A widely distributed metalloenzyme class enables gut microbial metabolism of host- and diet-derived catechols

Enhancement of the gut barrier integrity by a microbial metabolite through the Nrf2 pathway

(2019) Rajbir Singh et al.   Nature Communications

Dopamine Is a Siderophore-Like Iron Chelator That Promotes Salmonella enterica Serovar Typhimurium Virulence in Mice

(2019) Stefanie Dichtl et al.   mBio

Occurrence and diversity of the oxidative hydroxyhydroquinone pathway for the anaerobic degradation of aromatic compounds in nitrate‐reducing bacteria

(2019) Daniel Pacheco‐Sánchez et al.   Environmental Microbiology Reports

Separating host and microbiome contributions to drug pharmacokinetics and toxicity

(2019) Michael Zimmermann et al.   SCIENCE

A glycyl radical enzyme enables hydrogen sulfide production by the human intestinal bacterium Bilophila wadsworthia

(2019) Spencer C. Peck et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discovery and inhibition of an interspecies gut bacterial pathway for Levodopa metabolism

(2019) Vayu Maini Rekdal et al.   SCIENCE

Host diet and evolutionary history explain different aspects of gut microbiome diversity among vertebrate clades

(2019) Nicholas D. Youngblut et al.   Nature Communications

Genetic basis for the cooperative bioactivation of plant lignans by Eggerthella lenta and other human gut bacteria

(2019) Elizabeth N. Bess et al.   Nature Microbiology

Discovery and characterization of a prevalent human gut bacterial enzyme sufficient for the inactivation of a family of plant toxins

(2018) Nitzan Koppel et al.   eLife

A selective gut bacterial bile salt hydrolase alters host metabolism

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Similarity of the dog and human gut microbiomes in gene content and response to diet

(2018) Luis Pedro Coelho et al.   Microbiome

DbdR, a New Member of the LysR Family of Transcriptional Regulators, Coordinately Controls Four Promoters in the Thauera aromatica AR-1 3,5-Dihydroxybenzoate Anaerobic Degradation Pathway

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Two immunoassays for the detection of 2C-B and related hallucinogenic phenethylamines

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GABA-modulating bacteria of the human gut microbiota

(2018) Philip Strandwitz et al.   Nature Microbiology

Microbial nitrogen limitation in the mammalian large intestine

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Complex pectin metabolism by gut bacteria reveals novel catalytic functions

(2017) Didier Ndeh et al.   NATURE

A prominent glycyl radical enzyme in human gut microbiomes metabolizestrans-4-hydroxy-l-proline

(2017) B. J. Levin et al.   SCIENCE

Chemical transformation of xenobiotics by the human gut microbiota

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Gut microbiome modulates response to anti–PD-1 immunotherapy in melanoma patients

(2017) V. Gopalakrishnan et al.   SCIENCE

Transformation of the Anticancer Drug Doxorubicin in the Human Gut Microbiome

(2017) Austin Yan et al.   ACS Infectious Diseases

A Dietary Fiber-Deprived Gut Microbiota Degrades the Colonic Mucus Barrier and Enhances Pathogen Susceptibility

(2016) Mahesh S. Desai et al.   CELL

Modulation of a Circulating Uremic Solute via Rational Genetic Manipulation of the Gut Microbiota

(2016) A. Sloan Devlin et al.   Cell Host & Microbe

Green Tea Catechin Metabolites Exert Immunoregulatory Effects on CD4+ T Cell and Natural Killer Cell Activities

(2016) Yoon Hee Kim et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents

(2016) Dongryeol Ryu et al.   NATURE MEDICINE

Interactive tree of life (iTOL) v3: an online tool for the display and annotation of phylogenetic and other trees

(2016) Ivica Letunic et al.   NUCLEIC ACIDS RESEARCH

ONO-pincer ruthenium complex-bound norvaline for efficient catalytic oxidation of methoxybenzenes with hydrogen peroxide

