Yeast-Derived β-Glucan in Cancer: Novel Uses of a Traditional Therapeutic

Regulation of the innate immune system by autophagy: monocytes, macrophages, dendritic cells and antigen presentation

(2019) Nina Germic et al.   CELL DEATH AND DIFFERENTIATION

A PHASE 2 CLINICAL TRIAL OF RITUXIMAB AND β-GLUCAN PGG IN RELAPSED/REFRACTORY INDOLENT B-CELL NON-HODGKIN LYMPHOMA

(2019) C.A. Jacobson et al.   HEMATOLOGICAL ONCOLOGY

Synthesis of Beta-glucan Nanoparticles for the Delivery of Single Strand DNA

(2018) Jangsun Hwang et al.   BIOTECHNOLOGY AND BIOPROCESS ENGINEERING

Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity

(2018) Ioannis Mitroulis et al.   CELL

Metabolic Induction of Trained Immunity through the Mevalonate Pathway

(2018) Siroon Bekkering et al.   CELL

BCG Vaccination Protects against Experimental Viral Infection in Humans through the Induction of Cytokines Associated with Trained Immunity

(2018) Rob J.W. Arts et al.   Cell Host & Microbe

Trained immunity as a novel therapeutic strategy

(2018) Vera P Mourits et al.   CURRENT OPINION IN PHARMACOLOGY

Optimizing Tumor Microenvironment for Cancer Immunotherapy: β-Glucan-Based Nanoparticles

(2018) Mei Zhang et al.   Frontiers in Immunology

The Complexity of Fungal β-Glucan in Health and Disease: Effects on the Mononuclear Phagocyte System

(2018) Giorgio Camilli et al.   Frontiers in Immunology

Beta-glucan-induced inflammatory monocytes mediate antitumor efficacy in the murine lung

(2018) Matthew P. Alexander et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Consumption of β-glucans to spice up T cell treatment of tumors: a review

(2018) Priscilla de Graaff et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

β-glucans as potential immunoadjuvants: A review on the adjuvanticity, structure-activity relationship and receptor recognition properties

(2018) Yiming Jin et al.   VACCINE

A randomized, open-label, multicenter, phase II study evaluating the efficacy and safety of BTH1677 (1,3–1,6 beta glucan; Imprime PGG) in combination with cetuximab and chemotherapy in patients with advanced non-small cell lung cancer

(2017) M. Thomas et al.   INVESTIGATIONAL NEW DRUGS

Extraction and Isolation of β-Glucan from Grain Sources-A Review

(2017) Gunjan Maheshwari et al.   JOURNAL OF FOOD SCIENCE

Hypothesis: stimulation of trained immunity as adjunctive immunotherapy in cancer

(2017) Mihai G. Netea et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Uptake of intraperitoneally administrated triple helical β-glucan for antitumor activity in murine tumor models

(2017) Xing Zheng et al.   Journal of Materials Chemistry B

Extended chain conformation of β-glucan and its effect on antitumor activity

(2017) Xing Zheng et al.   Journal of Materials Chemistry B

β-Glucan Size Controls Dectin-1-Mediated Immune Responses in Human Dendritic Cells by Regulating IL-1β Production

(2017) Matthew J. Elder et al.   Frontiers in Immunology

β-Glucan Reverses the Epigenetic State of LPS-Induced Immunological Tolerance

(2016) Boris Novakovic et al.   CELL

A Phase II Efficacy and Safety, Open-Label, Multicenter Study of Imprime PGG Injection in Combination With Cetuximab in Patients With Stage IV KRAS-Mutant Colorectal Cancer

(2016) Neil H. Segal et al.   Clinical Colorectal Cancer

Yeast-Derived Particulate β-Glucan Treatment Subverts the Suppression of Myeloid-Derived Suppressor Cells (MDSC) by Inducing Polymorphonuclear MDSC Apoptosis and Monocytic MDSC Differentiation to APC in Cancer

(2016) Sabrin H. Albeituni et al.   JOURNAL OF IMMUNOLOGY

Driving CAR T-cells forward

(2016) Hollie J. Jackson et al.   Nature Reviews Clinical Oncology

Fungal Ferromanganese Mineralisation in Cretaceous Dinosaur Bones from the Gobi Desert, Mongolia

(2016) Krzysztof Owocki et al.   PLoS One

Modulating mammary tumor growth, metastasis and immunosuppression by siRNA-induced MIF reduction in tumor microenvironment

(2015) M Zhang et al.   CANCER GENE THERAPY

Microparticulate β-glucan vaccine conjugates phagocytized by dendritic cells activate both naïve CD4 and CD8 T cells in vitro

(2015) Vanessa K. Berner et al.   CELLULAR IMMUNOLOGY

Network Integration of Parallel Metabolic and Transcriptional Data Reveals Metabolic Modules that Regulate Macrophage Polarization

(2015) Abhishek K. Jha et al.   IMMUNITY

Dectin-1 Activation by a Natural Product β-Glucan Converts Immunosuppressive Macrophages into an M1-like Phenotype

(2015) Min Liu et al.   JOURNAL OF IMMUNOLOGY

 -Glucan-Activated Human B Lymphocytes Participate in Innate Immune Responses by Releasing Proinflammatory Cytokines and Stimulating Neutrophil Chemotaxis

(2015) M. F. Ali et al.   JOURNAL OF IMMUNOLOGY

Trained immunity: A smart way to enhance innate immune defence

(2015) Jos W.M. van der Meer et al.   MOLECULAR IMMUNOLOGY

Non-Viral Nanoparticle Delivers Small Interfering RNA to Macrophages In Vitro and In Vivo

(2015) Mei Zhang et al.   PLoS One

Phase I Trial of a Bivalent Gangliosides Vaccine in Combination with β-Glucan for High-Risk Neuroblastoma in Second or Later Remission

(2014) Brian H. Kushner et al.   CLINICAL CANCER RESEARCH

Immune-modulatory effects of dietary Yeast Beta-1,3/1,6-D-glucan

(2014) Heike Stier et al.   Nutrition Journal

The Effects of Orally Administered Beta-Glucan on Innate Immune Responses in Humans, a Randomized Open-Label Intervention Pilot-Study

(2014) Jenneke Leentjens et al.   PLoS One

mTOR- and HIF-1 -mediated aerobic glycolysis as metabolic basis for trained immunity

(2014) S.-C. Cheng et al.   SCIENCE

Autophagy Controls BCG-Induced Trained Immunity and the Response to Intravesical BCG Therapy for Bladder Cancer

(2014) Kathrin Buffen et al.   PLoS Pathogens

Reprogramming Tumor-Infiltrating Dendritic Cells for CD103+CD8+ Mucosal T-cell Differentiation and Breast Cancer Rejection

(2014) T.-C. Wu et al.   Cancer Immunology Research

Immunostimulatory properties and antitumor activities of glucans

(2013) LUCA VANNUCCI et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Microenvironmental regulation of tumor progression and metastasis

(2013) Daniela F Quail et al.   NATURE MEDICINE

Immune modulation of the tumor microenvironment for enhancing cancer immunotherapy

(2013) Christel Devaud et al.   OncoImmunology

Anti-GD2 antibody 3F8 and barley-derived (1 → 3),(1 → 4)-β-D-glucan

(2013) Shakeel Modak et al.   OncoImmunology

Signaling by Myeloid C-Type Lectin Receptors in Immunity and Homeostasis

(2012) David Sancho et al.   Annual Review of Immunology

Immunomodulation of Fungal β-Glucan in Host Defense Signaling by Dectin-1

(2012) Sainkhuu Batbayar et al.   Biomolecules & Therapeutics

Induction of autophagy is essential for monocyte-macrophage differentiation

(2012) Y. Zhang et al.   BLOOD

Bacillus Calmette-Guerin (BCG) immunotherapy for bladder cancer: Current understanding and perspectives on engineered BCG vaccine

(2012) Koji Kawai et al.   CANCER SCIENCE

Structural diversity of fungal glucans

(2012) Andriy Synytsya et al.   CARBOHYDRATE POLYMERS

Candida albicans Infection Affords Protection against Reinfection via Functional Reprogramming of Monocytes

(2012) Jessica Quintin et al.   Cell Host & Microbe

How does doxorubicin work?

(2012) Anand G Patel et al.   eLife

Glucan particles for selective delivery of siRNA to phagocytic cells in mice

(2011) Gregory J. Tesz et al.   BIOCHEMICAL JOURNAL

Differential pathways regulating innate and adaptive antitumor immune responses by particulate and soluble yeast-derived  -glucans

(2011) C. Qi et al.   BLOOD

Trained Immunity: A Memory for Innate Host Defense

(2011) Mihai G. Netea et al.   Cell Host & Microbe

Tumor-associated macrophages correlate with response to epidermal growth factor receptor-tyrosine kinase inhibitors in advanced non-small cell lung cancer

