Promiscuous Targets for Antitubercular Drug Discovery: The Paradigm of DprE1 and MmpL3
Published 2020 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Promiscuous Targets for Antitubercular Drug Discovery: The Paradigm of DprE1 and MmpL3
Authors
Keywords
-
Journal
Applied Sciences-Basel
Volume 10, Issue 2, Pages 623
Publisher
MDPI AG
Online
2020-01-17
DOI
10.3390/app10020623
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Direct Inhibition of MmpL3 by Novel Antitubercular Compounds
- (2019) Wei Li et al. ACS Infectious Diseases
- An Overview on the Potential Antimycobacterial Agents Targeting Serine/Threonine Protein Kinases from Mycobacterium tuberculosis
- (2019) Matteo Mori et al. CURRENT TOPICS IN MEDICINAL CHEMISTRY
- Crystal Structures of Membrane Transporter MmpL3, an Anti-TB Drug Target
- (2019) Bing Zhang et al. CELL
- MmpL3 is a lipid transporter that binds trehalose monomycolate and phosphatidylethanolamine
- (2019) Chih-Chia Su et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The MmpL3 interactome reveals a complex crosstalk between cell envelope biosynthesis and cell elongation and division in mycobacteria
- (2019) Juan Manuel Belardinelli et al. Scientific Reports
- Pretomanid: First Approval
- (2019) Susan J. Keam DRUGS
- HC2091 Kills Mycobacterium tuberculosis by Targeting the MmpL3 Mycolic Acid Transporter
- (2018) Huiqing Zheng et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Structure-based drug design and characterization of sulfonyl-piperazine benzothiazinone inhibitors of DprE1 from Mycobacterium tuberculosis
- (2018) Jérémie Piton et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Decaprenyl-phosphoryl-ribose 2′-epimerase (DprE1): challenging target for antitubercular drug discovery
- (2018) Jineetkumar Gawad et al. Chemistry Central Journal
- Therapeutic potential of promiscuous targets in Mycobacterium tuberculosis
- (2018) Bei Shi Lee et al. CURRENT OPINION IN PHARMACOLOGY
- Drug discovery in tuberculosis. New drug targets and antimycobacterial agents
- (2018) André Campaniço et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Overview of the Development of DprE1 Inhibitors for Combating the Menace of Tuberculosis
- (2018) Rupesh V. Chikhale et al. JOURNAL OF MEDICINAL CHEMISTRY
- An optimized background regimen for treatment of active tuberculosis with the next-generation benzothiazinone Macozinone (PBTZ169)
- (2018) Andréanne Lupien et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- A class of hydrazones are active against non-replicating Mycobacterium tuberculosis
- (2018) Shilah A. Bonnett et al. PLoS One
- Novel insight into the reaction of nitro, nitroso and hydroxylamino benzothiazinones and of benzoxacinones with Mycobacterium tuberculosis DprE1
- (2018) Adrian Richter et al. Scientific Reports
- Discovery and Structure–Activity-Relationship Study of N-Alkyl-5-hydroxypyrimidinone Carboxamides as Novel Antitubercular Agents Targeting Decaprenylphosphoryl-β-d-ribose 2′-Oxidase
- (2018) Sangmi Oh et al. JOURNAL OF MEDICINAL CHEMISTRY
- Novel Acetamide Indirectly Targets Mycobacterial Transporter MmpL3 by Proton Motive Force Disruption
- (2018) Annanya Shetty et al. Frontiers in Microbiology
- Crystal structures of theBurkholderia multivoranshopanoid transporter HpnN
- (2017) Nitin Kumar et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- MmpL3 is the flippase for mycolic acids in mycobacteria
- (2017) Zhujun Xu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Promoter mutagenesis for fine-tuning expression of essential genes in Mycobacterium tuberculosis
- (2017) Francesca Boldrin et al. Microbial Biotechnology
