The Many Facets of Erythropoietin Physiologic and Metabolic Response

Fpr2 Deficiency Alleviates Diet-Induced Insulin Resistance Through Reducing Body Weight Gain and Inhibiting Inflammation Mediated by Macrophage Chemotaxis and M1 Polarization

(2019) Xiaofang Chen et al.   DIABETES

Mobilization of Transplanted Bone Marrow Mesenchymal Stem Cells by Erythropoietin Facilitates the Reconstruction of Segmental Bone Defect

(2019) Jun Li et al.   Stem Cells International

The Neural Crest as the First Production Site of the Erythroid Growth Factor Erythropoietin

(2019) Ikuo Hirano et al.   Frontiers in Cell and Developmental Biology

Palmitate deranges erythropoietin production via transcription factor ATF4 activation of unfolded protein response

(2018) Thitinun Anusornvongchai et al.   KIDNEY INTERNATIONAL

Anemia in conventional hemodialysis: Finding the optimal treatment balance

(2018) Takeshi Hasegawa et al.   SEMINARS IN DIALYSIS

EPO does not promote interaction between the erythropoietin and beta-common receptors

(2018) Karen S. Cheung Tung Shing et al.   Scientific Reports

Erythropoietin and long-acting erythropoiesis stimulating agent ameliorate non-alcoholic fatty liver disease by increasing lipolysis and decreasing lipogenesis via EPOR/STAT pathway

(2018) Yusuke Tsuma et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Regulation of hypoxia-inducible gene expression after HIF activation

(2017) Norio Suzuki et al.   EXPERIMENTAL CELL RESEARCH

New horizons in hypoxia signaling pathways

(2017) Christopher W. Pugh et al.   EXPERIMENTAL CELL RESEARCH

Sex difference in mouse metabolic response to erythropoietin

(2017) Yuanyuan Zhang et al.   FASEB JOURNAL

Erythropoietin stimulates murine and human fibroblast growth factor-23, revealing novel roles for bone and bone marrow

(2017) Erica L. Clinkenbeard et al.   HAEMATOLOGICA

Erythropoietin inhibits osteoblast function in myelodysplastic syndromes via the canonical Wnt pathway

(2017) Ekaterina Balaian et al.   HAEMATOLOGICA

Asymmetric Dimethylarginine Contributes to the Impaired Response to Erythropoietin in CKD-Anemia

(2017) Miyuki Yokoro et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Hypoxia-inducible factor prolyl-4-hydroxylation in FOXD1 lineage cells is essential for normal kidney development

(2017) Hanako Kobayashi et al.   KIDNEY INTERNATIONAL

Prophylactic Early Erythropoietin for Neuroprotection in Preterm Infants: A Meta-analysis

(2017) Hendrik S. Fischer et al.   PEDIATRICS

Metabolic basis to Sherpa altitude adaptation

(2017) James A. Horscroft et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

EV-3, an endogenous human erythropoietin isoform with distinct functional relevance

(2017) Christel Bonnas et al.   Scientific Reports

Erythropoietin stimulates murine and human fibroblast growth factor-23, revealing novel roles for bone and bone marrow

(2017) Erica L. Clinkenbeard et al.   HAEMATOLOGICA

Erythropoietin inhibits osteoblast function in myelodysplastic syndromes via the canonical Wnt pathway

(2017) Ekaterina Balaian et al.   HAEMATOLOGICA

The Insect Ortholog of the Human Orphan Cytokine Receptor CRLF3 Is a Neuroprotective Erythropoietin Receptor

(2017) Nina Hahn et al.   Frontiers in Molecular Neuroscience

Erythropoietin (EPO) ameliorates obesity and glucose homeostasis by promoting thermogenesis and endocrine function of classical brown adipose tissue (BAT) in diet-induced obese mice

(2017) Kazuki Kodo et al.   PLoS One

Cibinetide dampens innate immune cell functions thus ameliorating the course of experimental colitis

(2017) Manfred Nairz et al.   Scientific Reports

Increased bone formation in a rabbit long-bone defect model after single local and single systemic application of erythropoietin

(2016) Georg W Omlor et al.   Acta Orthopaedica

Chronic Mountain Sickness: Clinical Aspects, Etiology, Management, and Treatment

(2016) Francisco C. Villafuerte et al.   HIGH ALTITUDE MEDICINE & BIOLOGY

Increased EPO Levels Are Associated With Bone Loss in Mice Lacking PHD2 in EPO-Producing Cells

(2016) Martina Rauner et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Partial white and grey matter protection with prolonged infusion of recombinant human erythropoietin after asphyxia in preterm fetal sheep

