Various Tastes of Sugar: The Potential of Glycosylation in Targeting and Modulating Human Immunity via C-Type Lectin Receptors

Antigens reversibly conjugated to a polymeric glyco-adjuvant induce protective humoral and cellular immunity

(2019) D. Scott Wilson et al.   NATURE MATERIALS

In vitro activation and maturation of human mononuclear phagocytes by stimulation with liposomes coated with a neoglycolipid containing α1–3, α1–6-mannotriose

(2019) Yuko Matsuoka et al.   GLYCOCONJUGATE JOURNAL

N ‐linked glycans in the variable domain of ACPA ‐IgG predict the development of rheumatoid arthritis

(2019) Lise Hafkenscheid et al.   Arthritis & Rheumatology

A Specific, Glycomimetic Langerin Ligand for Human Langerhans Cell Targeting

(2019) Eike-Christian Wamhoff et al.   ACS Central Science

Yeast-Derived β-Glucan in Cancer: Novel Uses of a Traditional Therapeutic

(2019) Anne Geller et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Costimulatory Molecules and Immune Checkpoints Are Differentially Expressed on Different Subsets of Dendritic Cells

(2019) Claudia Carenza et al.   Frontiers in Immunology

S-Layer Glycoprotein From Lactobacillus kefiri Exerts Its Immunostimulatory Activity Through Glycan Recognition by Mincle

(2019) Mariano Malamud et al.   Frontiers in Immunology

Controlled rapid synthesis and in vivo immunomodulatory effects of LM α(1,6)mannan with an amine linker

(2018) Warunda Bunthitsakda et al.   CARBOHYDRATE POLYMERS

Synthesis, Liposomal Formulation, and Immunological Evaluation of a Minimalistic Carbohydrate-α-GalCer Vaccine Candidate

(2018) Felix Broecker et al.   JOURNAL OF MEDICINAL CHEMISTRY

The B cell response to citrullinated antigens in the development of rheumatoid arthritis

(2018) Hans Ulrich Scherer et al.   Nature Reviews Rheumatology

Cell-based glycan arrays for probing glycan–glycan binding protein interactions

(2018) Jennie Grace Briard et al.   Nature Communications

Flexible Signaling of Myeloid C-Type Lectin Receptors in Immunity and Inflammation

(2018) Carlos del Fresno et al.   Frontiers in Immunology

Hypersialylation in Cancer: Modulation of Inflammation and Therapeutic Opportunities

(2018) Emily Rodrigues et al.   Cancers

Antitumor effect of a liposome-encapsulated β1,4-galactosyltransferase inhibitor

(2018) Guangsheng Cai et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

DNGR-1 in dendritic cells limits tissue damage by dampening neutrophil recruitment

(2018) Carlos del Fresno et al.   SCIENCE

Glycans as Key Checkpoints of T Cell Activity and Function

(2018) Márcia S. Pereira et al.   Frontiers in Immunology

Selectins in cancer immunity

(2017) Lubor Borsig   GLYCOBIOLOGY

Targeting C-type lectin receptors: a high-carbohydrate diet for dendritic cells to improve cancer vaccines

(2017) Dieke van Dinther et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Modulating IgG effector function by Fc glycan engineering

(2017) Tiezheng Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HemITAM: A single tyrosine motif that packs a punch

(2017) Björn Bauer et al.   Science Signaling

Parasite-Derived Proteins for the Treatment of Allergies and Autoimmune Diseases

(2017) Zhenyu Wu et al.   Frontiers in Microbiology

HemITAM: A single tyrosine motif that packs a punch

(2017) Björn Bauer et al.   Science Signaling

Autologous tolerogenic dendritic cells for rheumatoid and inflammatory arthritis

(2016) G M Bell et al.   ANNALS OF THE RHEUMATIC DISEASES

Tumor-associated Glycans and Tregs in Immunogenicity of an Autologous Cell-based Vaccine

(2016) Behjatolah Monzavi-Karbassi et al.   IMMUNOLOGICAL INVESTIGATIONS

Novel vaccines targeting dendritic cells by coupling allergoids to nonoxidized mannan enhance allergen uptake and induce functional regulatory T cells through programmed death ligand 1

(2016) Sofía Sirvent et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Orchestrating immune responses: How size, shape and rigidity affect the immunogenicity of particulate vaccines

(2016) Naomi Benne et al.   JOURNAL OF CONTROLLED RELEASE

Sialic acid-modified antigens impose tolerance via inhibition of T-cell proliferation and de novo induction of regulatory T cells

(2016) Maurizio Perdicchio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human dendritic cell subsets and function in health and disease

(2015) Meredith O’Keeffe et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

C-type lectins in immunity: recent developments

(2015) Ivy M Dambuza et al.   CURRENT OPINION IN IMMUNOLOGY

Antigen presenting cell-selective drug delivery by glycan-decorated nanocarriers

(2015) Theresa Frenz et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Signalling versatility following self and non-self sensing by myeloid C-type lectin receptors

(2015) Salvador Iborra et al.   IMMUNOBIOLOGY

MPLA incorporation into DC-targeting glycoliposomes favours anti-tumour T cell responses

(2015) Martine A. Boks et al.   JOURNAL OF CONTROLLED RELEASE

Cross-presentation through langerin and DC-SIGN targeting requires different formulations of glycan-modified antigens

(2015) Cynthia M. Fehres et al.   JOURNAL OF CONTROLLED RELEASE

Restricted dendritic cell and monocyte progenitors in human cord blood and bone marrow

(2015) Jaeyop Lee et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Langerhans Cell–Dendritic Cell Cross-Talk via Langerin and Hyaluronic Acid Mediates Antigen Transfer and Cross-Presentation of HIV-1

(2015) Linda M. van den Berg et al.   JOURNAL OF IMMUNOLOGY

Citrullinated peptide dendritic cell immunotherapy in HLA risk genotype–positive rheumatoid arthritis patients

(2015) Helen Benham et al.   Science Translational Medicine

Cationic antimicrobial peptides in psoriatic skin cooperate to break innate tolerance to self-DNA

(2014) Roberto Lande et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Human skin dendritic cells can be targetedin situby intradermal injection of antibodies against lectin receptors

(2014) Patrizia Stoitzner et al.   EXPERIMENTAL DERMATOLOGY

Human Dermal CD14 + Cells Are a Transient Population of Monocyte-Derived Macrophages

(2014) Naomi McGovern et al.   IMMUNITY

The Induction of Inflammation by Dectin-1 In Vivo Is Dependent on Myeloid Cell Programming and the Progression of Phagocytosis

(2014) M. Rosas et al.   JOURNAL OF IMMUNOLOGY

Fucose-specific DC-SIGN signalling directs T helper cell type-2 responses via IKKε- and CYLD-dependent Bcl3 activation

(2014) Sonja I. Gringhuis et al.   Nature Communications

Reprogramming Tumor-Infiltrating Dendritic Cells for CD103+CD8+ Mucosal T-cell Differentiation and Breast Cancer Rejection

(2014) T.-C. Wu et al.   Cancer Immunology Research

Plasmacytoid Dendritic Cells: No Longer an Enigma and Now Key to Transplant Tolerance?

(2013) N.M. Rogers et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Signalling C-Type lectin receptors, microbial recognition and immunity

(2013) J. Claire Hoving et al.   CELLULAR MICROBIOLOGY

Human dendritic cells - stars in the skin

(2013) Eynav Klechevsky   EUROPEAN JOURNAL OF IMMUNOLOGY

Human Inflammatory Dendritic Cells Induce Th17 Cell Differentiation

(2013) Elodie Segura et al.   IMMUNITY

Dendritic cell immunoreceptor: A novel receptor for intravenous immunoglobulin mediates induction of regulatory T cells

(2013) Amir H. Massoud et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Adaptive immune activation: glycosylation does matter

(2013) Margreet A Wolfert et al.   Nature Chemical Biology

Comparative transcriptional and functional profiling defines conserved programs of intestinal DC differentiation in humans and mice

(2013) Payal B Watchmaker et al.   NATURE IMMUNOLOGY

The regulatory power of glycans and their binding partners in immunity

(2013) Jenny L. Johnson et al.   TRENDS IN IMMUNOLOGY

Glycoconjugates in Host-Helminth Interactions

(2013) Nina Salinger Prasanphanich et al.   Frontiers in Immunology

Treg inducing adjuvants for therapeutic vaccination against chronic inflammatory diseases

(2013) Chantal Keijzer   Frontiers in Immunology

Glycobiology of immune responses

(2012) Gabriel A. Rabinovich et al.   Annals of the New York Academy of Sciences

Signaling by Myeloid C-Type Lectin Receptors in Immunity and Homeostasis

(2012) David Sancho et al.   Annual Review of Immunology

Auto-Antigenic Protein-DNA Complexes Stimulate Plasmacytoid Dendritic Cells to Promote Atherosclerosis

(2012) Yvonne Döring et al.   CIRCULATION

Comparison of the Fc glycosylation of fetal and maternal immunoglobulin G

(2012) Helga K. Einarsdottir et al.   GLYCOCONJUGATE JOURNAL

Regulatory Circuits Mediated by Lectin-Glycan Interactions in Autoimmunity and Cancer

(2012) Gabriel A. Rabinovich et al.   IMMUNITY

PAMPs and DAMPs: signal 0s that spur autophagy and immunity

(2012) Daolin Tang et al.   IMMUNOLOGICAL REVIEWS

Glycan-modified liposomes boost CD4+ and CD8+ T-cell responses by targeting DC-SIGN on dendritic cells

(2012) Wendy W.J. Unger et al.   JOURNAL OF CONTROLLED RELEASE

HIV-1 Capture and Antigen Presentation by Dendritic Cells: Enhanced Viral Capture Does Not Correlate with Better T Cell Activation

(2012) M. T. Rodriguez-Plata et al.   JOURNAL OF IMMUNOLOGY

Molecular engineering of antibodies for therapeutic and diagnostic purposes

(2012) Frédéric Ducancel et al.   mAbs

Host glycans and antigen presentation

(2012) Sean O. Ryan et al.   MICROBES AND INFECTION

Induction of protective immunity against Mycobacterium tuberculosis by delivery of ESX antigens into airway dendritic cells

(2012) H Dong et al.   Mucosal Immunology

Targeting Viral Antigens to CD11c on Dendritic Cells Induces Retrovirus-Specific T Cell Responses

(2012) Asim Ejaz et al.   PLoS One

Intradermally administered TLR4 agonist GLA-SE enhances the capacity of human skin DCs to activate T cells and promotes emigration of Langerhans cells

(2012) Laura P. Schneider et al.   VACCINE

Targeting DC-SIGN via its neck region leads to prolonged antigen residence in early endosomes, delayed lysosomal degradation, and cross-presentation

(2011) P. J. Tacken et al.   BLOOD

Design of neo-glycoconjugates that target the mannose receptor and enhance TLR-independent cross-presentation and Th1 polarization

(2011) Satwinder Kaur Singh et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Human Langerhans cells capture measles virus through Langerin and present viral antigens to CD4+ T cells but are incapable of cross-presentation

(2011) Michiel van der Vlist et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Myeloid C-type Lectin Receptors in Pathogen Recognition and Host Defense

(2011) Fabiola Osorio et al.   IMMUNITY

Vitamin D3 targets epidermal and dermal dendritic cells for induction of distinct regulatory T cells

(2011) Angelic M.G. van der Aar et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Activation of the innate immune receptor Dectin-1 upon formation of a ‘phagocytic synapse’

(2011) Helen S. Goodridge et al.   NATURE

Cancer Immunotherapy: Sipuleucel-T and Beyond

(2011) Aimee E Hammerstrom et al.   PHARMACOTHERAPY

Inhibitory Fc  Receptor Engagement Drives Adjuvant and Anti-Tumor Activities of Agonistic CD40 Antibodies

(2011) F. Li et al.   SCIENCE

C-type lectin DC-SIGN: An adhesion, signalling and antigen-uptake molecule that guides dendritic cells in immunity

(2010) Urban Švajger et al.   CELLULAR SIGNALLING

Viruses and Langerhans cells

(2010) Anthony L Cunningham et al.   IMMUNOLOGY AND CELL BIOLOGY

Concomitant Activation and Antigen Uptake via Human Dectin-1 Results in Potent Antigen-Specific CD8+ T Cell Responses

(2010) L. Ni et al.   JOURNAL OF IMMUNOLOGY

Antibody-Targeted NY-ESO-1 to Mannose Receptor or DEC-205 In Vitro Elicits Dual Human CD8+ and CD4+ T Cell Responses with Broad Antigen Specificity

(2010) T. Tsuji et al.   JOURNAL OF IMMUNOLOGY

Sipuleucel-T Immunotherapy for Castration-Resistant Prostate Cancer

(2010) Philip W. Kantoff et al.   NEW ENGLAND JOURNAL OF MEDICINE

Internalization of Dectin-1 terminates induction of inflammatory responses

(2009) Patricia Hernanz-Falcón et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The expanding roles of ITAM adapters FcRγ and DAP12 in myeloid cells

(2009) Jessica A. Hamerman et al.   IMMUNOLOGICAL REVIEWS

Endogenous ligands for C-type lectin receptors: the true regulators of immune homeostasis

(2009) Juan J. García-Vallejo et al.   IMMUNOLOGICAL REVIEWS

Epidermal Langerhans Cells Rapidly Capture and Present Antigens from C-Type Lectin-Targeting Antibodies Deposited in the Dermis

(2009) Vincent Flacher et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The repertoire of glycan determinants in the human glycome

(2009) Richard D. Cummings   Molecular BioSystems

Dectin-1 directs T helper cell differentiation by controlling noncanonical NF-κB activation through Raf-1 and Syk

(2009) Sonja I Gringhuis et al.   NATURE IMMUNOLOGY

Lung Dendritic Cells: Targets for Therapy in Allergic Disease

(2008) Bart Lambrecht   CURRENT MOLECULAR MEDICINE

Functional Specializations of Human Epidermal Langerhans Cells and CD14+ Dermal Dendritic Cells

(2008) Eynav Klechevsky et al.   IMMUNITY

Plasmacytoid Dendritic Cells Mediate Oral Tolerance

(2008) Anne Goubier et al.   IMMUNITY

Regulation of Glycan Structures in Animal Tissues

(2008) Alison V. Nairn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Resident and “Inflammatory” Dendritic Cells in Human Skin

(2008) Lisa C. Zaba et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The innate immune system in SLE: type I interferons and dendritic cells

(2008) L Rönnblom et al.   LUPUS

Evaluation of the serum N-linked glycome for the diagnosis of cancer and chronic inflammation

(2008) James N. Arnold et al.   PROTEOMICS