Article
Biochemistry & Molecular Biology
Peijun Zhao, Na Hyun Park, Md Badrul Alam, Sang-Han Lee
Summary: The hexane fraction of Fuzhuan brick tea reduces reactive oxygen species generation, increases melanin production, and activates the MAP-kinase pathway to protect against hydroquinone-induced hair pigment loss.
Review
Biology
Alena Rysava, Jitka Vostalova, Alena Rajnochova Svobodova
Summary: Excessive exposure of skin to solar radiation can lead to oxidative stress, inflammation, and various skin disorders. UV radiation triggers cellular changes, with the Nrf2 signaling pathway playing a key role in response to oxidative damage.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2021)
Article
Immunology
Jie-Qiong Ma, Yu-Jia Zhang, Zhi-Kai Tian, Chan-Min Liu
Summary: Bixin extracted from Bixa orellana seeds possesses anti-inflammatory, antioxidant, and anti-fibrosis properties by regulating the Nrf2/TLR4/MyD88 and PPAR-gamma/TGF-beta 1/Smad3 pathways, improving renal damage induced by carbon tetrachloride in mice.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Leepica Kapoor, S. Udhaya Kumar, Sourav De, Sujithra Vijayakumar, Nitin Kapoor, S. K. Ashok Kumar, C. George Priya Doss, Siva Ramamoorthy
Summary: This study evaluated the potential of bixin as an anti-skin aging agent and investigated its inhibitory mechanism on skin aging-related enzymes. Through a series of experiments, it was found that bixin possesses antioxidant activity and inhibitory effects on enzyme activity, while also having the ability to combat UVA-induced photoaging. Furthermore, the findings of this study lay a foundation for exploring the pharmaceutical applications of bixin in other biochemical pathways.
Article
Dermatology
Olayemi Bello, Holger Sudhoff, Peter Goon
Summary: The survey found that individuals of African Ancestry with lighter skin tones are more prone to sunburn, with a significant portion attributing sunburn incidents to not using sunscreen. The results highlight the importance of practicing sun protection measures in sunny climates to prevent sunburn.
CLINICAL COSMETIC AND INVESTIGATIONAL DERMATOLOGY
(2021)
Review
Engineering, Biomedical
Xiyong Huang, Andrew N. Chalmers
Summary: Sunlight is a vital environmental resource for all living organisms on Earth, with UV radiation playing a crucial role in synthesizing vitamin D in the human body. While sun exposure has health benefits, excessive UV exposure can lead to adverse effects such as eye diseases and skin cancers. UV intensity depends on environmental factors, personal outdoor activities, and skin sensitivity. Various UV sensors have been developed over the years to monitor personal UV exposure and protect individuals from potential health risks.
ANNALS OF BIOMEDICAL ENGINEERING
(2021)
Article
Medicine, Research & Experimental
Jinping Zhang, Yongchun Zheng, Bo Hong, Lina Ma, Yingchun Zhao, Shuai Zhang, Shuwen Sun, Qiteng Ding, Yue Wang, Wencong Liu, Chuanbo Ding
Summary: The study found that Dihydroquercetin composite nanofiber membrane (CPD) can reduce skin inflammation and photodamage caused by UVA radiation by enhancing the activity of antioxidant enzymes and reducing ROS expression. CPD also prevents inflammation, apoptosis, and oxidative stress induced by MAPK/Nrf2 signaling pathway. Immunofluorescence experiments showed that CPD can reduce the fluorescence intensity of Caspase-3 and TNF-alpha.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Dermatology
Rhonda M. Brand, John Mark Stottlemyer, Melissa C. Paglia, Cara Donahue Carey, Louis D. Falo
Summary: Excessive UV radiation disrupts skin homeostasis by multiple mechanisms beyond simple erythema, and combined UV exposure with excessive alcohol consumption synergistically increase local skin damage severity, impairing melanin responses, reducing antioxidants, increasing DNA damage, and dysfunctioning immune responses.