(2016) Guido Wassink et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Distinct subpopulations of FOXD1 stroma-derived cells regulate renal erythropoietin

(2016) Hanako Kobayashi et al.   JOURNAL OF CLINICAL INVESTIGATION

Evolution of Cytokine Receptor Signaling

(2016) Clifford Liongue et al.   JOURNAL OF IMMUNOLOGY

Non-hematopoietic effects of endogenous erythropoietin on lean mass and body weight regulation

(2016) Martin Reinhardt et al.   Obesity

Iron Balance and the Role of Hepcidin in Chronic Kidney Disease

(2016) Tomas Ganz et al.   SEMINARS IN NEPHROLOGY

Erythropoietin Does Not Enhance Skeletal Muscle Protein Synthesis Following Exercise in Young and Older Adults

(2016) Séverine Lamon et al.   Frontiers in Physiology

The Erythropoietin Receptor

(2016) Stephanie S. Watowich   JOURNAL OF INVESTIGATIVE MEDICINE

Emerging EPO and EPO receptor regulators and signal transducers

(2015) D. Kuhrt et al.   BLOOD

Erythropoietin negatively regulates pituitary ACTH secretion

(2015) Soumyadeep Dey et al.   BRAIN RESEARCH

The dynamics of adult haematopoiesis in the bone and bone marrow environment

(2015) Miriel S. H. Ho et al.   BRITISH JOURNAL OF HAEMATOLOGY

Erythropoietin Stimulates Tumor Growth via EphB4

(2015) Sunila Pradeep et al.   CANCER CELL

Association of Erythropoietin Dose and Route of Administration with Clinical Outcomes for Patients on Hemodialysis in the United States

(2015) D. G. Wright et al.   Clinical Journal of the American Society of Nephrology

Erythropoietin directly stimulates osteoclast precursors and induces bone loss

(2015) Sahar Hiram-Bab et al.   FASEB JOURNAL

Adaptation of iron requirement to hypoxic conditions at high altitude

(2015) Max Gassmann et al.   JOURNAL OF APPLIED PHYSIOLOGY

Erythropoietin Promotes Bone Formation through EphrinB2/EphB4 Signaling

(2015) C. Li et al.   JOURNAL OF DENTAL RESEARCH

Erythropoietin regulates POMC expression via STAT3 and potentiates leptin response

(2015) Soumyadeep Dey et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Satellite cell response to erythropoietin treatment and endurance training in healthy young men

(2015) Andrea Hoedt et al.   JOURNAL OF PHYSIOLOGY-LONDON

Erythropoietin and obesity-induced white adipose tissue inflammation: redefining the boundaries of the immunometabolism territory

(2015) Mawadda Alnaeeli et al.   Adipocyte

A single topical dose of erythropoietin applied on a collagen carrier enhances calvarial bone healing in pigs

(2014) Jan Hendrik Duedal Rölfing et al.   Acta Orthopaedica

Erythropoietin Signaling: A Novel Regulator of White Adipose Tissue Inflammation During Diet-Induced Obesity

(2014) M. Alnaeeli et al.   DIABETES

Erythropoietin, a Novel Versatile Player Regulating Energy Metabolism beyond the Erythroid System

(2014) Li Wang et al.   International Journal of Biological Sciences

Erythropoietin Action in Stress Response, Tissue Maintenance and Metabolism

(2014) Yuanyuan Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Erythropoietin-induced hypertension and vascular injury in mice overexpressing human endothelin-1

(2014) Tlili Barhoumi et al.   JOURNAL OF HYPERTENSION

Unknown

(2014) Albert Dahan et al.   MOLECULAR MEDICINE

Safety and tolerability of carbamylated erythropoietin in Friedreich's ataxia

(2014) Sylvia Boesch et al.   MOVEMENT DISORDERS

The Role of Erythropoietin and Bone Marrow Concentrate in the Treatment of Osteochondral Defects in Mini-Pigs

(2014) Marcel Betsch et al.   PLoS One

Lower Obesity Rate during Residence at High Altitude among a Military Population with Frequent Migration: A Quasi Experimental Model for Investigating Spatial Causation

(2014) Jameson D. Voss et al.   PLoS One

Physiology and Pharmacology of Erythropoietin

(2014) Wolfgang Jelkmann   TRANSFUSION MEDICINE AND HEMOTHERAPY

Primitive and definitive erythropoiesis in mammals

(2014) James Palis   Frontiers in Physiology

The effect of erythropoietin on autologous stem cell-mediated bone regeneration

(2013) Ashwin M. Nair et al.   BIOMATERIALS

Chronic myeloproliferative neoplasms and risk of osteoporotic fractures; a nationwide population-based cohort study

(2013) Sarah Farmer et al.   BRITISH JOURNAL OF HAEMATOLOGY

PPAR  and Sirt1 Mediate Erythropoietin Action in Increasing Metabolic Activity and Browning of White Adipocytes to Protect Against Obesity and Metabolic Disorders

(2013) L. Wang et al.   DIABETES

In Vivo Knockdown of Adipocyte Erythropoietin Receptor Does Not Alter Glucose or Energy Homeostasis

(2013) Cynthia T. Luk et al.   ENDOCRINOLOGY

Erythropoietin critically regulates the terminal maturation of murine and human primitive erythroblasts

(2013) J. Malik et al.   HAEMATOLOGICA

Erythropoietin contributes to slow oxidative muscle fiber specification via PGC-1α and AMPK activation

(2013) Li Wang et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Association of elevation, urbanization and ambient temperature with obesity prevalence in the United States

(2013) J D Voss et al.   INTERNATIONAL JOURNAL OF OBESITY

Immune Regulation in Obesity-Associated Adipose Inflammation

(2013) J. M. Han et al.   JOURNAL OF IMMUNOLOGY

White Matter Changes in Patients with Friedreich Ataxia after Treatment with Erythropoietin

(2013) Karl Egger et al.   JOURNAL OF NEUROIMAGING

Erythropoietin Inhibits Gluconeogenesis and Inflammation in the Liver and Improves Glucose Intolerance in High-Fat Diet-Fed Mice

(2013) Ran Meng et al.   PLoS One

The Osteogenic Effect of Erythropoietin on Human Mesenchymal Stromal Cells is Dose-Dependent and Involves Non-Hematopoietic Receptors and Multiple Intracellular Signaling Pathways

(2013) Jan Hendrik Duedal Rölfing et al.   Stem Cell Reviews and Reports

Erythropoietin production in neuroepithelial and neural crest cells during primitive erythropoiesis

(2013) Norio Suzuki et al.   Nature Communications

Skeletal muscle alterations and exercise performance decrease in erythropoietin-deficient mice: a comparative study

(2012) Laurence Mille-Hamard et al.   BMC Medical Genomics

The HIF Signaling Pathway in Osteoblasts Directly Modulates Erythropoiesis through the Production of EPO

(2012) Erinn B. Rankin et al.   CELL

Endogenous erythropoietin signaling facilitates skeletal muscle repair and recovery following pharmacologically induced damage

(2012) Yi Jia et al.   FASEB JOURNAL

GATA-binding Protein 4 (GATA-4) and T-cell Acute Leukemia 1 (TAL1) Regulate Myogenic Differentiation and Erythropoietin Response via Cross-talk with Sirtuin1 (Sirt1)

(2012) Li Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

T-cell Acute Leukemia 1 (TAL1) Regulation of Erythropoietin Receptor and Association with Excessive Erythrocytosis

(2012) Heather Rogers et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Treatment of Mild Traumatic Brain Injury with an Erythropoietin-Mimetic Peptide

(2012) Claudia S. Robertson et al.   JOURNAL OF NEUROTRAUMA

Erythropoietin Modulates the Structure of Bone Morphogenetic Protein 2–Engineered Cranial Bone

(2012) Hongli Sun et al.   TISSUE ENGINEERING PART A

Erythropoietin Treatment Enhances Muscle Mitochondrial Capacity in Humans

(2012) Ulla Plenge et al.   Frontiers in Physiology

Endogenous Plasma Erythropoietin, Cardiovascular Mortality and All-Cause Mortality in Renal Transplant Recipients

(2011) S. J. Sinkeler et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Acute erythropoietin cardioprotection is mediated by endothelial response

(2011) Ruifeng Teng et al.   BASIC RESEARCH IN CARDIOLOGY

Erythropoietin couples erythropoiesis, B-lymphopoiesis, and bone homeostasis within the bone marrow microenvironment

(2011) S. Singbrant et al.   BLOOD

Erythropoietin and hypoxia increase erythropoietin receptor and nitric oxide levels in lung microvascular endothelial cells

(2011) Bojana B. Beleslin-Čokić et al.   CYTOKINE

Effects of erythropoietin on the bone microenvironment

(2011) S. J. McGee et al.   GROWTH FACTORS

Erythropoietin Contrastingly Affects Bacterial Infection and Experimental Colitis by Inhibiting Nuclear Factor-κB-Inducible Immune Pathways