(2016) Ryota Yoshida et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

QseC inhibition as an antivirulence approach for colitis-associated bacteria

(2016) Michelle G. Rooks et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Siderophores in Iron Metabolism: From Mechanism to Therapy Potential

(2016) Briana R. Wilson et al.   TRENDS IN MOLECULAR MEDICINE

Discovery of KLS-13019, a Cannabidiol-Derived Neuroprotective Agent, with Improved Potency, Safety, and Permeability

(2016) William A. Kinney et al.   ACS Medicinal Chemistry Letters

The Reciprocal Interactions between Polyphenols and Gut Microbiota and Effects on Bioaccessibility

(2016) Tugba Ozdal et al.   Nutrients

Improvements in Metabolic Health with Consumption of Ellagic Acid and Subsequent Conversion into Urolithins: Evidence and Mechanisms

(2016) Inhae Kang et al.   Advances in Nutrition

Revised Estimates for the Number of Human and Bacteria Cells in the Body

(2016) Ron Sender et al.   PLOS BIOLOGY

Identification of the Gene Cluster for the Anaerobic Degradation of 3,5-Dihydroxybenzoate (α-Resorcylate) in Thauera aromatica Strain AR-1

(2015) Águeda Molina-Fuentes et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Enzyme Function Initiative-Enzyme Similarity Tool (EFI-EST): A web tool for generating protein sequence similarity networks

(2015) John A. Gerlt et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

MetaQuery: a web server for rapid annotation and quantitative analysis of specific genes in the human gut microbiome

(2015) Stephen Nayfach et al.   BIOINFORMATICS

Bioconversion of (−)-Epicatechin, (+)-Epicatechin, (−)-Catechin, and (+)-Catechin by (−)-Epigallocatechin-Metabolizing Bacteria

(2015) Akiko Takagaki et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

A biosynthetic pathway for a prominent class of microbiota-derived bile acids

(2015) A Sloan Devlin et al.   Nature Chemical Biology

Simultaneous generation of many RNA-seq libraries in a single reaction

(2015) Alexander A Shishkin et al.   NATURE METHODS

Intestinal Microbiota Composition Modulates Choline Bioavailability from Diet and Accumulation of the Proatherogenic Metabolite Trimethylamine- N -Oxide

(2015) Kymberleigh A. Romano et al.   mBio

Characterization and Detection of a Widely Distributed Gene Cluster That Predicts Anaerobic Choline Utilization by Human Gut Bacteria

(2015) Ana Martínez-del Campo et al.   mBio

Glycan complexity dictates microbial resource allocation in the large intestine

(2015) Artur Rogowski et al.   Nature Communications

Discovery and Characterization of Gut Microbiota Decarboxylases that Can Produce the Neurotransmitter Tryptamine

(2014) Brianna B. Williams et al.   Cell Host & Microbe

Whole-Cell Carboxylate Reduction for the Synthesis of 3-Hydroxytyrosol

(2014) Kamila Napora-Wijata et al.   ChemCatChem

The Mononuclear Molybdenum Enzymes

(2014) Russ Hille et al.   CHEMICAL REVIEWS

Gordonibacter urolithinfaciens sp. nov., a urolithin-producing bacterium isolated from the human gut

(2014) M. V. Selma et al.   INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY

Shifting the metallocentric molybdoenzyme paradigm: the importance of pyranopterin coordination

(2014) Richard A. Rothery et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

A discrete genetic locus confers xyloglucan metabolism in select human gut Bacteroidetes

(2014) Johan Larsbrink et al.   NATURE

Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile

(2014) Charlie G. Buffie et al.   NATURE

Azoarcus sp. CIB, an Anaerobic Biodegrader of Aromatic Compounds Shows an Endophytic Lifestyle

(2014) Helga Fernández et al.   PLoS One

Catabolism of (+)-Catechin and (−)-Epicatechin by Rat Intestinal Microbiota

(2013) Akiko Takagaki et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

SAR Based Design of Nicotinamides as a Novel Class of Androgen Receptor Antagonists for Prostate Cancer

