Regulatory T-cell differentiation versus clonal deletion of autoreactive thymocytes

Adaptable TCR Avidity Thresholds for Negative Selection

(2014) M. Stojakovic et al.   JOURNAL OF IMMUNOLOGY

A Function for IL-7R for CD4+CD25+Foxp3+ T Regulatory Cells

(2014) A. L. Bayer et al.   JOURNAL OF IMMUNOLOGY

IL-2, -7, and -15, but Not Thymic Stromal Lymphopoeitin, Redundantly Govern CD4+Foxp3+ Regulatory T Cell Development

(2014) K. B. Vang et al.   JOURNAL OF IMMUNOLOGY

Affinity-Based Selection of Regulatory T Cells Occurs Independent of Agonist-Mediated Induction of Foxp3 Expression

(2014) L. M. Relland et al.   JOURNAL OF IMMUNOLOGY

Plasmacytoid dendritic cells resident in human thymus drive natural Treg cell development

(2010) E. Martin-Gayo et al.   BLOOD

Transforming Growth Factor-β Signaling Curbs Thymic Negative Selection Promoting Regulatory T Cell Development

(2010) Weiming Ouyang et al.   IMMUNITY

CD28 Facilitates the Generation of Foxp3- Cytokine Responsive Regulatory T Cell Precursors

(2010) C. W. J. Lio et al.   JOURNAL OF IMMUNOLOGY

Thymic Stromal Lymphopoietin-Activated Plasmacytoid Dendritic Cells Induce the Generation of FOXP3+ Regulatory T Cells in Human Thymus

(2010) S. Hanabuchi et al.   JOURNAL OF IMMUNOLOGY

How specificity for self-peptides shapes the development and function of regulatory T cells

(2010) Donald M. Simons et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate

(2010) Ye Zheng et al.   NATURE

Autonomous role of medullary thymic epithelial cells in central CD4+ T cell tolerance

(2010) Maria Hinterberger et al.   NATURE IMMUNOLOGY

Aire

(2009) Diane Mathis et al.   Annual Review of Immunology

Thymocyte deletion can bias Treg formation toward low-abundance self-peptide

(2009) Cristina Cozzo Picca et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Control of Regulatory T Cell Lineage Commitment and Maintenance

(2009) Steven Z. Josefowicz et al.   IMMUNITY

TCR-dependent differentiation of thymic Foxp3+cells is limited to small clonal sizes

(2009) Monica W.L. Leung et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The thymic medulla: a unique microenvironment for intercellular self-antigen transfer

(2009) Christian Koble et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Constitutive ablation of dendritic cells breaks self-tolerance of CD4 T cells and results in spontaneous fatal autoimmunity

(2009) Caspar Ohnmacht et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Thymus-Blood Protein Interactions Are Highly Effective in Negative Selection and Regulatory T Cell Induction

(2009) D. F. Atibalentja et al.   JOURNAL OF IMMUNOLOGY

Rare Development of Foxp3+ Thymocytes in the CD4+CD8+ Subset

(2009) H. M. Lee et al.   JOURNAL OF IMMUNOLOGY

CTLA-4 suppresses the pathogenicity of self antigen–specific T cells by cell-intrinsic and cell-extrinsic mechanisms

(2009) Wataru Ise et al.   NATURE IMMUNOLOGY

Intraclonal competition limits the fate determination of regulatory T cells in the thymus

(2009) Jhoanne L Bautista et al.   NATURE IMMUNOLOGY

Regulatory T cell differentiation of thymocytes does not require a dedicated antigen-presenting cell but is under T cell-intrinsic developmental control

(2009) G. Wirnsberger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TGF-β: A Master of All T Cell Trades

(2008) Ming O. Li et al.   CELL

Low Ligand Requirement for Deletion and Lack of Synapses in Positive Selection Enforce the Gauntlet of Thymic T Cell Maturation

(2008) Peter J.R. Ebert et al.   IMMUNITY

Linked T Cell Receptor and Cytokine Signaling Govern the Development of the Regulatory T Cell Repertoire

(2008) Matthew A. Burchill et al.   IMMUNITY

A Two-Step Process for Thymic Regulatory T Cell Development

(2008) Chan-Wang Joaquim Lio et al.   IMMUNITY

Special regulatory T-cell review: A rose by any other name: from suppressor T cells to Tregs, approbation to unbridled enthusiasm

(2008) Ronald N. Germain   IMMUNOLOGY

A critical function for TGF-β signaling in the development of natural CD4+CD25+Foxp3+ regulatory T cells

(2008) Yongzhong Liu et al.   NATURE IMMUNOLOGY

Differentiation of regulatory Foxp3+ T cells in the thymic cortex

(2008) A. Liston et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dendritic cells in the thymus contribute to T-regulatory cell induction

(2008) A. I. Proietto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR

(2008) S. Sauer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA