PALB2 chromatin recruitment restores homologous recombination in BRCA1-deficient cells depleted of 53BP1

The Tumor Suppressor PALB2: Inside Out

(2019) Mandy Ducy et al.   TRENDS IN BIOCHEMICAL SCIENCES

BRCA1 Haploinsufficiency Is Masked by RNF168-Mediated Chromatin Ubiquitylation

(2019) Dali Zong et al.   MOLECULAR CELL

Novel RNA and DNA strand exchange activity of the PALB2 DNA binding domain and its critical role for DNA repair in cells

(2019) Jaigeeth Deveryshetty et al.   eLife

53BP1 Enforces Distinct Pre- and Post-resection Blocks on Homologous Recombination

(2019) Elsa Callen et al.   MOLECULAR CELL

Stabilization of chromatin topology safeguards genome integrity

(2019) Fena Ochs et al.   NATURE

Retroviral integration into nucleosomes through DNA looping and sliding along the histone octamer

(2019) Marcus D. Wilson et al.   Nature Communications

Shieldin complex promotes DNA end-joining and counters homologous recombination in BRCA1-null cells

(2018) Harveer Dev et al.   NATURE CELL BIOLOGY

Assembling a protective shield

(2018) Roger A Greenberg   NATURE CELL BIOLOGY

SHLD2/FAM35A co‐operates with REV7 to coordinate DNA double‐strand break repair pathway choice

(2018) Steven Findlay et al.   EMBO JOURNAL

The shieldin complex mediates 53BP1-dependent DNA repair

(2018) Sylvie M. Noordermeer et al.   NATURE

BRCA1 Mutation-Specific Responses to 53BP1 Loss-Induced Homologous Recombination and PARP Inhibitor Resistance

(2018) Joseph Nacson et al.   Cell Reports

ATR inhibition disrupts rewired homologous recombination and fork protection pathways in PARP inhibitor-resistant BRCA-deficient cancer cells

(2017) Stephanie A. Yazinski et al.   GENES & DEVELOPMENT

BRCA1–BARD1 promotes RAD51-mediated homologous DNA pairing

(2017) Weixing Zhao et al.   NATURE

Reading chromatin signatures after DNA double-strand breaks

(2017) Marcus D. Wilson et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

A PALB2-interacting domain in RNF168 couples homologous recombination to DNA break-induced chromatin ubiquitylation

(2017) Martijn S Luijsterburg et al.   eLife

Recognition of the nucleosome by chromatin factors and enzymes

(2016) Robert K McGinty et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

The structural basis of modified nucleosome recognition by 53BP1

(2016) Marcus D. Wilson et al.   NATURE

Human BRCA1–BARD1 ubiquitin ligase activity counteracts chromatin barriers to DNA resection

(2016) Ruth M Densham et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Human BRCA1–BARD1 ubiquitin ligase activity counteracts chromatin barriers to DNA resection

(2016) Ruth M Densham et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

CRISPR-Cas9D10A nickase-based genotypic and phenotypic screening to enhance genome editing

(2016) Ting-Wei Will Chiang et al.   Scientific Reports

Structural basis for retroviral integration into nucleosomes

(2015) Daniel P. Maskell et al.   NATURE

CtIP tetramer assembly is required for DNA-end resection and repair

(2015) Owen R Davies et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Homologous Recombination and Human Health: The Roles of BRCA1, BRCA2, and Associated Proteins

(2015) Rohit Prakash et al.   Cold Spring Harbor Perspectives in Biology

CtIP tetramer assembly is required for DNA-end resection and repair

(2015) Owen R Davies et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

CtIP-mediated resection is essential for viability and can operate independently of BRCA1

(2014) Federica Polato et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Generation of nonhydrolyzable ubiquitin–histone mimics

(2014) Lindsey Long et al.   METHODS

BRCA1 Accelerates CtIP-Mediated DNA-End Resection

(2014) Andrés Cruz-García et al.   Cell Reports

RIF1 Counteracts BRCA1-mediated End Resection during DNA Repair

(2013) Lin Feng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The interaction between CtIP and BRCA1 is not essential for resection-mediated DNA repair or tumor suppression

(2013) Colleen R. Reczek et al.   JOURNAL OF CELL BIOLOGY

The role of the nucleosome acidic patch in modulating higher order chromatin structure

(2013) A. A. Kalashnikova et al.   Journal of the Royal Society Interface

A Cell Cycle-Dependent Regulatory Circuit Composed of 53BP1-RIF1 and BRCA1-CtIP Controls DNA Repair Pathway Choice

(2013) Cristina Escribano-Díaz et al.   MOLECULAR CELL

53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark

(2013) Amélie Fradet-Turcotte et al.   NATURE

The N-terminal acetylation of Sir3 stabilizes its binding to the nucleosome core particle

(2013) Nadia Arnaudo et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Quantitation of DNA double-strand break resection intermediates in human cells

(2013) Yi Zhou et al.   NUCLEIC ACIDS RESEARCH

Breast cancer-associated missense mutants of the PALB2 WD40 domain, which directly binds RAD51C, RAD51 and BRCA2, disrupt DNA repair

(2013) J-Y Park et al.   ONCOGENE

Palb2 synergizes with Trp53 to suppress mammary tumor formation in a model of inherited breast cancer

(2013) C. Bowman-Colin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BRCA1-associated exclusion of 53BP1 from DNA damage sites underlies temporal control of DNA repair

(2012) J. R. Chapman et al.   JOURNAL OF CELL SCIENCE

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

ChAM, a novel motif that mediates PALB2 intrinsic chromatin binding and facilitates DNA repair

(2011) Jean-Yves Bleuyard et al.   EMBO REPORTS

BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair

(2011) A. V. Nimonkar et al.   GENES & DEVELOPMENT

APC15 drives the turnover of MCC-CDC20 to make the spindle assembly checkpoint responsive to kinetochore attachment

(2011) Jörg Mansfeld et al.   NATURE CELL BIOLOGY

Tracking genome engineering outcome at individual DNA breakpoints

(2011) Michael T Certo et al.   NATURE METHODS

53BP1 Inhibits Homologous Recombination in Brca1-Deficient Cells by Blocking Resection of DNA Breaks

(2010) Samuel F. Bunting et al.   CELL

MRG15 binds directly to PALB2 and stimulates homology-directed repair of chromosomal breaks

(2010) T. Hayakawa et al.   JOURNAL OF CELL SCIENCE

Crystal Structures of Nucleosome Core Particles Containing the ‘601’ Strong Positioning Sequence

(2010) Dileep Vasudevan et al.   JOURNAL OF MOLECULAR BIOLOGY

Purified human BRCA2 stimulates RAD51-mediated recombination

(2010) Ryan B. Jensen et al.   NATURE

Human BRCA2 protein promotes RAD51 filament formation on RPA-covered single-stranded DNA

(2010) Jie Liu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers

(2010) Peter Bouwman et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cooperation of breast cancer proteins PALB2 and piccolo BRCA2 in stimulating homologous recombination

(2010) Rémi Buisson et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

PALB2 Links BRCA1 and BRCA2 in the DNA-Damage Response

(2009) Feng Zhang et al.   CURRENT BIOLOGY

MRG15 Is a Novel PALB2-interacting Factor Involved in Homologous Recombination

(2009) Shirley M.-H. Sy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PALB2 Functionally Connects the Breast Cancer Susceptibility Proteins BRCA1 and BRCA2

(2009) F. Zhang et al.   MOLECULAR CANCER RESEARCH

Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks

(2009) Yaron Galanty et al.   NATURE

Subdiffraction Multicolor Imaging of the Nuclear Periphery with 3D Structured Illumination Microscopy

(2008) L. Schermelleh et al.   SCIENCE