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Dynamics and number of trans-SNARE complexes determine nascent fusion pore properties

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Molecular mechanism of fusion pore formation driven by the neuronal SNARE complex

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Fusion pores and their control of neurotransmitter and hormone release

(2017) Che-Wei Chang et al.   JOURNAL OF GENERAL PHYSIOLOGY

Synaptotagmin isoforms confer distinct activation kinetics and dynamics to chromaffin cell granules

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The primed SNARE–complexin–synaptotagmin complex for neuronal exocytosis

(2017) Qiangjun Zhou et al.   NATURE

Sec17 (α-SNAP) and an SM-tethering complex regulate the outcome of SNARE zippering in vitro and in vivo

(2017) Matthew L Schwartz et al.   eLife

Dilation of fusion pores by crowding of SNARE proteins

(2017) Zhenyong Wu et al.   eLife

Functional analysis of the interface between the tandem C2 domains of synaptotagmin-1

(2016) Chantell S. Evans et al.   MOLECULAR BIOLOGY OF THE CELL

Covalently circularized nanodiscs for studying membrane proteins and viral entry

(2016) Mahmoud L Nasr et al.   NATURE METHODS

Peptide- and proton-driven allosteric clamps catalyze anthrax toxin translocation across membranes

(2016) Debasis Das et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Different states of synaptotagmin regulate evoked versus spontaneous release

(2016) Hua Bai et al.   Nature Communications

Nanodisc-cell fusion: control of fusion pore nucleation and lifetimes by SNARE protein transmembrane domains

(2016) Zhenyong Wu et al.   Scientific Reports

Synaptotagmin-1 Is an Antagonist for Munc18-1 in SNARE Zippering

(2015) Xiaochu Lou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Engineered Metal Sensor Tunes the Kinetics of Synaptic Transmission

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Mechanistic insights into the recycling machine of the SNARE complex

(2015) Minglei Zhao et al.   NATURE

Architecture of the synaptotagmin–SNARE machinery for neuronal exocytosis

(2015) Qiangjun Zhou et al.   NATURE

Dynamic binding mode of a Synaptotagmin-1–SNARE complex in solution

(2015) Kyle D Brewer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Exocytotic fusion pores are composed of both lipids and proteins

(2015) Huan Bao et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Spring-loaded unraveling of a single SNARE complex by NSF in one round of ATP turnover

(2015) J.-K. Ryu et al.   SCIENCE

Dynamic binding mode of a Synaptotagmin-1–SNARE complex in solution

(2015) Kyle D Brewer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Exocytotic fusion pores are composed of both lipids and proteins

(2015) Huan Bao et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Munc18-1-regulated stage-wise SNARE assembly underlying synaptic exocytosis

(2015) Lu Ma et al.   eLife

Multiple conformations of a single SNAREpin between two nanodisc membranes reveal diverse pre-fusion states

(2014) Jaeil Shin et al.   BIOCHEMICAL JOURNAL

Distinct fusion properties of synaptotagmin-1 and synaptotagmin-7 bearing dense core granules

(2014) Tejeshwar C. Rao et al.   MOLECULAR BIOLOGY OF THE CELL

Linker mutations reveal the complexity of synaptotagmin 1 action during synaptic transmission

(2014) Huisheng Liu et al.   NATURE NEUROSCIENCE

Common intermediates and kinetics, but different energetics, in the assembly of SNARE proteins

(2014) Sylvain Zorman et al.   eLife

Reconstitution of the Vital Functions of Munc18 and Munc13 in Neurotransmitter Release

(2012) C. Ma et al.   SCIENCE

SNARE Proteins: One to Fuse and Three to Keep the Nascent Fusion Pore Open

(2012) L. Shi et al.   SCIENCE

Single Reconstituted Neuronal SNARE Complexes Zipper in Three Distinct Stages

(2012) Y. Gao et al.   SCIENCE

Perspectives on Kiss-and-Run: Role in Exocytosis, Endocytosis, and Neurotransmission

(2011) AbdulRasheed A. Alabi et al.   Annual Review of Physiology

Reconstituted synaptotagmin I mediates vesicle docking, priming, and fusion

(2011) Zhao Wang et al.   JOURNAL OF CELL BIOLOGY

At the junction of SNARE and SM protein function

(2010) Chavela M Carr et al.   CURRENT OPINION IN CELL BIOLOGY

Regulation of Exocytosis and Fusion Pores by Synaptotagmin-Effector Interactions

(2010) Zhen Zhang et al.   MOLECULAR BIOLOGY OF THE CELL

Helical extension of the neuronal SNARE complex into the membrane

(2009) Alexander Stein et al.   NATURE

How Does Synaptotagmin Trigger Neurotransmitter Release?

(2008) Edwin R. Chapman   Annual Review of Biochemistry

Synaptotagmin arrests the SNARE complex before triggering fast, efficient membrane fusion in response to Ca2+

(2008) Michael C Chicka et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The role of the C terminus of the SNARE protein SNAP-25 in fusion pore opening and a model for fusion pore mechanics

(2008) Q. Fang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA