The B cell response to citrullinated antigens in the development of rheumatoid arthritis

Two rheumatoid arthritis–specific autoantigens correlate microbial immunity with autoimmune responses in joints

(2017) Annalisa Pianta et al.   JOURNAL OF CLINICAL INVESTIGATION

Beyond citrullination: other post-translational protein modifications in rheumatoid arthritis

(2017) Leendert A. Trouw et al.   Nature Reviews Rheumatology

Anti-citrullinated protein antibody positive rheumatoid arthritis is primarily determined by rheumatoid factor titre and the shared epitope rather than smoking per se

(2017) Dan Murphy et al.   PLoS One

Effects of DMARDs on citrullinated peptide autoantibody levels in RA patients—A longitudinal analysis

(2017) Carolin Wunderlich et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

Decoding the Human Immunoglobulin G-Glycan Repertoire Reveals a Spectrum of Fc-Receptor- and Complement-Mediated-Effector Activities

(2017) Gillian Dekkers et al.   Frontiers in Immunology

EULAR definition of arthralgia suspicious for progression to rheumatoid arthritis

(2016) Hanna W van Steenbergen et al.   ANNALS OF THE RHEUMATIC DISEASES

Synovial fluid mononuclear cells provide an environment for long-term survival of antibody-secreting cells and promote the spontaneous production of anti-citrullinated protein antibodies

(2016) Priscilla F Kerkman et al.   ANNALS OF THE RHEUMATIC DISEASES

The Emerging Importance of IgG Fab Glycosylation in Immunity

(2016) Fleur S. van de Bovenkamp et al.   JOURNAL OF IMMUNOLOGY

Structural Analysis of Variable Domain Glycosylation of Anti-Citrullinated Protein Antibodies in Rheumatoid Arthritis Reveals the Presence of Highly Sialylated Glycans

(2016) Lise Hafkenscheid et al.   MOLECULAR & CELLULAR PROTEOMICS

Regulation of autoantibody activity by the IL-23–TH17 axis determines the onset of autoimmune disease

(2016) René Pfeifle et al.   NATURE IMMUNOLOGY

Sialylation converts arthritogenic IgG into inhibitors of collagen-induced arthritis

(2016) Yuhsuke Ohmi et al.   Nature Communications

Reply

(2016) Karine Chemin et al.   Arthritis & Rheumatology

Autoantibodies From Single Circulating Plasmablasts React With Citrullinated Antigens andPorphyromonas gingivalisin Rheumatoid Arthritis

(2016) Song Li et al.   Arthritis & Rheumatology

Clinical factors, anticitrullinated peptide antibodies and MRI-detected subclinical inflammation in relation to progression from clinically suspect arthralgia to arthritis

(2015) Hanna W van Steenbergen et al.   ANNALS OF THE RHEUMATIC DISEASES

Enriching case selection for imminent RA: the use of anti-CCP antibodies in individuals with new non-specific musculoskeletal symptoms – a cohort study

(2015) Jacqueline L Nam et al.   ANNALS OF THE RHEUMATIC DISEASES

Identification and characterisation of citrullinated antigen-specific B cells in peripheral blood of patients with rheumatoid arthritis

(2015) Priscilla F Kerkman et al.   ANNALS OF THE RHEUMATIC DISEASES

Protective effect of HLA-DRB1*13 alleles during specific phases in the development of ACPA-positive RA

(2015) Jurgen van Heemst et al.   ANNALS OF THE RHEUMATIC DISEASES

Single cell cloning and recombinant monoclonal antibodies generation from RA synovial B cells reveal frequent targeting of citrullinated histones of NETs

(2015) Elisa Corsiero et al.   ANNALS OF THE RHEUMATIC DISEASES

Autoantibodies to citrullinated proteins induce joint pain independent of inflammation via a chemokine-dependent mechanism

(2015) Gustaf Wigerblad et al.   ANNALS OF THE RHEUMATIC DISEASES

Identification of a novel chemokine-dependent molecular mechanism underlying rheumatoid arthritis-associated autoantibody-mediated bone loss

(2015) Akilan Krishnamurthy et al.   ANNALS OF THE RHEUMATIC DISEASES

Extensive glycosylation of ACPA-IgG variable domains modulates binding to citrullinated antigens in rheumatoid arthritis

(2015) Yoann Rombouts et al.   ANNALS OF THE RHEUMATIC DISEASES

Association between susceptibility to rheumatoid arthritis and PADI4 polymorphisms: a meta-analysis

(2015) Young Ho Lee et al.   CLINICAL RHEUMATOLOGY

Checkpoints that control B cell development

(2015) Fritz Melchers   JOURNAL OF CLINICAL INVESTIGATION

Receptor editing and genetic variability in human autoreactive B cells

(2015) Julie Lang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Crossreactivity to vinculin and microbes provides a molecular basis for HLA-based protection against rheumatoid arthritis

(2015) Jurgen van Heemst et al.   Nature Communications

Safety and Efficacy of Atacicept in Combination With Rituximab for Reducing the Signs and Symptoms of Rheumatoid Arthritis: A Phase II, Randomized, Double-Blind, Placebo-Controlled Pilot Trial

(2015) R. F. van Vollenhoven et al.   Arthritis & Rheumatology

Monoclonal Antibody Against Citrullinated Peptides Obtained From Rheumatoid Arthritis Patients Reacts With Numerous Citrullinated Microbial and Food Proteins

(2015) Reina Tsuda et al.   Arthritis & Rheumatology

Toll-like receptor triggering augments activation of human mast cells by anti-citrullinated protein antibodies

(2014) J Suurmond et al.   ANNALS OF THE RHEUMATIC DISEASES

Detailed profiling of anti-desmoglein autoantibodies identifies anti-Dsg1 reactivity as a key driver of disease activity and clinical expression in pemphigus vulgaris

(2014) S. Y. Naseer et al.   AUTOIMMUNITY

In ACPA-positive RA patients, antibodies to EBNA35-58Cit, a citrullinated peptide from the Epstein–Barr nuclear antigen-1, strongly cross-react with the peptide β60-74Cit which bears the immunodominant epitope of citrullinated fibrin

(2014) M. Cornillet et al.   IMMUNOLOGIC RESEARCH

Redemption of autoantibodies on anergic B cells by variable-region glycosylation and mutation away from self-reactivity

(2014) Z. Sabouri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of Smoking and Shared Epitope on the Production of Anti-Citrullinated Peptide Antibody in a Japanese Adult Population

(2014) Chikashi Terao et al.   ARTHRITIS CARE & RESEARCH

Citrulline-Specific Th1 Cells Are Increased in Rheumatoid Arthritis and Their Frequency Is Influenced by Disease Duration and Therapy

(2014) Eddie A. James et al.   Arthritis & Rheumatology

Circulating plasmablasts/plasmacells as a source of anticitrullinated protein antibodies in patients with rheumatoid arthritis

(2013) Priscilla F Kerkman et al.   ANNALS OF THE RHEUMATIC DISEASES

The concentration of anticitrullinated protein antibodies in serum and synovial fluid in relation to total immunoglobulin concentrations

(2013) Annemiek Willemze et al.   ANNALS OF THE RHEUMATIC DISEASES

Environmental and genetic factors in the development of anticitrullinated protein antibodies (ACPAs) and ACPA-positive rheumatoid arthritis: an epidemiological investigation in twins

(2013) Aase Haj Hensvold et al.   ANNALS OF THE RHEUMATIC DISEASES

Anti-citrullinated protein antibodies acquire a pro-inflammatory Fc glycosylation phenotype prior to the onset of rheumatoid arthritis

(2013) Yoann Rombouts et al.   ANNALS OF THE RHEUMATIC DISEASES

Performance of Anti-Cyclic Citrullinated Peptide Assays Differs in Subjects at Increased Risk of Rheumatoid Arthritis and Subjects With Established Disease

(2013) M. Kristen Demoruelle et al.   ARTHRITIS AND RHEUMATISM

Monoclonal IgG antibodies generated from joint-derived B cells of RA patients have a strong bias toward citrullinated autoantigen recognition

(2013) Khaled Amara et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Association between Galactosylation of Immunoglobulin G and Improvement of Rheumatoid Arthritis during Pregnancy Is Independent of Sialylation

(2013) Albert Bondt et al.   JOURNAL OF PROTEOME RESEARCH

PADI2 Is Significantly Associated with Rheumatoid Arthritis

(2013) Xiaotian Chang et al.   PLoS One

General mechanism for modulating immunoglobulin effector function

(2013) P. Sondermann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immune-Mediated Pore-Forming Pathways Induce Cellular Hypercitrullination and Generate Citrullinated Autoantigens in Rheumatoid Arthritis

(2013) V. Romero et al.   Science Translational Medicine

NETs Are a Source of Citrullinated Autoantigens and Stimulate Inflammatory Responses in Rheumatoid Arthritis

(2013) R. Khandpur et al.   Science Translational Medicine

CD22 ligation inhibits downstream B cell receptor signaling and Ca2+flux upon activation

(2012) N. Sieger et al.   ARTHRITIS AND RHEUMATISM

Induction of osteoclastogenesis and bone loss by human autoantibodies against citrullinated vimentin

(2012) Ulrike Harre et al.   JOURNAL OF CLINICAL INVESTIGATION

Production of Autoantibodies against Citrullinated Antigens/Peptides by Human B Cells

(2012) M. F. Bellatin et al.   JOURNAL OF IMMUNOLOGY

Anticitrullinated Protein Antibody, But Not Its Titer, Is a Predictor of Radiographic Progression and Disease Activity in Rheumatoid Arthritis

(2012) K. SHIOZAWA et al.   JOURNAL OF RHEUMATOLOGY

Autoantibody Epitope Spreading in the Pre-Clinical Phase Predicts Progression to Rheumatoid Arthritis

(2012) Jeremy Sokolove et al.   PLoS One

Monoclonal anti-citrullinated protein antibodies selected on citrullinated fibrinogen have distinct targets with different cross-reactivity patterns

(2012) L. A. van de Stadt et al.   RHEUMATOLOGY

The frequency of antibodies against cyclic citrullinated peptides and rheumatoid factor in healthy population: a field study of rheumatoid arthritis from northern turkey

(2012) Turker Tasliyurt et al.   RHEUMATOLOGY INTERNATIONAL

Citrullinated vimentin stimulates proliferation, pro-inflammatory cytokine secretion, and PADI4 and RANKL expression of fibroblast-like synoviocytes in rheumatoid arthritis

(2012) LY Fan et al.   SCANDINAVIAN JOURNAL OF RHEUMATOLOGY

Acute Gastrointestinal Infection Induces Long-Lived Microbiota-Specific T Cell Responses

(2012) T. W. Hand et al.   SCIENCE

Induction of long-term B-cell depletion in refractory rheumatoid arthritis patients preferentially affects autoreactive more than protective humoral immunity

(2012) YK Onno Teng et al.   ARTHRITIS RESEARCH & THERAPY

Hypogalactosylation of serum N-glycans fails to predict clinical response to methotrexate and TNF inhibition in rheumatoid arthritis

(2012) Altan Ercan et al.   ARTHRITIS RESEARCH & THERAPY

Fc  receptor profile of monocytes and macrophages from rheumatoid arthritis patients and their response to immune complexes formed with autoantibodies to citrullinated proteins

(2011) L. Laurent et al.   ANNALS OF THE RHEUMATIC DISEASES

The ACPA recognition profile and subgrouping of ACPA-positive RA patients

(2011) Annemiek Willemze et al.   ANNALS OF THE RHEUMATIC DISEASES

Development of the anti-citrullinated protein antibody repertoire prior to the onset of rheumatoid arthritis

(2011) Lotte A. van de Stadt et al.   ARTHRITIS AND RHEUMATISM

Atacicept in patients with rheumatoid arthritis and an inadequate response to methotrexate: Results of a phase II, randomized, placebo-controlled trial

(2011) R. F. van Vollenhoven et al.   ARTHRITIS AND RHEUMATISM

Atacicept in patients with rheumatoid arthritis and an inadequate response to tumor necrosis factor antagonist therapy: Results of a phase II, randomized, placebo-controlled, dose-finding trial

(2011) M. C. Genovese et al.   ARTHRITIS AND RHEUMATISM

Avidity maturation of anti-citrullinated protein antibodies in rheumatoid arthritis

(2011) P. Suwannalai et al.   ARTHRITIS AND RHEUMATISM

Ex vivo characterization and isolation of rare memory B cells with antigen tetramers

(2011) B. Franz et al.   BLOOD

The PTPN22 allele encoding an R620W variant interferes with the removal of developing autoreactive B cells in humans

(2011) Laurence Menard et al.   JOURNAL OF CLINICAL INVESTIGATION

The fine specificity of IgM anti-citrullinated protein antibodies (ACPA) is different from that of IgG ACPA

(2011) Parawee Suwannalai et al.   ARTHRITIS RESEARCH & THERAPY

Epitope spreading of the anti-citrullinated protein antibody response occurs before disease onset and is associated with the disease course of early arthritis

(2010) D. van der Woude et al.   ANNALS OF THE RHEUMATIC DISEASES

Anti-citrullinated protein antibodies have a low avidity compared with antibodies against recall antigens

(2010) P. Suwannalai et al.   ANNALS OF THE RHEUMATIC DISEASES

The extent of the anti-citrullinated protein antibody repertoire is associated with arthritis development in patients with seropositive arthralgia

(2010) L. A. van de Stadt et al.   ANNALS OF THE RHEUMATIC DISEASES

A matrix risk model for the prediction of rapid radiographic progression in patients with rheumatoid arthritis receiving different dynamic treatment strategies: post hoc analyses from the BeSt study

(2010) K. Visser et al.   ANNALS OF THE RHEUMATIC DISEASES

Th17 cells, but not Th1 cells, from patients with early rheumatoid arthritis are potent inducers of matrix metalloproteinases and proinflammatory cytokines upon synovial fibroblast interaction, including autocrine interleukin-17A production

(2010) J. P. van Hamburg et al.   ARTHRITIS AND RHEUMATISM

Immune complexes containing citrullinated fibrinogen costimulate macrophages via Toll-like receptor 4 and Fcγ receptor

