Cortical and Striatal Circuits in Huntington’s Disease

Alterations in Synaptic Function and Plasticity in Huntington Disease

(2019) Amy I. Smith‐Dijak et al.   JOURNAL OF NEUROCHEMISTRY

Dysfunctional striatal dopamine signaling in Huntington's disease

(2019) Ellen T. Koch et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Cortical circuit alterations precede motor impairments in Huntington’s disease mice

(2019) Johanna Burgold et al.   Scientific Reports

Strong preference for autaptic self-connectivity of neocortical PV interneurons facilitates their tuning to γ-oscillations

(2019) Charlotte Deleuze et al.   PLOS BIOLOGY

Cortical Network Dynamics Is Altered in Mouse Models of Huntington’s Disease

(2019) Elissa J Donzis et al.   CEREBRAL CORTEX

Functional flexibility in cortical circuits

(2019) Jessica A Cardin   CURRENT OPINION IN NEUROBIOLOGY

Astrocyte molecular signatures in Huntington’s disease

(2019) Blanca Diaz-Castro et al.   Science Translational Medicine

Circuit Mechanisms of Neurodegenerative Diseases: A New Frontier With Miniature Fluorescence Microscopy

(2019) Craig T. Werner et al.   Frontiers in Neuroscience

Sex-dependent impaired locomotion and motor coordination in the HdhQ200/200 mouse model of Huntington's Disease

(2019) Jessica K. Cao et al.   NEUROBIOLOGY OF DISEASE

Functional Relevance of Endocannabinoid-Dependent Synaptic Plasticity in the Central Nervous System

(2018) Shana M. Augustin et al.   ACS Chemical Neuroscience

Disrupted striatal neuron inputs and outputs in Huntington's disease

(2018) Anton Reiner et al.   CNS Neuroscience & Therapeutics

Corticostriatal network dysfunction in Huntington's disease: Deficits in neural processing, glutamate transport, and ascorbate release

(2018) George V. Rebec   CNS Neuroscience & Therapeutics

Molecular insights into cortico-striatal miscommunications in Huntington's disease

(2018) Matthew B Veldman et al.   CURRENT OPINION IN NEUROBIOLOGY

Interrogating cortical function with transcranial magnetic stimulation: insights from neurodegenerative disease and stroke

(2018) Smriti Agarwal et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Complex Dynamics in the Basal Ganglia: Health and Disease Beyond the Motor System

(2018) Daniela S. Andres et al.   JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES

Integrative Characterization of the R6/2 Mouse Model of Huntington’s Disease Reveals Dysfunctional Astrocyte Metabolism

(2018) Niels H. Skotte et al.   Cell Reports

Reconstituting Corticostriatal Network on-a-Chip Reveals the Contribution of the Presynaptic Compartment to Huntington’s Disease

(2018) Amandine Virlogeux et al.   Cell Reports

Metformin reverses early cortical network dysfunction and behavior changes in Huntington’s disease

(2018) Isabelle Arnoux et al.   eLife

Striatal GABA ergic interneuron dysfunction in the Q175 mouse model of Huntington's disease

(2018) Sandra M. Holley et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Thinking Outside the Box (and Arrow): Current Themes in Striatal Dysfunction in Movement Disorders

(2018) Joshua L. Plotkin et al.   NEUROSCIENTIST

Decreased BDNF Release in Cortical Neurons of a Knock-in Mouse Model of Huntington’s Disease

(2018) Chenglong Yu et al.   Scientific Reports

Insights into GABA A ergic system alteration in Huntington's disease

(2018) Yi-Ting Hsu et al.   Open Biology

Endocannabinoid-Specific Impairment in Synaptic Plasticity in Striatum of Huntington's Disease Mouse Model

(2017) Marja D. Sepers et al.   JOURNAL OF NEUROSCIENCE

Cortical gamma band synchronization through somatostatin interneurons

(2017) Julia Veit et al.   NATURE NEUROSCIENCE

Developmental alterations in Huntington's disease neural cells and pharmacological rescue in cells and mice

(2017) Ryan G Lim et al.   NATURE NEUROSCIENCE

Differential electrophysiological and morphological alterations of thalamostriatal and corticostriatal projections in the R6/2 mouse model of Huntington's disease

(2017) Anna Parievsky et al.   NEUROBIOLOGY OF DISEASE

Endocannabinoid Actions on Cortical Terminals Orchestrate Local Modulation of Dopamine Release in the Nucleus Accumbens

(2017) Yolanda Mateo et al.   NEURON

Parvalbumin Interneurons Modulate Striatal Output and Enhance Performance during Associative Learning

(2017) Kwang Lee et al.   NEURON

Distinct Inhibitory Circuits Orchestrate Cortical beta and gamma Band Oscillations

(2017) Guang Chen et al.   NEURON

The Spatiotemporal Organization of the Striatum Encodes Action Space

(2017) Andreas Klaus et al.   NEURON

Unravelling and Exploiting Astrocyte Dysfunction in Huntington’s Disease

(2017) Baljit S. Khakh et al.   TRENDS IN NEUROSCIENCES

Dysfunction of ventrolateral striatal dopamine receptor type 2-expressing medium spiny neurons impairs instrumental motivation

(2017) Iku Tsutsui-Kimura et al.   Nature Communications

Spatiotemporal Proteomic Profiling of Huntington’s Disease Inclusions Reveals Widespread Loss of Protein Function

(2017) Fabian Hosp et al.   Cell Reports

Cortical inhibitory deficits in premanifest and early Huntington’s disease

(2016) April L. Philpott et al.   BEHAVIOURAL BRAIN RESEARCH

Corticostriatal Dysfunction in Huntington’s Disease: The Basics

(2016) Kendra D. Bunner et al.   Frontiers in Human Neuroscience

Astrocytes are key but indirect contributors to the development of the symptomatology and pathophysiology of Huntington's disease

(2016) Cécile Meunier et al.   GLIA

Differential Contributions of Ventral and Dorsal Striatum to Early and Late Phases of Cognitive Set Reconfiguration

(2016) Brianna J. Sleezer et al.   JOURNAL OF COGNITIVE NEUROSCIENCE

Functional Indicators of Glutamate Transport in Single Striatal Astrocytes and the Influence of Kir4.1 in Normal and Huntington Mice

(2016) Anton Dvorzhak et al.   JOURNAL OF NEUROSCIENCE

Compromised Dopaminergic Encoding of Reward Accompanying Suppressed Willingness to Overcome High Effort Costs Is a Prominent Prodromal Characteristic of the Q175 Mouse Model of Huntington's Disease

(2016) Dan P. Covey et al.   JOURNAL OF NEUROSCIENCE

Dysfunctional Calcium and Glutamate Signaling in Striatal Astrocytes from Huntington's Disease Model Mice

(2016) R. Jiang et al.   JOURNAL OF NEUROSCIENCE

The mouse cortico-striatal projectome

(2016) Houri Hintiryan et al.   NATURE NEUROSCIENCE

Integrated genomics and proteomics define huntingtin CAG length–dependent networks in mice

(2016) Peter Langfelder et al.   NATURE NEUROSCIENCE

Adult mouse cortical cell taxonomy revealed by single cell transcriptomics

(2016) Bosiljka Tasic et al.   NATURE NEUROSCIENCE

Dysregulation of the dopamine system in the pathophysiology of schizophrenia and depression

(2016) Anthony A. Grace   NATURE REVIEWS NEUROSCIENCE

Symptom heterogeneity in Huntington's disease correlates with neuronal degeneration in the cerebral cortex

(2016) Nasim F. Mehrabi et al.   NEUROBIOLOGY OF DISEASE

Differential changes in thalamic and cortical excitatory synapses onto striatal spiny projection neurons in a Huntington disease mouse model

(2016) Karolina Kolodziejczyk et al.   NEUROBIOLOGY OF DISEASE

Spatially Compact Neural Clusters in the Dorsal Striatum Encode Locomotion Relevant Information

(2016) Giovanni Barbera et al.   NEURON

Principles of Synaptic Organization of GABAergic Interneurons in the Striatum

(2016) Christoph Straub et al.   NEURON

Endocannabinoid Modulation of Orbitostriatal Circuits Gates Habit Formation

(2016) Christina M. Gremel et al.   NEURON

GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits

(2016) Robin Tremblay et al.   NEURON

Neuropsychiatric symptoms are very common in premanifest and early stage Huntington's Disease

(2016) Saul Martinez-Horta et al.   PARKINSONISM & RELATED DISORDERS

Real-time imaging of glutamate clearance reveals normal striatal uptake in Huntington disease mouse models

(2016) Matthew P. Parsons et al.   Nature Communications

Cellular Taxonomy of the Mouse Striatum as Revealed by Single-Cell RNA-Seq

(2016) Ozgun Gokce et al.   Cell Reports

Cognitive Training at a Young Age Attenuates Deficits in the zQ175 Mouse Model of HD

(2016) Paul C. P. Curtin et al.   Frontiers in Behavioral Neuroscience

Early dysfunction and progressive degeneration of the subthalamic nucleus in mouse models of Huntington's disease

(2016) Jeremy F Atherton et al.   eLife

The CB1 cannabinoid receptor signals striatal neuroprotection via a PI3K/Akt/mTORC1/BDNF pathway

(2015) C Blázquez et al.   CELL DEATH AND DIFFERENTIATION

Corticostriatal synaptic adaptations in Huntington's disease

(2015) Joshua L Plotkin et al.   CURRENT OPINION IN NEUROBIOLOGY

Altered excitatory and inhibitory inputs to striatal medium-sized spiny neurons and cortical pyramidal neurons in the Q175 mouse model of Huntington's disease

(2015) Tim Indersmitten et al.   JOURNAL OF NEUROPHYSIOLOGY

Altered Sensory Experience Exacerbates Stable Dendritic Spine and Synapse Loss in a Mouse Model of Huntington's Disease

(2015) R. P. Murmu et al.   JOURNAL OF NEUROSCIENCE

Relationship between subthalamic nucleus neuronal activity and electrocorticogram is altered in the R6/2 mouse model of Huntington's disease

(2015) Joshua W. Callahan et al.   JOURNAL OF PHYSIOLOGY-LONDON

Endocannabinoids mediate bidirectional striatal spike-timing-dependent plasticity

(2015) Yihui Cui et al.   JOURNAL OF PHYSIOLOGY-LONDON

Age-dependent alterations in the cortical entrainment of subthalamic nucleus neurons in the YAC128 mouse model of Huntington's disease

(2015) Joshua W. Callahan et al.   NEUROBIOLOGY OF DISEASE

Pathological gamma oscillations, impaired dopamine release, synapse loss and reduced dynamic range of unitary glutamatergic synaptic transmission in the striatum of hypokinetic Q175 Huntington mice

(2015) T. Rothe et al.   NEUROSCIENCE

Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq

(2015) A. Zeisel et al.   SCIENCE

Modulation of the glutamatergic transmission by Dopamine: a focus on Parkinson, Huntington and Addiction diseases

(2015) Fabrizio Gardoni et al.   Frontiers in Cellular Neuroscience

Cortical interneuron loss and symptom heterogeneity in Huntington disease

(2014) Eric H. Kim et al.   ANNALS OF NEUROLOGY

Astrocyte Kir4.1 ion channel deficits contribute to neuronal dysfunction in Huntington's disease model mice

(2014) Xiaoping Tong et al.   NATURE NEUROSCIENCE

Huntington disease: natural history, biomarkers and prospects for therapeutics

(2014) Christopher A. Ross et al.   Nature Reviews Neurology

Genetic rescue of CB1 receptors on medium spiny neurons prevents loss of excitatory striatal synapses but not motor impairment in HD mice

(2014) Alipi V. Naydenov et al.   NEUROBIOLOGY OF DISEASE

Toward a Genetic Dissection of Cortical Circuits in the Mouse

(2014) Z. Josh Huang   NEURON

Autaptic Connections and Synaptic Depression Constrain and Promote Gamma Oscillations

(2014) William M. Connelly   PLoS One

A restricted population of CB1 cannabinoid receptors with neuroprotective activity

(2014) A. Chiarlone et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fast-spiking, parvalbumin+ GABAergic interneurons: From cellular design to microcircuit function

(2014) H. Hu et al.   SCIENCE

Dendritic Spine Instability Leads to Progressive Neocortical Spine Loss in a Mouse Model of Huntington's Disease

(2013) R. P. Murmu et al.   JOURNAL OF NEUROSCIENCE

Multiple Sources of Striatal Inhibition Are Differentially Affected in Huntington's Disease Mouse Models

(2013) C. Cepeda et al.   JOURNAL OF NEUROSCIENCE

Striatal parvalbuminergic neurons are lost in Huntington's disease: implications for dystonia

(2013) Anton Reiner et al.   MOVEMENT DISORDERS

Concurrent activation of striatal direct and indirect pathways during action initiation

(2013) Guohong Cui et al.   NATURE

Cerebral organoids model human brain development and microcephaly

(2013) Madeline A. Lancaster et al.   NATURE

Inhibition of inhibition in visual cortex: the logic of connections between molecularly distinct interneurons

(2013) Carsten K Pfeffer et al.   NATURE NEUROSCIENCE

New insights into the classification and nomenclature of cortical GABAergic interneurons

(2013) Javier DeFelipe et al.   NATURE REVIEWS NEUROSCIENCE

Choosing an animal model for the study of Huntington's disease

(2013) Mahmoud A. Pouladi et al.   NATURE REVIEWS NEUROSCIENCE

Loss of corticostriatal and thalamostriatal synaptic terminals precedes striatal projection neuron pathology in heterozygous Q140 Huntington's disease mice

(2013) Y.P. Deng et al.   NEUROBIOLOGY OF DISEASE

Hyperactivity and cortical disinhibition in mice with restricted expression of mutant huntingtin to parvalbumin-positive cells

(2013) S.E. Dougherty et al.   NEUROBIOLOGY OF DISEASE

Role of cerebral cortex in the neuropathology of Huntington's disease

(2013) Ana M. Estrada-Sánchez et al.   Frontiers in Neural Circuits

Dopamine imbalance in Huntington's disease: a mechanism for the lack of behavioral flexibility

(2013) Jane Y. Chen et al.   Frontiers in Neuroscience

Downregulation of cannabinoid receptor 1 from neuropeptide Y interneurons in the basal ganglia of patients with Huntington's disease and mouse models

(2012) Eric A. Horne et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Marked differences in neurochemistry and aggregates despite similar behavioural and neuropathological features of Huntington disease in the full-length BACHD and YAC128 mice

(2012) M. A. Pouladi et al.   HUMAN MOLECULAR GENETICS

Striatal neuronal loss correlates with clinical motor impairment in Huntington's disease

(2012) Zhihong Guo et al.   MOVEMENT DISORDERS

The origin of extracellular fields and currents — EEG, ECoG, LFP and spikes

(2012) György Buzsáki et al.   NATURE REVIEWS NEUROSCIENCE

Dopaminergic Modulation of Synaptic Transmission in Cortex and Striatum

(2012) Nicolas X. Tritsch et al.   NEURON

Network Organization of the Huntingtin Proteomic Interactome in Mammalian Brain

(2012) Dyna I. Shirasaki et al.   NEURON

Impaired cortico-striatal functional connectivity in prodromal Huntington's Disease

(2012) Paul G. Unschuld et al.   NEUROSCIENCE LETTERS

Comprehensive Behavioral and Molecular Characterization of a New Knock-In Mouse Model of Huntington’s Disease: zQ175

(2012) Liliana B. Menalled et al.   PLoS One

Characterization of Neurophysiological and Behavioral Changes, MRI Brain Volumetry and 1H MRS in zQ175 Knock-In Mouse Model of Huntington's Disease

(2012) Taneli Heikkinen et al.   PLoS One

Dysfunctional Behavioral Modulation of Corticostriatal Communication in the R6/2 Mouse Model of Huntington’s Disease

(2012) S. Lee Hong et al.   PLoS One

Striatal microcircuitry and movement disorders

(2012) Aryn H. Gittis et al.   TRENDS IN NEUROSCIENCES

Modulation of Striatal Projection Systems by Dopamine

(2011) Charles R. Gerfen et al.   Annual Review of Neuroscience

Differential Electrophysiological Changes in Striatal Output Neurons in Huntington's Disease

(2011) V. M. Andre et al.   JOURNAL OF NEUROSCIENCE

Worsening of Huntington disease phenotype in CB1 receptor knockout mice

(2011) Stéphane Mievis et al.   NEUROBIOLOGY OF DISEASE

Reduced expression of conditioned fear in the R6/2 mouse model of Huntington's disease is related to abnormal activity in prelimbic cortex

(2011) Adam G. Walker et al.   NEUROBIOLOGY OF DISEASE

Impaired Long-Term Potentiation in the Prefrontal Cortex of Huntington’s Disease Mouse Models: Rescue by D1 Dopamine Receptor Activation

(2011) G.M. Dallérac et al.   Neurodegenerative Diseases

Pathophysiology of Huntington's disease: time-dependent alterations in synaptic and receptor function

(2011) L.A. Raymond et al.   NEUROSCIENCE

Huntington's disease: a clinical review

(2011) Raymund A.C. Roos   Orphanet Journal of Rare Diseases

Alterations in Striatal Synaptic Transmission are Consistent across Genetic Mouse Models of Huntington's Disease