- Essentiality of mmpL3 and impact of its silencing on Mycobacterium tuberculosis gene expression
- (2017) Giulia Degiacomi et al. Scientific Reports
- Therapeutic Potential of the Mycobacterium tuberculosis Mycolic Acid Transporter, MmpL3
- (2016) Wei Li et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Inhibition of Leishmania mexicana Growth by the Tuberculosis Drug SQ109
- (2016) Verónica García-García et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Structural Insights into the Niemann-Pick C1 (NPC1)-Mediated Cholesterol Transfer and Ebola Infection
- (2016) Xin Gong et al. CELL
- Nitroarenes as Antitubercular Agents: Stereoelectronic Modulation to Mitigate Mutagenicity
- (2016) Sudhir Landge et al. ChemMedChem
- Iron Acquisition Pathways as Targets for Antitubercular Drugs
- (2016) Fiorella Meneghetti et al. CURRENT MEDICINAL CHEMISTRY
- New and Old Hot Drug Targets in Tuberculosis
- (2016) Laurent Roberto Chiarelli et al. CURRENT MEDICINAL CHEMISTRY
- A new piperidinol derivative targeting mycolic acid transport inMycobacterium abscessus
- (2016) Christian Dupont et al. MOLECULAR MICROBIOLOGY
- Mycobacterial cell wall biosynthesis: a multifaceted antibiotic target
- (2016) KATHERINE A. ABRAHAMS et al. PARASITOLOGY
- InhibitingMycobacterium tuberculosiswithin and without
- (2016) Stewart T. Cole PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
- Design, Syntheses, and Anti-TB Activity of 1,3-Benzothiazinone Azide and Click Chemistry Products Inspired by BTZ043
- (2016) Rohit Tiwari et al. ACS Medicinal Chemistry Letters
- Structure–Function Profile of MmpL3, the Essential Mycolic Acid Transporter from Mycobacterium tuberculosis
- (2016) Juan Manuel Belardinelli et al. ACS Infectious Diseases
- DprE1 Is a Vulnerable Tuberculosis Drug Target Due to Its Cell Wall Localization
- (2015) Miroslav Brecik et al. ACS Chemical Biology
- The 8-Pyrrole-Benzothiazinones Are Noncovalent Inhibitors of DprE1 from Mycobacterium tuberculosis
- (2015) Vadim Makarov et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- SQ109, a New Drug Lead for Chagas Disease
- (2015) Phercyles Veiga-Santos et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Discovery of benzothiazoles as antimycobacterial agents: Synthesis, structure–activity relationships and binding studies with Mycobacterium tuberculosis decaprenylphosphoryl-β-d-ribose 2′-oxidase
- (2015) Sudhir Landge et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Development of selective DprE1 inhibitors: Design, synthesis, crystal structure and antitubercular activity of benzothiazolylpyrimidine-5-carboxamides
- (2015) Rupesh Chikhale et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Early phase evaluation of SQ109 alone and in combination with rifampicin in pulmonary TB patients
- (2015) Norbert Heinrich et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- Whole Cell Target Engagement Identifies Novel Inhibitors of Mycobacterium tuberculosis Decaprenylphosphoryl-β-d-ribose Oxidase
- (2015) Sarah M. Batt et al. ACS Infectious Diseases
- Structure, Dynamics, and Interaction of Mycobacterium tuberculosis (Mtb) DprE1 and DprE2 Examined by Molecular Modeling, Simulation, and Electrostatic Studies
- (2015) Isha Bhutani et al. PLoS One
- 2-Carboxyquinoxalines Kill Mycobacterium tuberculosis through Noncovalent Inhibition of DprE1
- (2014) João Neres et al. ACS Chemical Biology
- Cross-Resistance between Clofazimine and Bedaquiline through Upregulation of MmpL5 in Mycobacterium tuberculosis
- (2014) R. C. Hartkoorn et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Novel Insights into the Mechanism of Inhibition of MmpL3, a Target of Multiple Pharmacophores in Mycobacterium tuberculosis
- (2014) Wei Li et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- 1,4-Azaindole, a Potential Drug Candidate for Treatment of Tuberculosis
- (2014) Monalisa Chatterji et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Delamanid: First Global Approval
- (2014) Nicola J. Ryan et al. DRUGS
- Towards a new combination therapy for tuberculosis with next generation benzothiazinones
- (2014) V. Makarov et al. EMBO Molecular Medicine
- Tuberculosis drug discovery in the post-post-genomic era
- (2014) Benoit Lechartier et al. EMBO Molecular Medicine
- Elucidation of a protein-protein interaction network involved in Corynebacterium glutamicum cell wall biosynthesis as determined by bacterial two-hybrid analysis
- (2014) Monika Jankute et al. GLYCOCONJUGATE JOURNAL
- Biosynthesis and Translocation of Unsulfated Acyltrehaloses inMycobacterium tuberculosis
- (2014) Juan Manuel Belardinelli et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Lead Optimization of 1,4-Azaindoles as Antimycobacterial Agents
- (2014) Pravin S. Shirude et al. JOURNAL OF MEDICINAL CHEMISTRY
- 4-Aminoquinolone Piperidine Amides: Noncovalent Inhibitors of DprE1 with Long Residence Time and Potent Antimycobacterial Activity
- (2014) Maruti Naik et al. JOURNAL OF MEDICINAL CHEMISTRY
- Discovery of Pyrazolopyridones as a Novel Class of Noncovalent DprE1 Inhibitor with Potent Anti-Mycobacterial Activity
- (2014) Manoranjan Panda et al. JOURNAL OF MEDICINAL CHEMISTRY
- Assessing the essentiality of the decaprenyl-phospho-d-arabinofuranose pathway inMycobacterium tuberculosisusing conditional mutants
- (2014) Gaëlle S. Kolly et al. MOLECULAR MICROBIOLOGY
- Mycobacterium tuberculosis Proteins Involved in Mycolic Acid Synthesis and Transport Localize Dynamically to the Old Growing Pole and Septum
- (2014) Clément Carel et al. PLoS One
- Crystal Structure of the Neisseria gonorrhoeae MtrD Inner Membrane Multidrug Efflux Pump
- (2014) Jani Reddy Bolla et al. PLoS One
- Identification of Novel Inhibitors of Nonreplicating Mycobacterium tuberculosis Using a Carbon Starvation Model
- (2013) Sarah Schmidt Grant et al. ACS Chemical Biology
- The DprE1 enzyme, one of the most vulnerable targets of Mycobacterium tuberculosis
- (2013) Giovanna Riccardi et al. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
- MmpL11 Protein Transports Mycolic Acid-containing Lipids to the Mycobacterial Cell Wall and Contributes to Biofilm Formation in Mycobacterium smegmatis
- (2013) Sophia A. Pacheco et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Azaindoles: Noncovalent DprE1 Inhibitors from Scaffold Morphing Efforts, Kill Mycobacterium tuberculosis and Are Efficacious in Vivo
- (2013) Pravin S. Shirude et al. JOURNAL OF MEDICINAL CHEMISTRY
- Thiolates Chemically Induce Redox Activation of BTZ043 and Related Potent Nitroaromatic Anti-Tuberculosis Agents
- (2013) Rohit Tiwari et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Antituberculosis thiophenes define a requirement for Pks13 in mycolic acid biosynthesis
- (2013) Regina Wilson et al. Nature Chemical Biology
- Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis
- (2013) Kevin Pethe et al. NATURE MEDICINE
- Identification of Novel Imidazo[1,2-a]pyridine Inhibitors Targeting M. tuberculosis QcrB
- (2013) Katherine A. Abrahams et al. PLoS One
- Tetrahydropyrazolo[1,5-a]Pyrimidine-3-Carboxamide and N-Benzyl-6′,7′-Dihydrospiro[Piperidine-4,4′-Thieno[3,2-c]Pyran] Analogues with Bactericidal Efficacy against Mycobacterium tuberculosis Targeting MmpL3
- (2013) Modesto J. Remuiñán et al. PLoS One
- Identification of a small molecule with activity against drug-resistant and persistent tuberculosis
- (2013) F. Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Crystal structure of decaprenylphosphoryl-β-D-ribose 2'-epimerase fromMycobacterium smegmatis
- (2013) Hua Li et al. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
- Indolcarboxamide Is a Preclinical Candidate for Treating Multidrug-Resistant Tuberculosis
- (2013) S. P. S. Rao et al. Science Translational Medicine
- Discovery of a Siderophore Export System Essential for Virulence of Mycobacterium tuberculosis
- (2013) Ryan M. Wells et al. PLoS Pathogens
- Identification of Novel Inhibitors of M. tuberculosis Growth Using Whole Cell Based High-Throughput Screening
- (2012) Sarah A. Stanley et al. ACS Chemical Biology
- SQ109 Targets MmpL3, a Membrane Transporter of Trehalose Monomycolate Involved in Mycolic Acid Donation to the Cell Wall Core of Mycobacterium tuberculosis
- (2012) Kapil Tahlan et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Inhibition of mycolic acid transport across the Mycobacterium tuberculosis plasma membrane
- (2012) Anna E Grzegorzewicz et al. Nature Chemical Biology
- Structural basis of inhibition of Mycobacterium tuberculosis DprE1 by benzothiazinone inhibitors
- (2012) S. M. Batt et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structural Basis for Benzothiazinone-Mediated Killing of Mycobacterium tuberculosis
- (2012) J. Neres et al. Science Translational Medicine
- MmpL3 Is the Cellular Target of the Antitubercular Pyrrole Derivative BM212
- (2011) Valentina La Rosa et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Elucidation and Chemical Modulation of Sulfolipid-1 Biosynthesis inMycobacterium tuberculosis
- (2011) Jessica C. Seeliger et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Benzothiazinones Are Suicide Inhibitors of Mycobacterial Decaprenylphosphoryl-β-d-ribofuranose 2′-Oxidase DprE1
- (2011) Claudia Trefzer et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Structure and function of a membrane component SecDF that enhances protein export
- (2011) Tomoya Tsukazaki et al. NATURE
- Analogous Mechanisms of Resistance to Benzothiazinones and Dinitrobenzamides in Mycobacterium smegmatis
- (2011) Ana Luisa de Jesus Lopes Ribeiro et al. PLoS One
- In Vitro Interactions between New Antitubercular Drug Candidates SQ109 and TMC207
- (2010) V. M. Reddy et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Biological and structural characterization of the Mycobacterium smegmatis nitroreductase NfnB, and its role in benzothiazinone resistance
- (2010) Giulia Manina et al. MOLECULAR MICROBIOLOGY
- Leads for antitubercular compounds from kinase inhibitor library screens
- (2010) Sophie Magnet et al. TUBERCULOSIS
- Crystal Structure of the Multidrug Exporter MexB from Pseudomonas aeruginosa
- (2009) Gaby Sennhauser et al. JOURNAL OF MOLECULAR BIOLOGY
- Benzothiazinones Kill Mycobacterium tuberculosis by Blocking Arabinan Synthesis
- (2009) V. Makarov et al. SCIENCE
- High Content Screening Identifies Decaprenyl-Phosphoribose 2′ Epimerase as a Target for Intracellular Antimycobacterial Inhibitors
- (2009) Thierry Christophe et al. PLoS Pathogens
- Construction of Mycobacterium abscessus Defined Glycopeptidolipid Mutants: Comparison of Genetic Tools
- (2008) H. Medjahed et al. APPLIED AND ENVIRONMENTAL MICROBIOLOGY
- The AcrB Efflux Pump: Conformational Cycling and Peristalsis Lead to Multidrug Resistance
- (2008) Markus Seeger et al. CURRENT DRUG TARGETS
- Biosynthesis of D-arabinose in mycobacteria - a novel bacterial pathway with implications for antimycobacterial therapy
- (2008) Beata A. Wolucka FEBS Journal
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search