Herbal Medicines Attenuate PD-L1 Expression to Induce Anti-Proliferation in Obesity-Related Cancers

The ‘obesity paradox’ in action with cancer immunotherapy

(2019) Joanne Lysaght   Nature Reviews Endocrinology

A multicenter study of body mass index in cancer patients treated with anti-PD-1/PD-L1 immune checkpoint inhibitors: when overweight becomes favorable

(2019) Alessio Cortellini et al.   Journal for ImmunoTherapy of Cancer

Resveratrol antagonizes thyroid hormone-induced expression of checkpoint and proliferative genes in oral cancer cells

(2019) Chia-Cheng Lin et al.   Journal of Dental Sciences

Influence of Resveratrol on the Immune Response

(2019) Malaguarnera   Nutrients

Thyroid hormone-induced expression of inflammatory cytokines interfere with resveratrol-induced anti-proliferation of oral cancer cells

(2019) Yi-Ru Chen et al.   FOOD AND CHEMICAL TOXICOLOGY

Curcumin enhances anti-tumor immune response in tongue squamous cell carcinoma

(2018) Feng Liao et al.   ARCHIVES OF ORAL BIOLOGY

Thyroxine inhibits resveratrol-caused apoptosis by PD-L1 in ovarian cancer cells

(2018) Yu-Tang Chin et al.   ENDOCRINE-RELATED CANCER

Nano-diamino-tetrac (NDAT) inhibits PD-L1 expression which is essential for proliferation in oral cancer cells

(2018) Shan-Jen Lin et al.   FOOD AND CHEMICAL TOXICOLOGY

Molecular Mechanisms of T Cells Activation by Dendritic Cells in Autoimmune Diseases

(2018) Yu Tai et al.   Frontiers in Pharmacology

Thyroid Hormone Promotes β-Catenin Activation and Cell Proliferation in Colorectal Cancer

(2018) Yee-Shin Lee et al.   Hormones & Cancer

Nano-Diamino-Tetrac (NDAT) Enhances Resveratrol-Induced Antiproliferation by Action on the RRM2 Pathway in Colorectal Cancers

(2018) André Wendindondé Nana et al.   Hormones & Cancer

Anti-PD-1 and Anti-CTLA-4 Therapies in Cancer: Mechanisms of Action, Efficacy, and Limitations

(2018) Judith A. Seidel et al.   Frontiers in Oncology

Thyroid disorders induced by checkpoint inhibitors

(2018) Silvia Martina Ferrari et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

Inhibitory Effect of Anoectochilus formosanus Extract on Hyperglycemia-Related PD-L1 Expression and Cancer Proliferation

(2018) Yih Ho et al.   Frontiers in Pharmacology

Apigenin suppresses PD-L1 expression in melanoma and host dendritic cells to elicit synergistic therapeutic effects

(2018) Lu Xu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Paradoxical effects of obesity on T cell function during tumor progression and PD-1 checkpoint blockade

(2018) Ziming Wang et al.   NATURE MEDICINE

Tetrac downregulates β-catenin and HMGA2 to promote the effect of resveratrol in colon cancer

(2017) André Wendindondé Nana et al.   ENDOCRINE-RELATED CANCER

Inflammatory cytokines IL-17 and TNF-α up-regulate PD-L1 expression in human prostate and colon cancer cells

(2017) Xun Wang et al.   IMMUNOLOGY LETTERS

PD-L1 induced by IFN-γ from tumor-associated macrophages via the JAK/STAT3 and PI3K/AKT signaling pathways promoted progression of lung cancer

(2017) Xiaohui Zhang et al.   International Journal of Clinical Oncology

Posttranscriptional Control of PD-L1 Expression by 17β-Estradiol via PI3K/Akt Signaling Pathway in ERα-Positive Cancer Cell Lines

(2017) Lingyun Yang et al.   INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

The Role of Resveratrol in Cancer Therapy

(2017) Jeong-Hyeon Ko et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Hormonal vitamin D up-regulates tissue-specific PD-L1 and PD-L2 surface glycoprotein expression in humans but not mice

(2017) Vassil Dimitrov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The JAK/STAT pathway is involved in the upregulation of PD-L1 expression in pancreatic cancer cell lines

(2017) Toshifumi Doi et al.   ONCOLOGY REPORTS

Bisdemethoxycurcumin in combination with α-PD-L1 antibody boosts immune response against bladder cancer

(2017) Yiqun Shao et al.   OncoTargets and Therapy

A blockade of PD-L1 produced antitumor and antimetastatic effects in an orthotopic mouse pancreatic cancer model via the PI3K/AkT/MTOR signaling pathway

(2017) Lei Zhao et al.   OncoTargets and Therapy

Increased BTLA and HVEM in gastric cancer are associated with progression and poor prognosis

(2017) Xiuwen Lan et al.   OncoTargets and Therapy

Effects of Resveratrol against Lung Cancer: In Vitro and In Vivo Studies

(2017) Michael Yousef et al.   Nutrients

Cytokine-Induced Killer Cells As Pharmacological Tools for Cancer Immunotherapy

(2017) Xingchun Gao et al.   Frontiers in Immunology

CTLA-4 and PD-1 Pathways

(2016) Elizabeth I. Buchbinder et al.   AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS

Curcumin, the golden nutraceutical: multitargeting for multiple chronic diseases

(2016) Ajaikumar B Kunnumakkara et al.   BRITISH JOURNAL OF PHARMACOLOGY

Deubiquitination and Stabilization of PD-L1 by CSN5

(2016) Seung-Oe Lim et al.   CANCER CELL

Curcumin alleviates glucocorticoid-induced osteoporosis by protecting osteoblasts from apoptosisin vivoandin vitro

(2016) Zhiguang Chen et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Thyroid Hormones, Oxidative Stress, and Inflammation

(2016) Antonio Mancini et al.   MEDIATORS OF INFLAMMATION

Anti-Oxidant, Anti-Inflammatory and Anti-Angiogenic Properties of Resveratrol in Ocular Diseases

(2016) Allan Lançon et al.   MOLECULES

Actions of l -thyroxine and Nano-diamino-tetrac (Nanotetrac) on PD-L1 in cancer cells

(2016) Hung-Yun Lin et al.   STEROIDS

Visceral fat adipocytes from obese and colorectal cancer subjects exhibit distinct secretory and ω6 polyunsaturated fatty acid profiles and deliver immunosuppressive signals to innate immunity cells

(2016) Manuela Del Cornò et al.   Oncotarget

Crosstalk between integrin αvβ3 and ERα contributes to thyroid hormone-induced proliferation of ovarian cancer cells

(2016) Meng-Ti Hsieh et al.   Oncotarget

Antidiabetic Effects of Resveratrol: The Way Forward in Its Clinical Utility

(2016) Omolola R. Oyenihi et al.   Journal of Diabetes Research

Curcumin: A Natural Product for Diabetes and its Complications

(2015) Seyed Nabavi et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Intercellular interplay between Sirt1 signalling and cell metabolism in immune cell biology

(2015) Xi Chen et al.   IMMUNOLOGY

Role of Oxidative Stress in Thyroid Hormone-Induced Cardiomyocyte Hypertrophy and Associated Cardiac Dysfunction: An Undisclosed Story

(2015) Mohammad T. Elnakish et al.   Oxidative Medicine and Cellular Longevity

Curcumin and tumor immune-editing: resurrecting the immune system

(2015) Sayantan Bose et al.   Cell Division

Anti-Rods/Rings: A Human Model of Drug-Induced Autoantibody Generation

(2015) S. John Calise et al.   Frontiers in Immunology

Inducible but Not Constitutive Expression of PD-L1 in Human Melanoma Cells Is Dependent on Activation of NF-κB

(2015) Kavitha Gowrishankar et al.   PLoS One

Tumor Necrosis Factor Superfamily in Innate Immunity and Inflammation

(2014) John Šedý et al.   Cold Spring Harbor Perspectives in Biology

Regulatory effects of resveratrol on glucose metabolism and T-lymphocyte subsets in the development of high-fat diet-induced obesity in C57BL/6 mice

(2014) Bin Wang et al.   Food & Function

Hyperglycemia as a Risk Factor for Cancer Progression

(2014) Tae Young Ryu et al.   Diabetes & Metabolism Journal

Anti-Inflammatory Potency of Nano-Formulated Puerarin and Curcumin in Rats Subjected to the Lipopolysaccharide-Induced Inflammation

(2013) Ashok K. Singh et al.   JOURNAL OF MEDICINAL FOOD

Resveratrol prevents suppression of regulatory T-cell production, oxidative stress, and inflammation of mice prone or resistant to high-fat diet–induced obesity

(2013) Bin Wang et al.   NUTRITION RESEARCH

Overexpression of B7-H1 correlates with malignant cell proliferation in pancreatic cancer

(2013) XIAO SONG et al.   ONCOLOGY REPORTS

The Role of Thyroid Hormones as Inductors of Oxidative Stress and Neurodegeneration

(2013) I. Villanueva et al.   Oxidative Medicine and Cellular Longevity

Resveratrol Inhibits CD4+ T Cell Activation by Enhancing the Expression and Activity of Sirt1

(2013) Ting Zou et al.   PLoS One

Resveratrol and its metabolites inhibit pro-inflammatory effects of lipopolysaccharides in U-937 macrophages in plasma-representative concentrations

(2013) Jessica Walker et al.   Food & Function

Curcumin differentially regulates the expression of superoxide dismutase in cerebral cortex and cerebellum of l-thyroxine (T4)-induced hyperthyroid rat brain

(2012) Srikanta Jena et al.   NEUROLOGICAL SCIENCES

The signaling networks of the herpesvirus entry mediator (TNFRSF14) in immune regulation

(2011) Marcos W. Steinberg et al.   IMMUNOLOGICAL REVIEWS

Crosstalk between Integrin αvβ3 and Estrogen Receptor-α Is Involved in Thyroid Hormone-Induced Proliferation in Human Lung Carcinoma Cells

(2011) Ran Meng et al.   PLoS One

Diet-Induced Obesity Impairs the T Cell Memory Response to Influenza Virus Infection

(2010) E. A. Karlsson et al.   JOURNAL OF IMMUNOLOGY

Age-dependent different action of curcumin in thyroid of rat.

(2008) Monika A Papiez et al.   FOLIA HISTOCHEMICA ET CYTOBIOLOGICA