(2011) Manfred Nairz et al.   IMMUNITY

The Effects of Erythropoietin Dose Titration during High-Fat Diet-Induced Obesity

(2011) Amanda Foskett et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Erythropoietin mediated bone formation is regulated by mTOR signaling

(2011) Jinkoo Kim et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Inflammatory links between obesity and metabolic disease

(2011) Carey N. Lumeng et al.   JOURNAL OF CLINICAL INVESTIGATION

Unknown

(2011) Hannelore Ehrenreich et al.   MOLECULAR MEDICINE

Disrupted erythropoietin signalling promotes obesity and alters hypothalamus proopiomelanocortin production

(2011) Ruifeng Teng et al.   Nature Communications

Erythropoietin improves neurodevelopmental outcome of extremely preterm infants

(2010) Achim-Peter Neubauer et al.   ANNALS OF NEUROLOGY

The human side of hypoxia-inducible factor

(2010) Thomas G. Smith et al.   BRITISH JOURNAL OF HAEMATOLOGY

Darbepoetin-mediated cardioprotection after myocardial infarction involves multiple mechanisms independent of erythropoietin receptor-common β-chain heteroreceptor

(2010) Peter Kanellakis et al.   BRITISH JOURNAL OF PHARMACOLOGY

Effect of erythropoietin levels on mortality in old age: the Leiden 85-plus Study

(2010) W. P. J. den Elzen et al.   CANADIAN MEDICAL ASSOCIATION JOURNAL

Genome-wide identification of TAL1's functional targets: Insights into its mechanisms of action in primary erythroid cells

(2010) M. T. Kassouf et al.   GENOME RESEARCH

Epo Is Relevant Neither for Microvascular Formation Nor for the New Formation and Maintenance of Mice Skeletal Muscle Fibres in Both Normoxia and Hypoxia

(2010) Luciana Hagström et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Erythropoietin treatment leads to reduced blood glucose levels and body mass: insights from murine models

(2010) Odelia Katz et al.   JOURNAL OF ENDOCRINOLOGY

Erythropoietin protects against diabetes through direct effects on pancreatic β cells

(2010) Diana Choi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Low dose erythropoietin stimulates bone healing in mice

(2010) P. Garcia et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Erythropoietin Couples Hematopoiesis with Bone Formation

(2010) Yusuke Shiozawa et al.   PLoS One

Involvement of oxygen-sensing pathways in physiologic and pathologic erythropoiesis

(2009) G. L. Semenza   BLOOD

Erythropoietin protects from reperfusion-induced myocardial injury by enhancing coronary endothelial nitric oxide production☆☆☆

(2009) Deyan Mihov et al.   EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY

Activation of the erythropoietin receptor in human skeletal muscle

(2009) Helene Rundqvist et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Erythropoietin signaling promotes transplanted progenitor cell survival

(2009) Yi Jia et al.   FASEB JOURNAL

Effects of Recombinant Human Erythropoietin on Mandibular Distraction Osteogenesis

(2009) Ahmet Mihmanli et al.   JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY

Erythropoietin Over-Expression Protects against Diet-Induced Obesity in Mice through Increased Fat Oxidation in Muscles

(2009) Pernille Hojman et al.   PLoS One

Recombinant Human Erythropoietin in the Treatment of Acute Ischemic Stroke

(2009) Hannelore Ehrenreich et al.   STROKE

Repression via the GATA box is essential for tissue-specific erythropoietin gene expression

(2008) N. Obara et al.   BLOOD

Does recombinant human Epo increase exercise capacity by means other than augmenting oxygen transport?

(2008) C. Lundby et al.   JOURNAL OF APPLIED PHYSIOLOGY

A Gain-of-Function Mutation in theHIF2AGene in Familial Erythrocytosis

(2008) Melanie J. Percy et al.   NEW ENGLAND JOURNAL OF MEDICINE

An Approach to Using Recombinant Erythropoietin for Neuroprotection in Very Preterm Infants

(2008) J.-C. Fauchere et al.   PEDIATRICS

A Phase I/II Trial of High-Dose Erythropoietin in Extremely Low Birth Weight Infants: Pharmacokinetics and Safety

(2008) S. E. Juul et al.   PEDIATRICS

Nonerythropoietic, tissue-protective peptides derived from the tertiary structure of erythropoietin

(2008) M. Brines et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of adult erythropoiesis by prolyl hydroxylase domain proteins

(2007) K. Takeda et al.   BLOOD

Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure

(2007) Y. A. Minamishima et al.   BLOOD