The CB1 cannabinoid receptor signals striatal neuroprotection via a PI3K/Akt/mTORC1/BDNF pathway

Impaired TrkB Receptor Signaling Underlies Corticostriatal Dysfunction in Huntington’s Disease

(2014) Joshua L. Plotkin et al.   NEURON

A restricted population of CB1 cannabinoid receptors with neuroprotective activity

(2014) A. Chiarlone et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DREADDs: novel tools for drug discovery and development

(2013) Hyeong-Min Lee et al.   DRUG DISCOVERY TODAY

A role for the endocannabinoid system in exercise-induced spatial memory enhancement in mice

(2013) Talita H. Ferreira-Vieira et al.   HIPPOCAMPUS

Small-molecule TrkB receptor agonists improve motor function and extend survival in a mouse model of Huntington's disease

(2013) M. Jiang et al.   HUMAN MOLECULAR GENETICS

Neuron-type specific cannabinoid-mediated G protein signalling in mouse hippocampus

(2013) Frauke Steindel et al.   JOURNAL OF NEUROCHEMISTRY

A Small Molecule TrkB Ligand Reduces Motor Impairment and Neuropathology in R6/2 and BACHD Mouse Models of Huntington's Disease

(2013) D. A. Simmons et al.   JOURNAL OF NEUROSCIENCE

The activity-dependent transcription factor NPAS4 regulates domain-specific inhibition

(2013) Brenda L. Bloodgood et al.   NATURE

Neurotrophin regulation of neural circuit development and function

(2012) Hyungju Park et al.   NATURE REVIEWS NEUROSCIENCE

Conditional ablation of brain-derived neurotrophic factor-TrkB signaling impairs striatal neuron development

(2012) Y. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prospects for cannabinoid therapies in basal ganglia disorders

(2011) Javier Fernández-Ruiz et al.   BRITISH JOURNAL OF PHARMACOLOGY

Endocannabinoids and traumatic brain injury

(2011) Esther Shohami et al.   BRITISH JOURNAL OF PHARMACOLOGY

Metabolic and Type 1 cannabinoid receptor imaging of a transgenic rat model in the early phase of Huntington disease

(2011) C. Casteels et al.   EXPERIMENTAL NEUROLOGY

Identification of cis-Elements and Transcription Factors Regulating Neuronal Activity-Dependent Transcription of Human BDNF Gene

(2011) P. Pruunsild et al.   JOURNAL OF NEUROSCIENCE

Worsening of Huntington disease phenotype in CB1 receptor knockout mice

(2011) Stéphane Mievis et al.   NEUROBIOLOGY OF DISEASE

Regulation of Brain-Derived Neurotrophic Factor Exon IV Transcription through Calcium Responsive Elements in Cortical Neurons

(2011) Fei Zheng et al.   PLoS One

Loss of striatal type 1 cannabinoid receptors is a key pathogenic factor in Huntington’s disease

(2010) Cristina Blázquez et al.   BRAIN

The Multiplicity of Action of Cannabinoids: Implications for Treating Neurodegeneration

(2010) Aoife Gowran et al.   CNS Neuroscience & Therapeutics

BDNF Overexpression in the Forebrain Rescues Huntington's Disease Phenotypes in YAC128 Mice

(2010) Y. Xie et al.   JOURNAL OF NEUROSCIENCE

Brain-Derived Neurotrophic Factor Controls Cannabinoid CB1 Receptor Function in the Striatum

(2010) V. De Chiara et al.   JOURNAL OF NEUROSCIENCE

Global Deprivation of Brain-Derived Neurotrophic Factor in the CNS Reveals an Area-Specific Requirement for Dendritic Growth

(2010) S. Rauskolb et al.   JOURNAL OF NEUROSCIENCE

Depression-like phenotype following chronic CB1 receptor antagonism

(2010) Chad E. Beyer et al.   NEUROBIOLOGY OF DISEASE

International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid Receptors and Their Ligands: Beyond CB1 and CB2

(2010) R. G. Pertwee et al.   PHARMACOLOGICAL REVIEWS

AAV Vector-Mediated Overexpression of CB1 Cannabinoid Receptor in Pyramidal Neurons of the Hippocampus Protects against Seizure-Induced Excitoxicity

(2010) Stephan Guggenhuber et al.   PLoS One

Physiology and Pharmacology of Striatal Neurons

(2009) Anatol C. Kreitzer   Annual Review of Neuroscience

Brain-derived neurotrophic factor in neurodegenerative diseases

(2009) Chiara Zuccato et al.   Nature Reviews Neurology

Remote Control of Neuronal Activity in Transgenic Mice Expressing Evolved G Protein-Coupled Receptors

(2009) Georgia M. Alexander et al.   NEURON

Calcium signaling cascade links dopamine D1–D2 receptor heteromer to striatal BDNF production and neuronal growth

(2009) Ahmed Hasbi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Endocannabinoid System in Huntingtons Disease

(2008) M. Pazos et al.   CURRENT PHARMACEUTICAL DESIGN

Mechanisms of Control of Neuron Survival by the Endocannabinoid System

(2008) Ismael Galve-Roperh et al.   CURRENT PHARMACEUTICAL DESIGN

Calcineurin is involved in the early activation of NMDA-mediated cell death in mutant huntingtin knock-in striatal cells

(2008) Xavier Xifró et al.   JOURNAL OF NEUROCHEMISTRY

BDNF impairment in the hippocampus is related to enhanced despair behavior in CB1knockout mice

(2008) Ester Aso et al.   JOURNAL OF NEUROCHEMISTRY

Enhanced Sensitivity of Striatal Neurons to Axonal Transport Defects Induced by Mutant Huntingtin

(2008) L.-S. Her et al.   JOURNAL OF NEUROSCIENCE

Endocannabinoid signaling as a synaptic circuit breaker in neurological disease

(2008) István Katona et al.   NATURE MEDICINE

From Synapse to Nucleus: Calcium-Dependent Gene Transcription in the Control of Synapse Development and Function

(2008) Paul L. Greer et al.   NEURON

A Biological Function for the Neuronal Activity-Dependent Component of Bdnf Transcription in the Development of Cortical Inhibition

(2008) Elizabeth J. Hong et al.   NEURON

Preliminary evidence of cannabinoid effects on brain-derived neurotrophic factor (BDNF) levels in humans

(2008) Deepak Cyril D’Souza et al.   PSYCHOPHARMACOLOGY