Crosstalk Between Hypoxia and ER Stress Response: A Key Regulator of Macrophage Polarization

HIF Inhibitors: Status of Current Clinical Development

(2019) Jaleh Fallah et al.   Current Oncology Reports

Metabolic and Innate Immune Cues Merge into a Specific Inflammatory Response via the UPR

(2019) Denis A. Mogilenko et al.   CELL

Mechanism of interactions between endoplasmic reticulum stress and autophagy in hypoxia/reoxygenation‑induced injury of H9c2 cardiomyocytes

(2019) Gaopeng Guan et al.   Molecular Medicine Reports

Pharmacological targeting of the unfolded protein response for disease intervention

(2019) Claudio Hetz et al.   Nature Chemical Biology

Metabolic changes in tumor cells and tumor-associated macrophages: A mutual relationship

(2018) Romana T. Netea-Maier et al.   CANCER LETTERS

Advances in Hypoxia-Inducible Factor Biology

(2018) Hani Choudhry et al.   Cell Metabolism

Endoplasmic reticulum chaperone GRP78 regulates macrophage function and insulin resistance in diet-induced obesity

(2018) Jong Hun Kim et al.   FASEB JOURNAL

IRE1α Aggravates Ischemia Reperfusion Injury of Fatty Liver by Regulating Phenotypic Transformation of Kupffer Cells

(2018) Faji Yang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Regulation of macrophage immunometabolism in atherosclerosis

(2018) Graeme J. Koelwyn et al.   NATURE IMMUNOLOGY

Endoplasmic Reticulum Stress Affects Lipid Metabolism in Atherosclerosis Via CHOP Activation and Over-Expression of miR-33

(2018) Yan Sun et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

ER-stress regulates macrophage polarization through pancreatic EIF-2alpha kinase

(2018) Faji Yang et al.   CELLULAR IMMUNOLOGY

IL-6 mediates ER expansion during hyperpolarization of alternatively activated macrophages

(2018) Ehab A Ayaub et al.   IMMUNOLOGY AND CELL BIOLOGY

Molecular Repolarisation of Tumour-Associated Macrophages

(2018) Floris van Dalen et al.   MOLECULES

The role of macrophages in nonalcoholic fatty liver disease and nonalcoholic steatohepatitis

(2018) Konstantin Kazankov et al.   Nature Reviews Gastroenterology & Hepatology

Therapeutic Epigenetic Reprogramming of Trained Immunity in Myeloid Cells

(2018) R.M. Rodriguez et al.   TRENDS IN IMMUNOLOGY

M1 Means Kill; M2 Means Heal

(2017) Klaus Ley   JOURNAL OF IMMUNOLOGY

ER Stress Promotes Inflammation through Re-wIREd Macrophages in Obesity

(2017) Benjamin P. Garfinkel et al.   MOLECULAR CELL

Metabolic regulation of inflammation

(2017) Timo Gaber et al.   Nature Reviews Rheumatology

Targeting IRE1 with small molecules counteracts progression of atherosclerosis

(2017) Ozlem Tufanli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Unfolded protein response signaling impacts macrophage polarity to modulate breast cancer cell clearance and melanoma immune checkpoint therapy responsiveness

(2017) David R. Soto-Pantoja et al.   Oncotarget

ER Stress Protein CHOP Mediates Insulin Resistance by Modulating Adipose Tissue Macrophage Polarity

(2017) Toru Suzuki et al.   Cell Reports

Hypoxia-Inducible Factor-1α Expression in Macrophages Promotes Development of AtherosclerosisHighlights

(2016) Annemarie Aarup et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages

(2016) Evanna L. Mills et al.   CELL

The integrated stress response

(2016) Karolina Pakos‐Zebrucka et al.   EMBO REPORTS

Activation of the ATF6 branch of the unfolded protein response in neurons improves stroke outcome

(2016) Zhui Yu et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The impact of hypoxia on tumor-associated macrophages

(2016) Anne-Theres Henze et al.   JOURNAL OF CLINICAL INVESTIGATION

HIF1α and metabolic reprogramming in inflammation

(2016) Sarah E. Corcoran et al.   JOURNAL OF CLINICAL INVESTIGATION

Hypoxia-inducible factors: key regulators of myeloid cells during inflammation

(2016) Nan Lin et al.   JOURNAL OF CLINICAL INVESTIGATION

GRP78 and CHOP modulate macrophage apoptosis and the development of bleomycin-induced pulmonary fibrosis

(2016) Ehab A Ayaub et al.   JOURNAL OF PATHOLOGY

PHD2 Is a Regulator for Glycolytic Reprogramming in Macrophages

(2016) Annemarie Guentsch et al.   MOLECULAR AND CELLULAR BIOLOGY

The amino acid sensor GCN2 controls gut inflammation by inhibiting inflammasome activation

(2016) Rajesh Ravindran et al.   NATURE

Trained immunity: A program of innate immune memory in health and disease

(2016) M. G. Netea et al.   SCIENCE

Immunometabolic circuits in trained immunity

(2016) Rob J.W. Arts et al.   SEMINARS IN IMMUNOLOGY

Human umbilical cord blood-stem cells direct macrophage polarization and block inflammasome activation to alleviate rheumatoid arthritis

(2016) Tae-Hoon Shin et al.   Cell Death & Disease

HIF-1α-PDK1 axis-induced active glycolysis plays an essential role in macrophage migratory capacity

(2016) Hiroaki Semba et al.   Nature Communications

Autophagy decreases alveolar macrophage apoptosis by attenuating endoplasmic reticulum stress and oxidative stress

(2016) Tao Fan et al.   Oncotarget

CP-25, a novel compound, protects against autoimmune arthritis by modulating immune mediators of inflammation and bone damage

(2016) Yan Chang et al.   Scientific Reports

Mitochondrial Dysfunction Prevents Repolarization of Inflammatory Macrophages

(2016) Jan Van den Bossche et al.   Cell Reports

Macrophages and Their Role in Atherosclerosis: Pathophysiology and Transcriptome Analysis

(2016) Yuri V. Bobryshev et al.   Biomed Research International

The Atherosclerotic Plaque Vulnerability: Focus on the Oxidative and Endoplasmic Reticulum Stress in Orchestrating the Macrophage Apoptosis in the Formation of the Necrotic Core

(2015) Luciano Cominacini et al.   CURRENT MEDICINAL CHEMISTRY

The impact of hypoxia on bacterial infection

(2015) Kirsten Schaffer et al.   FEBS Journal

Network Integration of Parallel Metabolic and Transcriptional Data Reveals Metabolic Modules that Regulate Macrophage Polarization

(2015) Abhishek K. Jha et al.   IMMUNITY

Endoplasmic Reticulum Stress Interacts With Inflammation in Human Diseases

(2015) Stewart Siyan Cao et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Endoplasmic Reticulum Stress–Induced IRE1α Activation Mediates Cross-Talk of GSK-3β and XBP-1 To Regulate Inflammatory Cytokine Production

(2015) Sena Kim et al.   JOURNAL OF IMMUNOLOGY

Progress on hypoxia-inducible factor-3: Its structure, gene regulation and biological function (Review)

(2015) SHENG-LI YANG et al.   Molecular Medicine Reports

Epigenetic regulation by histone demethylases in hypoxia

(2015) Rebecca L Hancock et al.   Epigenomics

Hypoxia induces cyclophilin B through the activation of transcription factor 6 in gastric adenocarcinoma cells

(2015) KWON JEONG et al.   Oncology Letters

Metabolic Characterization of Polarized M1 and M2 Bone Marrow-derived Macrophages Using Real-time Extracellular Flux Analysis

(2015) Jan Van den Bossche et al.   Jove-Journal of Visualized Experiments

ATF6 Mediates a Pro-Inflammatory Synergy Between ER Stress and TLR Activation in the Pathogenesis of Liver Ischemia-Reperfusion Injury

(2014) J. Rao et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Metabolic Dysfunction Drives a Mechanistically Distinct Proinflammatory Phenotype in Adipose Tissue Macrophages

(2014) Mario Kratz et al.   Cell Metabolism

Moderate Hypoxia Potentiates Interleukin-1β Production in Activated Human Macrophages

(2014) Eduardo J. Folco et al.   CIRCULATION RESEARCH

Transcriptome-Based Network Analysis Reveals a Spectrum Model of Human Macrophage Activation

(2014) Jia Xue et al.   IMMUNITY

XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway

(2014) Xi Chen et al.   NATURE

Functional polarization of tumour-associated macrophages by tumour-derived lactic acid

(2014) Oscar R. Colegio et al.   NATURE

mTOR- and HIF-1 -mediated aerobic glycolysis as metabolic basis for trained immunity

(2014) S.-C. Cheng et al.   SCIENCE

Fine Tuning of the UPR by the Ubiquitin Ligases Siah1/2

(2014) Marzia Scortegagna et al.   PLoS Genetics

Mechanisms Driving Macrophage Diversity and Specialization in Distinct Tumor Microenvironments and Parallelisms with Other Tissues

(2014) Eva Van Overmeire et al.   Frontiers in Immunology

The Warburg effect then and now: From cancer to inflammatory diseases

(2013) Eva M. Palsson-McDermott et al.   BIOESSAYS

Tumor Hypoxia Does Not Drive Differentiation of Tumor-Associated Macrophages but Rather Fine-Tunes the M2-like Macrophage Population

(2013) D. Laoui et al.   CANCER RESEARCH

The Relationship between Metabolism and the Autophagy Machinery during the Innate Immune Response

(2013) Jennifer Martinez et al.   Cell Metabolism

Hypoxia in atherosclerosis and inflammation

(2013) Elke Marsch et al.   CURRENT OPINION IN LIPIDOLOGY

Activating Transcription Factor 4 Links Metabolic Stress to Interleukin-6 Expression in Macrophages

(2013) Y. Iwasaki et al.   DIABETES

C/EBP Homologous Protein-induced Macrophage Apoptosis Protects Mice from Steatohepatitis

(2013) Harmeet Malhi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HIF-1α influences myeloid cell antigen presentation and response to subcutaneous OVA vaccination

(2013) Tamara Bhandari et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

(2013) G. M. Tannahill et al.   NATURE

The eIF2α/ATF4 pathway is essential for stress-induced autophagy gene expression

(2013) Wafa B’chir et al.   NUCLEIC ACIDS RESEARCH

PERK/eIF2  signaling protects therapy resistant hypoxic cells through induction of glutathione synthesis and protection against ROS

(2013) K. M. Rouschop et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypoxia-Inducible Factors in Physiology and Medicine

(2012) Gregg L. Semenza   CELL

Endoplasmic Reticulum Stress Controls M2 Macrophage Differentiation and Foam Cell Formation

(2012) Jisu Oh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Macrophage plasticity and polarization: in vivo veritas

(2012) Antonio Sica et al.   JOURNAL OF CLINICAL INVESTIGATION

Clinical Significance of Tumor-Associated Inflammatory Cells in Metastatic Neuroblastoma

(2012) Shahab Asgharzadeh et al.   JOURNAL OF CLINICAL ONCOLOGY

Toll-like receptor activation suppresses ER stress factor CHOP and translation inhibition through activation of eIF2B

(2012) Connie W. Woo et al.   NATURE CELL BIOLOGY

Targeting the Lactate Transporter MCT1 in Endothelial Cells Inhibits Lactate-Induced HIF-1 Activation and Tumor Angiogenesis

(2012) Pierre Sonveaux et al.   PLoS One

Endoplasmic Reticulum Stress and Glycogen Synthase Kinase-3β Activation in Apolipoprotein E–Deficient Mouse Models of Accelerated Atherosclerosis

(2011) Cameron S. McAlpine et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Role of ATF4 in regulation of autophagy and resistance to drugs and hypoxia

(2011) Tomasz Rzymski et al.   CELL CYCLE

Hypoxia Is Present in Murine Atherosclerotic Plaques and Has Multiple Adverse Effects on Macrophage Lipid Metabolism

(2011) Sajesh Parathath et al.   CIRCULATION RESEARCH

Tumor-associated macrophages in breast cancer: distinct subsets, distinct functions

(2011) Damya Laoui et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Hypoxia and Inflammation

(2011) Holger K. Eltzschig et al.   NEW ENGLAND JOURNAL OF MEDICINE

Tumor-Associated Macrophages (TAMs) Form an Interconnected Cellular Supportive Network in Anaplastic Thyroid Carcinoma

(2011) Bernard Caillou et al.   PLoS One

Protein Folding and Quality Control in the ER

(2011) K. Araki et al.   Cold Spring Harbor Perspectives in Biology

ER stress negatively regulates AKT/TSC/mTOR pathway to enhance autophagy

(2010) Liang Qin et al.   Autophagy

Infiltration of tumour-associated macrophages in prostate biopsy specimens is predictive of disease progression after hormonal therapy for prostate cancer

(2010) Norio Nonomura et al.   BJU INTERNATIONAL

Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease

(2010) Gökhan S. Hotamisligil   CELL

Hypoxia causes epigenetic gene regulation in macrophages by attenuating Jumonji histone demethylase activity

(2010) Michaela Tausendschön et al.   CYTOKINE

Tauroursodeoxycholic Acid May Improve Liver and Muscle but Not Adipose Tissue Insulin Sensitivity in Obese Men and Women

(2010) Marleen Kars et al.   DIABETES

Differential activation and antagonistic function of HIF-  isoforms in macrophages are essential for NO homeostasis

(2010) N. Takeda et al.   GENES & DEVELOPMENT

Autophagy: cellular and molecular mechanisms

(2010) Danielle Glick et al.   JOURNAL OF PATHOLOGY

mTORC1 Signaling under Hypoxic Conditions Is Controlled by ATM-Dependent Phosphorylation of HIF-1α

(2010) Hakan Cam et al.   MOLECULAR CELL

Hypoxia-Inducible Factors and the Response to Hypoxic Stress

(2010) Amar J. Majmundar et al.   MOLECULAR CELL

TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages

(2010) Fabio Martinon et al.   NATURE IMMUNOLOGY

The mechanism of eukaryotic translation initiation and principles of its regulation

(2010) Richard J. Jackson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Transcriptional Regulation of VEGF-A by the Unfolded Protein Response Pathway

(2010) Rajarshi Ghosh et al.   PLoS One

Hypoxia-induced Expression of Carbonic Anhydrase 9 Is Dependent on the Unfolded Protein Response

(2009) Twan van den Beucken et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Surviving hypoxia by modulation of mRNA translation rate

(2009) Michael Fähling   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The transcription factor ATF4 regulates glucose metabolism in mice through its expression in osteoblasts

(2009) Tatsuya Yoshizawa et al.   JOURNAL OF CLINICAL INVESTIGATION

The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5

(2009) Kasper M.A. Rouschop et al.   JOURNAL OF CLINICAL INVESTIGATION

Macrophage Oxygen Sensing Modulates Antigen Presentation and Phagocytic Functions Involving IFN-  Production through the HIF-1  Transcription Factor

(2009) B. Acosta-Iborra et al.   JOURNAL OF IMMUNOLOGY

Mutual Regulation of Hypoxia-Inducible Factor and Mammalian Target of Rapamycin as a Function of Oxygen Availability

(2009) Karl X. Knaup et al.   MOLECULAR CANCER RESEARCH

Adaptive suppression of the ATF4–CHOP branch of the unfolded protein response by toll-like receptor signalling

(2009) Connie W. Woo et al.   NATURE CELL BIOLOGY

Reducing endoplasmic reticulum stress through a macrophage lipid chaperone alleviates atherosclerosis

(2009) Ebru Erbay et al.   NATURE MEDICINE

Molecular mechanisms of mTOR-mediated translational control

(2009) Xiaoju Max Ma et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Deficient carbonic anhydrase 9 expression in UPR-impaired cells is associated with reduced survival in an acidic microenvironment

(2009) Twan van den Beucken et al.   RADIOTHERAPY AND ONCOLOGY

Mitochondrial generation of free radicals and hypoxic signaling

(2009) Robert O. Poyton et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Regulation of hypoxia-inducible factor-1α by NF-κB

(2008) Patrick van Uden et al.   BIOCHEMICAL JOURNAL

XBP1 Links ER Stress to Intestinal Inflammation and Confers Genetic Risk for Human Inflammatory Bowel Disease

(2008) Arthur Kaser et al.   CELL

The unfolded protein response regulator GRP78/BiP is required for endoplasmic reticulum integrity and stress-induced autophagy in mammalian cells

(2008) J Li et al.   CELL DEATH AND DIFFERENTIATION

Increase in Endoplasmic Reticulum Stress-Related Proteins and Genes in Adipose Tissue of Obese, Insulin-Resistant Individuals

(2008) G. Boden et al.   DIABETES

Increased density of tumor-associated macrophages is associated with decreased survival in advanced thyroid cancer

(2008) M. Ryder et al.   ENDOCRINE-RELATED CANCER

Hypoxic Reactive Oxygen Species Regulate the Integrated Stress Response and Cell Survival

(2008) Liping Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The unfolded protein response signals through high-order assembly of Ire1

(2008) Alexei V. Korennykh et al.   NATURE