Article
Oncology
Yoshiaki Maru, Naotake Tanaka, Yasutoshi Tatsumi, Yuki Nakamura, Ryoji Yao, Tetsuo Noda, Makiko Itami, Yoshitaka Hippo
Summary: Genetically engineered organoids have been shown to develop tumors in immunocompromised mice, providing new insights into the interactions among genotype, cell type, and tumor phenotype in tumorigenesis.
JOURNAL OF PATHOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Eun-Ji Ko, Mee-Sun Ock, Yung-Hyun Choi, Juan L. Iovanna, Seyoung Mun, Kyudong Han, Heui-Soo Kim, Hee-Jae Cha
Summary: HERV-K env gene affects tumorigenic characteristics, including cell proliferation, migration, and tumor colonization through NUPR1 related pathway, as shown by knockout experiments in colorectal cancer cell lines using CRISPR-Cas9 system.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Christopher Godina, Vineesh Indira Chandran, Magdalena Barbachowska, Helga Tryggvadottir, Bjorn Nodin, Edward Visse, Signe Borgquist, Karin Jirstrom, Karolin Isaksson, Ana Bosch, Mattias Belting, Helena Jernstrom
Summary: CAV1 is associated with the progression and recurrence risk of breast cancer, particularly within the tumor microenvironment. Positive cytoplasmic CAV1 is associated with increased risk for contralateral disease, while strong stromal CAV1 is associated with increased risk for locoregional recurrence.
TRANSLATIONAL ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jingwen Tan, Mingjun Sun, Jinyao Yin, Qian Zhou, Ruihuan Zhao, Qian Chen, Huiwen Sun, Chenglan Jiang, Shuting Li, Yuefeng He
Summary: This study explored the role of hsa_circ_0005050 in mediating cell apoptosis and proliferation. It was found that hsa_circ_0005050 was highly expressed in individuals exposed to arsenic and could regulate the p53 and NF-KB signaling pathways to affect cell survival and proliferation. Additionally, hsa_circ_0005050 was found to interact with the RNA binding protein ILF3, influencing each other's formation.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Virology
Yann Breton, Corinne Barat, Michel J. Tremblay
Summary: The study revealed the significant regulatory role of p53 isoforms in HIV-1 infection, highlighting their importance in determining macrophage susceptibility to the virus. This new understanding sheds light on the intricate role of p53 in virus replication processes in myeloid cells.
JOURNAL OF VIROLOGY
(2021)
Article
Multidisciplinary Sciences
Larissa Dietz, Cara J. Ellison, Carlos Riechmann, C. Keith Cassidy, F. Daniel Felfoldi, Adan Pinto-Fernandez, Benedikt M. Kessler, Paul R. Elliott
Summary: Certain members of the inhibitor of apoptosis (IAP) family, including BIRC6, regulate cell death by inhibiting caspases, while SMAC antagonizes IAPs and promotes cell death. BIRC6 directly inhibits caspase-3 and-7 and ubiquitinates caspase-3,-7, and-9, working with noncanonical E1, UBA6. SMAC suppresses both mechanisms by competitively displacing caspases.
Article
Biochemical Research Methods
Sharon Guerstein, Victoria Romeo-Aznar, Ma'ayan Dekel, Oren Miron, Nadav Davidovitch, Rami Puzis, Shai Pilosof
Summary: This study examines the interaction effects of social distancing and vaccination in combating COVID19, with findings that prioritizing vaccines for the elderly can reduce hospitalizations when social distancing measures are applied to adults. It also suggests that different combination of intervention strategies can achieve the same reduction in hospitalizations, offering flexibility in public health policy decisions.
PLOS COMPUTATIONAL BIOLOGY
(2021)
Article
Environmental Sciences
Jinyao Yin, Qian Zhou, Jingwen Tan, Wangjun Che, Yuefeng He
Summary: Arsenic, a human carcinogen, poses a threat to global environmental health. This study investigated the effect of arsenic on MDM2, p53, and their phosphorylation. The findings suggest that arsenic and its methylated metabolites can modulate the expression and phosphorylation of MDM2 and p53, as well as the interaction between MDM2 and p53.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Endocrinology & Metabolism
Ahmed Khattab, R. Will Charlton
Summary: Treatment with Tildacerfont in males can effectively reduce A4 levels, correct A4/T ratio and increase LH levels, indicating the potential of the drug to enhance testicular testosterone production. However, more data is needed to confirm its favorable impact on male reproductive health.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Multidisciplinary Sciences
Yen-Li Li, Caroline A. Langley, Caleigh M. Azumaya, Ignacia Echeverria, Nicholas M. Chesarino, Michael Emerman, Yifan Cheng, John D. Gross
Summary: The APOBEC3 (A3) proteins are host antiviral cellular proteins that hypermutate the viral genome of diverse viral families. A3G protein of humans binds to HIV-1 Vif and inhibits its function by RNA-mediated mechanisms. This discovery sheds light on the molecular arms race between viruses and hosts.
Article
Biochemistry & Molecular Biology
Xu Dong, Jiabao Xing, Qingchun Liu, Mao Ye, Zhen Zhou, Yantao Li, Rongqin Huang, Zhenhui Li, Qinghua Nie
Summary: In this study, a circRNA-miRNA-mRNA interaction network was identified in chicken primary myoblasts' myogenesis. The circPLXNA2-gga-miR-12207-5P-MDM4 axis was found to play a critical role in regulating myogenesis by inhibiting apoptosis and promoting cell proliferation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Na Sun, Yuchuan Zhang, Jian Dong, Geng Liu, Zhenbin Liu, Jiamin Wang, Zilin Qiao, Jiayou Zhang, Kai Duan, Xuanxuan Nian, Zhongren Ma, Xiaoming Yang
Summary: This study explores the metabolic differences between MDCK cells with varying proliferative capabilities using untargeted and targeted metabolomics. The findings suggest that fluctuations in metabolite levels, such as choline, tryptophan, and tyrosine, may have a significant impact on cell proliferation.
Review
Nutrition & Dietetics
Sara Mancell, Karishma Manwani, Anil Dhawan, Kevin Whelan
Summary: Medium-chain triglyceride (MCT) supplementation is recommended for children with cholestatic liver disease, showing improved fat absorption, while a high percentage of MCT may lead to essential fatty acid deficiency. However, these conclusions are based on limited, mostly early observational studies. Further high-quality randomized controlled trials are needed to explore the effects of MCT at different percentages on growth, nutritional status, and clinical outcomes.
CLINICAL NUTRITION
(2023)
Article
Cell Biology
Raha Weigert, Sara Hetzel, Nina Bailly, Chuck Haggerty, Ibrahim A. Ilik, Philip Yuk Kwong Yung, Carmen Navarro, Adriano Bolondi, Abhishek Sampath Kumar, Chiara Anania, Bjoern Braendl, David Meierhofer, Dario G. Lupianez, Franz-Josef Mueller, Tugce Aktas, Simon J. Elsaesser, Helene Kretzmer, Zachary D. Smith, Alexander Meissner
Summary: Weigert et al. demonstrate that the balance between DNA methyltransferase and Polycomb activity is crucial for maintaining intermediate methylation levels in trophoblast stem cells. The extra-embryonic epigenome exhibits globally intermediate DNA methylation levels, which are maintained through dynamic recruitment of de novo methyltransferase and antagonism by Polycomb. Despite the disordered molecular appearance, a controlled equilibrium between repressors allows for stable maintenance of these methylation levels.
NATURE CELL BIOLOGY
(2023)
Article
Agricultural Engineering
Lili Wang, Kai Sun, Shuai Pan, Shunli Wang, Zhongkang Yan, Lianlian Zhu, Xingyuan Yang
Summary: This study aimed to explore the effect of antagonism between Trichoderma reesei (T.r) and Phanerochaete chrysosporium (P.c) on humification during fermentation of rice straw (RS) and canola straw (CS). The results showed that the addition of exogenous fungi accelerated straw degradation and enzyme activities. P.c inhibited the activity of LiP when co-existing with T.r, but promoted lignin degradation and the production of humus-like substances (HLS) and humic-like acid (HLA) in later fermentation. The recommended technology for converting crop straw into humus resources was RTP.
