNA

(2012) Filip M. Golebiowski et al.   FEBS Journal

miR-34a functions as a tumor suppressor modulating EGFR in glioblastoma multiforme

(2012) D Yin et al.   ONCOGENE

Redox regulation of cell migration and adhesion

(2012) Thomas Ryan Hurd et al.   TRENDS IN CELL BIOLOGY

Upsides and Downsides of Reactive Oxygen Species for Cancer: The Roles of Reactive Oxygen Species in Tumorigenesis, Prevention, and Therapy

(2011) Subash C. Gupta et al.   ANTIOXIDANTS & REDOX SIGNALING

EGFR Nuclear Translocation Modulates DNA Repair following Cisplatin and Ionizing Radiation Treatment

(2011) G. Liccardi et al.   CANCER RESEARCH

Manganese Superoxide Dismutase Is a p53-Regulated Gene That Switches Cancers between Early and Advanced Stages

(2011) S. K. Dhar et al.   CANCER RESEARCH

Identification of Genes Upregulated in ALK-Positive and EGFR/KRAS/ALK-Negative Lung Adenocarcinomas

(2011) H. Okayama et al.   CANCER RESEARCH

p53-Responsive miR-194 Inhibits Thrombospondin-1 and Promotes Angiogenesis in Colon Cancers

(2011) P. Sundaram et al.   CANCER RESEARCH

The antagonism between MCT-1 and p53 affects the tumorigenic outcomes

(2011) Ravi Kasiappan et al.   Molecular Cancer

Role of MnSOD and p66shc in Mitochondrial Response to p53

(2010) Giovambattista Pani et al.   ANTIOXIDANTS & REDOX SIGNALING

Comparative pharmacology of chemically distinct NADPH oxidase inhibitors

(2010) S Wind et al.   BRITISH JOURNAL OF PHARMACOLOGY

Morphologic transformation of human breast epithelial cells MCF-10A: dependence on an oxidative microenvironment and estrogen/epidermal growth factor receptors

(2010) Rita Yusuf et al.   Cancer Cell International

Oxidative stress promotes myofibroblast differentiation and tumour spreading

(2010) Aurore Toullec et al.   EMBO Molecular Medicine

Activities of Ligatin and MCT-1/DENR in eukaryotic translation initiation and ribosomal recycling

(2010) M. A. Skabkin et al.   GENES & DEVELOPMENT

Systematic Proteome Analysis Identifies Transcription Factor YY1 as a Direct Target of miR-34a

(2010) Qing-Rong Chen et al.   JOURNAL OF PROTEOME RESEARCH

p53 Regulates Hematopoietic Stem Cell Quiescence

(2009) Yan Liu et al.   Cell Stem Cell

Mechanisms of Tumor Cell Necrosis

(2009) Sergey Proskuryakov et al.   CURRENT PHARMACEUTICAL DESIGN

p47phox, the phagocyte NADPH oxidase/NOX2 organizer: structure, phosphorylation and implication in diseases

(2009) Jamel El-Benna et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Loss of p53 and MCT-1 Overexpression Synergistically Promote Chromosome Instability and Tumorigenicity

(2009) R. Kasiappan et al.   MOLECULAR CANCER RESEARCH

Activating and resistance mutations of EGFR in non-small-cell lung cancer: role in clinical response to EGFR tyrosine kinase inhibitors

(2009) A F Gazdar   ONCOGENE

Invasive ductal carcinoma of the breast with the “triple-negative” phenotype: prognostic implications of EGFR immunoreactivity

(2008) Giuseppe Viale et al.   BREAST CANCER RESEARCH AND TREATMENT

NEAP causes down-regulation of EGFR, subsequently induces the suppression of NGF-induced differentiation in PC12 cells

(2008) Jiz-Yuh Wang et al.   JOURNAL OF NEUROCHEMISTRY

Loss of p53 induces epidermal growth factor receptor promoter activity in normal human keratinocytes

(2008) A Bheda et al.   ONCOGENE

Post-transcriptional gene regulation by HuR promotes a more tumorigenic phenotype

(2008) K Mazan-Mamczarz et al.   ONCOGENE