MK-0677, a Ghrelin Agonist, Alleviates Amyloid Beta-Related Pathology in 5XFAD Mice, an Animal Model of Alzheimer’s Disease

Visualization of Altered Hippocampal Connectivity in an Animal Model of Alzheimer’s Disease

(2018) Seong Gak Jeon et al.   MOLECULAR NEUROBIOLOGY

Ghrelin Ameliorates Cognitive Dysfunction and Neurodegeneration in Intrahippocampal Amyloid-β1-42 Oligomer-Injected Mice

(2018) Minho Moon et al.   JOURNAL OF ALZHEIMERS DISEASE

Evidence for Early Cognitive Impairment Related to Frontal Cortex in the 5XFAD Mouse Model of Alzheimer's Disease

(2018) Stéphane D. Girard et al.   JOURNAL OF ALZHEIMERS DISEASE

Impaired Hippocampal Neurogenesis and its Enhancement with Ghrelin in 5XFAD Mice

(2018) Minho Moon et al.   JOURNAL OF ALZHEIMERS DISEASE

Neurogenic Effects of Ghrelin on the Hippocampus

(2017) Chanyang Kim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

From Belly to Brain: Targeting the Ghrelin Receptor in Appetite and Food Intake Regulation

(2017) Ken Howick et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Oral ghrelin receptor agonist MK-0677 increases serum insulin-like growth factor 1 in hemodialysis patients: a randomized blinded study*

(2017) Garland A Campbell et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Expression of the Ghrelin and Neurotensin Systems is Altered in the Temporal Lobe of Alzheimer's Disease Patients

(2017) Manuel D. Gahete et al.   JOURNAL OF ALZHEIMERS DISEASE

2016 Alzheimer's disease facts and figures

(2016)   Alzheimers & Dementia

Ghrelin protects against palmitic acid or lipopolysaccharide-induced hepatocyte apoptosis through inhibition of MAPKs/iNOS and restoration of Akt/eNOS pathways

(2016) Yuqing Mao et al.   BIOMEDICINE & PHARMACOTHERAPY

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Ghrelin regulates cell cycle-related gene expression in cultured hippocampal neural stem cells

(2016) Hyunju Chung et al.   JOURNAL OF ENDOCRINOLOGY

Two ghrelin receptor agonists for adults with malnutrition: a systematic review and meta-analysis

(2016) Jianhua Su et al.   Nutrition Journal

Ghrelin accelerates wound healing through GHS-R1a-mediated MAPK-NF-κB/GR signaling pathways in combined radiation and burn injury in rats

(2016) Cong Liu et al.   Scientific Reports

Ghrelin Protects Alveolar Macrophages Against Lipopolysaccharide-Induced Apoptosis Through Growth Hormone Secretagogue Receptor 1a-Dependent c-Jun N-Terminal Kinase and Wnt/β-Catenin Signaling and Suppresses Lung Inflammation

(2015) Bin Li et al.   ENDOCRINOLOGY

Acyl Ghrelin Improves Synapse Recovery in an In Vitro Model of Postanoxic Encephalopathy

(2015) Irina I. Stoyanova et al.   MOLECULAR NEUROBIOLOGY

Soluble amyloid-β oligomers as synaptotoxins leading to cognitive impairment in Alzheimer’s disease

(2015) Sergio T. Ferreira et al.   Frontiers in Cellular Neuroscience

Ghrelin agonist does not foster insulin resistance but improves cognition in an Alzheimer’s disease mouse model

(2015) Nicolas Kunath et al.   Scientific Reports

A new perspective on the role of the CREB family of transcription factors in memory consolidation via adult hippocampal neurogenesis

(2015) Sylvia Ortega-Martínez   Frontiers in Molecular Neuroscience

Hyperphosphorylation of Tau at Ser396 occurs in the much earlier stage than appearance of learning and memory disorders in 5XFAD mice

(2014) Takeshi Kanno et al.   BEHAVIOURAL BRAIN RESEARCH

The Opposing Effects of Ghrelin on Hypothalamic and Systemic Inflammatory Processes Are Modulated by Its Acylation Status and Food Intake in Male Rats

(2014) Cristina García-Cáceres et al.   ENDOCRINOLOGY

Onset of hippocampus-dependent memory impairments in 5XFAD transgenic mouse model of Alzheimer's disease

(2014) Stéphane D. Girard et al.   HIPPOCAMPUS

Models of β-amyloid induced Tau-pathology: the long and “folded” road to understand the mechanism

(2014) Ilie-Cosmin Stancu et al.   Molecular Neurodegeneration

Amyloid-β and Tau

(2014) George S. Bloom   JAMA Neurology

Effects of an Oral Ghrelin Mimetic on Body Composition and Clinical Outcomes in Healthy Older Adults

(2013) Ralf Nass et al.   ANNALS OF INTERNAL MEDICINE

Ghrelin

(2013) Geetali Pradhan et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Both Acyl and Des-Acyl Ghrelin Regulate Adiposity and Glucose Metabolism via Central Nervous System Ghrelin Receptors

(2013) K. M. Heppner et al.   DIABETES

Ghrelin directly stimulates adult hippocampal neurogenesis: implications for learning and memory

(2013) Endan Li et al.   ENDOCRINE JOURNAL

Ghrelin stimulates proliferation, migration and differentiation of neural progenitors from the subventricular zone in the adult mice

(2013) Endan Li et al.   EXPERIMENTAL NEUROLOGY

Macimorelin (AEZS-130)-Stimulated Growth Hormone (GH) Test: Validation of a Novel Oral Stimulation Test for the Diagnosis of Adult GH Deficiency

(2013) J. M. Garcia et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Multiple signaling pathways mediate ghrelin-induced proliferation of hippocampal neural stem cells

(2013) Hyunju Chung et al.   JOURNAL OF ENDOCRINOLOGY

Hunger in the Absence of Caloric Restriction Improves Cognition and Attenuates Alzheimer's Disease Pathology in a Mouse Model

(2013) Emily J. Dhurandhar et al.   PLoS One

The Central Role of AMP-Kinase and Energy Homeostasis Impairment in Alzheimer’s Disease: A Multifactor Network Analysis

(2013) Laura Caberlotto et al.   PLoS One

MECHANISMS IN ENDOCRINOLOGY: Ghrelin: the differences between acyl- and des-acyl ghrelin

(2012) Patric J D Delhanty et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Ghrelin and leptin secretion in patients with moderate Alzheimer’s disease

(2012) Anastasia Theodoropoulou et al.   Journal of Nutrition Health & Aging

Intraneuronal Aβ accumulation and neurodegeneration: Lessons from transgenic models

(2012) Oliver Wirths et al.   LIFE SCIENCES

Acylated ghrelin protects hippocampal neurons in pilocarpine-induced seizures of immature rats by inhibiting cell apoptosis

(2012) Ruiyun Zhang et al.   MOLECULAR BIOLOGY REPORTS

The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Guy M. McKhann et al.   Alzheimers & Dementia

Ghrelin protects spinal cord motoneurons against chronic glutamate-induced excitotoxicity via ERK1/2 and phosphatidylinositol-3-kinase/Akt/glycogen synthase kinase-3β pathways

(2011) Eunjin Lim et al.   EXPERIMENTAL NEUROLOGY

Downregulation of CREB expression in Alzheimer's brain and in Aβ-treated rat hippocampal neurons

(2011) Subbiah Pugazhenthi et al.   Molecular Neurodegeneration

Role of ghrelin system in neuroprotection and cognitive functions: Implications in Alzheimer's disease

(2011) Manuel D. Gahete et al.   PEPTIDES

The role of ghrelin in the hippocampal neuron plasticity

(2009) Masako Isokawa   Alzheimers & Dementia

Genetic reductions of β-site amyloid precursor protein-cleaving enzyme 1 and amyloid-β ameliorate impairment of conditioned taste aversion memory in 5XFAD Alzheimer’s disease model mice

(2009) Latha Devi et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Ghrelin Promotes and Protects Nigrostriatal Dopamine Function via a UCP2-Dependent Mitochondrial Mechanism

(2009) Z. B. Andrews et al.   JOURNAL OF NEUROSCIENCE

Desacyl-ghrelin and synthetic GH-secretagogues modulate the production of inflammatory cytokines in mouse microglia cells stimulated by β-amyloid fibrils

(2009) Ilaria Bulgarelli et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Enhanced Gastrointestinal Motility with Orally Active Ghrelin Receptor Agonists

(2009) S. Charoenthongtrakul et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Growth Hormone Secretagogues and Growth Hormone Releasing Peptides Act As Orthosteric Super-Agonists but Not Allosteric Regulators for Activation of the G Protein G o1 by the Ghrelin Receptor

(2009) K. A. Bennett et al.   MOLECULAR PHARMACOLOGY

Mechanisms underlying basal and learning-related intrinsic excitability in a mouse model of Alzheimer's disease

(2009) C.C. Kaczorowski et al.   NEUROBIOLOGY OF AGING

Failures to reconsolidate memory in a mouse model of Alzheimer’s disease

(2009) Masuo Ohno   NEUROBIOLOGY OF LEARNING AND MEMORY

Ghrelin protects against cell death of hippocampal neurons in pilocarpine-induced seizures in rats

(2009) Jingjing Xu et al.   NEUROSCIENCE LETTERS

Neuroprotective Effect of Ghrelin in the 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Mouse Model of Parkinson’s Disease by Blocking Microglial Activation

(2009) Minho Moon et al.   NEUROTOXICITY RESEARCH

Impairments in remote memory stabilization precede hippocampal synaptic and cognitive failures in 5XFAD Alzheimer mouse model

(2008) Ryoichi Kimura et al.   NEUROBIOLOGY OF DISEASE

Growth hormone secretagogue MK-677: No clinical effect on AD progression in a randomized trial

(2008) J. J. Sevigny et al.   NEUROLOGY

The Nonpeptide Growth Hormone Secretagogue, MK-0677, Activates Hypothalamic Arcuate Nucleus Neurons in vivo

(2003) Bailey et al.   JOURNAL OF NEUROENDOCRINOLOGY