Metformin reverses early cortical network dysfunction and behavior changes in Huntington’s disease

Blood–brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders

(2018) Melanie D. Sweeney et al.   Nature Reviews Neurology

Metformin ameliorates core deficits in a mouse model of fragile X syndrome

(2017) Ilse Gantois et al.   NATURE MEDICINE

Developmental alterations in Huntington's disease neural cells and pharmacological rescue in cells and mice

(2017) Ryan G Lim et al.   NATURE NEUROSCIENCE

BACE inhibition-dependent repair of Alzheimer’s pathophysiology

(2017) Aylin D. Keskin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Elimination of huntingtin in the adult mouse leads to progressive behavioral deficits, bilateral thalamic calcification, and altered brain iron homeostasis

(2017) Paula Dietrich et al.   PLoS Genetics

Molecular Imaging Markers to Track Huntington’s Disease Pathology

(2017) Heather Wilson et al.   Frontiers in Neurology

Metformin intake associates with better cognitive function in patients with Huntington's disease

(2017) David Hervás et al.   PLoS One

The pathogenic exon 1 HTT protein is produced by incomplete splicing in Huntington’s disease patients

(2017) Andreas Neueder et al.   Scientific Reports

Diminishing return for mechanistic therapeutics with neurodegenerative disease duration?

(2016) David C. Rubinsztein et al.   BIOESSAYS

Visuospatial Processing Deficits Linked to Posterior Brain Regions in Premanifest and Early Stage Huntington’s Disease

(2016) Izelle Labuschagne et al.   JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY

Gamma frequency entrainment attenuates amyloid load and modifies microglia

(2016) Hannah F. Iaccarino et al.   NATURE

Metformin Protects Cells from Mutant Huntingtin Toxicity Through Activation of AMPK and Modulation of Mitochondrial Dynamics

(2016) Jing Jin et al.   NEUROMOLECULAR MEDICINE

Activation of AMPK-induced autophagy ameliorates Huntington disease pathology in vitro

(2016) Carolin Walter et al.   NEUROPHARMACOLOGY

Impairments of neural circuit function in Alzheimer's disease

(2016) Marc Aurel Busche et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Selective expression of mutant huntingtin during development recapitulates characteristic features of Huntington’s disease

(2016) Aldrin E. Molero et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of mRNA Translation by MID1: A Common Mechanism of Expanded CAG Repeat RNAs

(2016) Nadine Griesche et al.   Frontiers in Cellular Neuroscience

Huntington's Disease as Neurodevelopmental Disorder: Altered Chromatin Regulation, Coding, and Non-Coding RNA Transcription

(2016) Emanuela Kerschbamer et al.   Frontiers in Neuroscience

Network topology and functional connectivity disturbances precede the onset of Huntington’s disease

(2015) Deborah L. Harrington et al.   BRAIN

AMPK activation protects from neuronal dysfunction and vulnerability across nematode, cellular and mouse models of Huntington's disease

(2015) Rafael P. Vázquez-Manrique et al.   HUMAN MOLECULAR GENETICS

Gene suppression strategies for dominantly inherited neurodegenerative diseases: lessons from Huntington's disease and spinocerebellar ataxia

(2015) Megan S. Keiser et al.   HUMAN MOLECULAR GENETICS

Rescue of long-range circuit dysfunction in Alzheimer's disease models

(2015) Marc Aurel Busche et al.   NATURE NEUROSCIENCE

Mitochondrial function in the brain links anxiety with social subordination

(2015) Fiona Hollis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metformin anti-tumor effect via disruption of the MID1 translational regulator complex and AR downregulation in prostate cancer cells

(2014) Ummuhan Demir et al.   BMC CANCER

Metformin: Its emerging role in oncology

(2014) Dragan Micic et al.   Hormones-International Journal of Endocrinology and Metabolism

Silencing Mutant Huntingtin by Adeno-Associated Virus-Mediated RNA Interference Ameliorates Disease Manifestations in the YAC128 Mouse Model of Huntington's Disease

(2014) Lisa M. Stanek et al.   HUMAN GENE THERAPY

Metabolism in HD: Still a relevant mechanism?

(2014) Wenzhen Duan et al.   MOVEMENT DISORDERS

Huntington disease: natural history, biomarkers and prospects for therapeutics

(2014) Christopher A. Ross et al.   Nature Reviews Neurology

Visual stimuli recruit intrinsically generated cortical ensembles

(2014) J.-e. K. Miller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metformin Retards Aging in C. elegans by Altering Microbial Folate and Methionine Metabolism

(2013) Filipe Cabreiro et al.   CELL

Choosing an animal model for the study of Huntington's disease

(2013) Mahmoud A. Pouladi et al.   NATURE REVIEWS NEUROSCIENCE

Treatment of Huntington’s Disease

(2013) Samuel Frank   Neurotherapeutics

Aberrant splicing of HTT generates the pathogenic exon 1 protein in Huntington disease

(2013) K. Sathasivam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Huntington's disease: underlying molecular mechanisms and emerging concepts

(2013) John Labbadia et al.   TRENDS IN BIOCHEMICAL SCIENCES

Translation of HTT mRNA with expanded CAG repeats is regulated by the MID1–PP2A protein complex

(2013) Sybille Krauß et al.   Nature Communications

Tissue-specific control of mitochondrial respiration in obesity-related insulin resistance and diabetes

(2012) Maria H. Holmström et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Default-mode network changes in preclinical Huntington's disease

(2012) Robert Christian Wolf et al.   EXPERIMENTAL NEUROLOGY

Consistent Neurodegeneration and Its Association with Clinical Progression in Huntington's Disease: A Coordinate-Based Meta-Analysis

(2012) Imis Dogan et al.   Neurodegenerative Diseases

“Huntingtin Holiday”: Progress toward an Antisense Therapy for Huntington's Disease

(2012) Xiao-Hong Lu et al.   NEURON

Sustained Therapeutic Reversal of Huntington's Disease by Transient Repression of Huntingtin Synthesis

(2012) Holly B. Kordasiewicz et al.   NEURON

Imaging Calcium in Neurons

(2012) Christine Grienberger et al.   NEURON

Critical role of soluble amyloid-  for early hippocampal hyperactivity in a mouse model of Alzheimer's disease

(2012) M. A. Busche et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Energy deficit in Huntington disease: why it matters

(2011) Fanny Mochel et al.   JOURNAL OF CLINICAL INVESTIGATION

Hippocampal Hyperactivation Associated with Cortical Thinning in Alzheimer's Disease Signature Regions in Non-Demented Elderly Adults

(2011) D. Putcha et al.   JOURNAL OF NEUROSCIENCE

Huntington's Disease: Can Mice Lead the Way to Treatment?

(2011) Zachary R. Crook et al.   NEURON

Longitudinal analysis of the behavioural phenotype in Hdh(CAG)150 Huntington's disease knock-in mice

(2010) Simon Brooks et al.   BRAIN RESEARCH BULLETIN

Is Huntington disease a developmental disorder?

(2010) Sandrine Humbert   EMBO REPORTS

The interrelationship between mitochondrial dysfunction and transcriptional dysregulation in Huntington disease

(2010) Youngnam N. Jin et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Neurocognitive signs in prodromal Huntington disease.

(2010) Julie C. Stout et al.   NEUROPSYCHOLOGY

Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling

(2010) E. Kickstein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondria in Huntington's disease

(2009) Maria Damiano et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Functional Clustering of Neurons in Motor Cortex Determined by Cellular Resolution Imaging in Awake Behaving Mice

(2009) D. A. Dombeck et al.   JOURNAL OF NEUROSCIENCE

Systematic behavioral evaluation of Huntington's disease transgenic and knock-in mouse models

(2009) Liliana Menalled et al.   NEUROBIOLOGY OF DISEASE

Clusters of Hyperactive Neurons Near Amyloid Plaques in a Mouse Model of Alzheimer's Disease

(2008) M. A. Busche et al.   SCIENCE