Biological and Technical Challenges in Unraveling the Role of N-Glycans in Immune Receptor Regulation

Glycosylation in health and disease

(2019) Colin Reily et al.   Nature Reviews Nephrology

Quantitative Super-Resolution Microscopy of the Mammalian Glycocalyx

(2019) Leonhard Möckl et al.   DEVELOPMENTAL CELL

N-Linked Glycosylation Regulates CD22 Organization and Function

(2019) Laabiah Wasim et al.   Frontiers in Immunology

Enhanced Imaging of Specific Cell-Surface Glycosylation Based on Multi-FRET

(2018) Baoyin Yuan et al.   ANALYTICAL CHEMISTRY

Molecular basis for intestinal mucin recognition by galectin-3 and C-type lectins

(2018) Charlotte Leclaire et al.   FASEB JOURNAL

The Glycoscience of Immunity

(2018) Julie Y. Zhou et al.   TRENDS IN IMMUNOLOGY

Galectin-9 binds IgM-BCR to regulate B cell signaling

(2018) Anh Cao et al.   Nature Communications

Current Technologies for Complex Glycoproteomics and Their Applications to Biology/Disease-Driven Glycoproteomics

(2018) Hisashi Narimatsu et al.   JOURNAL OF PROTEOME RESEARCH

Congenital disorders of glycosylation (CDG): Quo vadis?

(2017) Romain Péanne et al.   European Journal of Medical Genetics

Glycoproteomics: A Balance between High-Throughput and In-Depth Analysis

(2017) Yang Yang et al.   TRENDS IN BIOTECHNOLOGY

N-glycan mediated adhesion strengthening during pathogen-receptor binding revealed by cell-cell force spectroscopy

(2017) Joost te Riet et al.   Scientific Reports

Glycomic analysis of gastric carcinoma cells discloses glycans as modulators of RON receptor tyrosine kinase activation in cancer

(2016) Stefan Mereiter et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Glycosylation-Dependent IFN-γR Partitioning in Lipid and Actin Nanodomains Is Critical for JAK Activation

(2016) Cédric M. Blouin et al.   CELL

Importance of membrane-proximal N-glycosylation on integrin β1 in its activation and complex formation

(2016) Sicong Hou et al.   FASEB JOURNAL

Oligosaccharyltransferase inhibition induces senescence in RTK-driven tumor cells

(2016) Cecilia Lopez-Sambrooks et al.   Nature Chemical Biology

Proteome Based Construction of the Lymphocyte Function-Associated Antigen 1 (LFA-1) Interactome in Human Dendritic Cells

(2016) Christina Eich et al.   PLoS One

Using CRISPR-Cas9 to quantify the contributions of O-glycans, N-glycans and Glycosphingolipids to human leukocyte-endothelium adhesion

(2016) Gino Stolfa et al.   Scientific Reports

Targeted Delivery of a Sialic Acid-Blocking Glycomimetic to Cancer Cells Inhibits Metastatic Spread

(2015) Christian Büll et al.   ACS Nano

N-glycoprotein macroheterogeneity: biological implications and proteomic characterization

(2015) Lucia F. Zacchi et al.   GLYCOCONJUGATE JOURNAL

The galectin lattice at a glance

(2015) I. R. Nabi et al.   JOURNAL OF CELL SCIENCE

Tissue-Specific Glycosylation at the Glycopeptide Level

(2015) Katalin F. Medzihradszky et al.   MOLECULAR & CELLULAR PROTEOMICS

N-glycosylation controls the function of junctional adhesion molecule-A

(2015) David W. Scott et al.   MOLECULAR BIOLOGY OF THE CELL

Preventing E-cadherin aberrant N-glycosylation at Asn-554 improves its critical function in gastric cancer

(2015) S Carvalho et al.   ONCOGENE

Microglia-Secreted Galectin-3 Acts as a Toll-like Receptor 4 Ligand and Contributes to Microglial Activation

(2015) Miguel Angel Burguillos et al.   Cell Reports

Super-Resolution Imaging of Plasma Membrane Glycans

(2014) Sebastian Letschert et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

ST3Gal-4 is the primary sialyltransferase regulating the synthesis of E-, P-, and L-selectin ligands on human myeloid leukocytes

(2014) N. Mondal et al.   BLOOD

Enhanced receptor-clathrin interactions induced by N-glycan-mediated membrane micropatterning

(2014) J. A. Torreno-Pina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Beyond substrate analogues: new inhibitor chemotypes for glycosyltransferases

(2014) Lauren Tedaldi et al.   MedChemComm

Identification of a high-mannose ICAM-1 glycoform: effects of ICAM-1 hypoglycosylation on monocyte adhesion and outside in signaling

(2013) David W. Scott et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Partial IFN- R2 deficiency is due to protein misfolding and can be rescued by inhibitors of glycosylation

(2013) M. Moncada-Velez et al.   BLOOD

A Cis-Membrane FRET-Based Method for Protein-Specific Imaging of Cell-Surface Glycans

(2013) Wei Lin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Glycans Are a Novel Biomarker of Chronological and Biological Ages

(2013) Jasminka Krištić et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Ligand Binding and Signaling of Dendritic Cell Immunoreceptor (DCIR) Is Modulated by the Glycosylation of the Carbohydrate Recognition Domain

(2013) Karien Bloem et al.   PLoS One

T cells modulate glycans on CD43 and CD45 during development and activation, signal regulation, and survival

(2012) Mary C. Clark et al.   Annals of the New York Academy of Sciences

Silencing α1,3-Fucosyltransferases in Human Leukocytes Reveals a Role for FUT9 Enzyme during E-selectin-mediated Cell Adhesion

(2012) Alexander Buffone et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Roles for major histocompatibility complex glycosylation in immune function

(2012) Sean O. Ryan et al.   Seminars in Immunopathology

MHCII glycosylation modulatesBacteroides fragiliscarbohydrate antigen presentation

(2011) Sean O. Ryan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Unraveling the human dendritic cell phagosome proteome by organellar enrichment ranking

(2011) Sonja I. Buschow et al.   Journal of Proteomics

A role for UDP-glucose glycoprotein glucosyltransferase in expression and quality control of MHC class I molecules

(2011) W. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Essential glycan-dependent interactions optimize MHC class I peptide loading

(2011) P. A. Wearsch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fungal recognition is mediated by the association of dectin-1 and galectin-3 in macrophages

(2011) A. Esteban et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetics and the environment converge to dysregulate N-glycosylation in multiple sclerosis

(2011) Haik Mkhikian et al.   Nature Communications

The effect of individual N-glycans on enzyme activity

(2009) Danielle Skropeta   BIOORGANIC & MEDICINAL CHEMISTRY

Metabolism, Cell Surface Organization, and Disease

(2009) James W. Dennis et al.   CELL

MUC2 mucin is a major carrier of the cancer-associated sialyl-Tn antigen in intestinal metaplasia and gastric carcinomas

(2009) Tim Conze et al.   GLYCOBIOLOGY

N-Glycosylation of the I-like Domain of β1 Integrin Is Essential for β1 Integrin Expression and Biological Function

(2009) Tomoya Isaji et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lattices, rafts, and scaffolds: domain regulation of receptor signaling at the plasma membrane

(2009) Patrick Lajoie et al.   JOURNAL OF CELL BIOLOGY

Adaptive Regulation at the Cell Surface byN-Glycosylation

(2009) James W. Dennis et al.   TRAFFIC

Protein-glycan interactions in the control of innate and adaptive immune responses

(2008) Yvette van Kooyk et al.   NATURE IMMUNOLOGY