Human dendritic cells - stars in the skin

Differential Capability of Human Cutaneous Dendritic Cell Subsets to Initiate Th17 Responses

(2014) A. R. Mathers et al.   JOURNAL OF IMMUNOLOGY

Targeting C-type lectin receptors with multivalent carbohydrate ligands

(2013) Bernd Lepenies et al.   ADVANCED DRUG DELIVERY REVIEWS

Targeting concatenated HIV antigens to human CD40 expands a broad repertoire of multifunctional CD4+ and CD8+ T cells

(2013) Anne-Laure Flamar et al.   AIDS

IL-12 receptor  1 deficiency alters in vivo T follicular helper cell response in humans

(2013) N. Schmitt et al.   BLOOD

Human CD1c+ dendritic cells secrete high levels of IL-12 and potently prime cytotoxic T-cell responses

(2013) G. Nizzoli et al.   BLOOD

IRF4 Transcription-Factor-Dependent CD103+CD11b+ Dendritic Cells Drive Mucosal T Helper 17 Cell Differentiation

(2013) Emma K. Persson et al.   IMMUNITY

IRF4 Transcription Factor-Dependent CD11b+ Dendritic Cells in Human and Mouse Control Mucosal IL-17 Cytokine Responses

(2013) Andreas Schlitzer et al.   IMMUNITY

Oncology Meets Immunology: The Cancer-Immunity Cycle

(2013) Daniel S. Chen et al.   IMMUNITY

Exclusive CX3CR1 dependence of kidney DCs impacts glomerulonephritis progression

(2013) Katharina Hochheiser et al.   JOURNAL OF CLINICAL INVESTIGATION

Coreceptor affinity for MHC defines peptide specificity requirements for TCR interaction with coagonist peptide–MHC

(2013) John A.H. Hoerter et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Antigen delivery to early endosomes eliminates the superiority of human blood BDCA3+dendritic cells at cross presentation

(2013) Lillian Cohn et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Clinical Adjuvant Combinations Stimulate Potent B-Cell Responses In Vitro by Activating Dermal Dendritic Cells

(2013) Katie Matthews et al.   PLoS One

A Unique Dermal Dendritic Cell Subset That Skews the Immune Response toward Th2

(2013) Ryuichi Murakami et al.   PLoS One

Blockade of the PD-1 pathway enhances the efficacy of adoptive cell therapy against cancer

(2013) Weiyi Peng et al.   OncoImmunology

The differential production of cytokines by human Langerhans cells and dermal CD14+ DCs controls CTL priming

(2012) J. Banchereau et al.   BLOOD

Internalization and endosomal degradation of receptor-bound antigens regulate the efficiency of cross presentation by human dendritic cells

(2012) B. Chatterjee et al.   BLOOD

E-cadherin: From epithelial glue to immunological regulator

(2012) Jan Van den Bossche et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Two Distinct Types of Langerhans Cells Populate the Skin during Steady State and Inflammation

(2012) Kristin Seré et al.   IMMUNITY

Human Epidermal Langerhans Cells Maintain Immune Homeostasis in Skin by Activating Skin Resident Regulatory T Cells

(2012) Julien Seneschal et al.   IMMUNITY

Human Tissues Contain CD141hi Cross-Presenting Dendritic Cells with Functional Homology to Mouse CD103+ Nonlymphoid Dendritic Cells

(2012) Muzlifah Haniffa et al.   IMMUNITY

The Dendritic Cell Receptor Clec9A Binds Damaged Cells via Exposed Actin Filaments

(2012) Jian-Guo Zhang et al.   IMMUNITY

Antigen-loaded pH-sensitive hydrogel microparticles are taken up by dendritic cells with no requirement for targeting antibodies

(2012) Laura E. Ruff et al.   Integrative Biology

Langerhans cells protect from allergic contact dermatitis in mice by tolerizing CD8+ T cells and activating Foxp3+ regulatory T cells

(2012) Mercedes Gomez de Agüero et al.   JOURNAL OF CLINICAL INVESTIGATION

Resident CD141 (BDCA3)+dendritic cells in human skin produce IL-10 and induce regulatory T cells that suppress skin inflammation

(2012) Chung-Ching Chu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Targeting self- and foreign antigens to dendritic cells via DC-ASGPR generates IL-10–producing suppressive CD4+T cells

(2012) Dapeng Li et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Potent Induction of Antibody-Secreting B Cells by Human Dermal-Derived CD14+ Dendritic Cells Triggered by Dual TLR Ligation

(2012) K. Matthews et al.   JOURNAL OF IMMUNOLOGY

CD70–CD27 Interaction Augments CD8+ T-Cell Activation by Human Epidermal Langerhans Cells

(2012) Marta E. Polak et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Functional diversity of human vaginal APC subsets in directing T-cell responses

(2012) D Duluc et al.   Mucosal Immunology

IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microglia

(2012) Yaming Wang et al.   NATURE IMMUNOLOGY

Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer

(2012) Suzanne L. Topalian et al.   NEW ENGLAND JOURNAL OF MEDICINE

Antibody-Antigen-Adjuvant Conjugates Enable Co-Delivery of Antigen and Adjuvant to Dendritic Cells in Cis but Only Have Partial Targeting Specificity

(2012) Martin Kreutz et al.   PLoS One

Differential Capacity of Human Skin Dendritic Cells to Polarize CD4+T Cells into IL-17, IL-21 and IL-22 Producing Cells

(2012) Karine Penel-Sotirakis et al.   PLoS One

Immunoglobulin-like transcript receptors on human dermal CD14+ dendritic cells act as a CD8-antagonist to control cytotoxic T cell priming

(2012) J. Banchereau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A simple approach for enhanced immune response using engineered dendritic cell targeted nanoparticles

(2012) Dharmendra Raghuwanshi et al.   VACCINE

Peptide-Loaded Langerhans Cells, Despite Increased IL15 Secretion and T-Cell Activation In Vitro, Elicit Antitumor T-Cell Responses Comparable to Peptide-Loaded Monocyte-Derived Dendritic Cells In Vivo

(2011) E. Romano et al.   CLINICAL CANCER RESEARCH

Human Langerhans cells capture measles virus through Langerin and present viral antigens to CD4+ T cells but are incapable of cross-presentation

(2011) Michiel van der Vlist et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Thymic but not splenic CD8+ DCs can efficiently cross-prime T cells in the absence of licensing factors

(2011) Christiane Dresch et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Skin-Resident Murine Dendritic Cell Subsets Promote Distinct and Opposing Antigen-Specific T Helper Cell Responses

(2011) Botond Z. Igyártó et al.   IMMUNITY

Cutting Edge: Virus Selectively Primes Human Langerhans Cells for CD70 Expression Promoting CD8+ T Cell Responses

(2011) A. M. G. van der Aar et al.   JOURNAL OF IMMUNOLOGY

Targeting Antigen to Mouse Dendritic Cells via Clec9A Induces Potent CD4 T Cell Responses Biased toward a Follicular Helper Phenotype

(2011) M. H. Lahoud et al.   JOURNAL OF IMMUNOLOGY

Intradermal Immunization Triggers Epidermal Langerhans Cell Mobilization Required for CD8 T-Cell Immune Responses

(2011) Christelle Liard et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Cancer immunotherapy comes of age

(2011) Ira Mellman et al.   NATURE

Immunization with HIV Gag targeted to dendritic cells followed by recombinant New York vaccinia virus induces robust T-cell immunity in nonhuman primates

(2011) B. J. Flynn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cross-priming CD8+ T cells by targeting antigens to human dendritic cells through DCIR

(2010) E. Klechevsky et al.   BLOOD

Comparative genomics as a tool to reveal functional equivalences between human and mouse dendritic cell subsets

(2010) Karine Crozat et al.   IMMUNOLOGICAL REVIEWS

Origin and functional heterogeneity of non-lymphoid tissue dendritic cells in mice

(2010) Julie Helft et al.   IMMUNOLOGICAL REVIEWS

The XC chemokine receptor 1 is a conserved selective marker of mammalian cells homologous to mouse CD8α+dendritic cells

(2010) Karine Crozat et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Human CD141+(BDCA-3)+dendritic cells (DCs) represent a unique myeloid DC subset that cross-presents necrotic cell antigens

(2010) Sarah L. Jongbloed et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Superior antigen cross-presentation and XCR1 expression define human CD11c+CD141+cells as homologues of mouse CD8+dendritic cells

(2010) Annabell Bachem et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-15 trans-presentation by pulmonary dendritic cells promotes effector CD8 T cell survival during influenza virus infection

(2010) Jodi McGill et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Characterization of human DNGR-1+BDCA3+leukocytes as putative equivalents of mouse CD8α+dendritic cells

(2010) Lionel Franz Poulin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Concomitant Activation and Antigen Uptake via Human Dectin-1 Results in Potent Antigen-Specific CD8+ T Cell Responses

(2010) L. Ni et al.   JOURNAL OF IMMUNOLOGY

MicroRNA-148/152 Impair Innate Response and Antigen Presentation of TLR-Triggered Dendritic Cells by Targeting CaMKII 

(2010) X. Liu et al.   JOURNAL OF IMMUNOLOGY

Human Langerhans Cells Are More Efficient Than CD14−CD1c+ Dermal Dendritic Cells at Priming Naive CD4+ T Cells

(2010) Laetitia Furio et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

CD1a-autoreactive T cells are a normal component of the human αβ T cell repertoire

(2010) Annemieke de Jong et al.   NATURE IMMUNOLOGY

Selective and site-specific mobilization of dermal dendritic cells and Langerhans cells by Th1- and Th2-polarizing adjuvants

(2010) D. Sen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Harnessing Human Dendritic Cell Subsets to Design Novel Vaccines

(2009) Jacques Banchereau et al.   Annals of the New York Academy of Sciences

Antigen presentation by dendritic cells in vivo

(2009) Elodie Segura et al.   CURRENT OPINION IN IMMUNOLOGY

Understanding human myeloid dendritic cell subsets for the rational design of novel vaccines

(2009) Eynav Klechevsky et al.   HUMAN IMMUNOLOGY

Macrophage- and Dendritic-Cell-Derived Interleukin-15 Receptor Alpha Supports Homeostasis of Distinct CD8+ T Cell Subsets

(2009) Erwan Mortier et al.   IMMUNITY

A T Cell-Dependent Mechanism for the Induction of Human Mucosal Homing Immunoglobulin A-Secreting Plasmablasts

(2009) Melissa Dullaers et al.   IMMUNITY

Langerhans Cells Suppress Contact Hypersensitivity Responses Via Cognate CD4 Interaction and Langerhans Cell-Derived IL-10

(2009) B. Z. Igyarto et al.   JOURNAL OF IMMUNOLOGY

Human Langerhans cells induce distinct IL-22-producing CD4+ T cells lacking IL-17 production

(2009) H. Fujita et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inflammasome-activating nanoparticles as modular systems for optimizing vaccine efficacy

(2009) Stacey L. Demento et al.   VACCINE

The dendritic cell subtype-restricted C-type lectin Clec9A is a target for vaccine enhancement

(2008) I. Caminschi et al.   BLOOD

Functional Specializations of Human Epidermal Langerhans Cells and CD14+ Dermal Dendritic Cells

(2008) Eynav Klechevsky et al.   IMMUNITY

Batf3 Deficiency Reveals a Critical Role for CD8 + Dendritic Cells in Cytotoxic T Cell Immunity

(2008) K. Hildner et al.   SCIENCE

Novel insights into the relationships between dendritic cell subsets in human and mouse revealed by genome-wide expression profiling

(2008) Scott H Robbins et al.   GENOME BIOLOGY