(2013) Su Hui Yang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Predicting and Manipulating Cardiac Drug Inactivation by the Human Gut Bacterium Eggerthella lenta

(2013) H. J. Haiser et al.   SCIENCE

Molybdenum enzymes, their maturation and molybdenum cofactor biosynthesis in Escherichia coli

(2012) Chantal Iobbi-Nivol et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Genomic determinants of organohalide-respiration in Geobacter lovleyi, an unusual member of the Geobacteraceae

(2012) Darlene D Wagner et al.   BMC GENOMICS

Complete genome, catabolic sub-proteomes and key-metabolites ofDesulfobacula toluolica Tol2, a marine, aromatic compound-degrading, sulfate-reducing bacterium

(2012) Lars Wöhlbrand et al.   ENVIRONMENTAL MICROBIOLOGY

Characterization of Yatakemycin Gene Cluster Revealing a Radical S-Adenosylmethionine Dependent Methyltransferase and Highlighting Spirocyclopropane Biosynthesis

(2012) Wei Huang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Microbial conversion of choline to trimethylamine requires a glycyl radical enzyme

(2012) S. Craciun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The ineluctable requirement for the trans-iron elements molybdenum and/or tungsten in the origin of life

(2012) Barbara Schoepp-Cothenet et al.   Scientific Reports

Lignan transformation by gut bacteria lowers tumor burden in a gnotobiotic rat model of breast cancer

(2011) H. B. Mabrok et al.   CARCINOGENESIS

Brønsted acid assisted activation of imide carbonyl group: regioselective synthesis of isoindoloisoquinolinone alkaloid (±)-nuevamine

(2011) Jayaraman Selvakumar et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Recognition and Degradation of Plant Cell Wall Polysaccharides by Two Human Gut Symbionts

(2011) Eric C. Martens et al.   PLOS BIOLOGY

Specificity of Polysaccharide Use in Intestinal Bacteroides Species Determines Diet-Induced Microbiota Alterations

(2010) Erica D. Sonnenburg et al.   CELL

Metabolism of Fostamatinib, the Oral Methylene Phosphate Prodrug of the Spleen Tyrosine Kinase Inhibitor R406 in Humans: Contribution of Hepatic and Gut Bacterial Processes to the Overall Biotransformation

(2010) D. J. Sweeny et al.   DRUG METABOLISM AND DISPOSITION

Metabolism of (−)-Epigallocatechin Gallate by Rat Intestinal Flora

(2010) Akiko Takagaki et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Exploring the Active Site of the Tungsten, Iron-Sulfur Enzyme Acetylene Hydratase

(2010) F. tenBrink et al.   JOURNAL OF BACTERIOLOGY

Transfer of carbohydrate-active enzymes from marine bacteria to Japanese gut microbiota

(2010) Jan-Hendrik Hehemann et al.   NATURE

A human gut microbial gene catalogue established by metagenomic sequencing

(2010) Junjie Qin et al.   NATURE

Clostridium ljungdahlii represents a microbial production platform based on syngas

(2010) M. Kopke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alleviating Cancer Drug Toxicity by Inhibiting a Bacterial Enzyme

(2010) B. D. Wallace et al.   SCIENCE

Fast and accurate short read alignment with Burrows-Wheeler transform

(2009) H. Li et al.   BIOINFORMATICS

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

Degradation and Metabolism of Catechin, Epigallocatechin-3-gallate (EGCG), and Related Compounds by the Intestinal Microbiota in the Pig Cecum Model

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Microbial metabolism of catechin stereoisomers by human faecal microbiota: Comparison of targeted analysis and a non-targeted metabolomics method

(2008) Anna-Marja Aura et al.   Phytochemistry Letters

The prokaryotic complex iron–sulfur molybdoenzyme family

(2007) Richard A. Rothery et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES