Structural Basis for Benzothiazinone-Mediated Killing of Mycobacterium tuberculosis

Surveillance of anti-tuberculosis drug resistance in the world: an updated analysis, 2007–2010

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New Drugs for the Treatment of Tuberculosis: Needs, Challenges, Promise, and Prospects for the Future

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Improvement of molecular-replacement models withSculptor

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Overview of theCCP4 suite and current developments

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Presenting your structures: theCCP4mgmolecular-graphics software

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New tuberculosis drugs on the horizon

(2011) Stewart T Cole et al.   CURRENT OPINION IN MICROBIOLOGY

Benzothiazinones Are Suicide Inhibitors of Mycobacterial Decaprenylphosphoryl-β-d-ribofuranose 2′-Oxidase DprE1

(2011) Claudia Trefzer et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Decaprenylphosphoryl-β-D-Ribose 2′-Epimerase, the Target of Benzothiazinones and Dinitrobenzamides, Is an Essential Enzyme in Mycobacterium smegmatis

(2011) Paul K. Crellin et al.   PLoS One

Analogous Mechanisms of Resistance to Benzothiazinones and Dinitrobenzamides in Mycobacterium smegmatis

(2011) Ana Luisa de Jesus Lopes Ribeiro et al.   PLoS One

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Clinical Isolates of Mycobacterium tuberculosis in Four European Hospitals Are Uniformly Susceptible to Benzothiazinones

(2010) M. R. Pasca et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Decaprenylphosphoryl-β-D-Ribose 2-Epimerase from Mycobacterium tuberculosis is a Magic Drug Target

(2010) G. Manina et al.   CURRENT MEDICINAL CHEMISTRY

Benzothiazinones: Prodrugs That Covalently Modify the Decaprenylphosphoryl-β-d-ribose 2′-epimerase DprE1 ofMycobacterium tuberculosis

(2010) Claudia Trefzer et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Leads for antitubercular compounds from kinase inhibitor library screens

(2010) Sophie Magnet et al.   TUBERCULOSIS

Totally drug-resistant tuberculosis strains: evidence of adaptation at the cellular level

(2009) A. A. Velayati et al.   EUROPEAN RESPIRATORY JOURNAL

Benzothiazinones Kill Mycobacterium tuberculosis by Blocking Arabinan Synthesis

(2009) V. Makarov et al.   SCIENCE

High Content Screening Identifies Decaprenyl-Phosphoribose 2′ Epimerase as a Target for Intracellular Antimycobacterial Inhibitors

(2009) Thierry Christophe et al.   PLoS Pathogens

Biosynthesis of D-arabinose in mycobacteria - a novel bacterial pathway with implications for antimycobacterial therapy

(2008) Beata A. Wolucka   FEBS Journal

Structural Analysis of the Catalytic Mechanism and Stereoselectivity inStreptomyces coelicolorAlditol Oxidase†,‡

(2007) Federico Forneris et al.   BIOCHEMISTRY