Review
Pharmacology & Pharmacy
Soumyadeep Dey, Jeeyoung Lee, Constance T. Noguchi
Summary: EPO, through EPOR expression, exerts protective effects in non-hematopoietic tissues, influencing metabolism in the brain, fat, and bones, especially in regulating obesity and inflammation.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Nutrition & Dietetics
Bojan Stojnic, Alba Serrano, Lana Susak, Andreu Palou, M. Luisa Bonet, Joan Ribot
Summary: The study showed that a combination treatment of beta-carotene and metformin can effectively alleviate the adverse effects of a high-fat diet, including reducing weight gain, improving adipose tissue status, increasing systemic energy expenditure, improving glucose control and insulin sensitivity, and decreasing hepatic lipid content.
Article
Cell Biology
Meredith Krause-Hauch, Julia Fedorova, Linda Ines Zoungrana, Hao Wang, Mohammad Kasim Fatmi, Zehui Li, Migdalia Iglesias, Lily Slotabec, Ji Li
Summary: This study aims to explore the interconnection between Nrf2 and Sesn2 during obesity-related stress and its role in cardio-protection. The results showed that the overexpression of Sesn2 has cardio-protective effects on the obese heart by reducing ROS and fibrosis and improving cardiac function. Similar results were observed in human heart samples. However, there was no observable pattern of Sesn2/Nrf2 expression in mouse samples.
Article
Pharmacology & Pharmacy
Yaoli Liu, Xiazhou Fu, Zhiyong Chen, Tingting Luo, Chunxia Zhu, Yaoting Ji, Zhuan Bian
Summary: Sulforaphane (SFN) shows potential as a nutritional factor in combating obesity by promoting the browning of white fat, which decreases fat mass, improves glucose metabolism, and enhances insulin sensitivity. This suggests that SFN could serve as a potential medicine in anti-obesity and related diseases.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Engineering, Biomedical
Bingyang Dai, Xu Li, Jiankun Xu, Yuwei Zhu, Le Huang, Wenxue Tong, Hao Yao, Dick Ho-kiu Chow, Ling Qin
Summary: The combination of magnesium and simvastatin showed synergistic effects in attenuating high-fat diet-induced bone loss in mice by inhibiting osteoclast formation and bone resorption, reducing hepatic cholesterol synthesis, and inhibiting matrix metallopeptidase 13 (Mmp13) expression in pre-osteoclasts. This combination therapy may be a cost-effective alternative treatment for obesity-related bone loss.
BIOACTIVE MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Prince K. K. Akowuah, Carolina Lema, Rolando E. E. Rumbaut, Alan R. R. Burns
Summary: Feeding mice with a high-fat/sucrose diet causes loss of corneal nerve function and impairs corneal wound healing. Changing to a low fat/sugar diet with enrichments in complex carbohydrates mitigates the reduction in nerve function, but its effect on corneal wound healing needs further investigation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Tengteng Ji, Bing Fang, Fang Wu, Yaqiong Liu, Le Cheng, Yixuan Li, Ran Wang, Longjiao Zhu
Summary: The number of obese people is increasing worldwide due to high-fat diets causing excess energy intake. A 12-week dietary intervention study on high-fat diet-induced obese mice showed that changing the diet significantly reduced weight gain and subcutaneous adipose tissue weight. Diet change also affected lipolysis, lipogenesis, and the proportion of adipocyte stem cells in different fat tissues.
Article
Biochemistry & Molecular Biology
Muhammad Aleem Abbas, Naila Boby, Eon-Bee Lee, Joo-Heon Hong, Seung-Chun Park
Summary: The study investigates the anti-obesity properties of E. cava and finds that it can suppress pre-adipocyte differentiation, reduce body weight and organ weight in obese rats, and lower the risk of liver injury and fatty liver. This suggests that E. cava could be a potential candidate for preventing obesity induced by a high-fat diet.
Article
Multidisciplinary Sciences
Woongjae Yoo, Jacob K. Zieba, Nora J. Foegeding, Teresa P. Torres, Catherine D. Shelton, Nicolas G. Shealy, Austin J. Byndloss, Stephanie A. Cevallos, Erik Gertz, Connor R. Tiffany, Julia D. Thomas, Yael Litvak, Henry Nguyen, Erin E. Olsan, Brian J. Bennett, Jeffrey C. Rathmell, Amy S. Major, Andreas J. Baumler, Mariana X. Byndloss
Summary: It was found that chronic exposure to a high-fat diet can increase levels of circulating trimethlamine N-oxide, a potentially harmful metabolite generated by gut microbiota.
Article
Biochemistry & Molecular Biology
Qi Guan, Xin-Wen Ding, Ling-Yue Zhong, Chuang Zhu, Pan Nie, Li-Hua Song
Summary: This study investigated the nutrients and phytochemicals of Lactobacillus-fermented black barley and found that fermentation significantly increased the content of beneficial compounds. Fermented black barley treatment showed an increase in antioxidant enzyme activity and a decrease in lipid metabolism products, suggesting its beneficial effects in reducing oxidative stress and hepatic steatosis.
Article
Dentistry, Oral Surgery & Medicine
Hong Luo, Hongyan Wu, Xi Tan, Yusi Ye, Lan Huang, Hongwei Dai, Li Mei
Summary: The study revealed that obesity induced by high-fat diet accelerates mechanically induced alveolar bone remodeling, leading to bone loss and changes in inflammatory cytokine expression, ultimately affecting orthodontic treatment outcomes.
Article
Food Science & Technology
Panying Xiang, Yushi Du, Guanyu Chen, Yihui Mao, Shuangshuang Li, Qing Li, Yuting Yang, Xueyu Li, Dongliang Wang
Summary: In this study, it is shown that a dietary achievable dose of PCA attenuates high-fat diet-induced adiposity by enhancing fatty acid oxidation without activating adipose thermogenesis.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Mingming Li, Yang Xiao, Lianggui Xiao, Yu Li, Mengting Jia, Yu Sun, Tingli Pan, Lei Zhou, Yixing Li
Summary: With improvements in living standards, obesity has become an increasingly serious health issue. This study found that epigoitrin (EP) from Radix isatidis has significant potential in preventing and treating obesity. EP reduced fat accumulation, promoted glucose uptake and glycogen storage, increased energy production, and improved lipid and glucose metabolism disorders.
Article
Nutrition & Dietetics
Yu Ra Lee, Hye-Bin Lee, Mi-Jin Oh, Yoonsook Kim, Ho-Young Park
Summary: This study found that thyme extract can alleviate obesity and gut derangements caused by a high-fat diet. It can reduce weight gain and body fat percentage, regulate serum biomarkers associated with obesity, and improve intestinal barrier function and colon shortening. Additionally, thyme extract can alter the levels of metabolites.
Article
Biochemistry & Molecular Biology
Wenting Wei, Manjiang Hu, Jie Huang, Siyan Yu, Xudong Li, Yanhui Li, Limei Mao
Summary: The study found that DHA and EPA have different mechanisms in anti-obesity in insulin-resistant mice. Specifically, 1% DHA and EPA can inhibit adipogenesis by regulating GPR120, while 4% DHA can stimulate browning of adipose tissue by up-regulating PPAR-γ, improving insulin resistance and inflammatory infiltration.