BIORESOURCE TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ling Chien, Min-Long Liang, Chu-Yuan Chang, Chen Wang, Linyi Chen
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2018)
Article
Neurosciences
Ya-Jean Wang, Chung-Pin Hsieh, Ming-Huan Chan, Tzu-Yi Chan, Linyi Chen, Hwei-Hisen Chen
NUTRITIONAL NEUROSCIENCE
(2019)
Article
Oncology
Baisen Li, Xiuhui Gu, Mingbo Wu, Ye Zhao, Jie Yang, Li Feng, Junjie Gou, Linyi Chen, Ting Li, Linpeng Li, Lan Wang, Li Zhu, Kun Zhang
Article
Oncology
Ravi Kasiappan, Indira Jutooru, Kumaravel Mohankumar, Keshav Karki, Alexandra Lacey, Stephen Safe
MOLECULAR CANCER RESEARCH
(2019)
Article
Cell Biology
Dheeran Rajarajan, Sweetha Selvarajan, Mamilla R. Charan Raja, Santanu Kar Mahapatra, Ravi Kasiappan
JOURNAL OF CELLULAR PHYSIOLOGY
(2019)
Article
Cell Biology
Yi-Ju Wu, Bor-Sheng Ko, Shu-Man Liang, Yi-Jhu Lu, Yee-Jee Jan, Shih-Sheng Jiang, Song-Kun Shyue, Linyi Chen, Jun-Yang Liou
CELL DEATH & DISEASE
(2019)
Review
Neurosciences
Chu-Yuan Chang, Min-Zong Liang, Linyi Chen
TRANSLATIONAL NEURODEGENERATION
(2019)
Article
Biochemistry & Molecular Biology
Chu-Yuan Chang, Min-Zong Liang, Ching-Chih Wu, Pei-Yuan Huang, Hong- Chen, Shaw-Fang Yet, Jin-Wu Tsai, Cheng-Fu Kao, Linyi Chen
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Chemistry, Multidisciplinary
Yao-Shen Huang, Ching-Hsiang Fan, Ning Hsu, Nai-Hua Chiu, Chun-Yao Wu, Chu -Yuan Chang, Bing-Huan Wu, Shi-Rong Hong, Ya-Chu Chan, Anthony Yan-Tang Wu, Vanessa Guo, Yueh-Chen Chiang, Wei -Chia Hsu, Linyi Chen, Charles Pin-Kuang Lai, Chih-Kuang Yeh, Yu-Chun Lin
Article
Pharmacology & Pharmacy
Yue-Zhi Lee, Huan-Chen Guo, Guan-Hao Zhao, Cheng-Wei Yang, Hsin-Yu Chang, Ruey-Bing Yang, Linyi Chen, Shiow-Ju Lee
PHARMACOLOGICAL RESEARCH
(2020)
Article
Biochemistry & Molecular Biology
Chu-Yuan Chang, Jui-Hung Hung, Liang-Wei Huang, Joye Li, Ka Shing Fung, Cheng-Fu Kao, Linyi Chen
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Cell Biology
Yen-Ling Lian, Kuan-Wei Chen, Yu-Ting Chou, Ting-Ling Ke, Bi-Chang Chen, Yu-Chun Lin, Linyi Chen
JOURNAL OF CELL SCIENCE
(2020)
Article
Biochemistry & Molecular Biology
Yen-Chi Tsao, Yu-Jung Chang, Chun-Hsien Wang, Linyi Chen
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Min-Zong Liang, Ting-Hsuan Lu, Linyi Chen
Summary: Patients with severe traumatic brain injury (TBI) have a higher risk of developing neurodegenerative diseases in the future. This study found that a mitochondrial protein called PGAM5 plays a role in sensing mitochondrial dysfunction and maintaining mitochondrial homeostasis during regeneration. It was also discovered that PGAM5 is cleaved by PARL, leading to an increase in mitochondrial biogenesis and functional recovery after TBI.
CELL AND BIOSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Kuan-Wei Chen, Yu-Jung Chang, Chia-Ming Yeh, Yen-Ling Lian, Michael W. Y. Chan, Cheng-Fu Kao, Linyi Chen
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
(2017)