JOURNAL OF DERMATOLOGICAL SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Camilla Morresi, Alessia Luccarini, Fabio Marcheggiani, Gianna Ferretti, Elisabetta Damiani, Tiziana Bacchetti
Summary: PON2, an intracellular protein, plays a protective role against cell oxidative stress and apoptosis. This study explored the modulation of PON2 in human dermal fibroblasts exposed to UVA radiation and found that PON2 is up-regulated immediately after UVA exposure and gradually decreases in the post-exposure phase. This upregulation may be related to the increase in intracellular reactive oxygen species (ROS) and could play an important role in mitigating UVA-induced damage and preventing the consequences of UV exposure.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Plant Sciences
Tao Liu, QingMei Xia, Yingshuang Lv, Zijing Wang, Shan Zhu, Wenxiao Qin, Yi Yang, Xiang Wang, Zhiyue Zhao, Hongfei Ma, Linlin Jia, Han Zhang, Zongpei Xu, Nan Li
Summary: This study aims to explore the role of ErZhiFormula (EZF) in the mechanism of skin photoaging induced by UV radiation. The fingerprint of EZF was identified using Ultra Performance Liquid Chromatography (UPLC), and photoaging models were established in mice and human immortalized keratinocytes (HaCaT). The results showed that EZF can improve UV-induced photoaging in HaCaT cells and mouse skin by regulating the Nrf2/HO-1/NQO1 pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Marija Petkovic, Ermelindo C. Leal, Ines Alves, Chanda Bose, Philip T. Palade, Preeti Singh, Sanjay Awasthi, Elisabet Borsheim, Louise T. Dalgaard, Sharda P. Singh, Eugenia Carvalho
Summary: The study found that dietary supplementation with SFN increased antioxidant capacities and gene expression related to the Nrf2 pathway in the skin of old mice. Protein levels for Nrf2 were also increased, while ROS and MMP9 levels decreased significantly. Furthermore, collagen deposition was improved in young mice and significantly improved in old mice with SFN treatment, indicating that SFN can ameliorate skin aging.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Article
Plant Sciences
Van-Long Truong, Young-Sam Keum, Woo-Sik Jeong
Summary: The study found that red ginseng oil can promote hair growth in mice, with specific compounds playing an important role in promoting hair growth. In addition, red ginseng oil also has a protective effect on skin damage caused by UV radiation.
JOURNAL OF GINSENG RESEARCH
(2021)
Article
Public, Environmental & Occupational Health
Andras Kolto, Lauren Rodriguez, Helen McAvoy, Saoirse Nic Gabhainn
Summary: The study revealed that sunburn, sun safety behaviors, and indoor tanning bed use are common among schoolchildren in Ireland. A high percentage of children experience sunburn frequently, with some never using any sun protection. Variations in sun safety behaviors and tanning bed use were observed across different age, gender, and socio-economic groups.
INTERNATIONAL JOURNAL OF PUBLIC HEALTH
(2021)
Article
Biochemistry & Molecular Biology
Jinlong Wei, Qin Zhao, Yuyu Zhang, Weiyan Shi, Huanhuan Wang, Zhuangzhuang Zheng, Lingbin Meng, Ying Xin, Xin Jiang
Summary: This study investigated the protective effect of sulforaphane on radiation-induced skin injury, finding that sulforaphane can suppress oxidative stress by upregulating the expression and function of Nrf2, thereby alleviating inflammation and DNA damage, and preventing and alleviating RISI.
Article
Biochemistry & Molecular Biology
Shahid H. Naikoo, Haroon Rashid, Ragni Gupta, Raghu Rai Sharma, Sanjay Kumar, Riyaz Ahmad, Satish Gudup, Parvinder P. Singh, Sheikh Tasduq Abdullah
Summary: Ultraviolet radiation (UVR) is the major exogenous factor that accelerates skin aging through the induction of oxidative stress, ER stress, and inflammation. In this study, 3-(1'-methyltetrahydropyridinyl)-2,4-6-trihydroxy acetophenone (IIIM-8) demonstrated significant photoprotective effects by alleviating UV-B-induced damage in skin cells and preventing collagen degradation. These findings suggest that IIIM-8 has the potential to be developed as a topical therapeutic/cosmeceutical agent against UV-B-induced photoaging.
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2023)