Hematopoietic cells as site of first-pass catabolism after subcutaneous dosing and contributors to systemic clearance of a monoclonal antibody in mice

Distribution of FcRn Across Species and Tissues

(2017) Sari Latvala et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

A generic whole body physiologically based pharmacokinetic model for therapeutic proteins in PK-Sim

(2017) Christoph Niederalt et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Impact of altered endogenous IgG on unspecific mAb clearance

(2017) Saskia Fuhrmann et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Quantitative Analysis of Human Neonatal Fc Receptor (FcRn) Tissue Expression in Transgenic Mice by Online Peptide Immuno-Affinity LC-HRMS

(2016) Yao-Yun Fan et al.   ANALYTICAL CHEMISTRY

Utility of a human FcRn transgenic mouse model in drug discovery for early assessment and prediction of human pharmacokinetics of monoclonal antibodies

(2016) Lindsay B. Avery et al.   mAbs

Antibodies to watch in 2017

(2016) Janice M. Reichert   mAbs

Tissue expression profile of human neonatal Fc receptor (FcRn) in Tg32 transgenic mice

(2016) Yao-Yun Fan et al.   mAbs

Aberrant bispecific antibody pharmacokinetics linked to liver sinusoidal endothelium clearance mechanism in cynomolgus monkeys

(2016) Amita Datta-Mannan et al.   mAbs

The role of albumin receptors in regulation of albumin homeostasis: Implications for drug delivery

(2015) Malin Bern et al.   JOURNAL OF CONTROLLED RELEASE

Collecting Lymphatic Vessel Permeability Facilitates Adipose Tissue Inflammation and Distribution of Antigen to Lymph Node–Homing Adipose Tissue Dendritic Cells

(2015) Emma L. Kuan et al.   JOURNAL OF IMMUNOLOGY

Unraveling the Interaction between FcRn and Albumin: Opportunities for Design of Albumin-Based Therapeutics

(2015) Kine Marita Knudsen Sand et al.   Frontiers in Immunology

Simulation of Monoclonal Antibody Pharmacokinetics in HumansUsing a Minimal Physiologically Based Model

(2014) Linzhong Li et al.   AAPS Journal

Extending Serum Half-life of Albumin by Engineering Neonatal Fc Receptor (FcRn) Binding

(2014) Jan Terje Andersen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Monoclonal antibody disposition: a simplified PBPK model and its implications for the derivation and interpretation of classical compartment models

(2014) Ludivine Fronton et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Interspecies Pharmacokinetic Modeling of Subcutaneous Absorption of Rituximab in Mice and Rats

(2014) Leonid Kagan et al.   PHARMACEUTICAL RESEARCH

Immunogenicity of Subcutaneously Administered Therapeutic Proteins—a Mechanistic Perspective

(2013) Anas M. Fathallah et al.   AAPS Journal

Correlations between pharmacokinetics of IgG antibodies in primates vs. FcRn-transgenic mice reveal a rodent model with predictive capabilities

(2013) Susan H. Tam et al.   mAbs

Pharmacokinetics, Lymph Node Uptake, and Mechanistic PK Model of Near-Infrared Dye-Labeled Bevacizumab After IV and SC Administration in Mice

(2012) Fang Wu et al.   AAPS Journal

Mechanistic Determinants of Biotherapeutics Absorption Following SC Administration

(2012) Wolfgang F. Richter et al.   AAPS Journal

Evaluation of a Catenary PBPK Model for Predicting the In Vivo Disposition of mAbs Engineered for High-Affinity Binding to FcRn

(2012) Yang Chen et al.   AAPS Journal

Pharmacokinetic Models for FcRn-Mediated IgG Disposition

(2012) Jim J. Xiao   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Monoclonal antibodies directed against human FcRn and their applications

(2012) Gregory J. Christianson et al.   mAbs

Minipig as a potential translatable model for monoclonal antibody pharmacokinetics after intravenous and subcutaneous administration

(2012) Yanan Zheng et al.   mAbs

Subcutaneous bioavailability of therapeutic antibodies as a function 
of FcRn binding affinity in mice

(2012) Rong Deng et al.   mAbs

Subcutaneous Absorption of Monoclonal Antibodies: Role of Dose, Site of Injection, and Injection Volume on Rituximab Pharmacokinetics in Rats

(2011) Leonid Kagan et al.   PHARMACEUTICAL RESEARCH

Population Pharmacokinetics of Therapeutic Monoclonal Antibodies

(2010) Nathanael L. Dirks et al.   CLINICAL PHARMACOKINETICS

An FcRn-Dependent Role for Anti-flagellin Immunoglobulin G in Pathogenesis of Colitis in Mice

(2009) Kanna Kobayashi et al.   GASTROENTEROLOGY

Conditional deletion of the MHC class I-related receptor FcRn reveals the sites of IgG homeostasis in mice

(2009) Héctor Pérez Montoyo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Monoclonal Antibody Pharmacokinetics and Pharmacodynamics

(2008) W Wang et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Podocytes use FcRn to clear IgG from the glomerular basement membrane

(2008) S. Akilesh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dependence of antibody-mediated presentation of antigen on FcRn

(2008) S.-W. Qiao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA