Neonatal Fc receptor antagonist efgartigimod safely and sustainably reduces IgGs in humans

Update on the use of immunoglobulin in human disease: A review of evidence

(2017) Elena E. Perez et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A comprehensive review of the neonatal Fc receptor and its application in drug delivery

(2016) João Pedro Martins et al.   PHARMACOLOGY & THERAPEUTICS

Therapeutic Apheresis in Hematologic, Autoimmune and Dermatologic Diseases With Immunologic Origin

(2016) Rolf Bambauer et al.   THERAPEUTIC APHERESIS AND DIALYSIS

Fc Engineering of Human IgG1 for Altered Binding to the Neonatal Fc Receptor Affects Fc Effector Functions

(2015) Algirdas Grevys et al.   JOURNAL OF IMMUNOLOGY

The neonatal Fc receptor (FcRn) binds independently to both sites of the IgG homodimer with identical affinity

(2015) Yasmina Noubia Abdiche et al.   mAbs

Fully Human Monoclonal Antibody Inhibitors of the Neonatal Fc Receptor Reduce Circulating IgG in Non-Human Primates

(2015) Andrew E. Nixon et al.   Frontiers in Immunology

pH-dependent Binding Engineering Reveals an FcRn Affinity Threshold That Governs IgG Recycling

(2014) M. Jack Borrok et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization and screening of IgG binding to the neonatal Fc receptor

(2014) Tobias Neuber et al.   mAbs

Neonatal Fc Receptor Expression in Dendritic Cells Mediates Protective Immunity against Colorectal Cancer

(2013) Kristi Baker et al.   IMMUNITY

Using multifocal plane microscopy to reveal novel trafficking processes in the recycling pathway

(2013) Z. Gan et al.   JOURNAL OF CELL SCIENCE

Autoantibody depletion ameliorates disease in murine experimental autoimmune encephalomyelitis

(2013) Dilip K. Challa et al.   mAbs

Multivalent immune complexes divert FcRn to lysosomes by exclusion from recycling sorting tubules

(2013) Andrew W. Weflen et al.   MOLECULAR BIOLOGY OF THE CELL

Adverse Effects of Human Immunoglobulin Therapy

(2013) E. Richard Stiehm   TRANSFUSION MEDICINE REVIEWS

EuroFlow antibody panels for standardized n-dimensional flow cytometric immunophenotyping of normal, reactive and malignant leukocytes

(2012) J J M van Dongen et al.   LEUKEMIA

Neonatal Fc Receptor Blockade by Fc Engineering Ameliorates Arthritis in a Murine Model

(2011) D. A. Patel et al.   JOURNAL OF IMMUNOLOGY

The neonatal Fc receptor as therapeutic target in IgG-mediated autoimmune diseases

(2010) Alina Sesarman et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Population Pharmacokinetics of Therapeutic Monoclonal Antibodies

(2010) Nathanael L. Dirks et al.   CLINICAL PHARMACOKINETICS

A Software Framework for the Analysis of Complex Microscopy Image Data

(2010) Jerry Chao et al.   IEEE TRANSACTIONS ON INFORMATION TECHNOLOGY IN BIOMEDICINE

Inhibitors of the FcRn:IgG Protein–Protein Interaction

(2009) Susan C. Low et al.   AAPS Journal

Current Proposed Mechanisms of Action of Intravenous Immunoglobulins in Inflammatory Neuropathies

(2009) Saiju Jacob et al.   Current Neuropharmacology

Recent insights in the epidemiology of autoimmune diseases: Improved prevalence estimates and understanding of clustering of diseases

(2009) Glinda S. Cooper et al.   JOURNAL OF AUTOIMMUNITY

Comparing the Autoantibody Levels and Clinical Efficacy of Double Filtration Plasmapheresis, Immunoadsorption, and Intravenous Immunoglobulin for the Treatment of Late-onset Myasthenia Gravis

(2009) Jun-Feng Liu et al.   THERAPEUTIC APHERESIS AND DIALYSIS

Serum Immunoglobulins and Risk of Infection: How Low Can You Go?

(2008) Daniel E. Furst   SEMINARS IN ARTHRITIS AND RHEUMATISM