(2010) Damian M Cummings et al.   ASN Neuro

Genetic Mouse Models of Huntington's Disease: Focus on Electrophysiological Mechanisms

(2010) Carlos Cepeda et al.   ASN Neuro

Loss of striatal type 1 cannabinoid receptors is a key pathogenic factor in Huntington’s disease

(2010) Cristina Blázquez et al.   BRAIN

Cell loss in the motor and cingulate cortex correlates with symptomatology in Huntington’s disease

(2010) Doris C. V. Thu et al.   BRAIN

Dopamine and Glutamate in Huntington's Disease: A Balancing Act

(2010) Véronique M. André et al.   CNS Neuroscience & Therapeutics

In vivo expression of polyglutamine-expanded huntingtin by mouse striatal astrocytes impairs glutamate transport: a correlation with Huntington's disease subjects

(2010) M. Faideau et al.   HUMAN MOLECULAR GENETICS

Widespread Decrease of Type 1 Cannabinoid Receptor Availability in Huntington Disease In Vivo

(2010) K. Van Laere et al.   JOURNAL OF NUCLEAR MEDICINE

Cerebral cortex structure in prodromal Huntington disease

(2010) Peggy C. Nopoulos et al.   NEUROBIOLOGY OF DISEASE

Early Increase in Extrasynaptic NMDA Receptor Signaling and Expression Contributes to Phenotype Onset in Huntington's Disease Mice

(2010) Austen J. Milnerwood et al.   NEURON

Abnormal Motor Cortex Excitability in Preclinical and Very Early Huntington's Disease

(2009) Sven Schippling et al.   BIOLOGICAL PSYCHIATRY

Phosphodiesterase type IV inhibition prevents sequestration of CREB binding protein, protects striatal parvalbumin interneurons and rescues motor deficits in the R6/2 mouse model of Huntington’s disease

(2009) Carmela Giampà et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Age-Dependent Alterations of Corticostriatal Activity in the YAC128 Mouse Model of Huntington Disease

(2009) P. R. Joshi et al.   JOURNAL OF NEUROSCIENCE

Alterations in Cortical Excitation and Inhibition in Genetic Mouse Models of Huntington's Disease

(2009) D. M. Cummings et al.   JOURNAL OF NEUROSCIENCE

Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin

(2009) Shu-ichi Okamoto et al.   NATURE MEDICINE

Dysregulation of coordinated neuronal firing patterns in striatum of freely behaving transgenic rats that model Huntington's disease

(2009) Benjamin R. Miller et al.   NEUROBIOLOGY OF DISEASE

Altered CB1 receptor and endocannabinoid levels precede motor symptom onset in a transgenic mouse model of Huntington's disease

(2009) M.J. Dowie et al.   NEUROSCIENCE

Expression of mutant huntingtin in mouse brain astrocytes causes age-dependent neurological symptoms

(2009) Jennifer Bradford et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cerebral cortex and the clinical expression of Huntington's disease: complexity and heterogeneity

(2008) H. D. Rosas et al.   BRAIN

Dysregulated Information Processing by Medium Spiny Neurons in Striatum of Freely Behaving Mouse Models of Huntington's Disease

(2008) Benjamin R. Miller et al.   JOURNAL OF NEUROPHYSIOLOGY

Altered Information Processing in the Prefrontal Cortex of Huntington's Disease Mouse Models

(2008) A. G. Walker et al.   JOURNAL OF NEUROSCIENCE

Full-Length Human Mutant Huntingtin with a Stable Polyglutamine Repeat Can Elicit Progressive and Selective Neuropathogenesis in BACHD Mice

(2008) M. Gray et al.   JOURNAL OF NEUROSCIENCE

Up-regulation of GLT1 expression increases glutamate uptake and attenuates the Huntington's disease phenotype in the R6/2 mouse

(2008) B.R. Miller et al.   NEUROSCIENCE

Progressive synaptic pathology of motor cortical neurons in a BAC transgenic mouse model of Huntington's disease

(2008) J. Spampanato et al.   NEUROSCIENCE

Symptom-related changes of endocannabinoid and palmitoylethanolamide levels in brain areas of R6/2 mice, a transgenic model of Huntington's disease

(2007) Tiziana Bisogno et al.   NEUROCHEMISTRY INTERNATIONAL