Charge and hydrophobicity are key features in sequence-trained machine learning models for predicting the biophysical properties of clinical-stage antibodies

Web-based display of protein surface and pH-dependent properties for assessing the developability of biotherapeutics

(2019) Max Hebditch et al.   Scientific Reports

Five computational developability guidelines for therapeutic antibody profiling

(2019) Matthew I. J. Raybould et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Optimization of a platform process operating space for a monoclonal antibody susceptible to reversible and irreversible aggregation using a solution stability screening approach

(2019) Adrian Man et al.   JOURNAL OF CHROMATOGRAPHY A

Cross interaction chromatography based QSAR model for early stage screening to facilitate enhanced developability of monoclonal antibody therapeutics

(2019) Arathi Kizhedath et al.   Biotechnology Journal

Ordered quantile normalization: a semiparametric transformation built for the cross-validation era

(2019) Ryan A. Peterson et al.   JOURNAL OF APPLIED STATISTICS

Homology modeling and structure-based design improve hydrophobic interaction chromatography behavior of integrin binding antibodies

(2018) Arif Jetha et al.   mAbs

Rational optimization of a monoclonal antibody for simultaneous improvements in its solution properties and biological activity

(2018) Sandeep Kumar et al.   PROTEIN ENGINEERING DESIGN & SELECTION

AggScore: Prediction of aggregation-prone regions in proteins based on the distribution of surface patches

(2018) Kannan Sankar et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Computational analysis of the amino acid interactions that promote or decrease protein solubility

(2018) Qingzhen Hou et al.   Scientific Reports

Models for Antibody Behavior in Hydrophobic Interaction Chromatography and in Self-Association

(2018) Max Hebditch et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Developability Assessment of Engineered Monoclonal Antibody Variants with a Complex Self-Association Behavior Using Complementary Analytical and in Silico Tools

(2018) Lu Shan et al.   MOLECULAR PHARMACEUTICS

The effect of charge mutations on the stability and aggregation of a human single chain Fv fragment

(2017) James I. Austerberry et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Characterization of 30 therapeutic antibodies and related products by size exclusion chromatography: Feasibility assessment for future mass spectrometry hyphenation

(2017) Alexandre Goyon et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Modeling and docking of antibody structures with Rosetta

(2017) Brian D Weitzner et al.   Nature Protocols

Biophysical properties of the clinical-stage antibody landscape

(2017) Tushar Jain et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ten quick tips for machine learning in computational biology

(2017) Davide Chicco   BioData Mining

Rapid and accurate in silico solubility screening of a monoclonal antibody library

(2017) Pietro Sormanni et al.   Scientific Reports

Ensemble Modeling and Intracellular Aggregation of an Engineered Immunoglobulin-Like Domain

(2016) Kyle Trainor et al.   JOURNAL OF MOLECULAR BIOLOGY

ABodyBuilder: Automated antibody structure prediction with data–driven accuracy estimation

(2016) Jinwoo Leem et al.   mAbs

Developability Assessment During the Selection of Novel Therapeutic Antibodies

(2015) Alexander Jarasch et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

A novel screening method to assess developability of antibody-like molecules

(2015) Neeraj Kohli et al.   mAbs

Aggregation risk prediction for antibodies and its application to biotherapeutic development

(2015) Olga Obrezanova et al.   mAbs

Building Predictive Models inRUsing thecaretPackage

(2015) Max Kuhn   Journal of Statistical Software

Antibody modeling using the Prediction of ImmunoGlobulin Structure (PIGS) web server

(2014) Paolo Marcatili et al.   Nature Protocols

PASTA 2.0: an improved server for protein aggregation prediction

(2014) Ian Walsh et al.   NUCLEIC ACIDS RESEARCH

In silico selection of therapeutic antibodies for development: Viscosity, clearance, and chemical stability

(2014) Vikas K. Sharma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cross-validation pitfalls when selecting and assessing regression and classification models

(2014) Damjan Krstajic et al.   Journal of Cheminformatics

Influence of the Cosolute Environment on IgG Solution Structure Analyzed by Small-Angle X-ray Scattering

(2012) Wayne G. Lilyestrom et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Interactions of formulation excipients with proteins in solution and in the dried state

(2011) Satoshi Ohtake et al.   ADVANCED DRUG DELIVERY REVIEWS

Protein–excipient interactions: Mechanisms and biophysical characterization applied to protein formulation development

(2011) Tim J. Kamerzell et al.   ADVANCED DRUG DELIVERY REVIEWS

Developability Index: A Rapid In Silico Tool for the Screening of Antibody Aggregation Propensity

(2011) Timothy M. Lauer et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Bimodal protein solubility distribution revealed by an aggregation analysis of the entire ensemble of Escherichia coli proteins

(2009) T. Niwa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Zyggregator method for predicting protein aggregation propensities

(2008) Gian Gaetano Tartaglia et al.   CHEMICAL SOCIETY REVIEWS

Analysis and improvements to Kabat and structurally correct numbering of antibody variable domains

(2008) K.R. Abhinandan et al.   MOLECULAR IMMUNOLOGY