(2011) Fu-Tsai Chung et al.   INTERNATIONAL JOURNAL OF CANCER

Genome Sequence of the Curdlan-Producing Agrobacterium sp. Strain ATCC 31749

(2011) A. M. Ruffing et al.   JOURNAL OF BACTERIOLOGY

Lectin Site Ligation of CR3 Induces Conformational Changes and Signaling

(2011) Xian M. O'Brien et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Influence of Cationic Lipid Composition on Gene Silencing Properties of Lipid Nanoparticle Formulations of siRNA in Antigen-Presenting Cells

(2011) Genc Basha et al.   MOLECULAR THERAPY

New Insights into the Structure of (1→3,1→6)-β-D-Glucan Side Chains in the Candida glabrata Cell Wall

(2011) Douglas W. Lowman et al.   PLoS One

Proliferating macrophages associated with high grade, hormone receptor negative breast cancer and poor clinical outcome

(2010) Michael J. Campbell et al.   BREAST CANCER RESEARCH AND TREATMENT

Chemical analysis of new water-soluble (1→6)-, (1→4)-α, β-glucan and water-insoluble (1→3)-, (1→4)-β-glucan (Calocyban) from alkaline extract of an edible mushroom, Calocybe indica (Dudh Chattu)

(2010) Soumitra Mandal et al.   CARBOHYDRATE RESEARCH

Mycobacterium bovisBacillus Calmette-Guérin-Induced Macrophage Cytotoxicity against Bladder Cancer Cells

(2010) Yi Luo et al.   Clinical & Developmental Immunology

Orally Administered Particulate  -Glucan Modulates Tumor-Capturing Dendritic Cells and Improves Antitumor T-Cell Responses in Cancer

(2010) B. Li et al.   CLINICAL CANCER RESEARCH

ISOLATION, PURIFICATION AND STRUCTURAL CHARACTERIZATION OF A NOVEL WATER-SOLUBLE GLUCAN FROM THE FRUITING BODIES OF PHELLINUS BAUMII PILÁT

(2010) QING GE et al.   JOURNAL OF FOOD BIOCHEMISTRY

Substrate Fate in Activated Macrophages: A Comparison between Innate, Classic, and Alternative Activation

(2010) J.-C. Rodriguez-Prados et al.   JOURNAL OF IMMUNOLOGY

Pilot Study of 1650-G: A Simplified Cellular Vaccine for Lung Cancer

(2010) Edward A. Hirschowitz et al.   Journal of Thoracic Oncology

Rational design of cationic lipids for siRNA delivery

(2010) Sean C Semple et al.   NATURE BIOTECHNOLOGY

Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm

(2010) Subhra K Biswas et al.   NATURE IMMUNOLOGY

PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors

(2010) M. A. Curran et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Folate Receptor   Is Expressed by Tumor-Associated Macrophages and Constitutes a Marker for M2 Anti-inflammatory/Regulatory Macrophages

(2009) A. Puig-Kroger et al.   CANCER RESEARCH

Pattern recognition: recent insights from Dectin-1

(2009) Delyth M Reid et al.   CURRENT OPINION IN IMMUNOLOGY

Differential regulation of iron homeostasis during human macrophage polarized activation

(2009) Stefania Recalcati et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The effects of β-glucan on human immune and cancer cells

(2009) Godfrey Chan et al.   Journal of Hematology & Oncology

Vertebrate Endothermy Restricts Most Fungi as Potential Pathogens

(2009) Vincent A. Robert et al.   JOURNAL OF INFECTIOUS DISEASES

Orally delivered siRNA targeting macrophage Map4k4 suppresses systemic inflammation

(2009) Myriam Aouadi et al.   NATURE

Inflaming metastasis

(2009) Alberto Mantovani   NATURE

Higher order structure of (1,3)-β-D-glucans and its influence on their biological activities and complexation abilities

(2008) Marit Sletmoen et al.   BIOPOLYMERS

Adoptive transfer of HER2/neu-specific T cells expanded with alternating gamma chain cytokines mediate tumor regression when combined with the depletion of myeloid-derived suppressor cells

(2008) Johanna K. Morales et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

DC activated via dectin-1 convert Treg into IL-17 producers

(2008) Fabiola Osorio et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

A phase I/II trial of beta-(1,3)/(1,6) D-glucan in the treatment of patients with advanced malignancies receiving chemotherapy

(2008) Alan B Weitberg   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

The tumor microenvironment and its role in promoting tumor growth

(2008) T L Whiteside   ONCOGENE

Role of MIF in Inflammation and Tumorigenesis

(2008) Jan-Philipp Bach et al.   ONCOLOGY

Dietary modulation of immune function by β-glucans

(2007) Julia J. Volman et al.   PHYSIOLOGY & BEHAVIOR