(2010) Jeremy Sokolove et al.   ARTHRITIS AND RHEUMATISM

Aberrant IgG galactosylation precedes disease onset, correlates with disease activity, and is prevalent in autoantibodies in rheumatoid arthritis

(2010) Altan Ercan et al.   ARTHRITIS AND RHEUMATISM

Protection against anti-citrullinated protein antibody-positive rheumatoid arthritis is predominantly associated with HLA-DRB1*1301: A meta-analysis of HLA-DRB1 associations with anti-citrullinated protein antibody-positive and anti-citrullinated protein

(2010) Diane van der Woude et al.   ARTHRITIS AND RHEUMATISM

Glycan profiling of anti-citrullinated protein antibodies isolated from human serum and synovial fluid

(2010) Hans U. Scherer et al.   ARTHRITIS AND RHEUMATISM

The continuous measurement of anti-CCP-antibodies does not help to evaluate the disease activity in anti-CCP-antibody-positive patients with rheumatoid arthritis

(2010) Thoren Landmann et al.   CLINICAL RHEUMATOLOGY

Anticytokine therapy impacting on B cells in autoimmune diseases

(2010) Capucine Daridon et al.   CURRENT OPINION IN RHEUMATOLOGY

Secondary Immunization Generates Clonally Related Antigen-Specific Plasma Cells and Memory B Cells

(2010) D. Frolich et al.   JOURNAL OF IMMUNOLOGY

Control systems and decision making for antibody production

(2010) Christopher C Goodnow et al.   NATURE IMMUNOLOGY

Anti-cyclic citrullinated peptide antibodies and rheumatoid factor in rheumatoid arthritis patients and relatives from Brazil

(2010) I. Goeldner et al.   RHEUMATOLOGY

Levels of anti-citrullinated protein antibodies and IgM rheumatoid factor are not associated with outcome in early arthritis patients: a cohort study

(2010) Jennie Ursum et al.   ARTHRITIS RESEARCH & THERAPY

The use of citrullinated peptides and proteins for the diagnosis of rheumatoid arthritis

(2010) Ger JM Pruijn et al.   ARTHRITIS RESEARCH & THERAPY

IgM-rheumatoid factor and anti-cyclic citrullinated peptide decrease by 50% during intensive treatment in early rheumatoid arthritis

(2009) L H D van Tuyl et al.   ANNALS OF THE RHEUMATIC DISEASES

Arthritis development in patients with arthralgia is strongly associated with anti-citrullinated protein antibody status: a prospective cohort study

(2009) W. H. Bos et al.   ANNALS OF THE RHEUMATIC DISEASES

Value of anti-modified citrullinated vimentin and third-generation anti-cyclic citrullinated peptide compared with second-generation anti-cyclic citrullinated peptide and rheumatoid factor in predicting disease outcome in undifferentiated arthritis and rheumatoid arthritis

(2009) Michael P. M. van der Linden et al.   ARTHRITIS AND RHEUMATISM

Anti-cyclic citrullinated peptide antibodies from rheumatoid arthritis patients activate complement via both the classical and alternative pathways

(2009) L. A. Trouw et al.   ARTHRITIS AND RHEUMATISM

Ectopic Lymphoid Structures Support Ongoing Production of Class-Switched Autoantibodies in Rheumatoid Synovium

(2009) Frances Humby et al.   PLOS MEDICINE

Marked differences in fine specificity and isotype usage of the anti-citrullinated protein antibody in health and disease

(2008) Andreea Ioan-Facsinay et al.   ARTHRITIS AND RHEUMATISM

Antibodies to citrullinated α-enolase peptide 1 are specific for rheumatoid arthritis and cross-react with bacterial enolase

(2008) Karin Lundberg et al.   ARTHRITIS AND RHEUMATISM

Terminal sugars of Fc glycans influence antibody effector functions of IgGs

(2008) T Shantha Raju   CURRENT OPINION IN IMMUNOLOGY

Immunoglobulin 1 (IgG1) Fc-glycosylation profiling of anti-citrullinated peptide antibodies from human serum

(2008) H. Ulrich Scherer et al.   Proteomics Clinical Applications

Cytokines, autoantibodies and viral antibodies in premorbid and postdiagnostic sera from patients with rheumatoid arthritis: case-control study nested in a cohort of Norwegian blood donors

(2007) K T Jorgensen et al.   ANNALS OF THE RHEUMATIC DISEASES

Duration of preclinical rheumatoid arthritis-related autoantibody positivity increases in subjects with older age at time of disease diagnosis

(2007) D S Majka et al.   ANNALS OF THE RHEUMATIC DISEASES

Remarkable selective glycosylation of the immunoglobulin variable region in follicular lymphoma

(2007) Katy J. McCann et al.   MOLECULAR IMMUNOLOGY