Intracellular signaling dynamics and their role in coordinating tissue repair

Cadherin-11–mediated adhesion of macrophages to myofibroblasts establishes a profibrotic niche of active TGF-β

(2019) Monika Lodyga et al.   Science Signaling

SOX2 epidermal overexpression promotes cutaneous wound healing via activation of EGFR/MEK/ERK signaling mediated by EGFR ligands

(2019) Akihiko Uchiyama et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Deletion of Calcineurin Promotes a Protumorigenic Fibroblast Phenotype

(2019) Allyson Lieberman et al.   CANCER RESEARCH

High-performance calcium sensors for imaging activity in neuronal populations and microcompartments

(2019) Hod Dana et al.   NATURE METHODS

Dynamic fibroblast contractions attract remote macrophages in fibrillar collagen matrix

(2019) Pardis Pakshir et al.   Nature Communications

Swainsonine inhibits proliferation and collagen synthesis of NIH-3T3 cells by declining miR-21

(2019) Chao Li et al.   Artificial Cells Nanomedicine and Biotechnology

Tissue fluidity promotes epithelial wound healing

(2019) Robert J. Tetley et al.   Nature Physics

The mechanical fingerprint of murine excisional wounds

(2018) Marco Pensalfini et al.   Acta Biomaterialia

A Switch-like Activation Relay of EGFR-ERK Signaling Regulates a Wave of Cellular Contractility for Epithelial Invagination

(2018) Yosuke Ogura et al.   DEVELOPMENTAL CELL

Hypoxia induces pulmonary fibroblast proliferation through NFAT signaling

(2018) Lakmini Kumari Senavirathna et al.   Scientific Reports

Single-color, ratiometric biosensors for detecting signaling activities in live cells

(2018) Brian L Ross et al.   eLife

Tensile forces drive a reversible fibroblast-to-myofibroblast transition during tissue growth in engineered clefts

(2018) Philip Kollmannsberger et al.   Science Advances

Cell Membranes Resist Flow

(2018) Zheng Shi et al.   CELL

Integrating chemical and mechanical signals through dynamic coupling between cellular protrusions and pulsed ERK activation

(2018) Jr-Ming Yang et al.   Nature Communications

Antifibrotic effects of cyclosporine A on TGF-β1–treated lung fibroblasts and lungs from bleomycin-treated mice: role of hypoxia-inducible factor-1α

(2017) Risa Yamazaki et al.   FASEB JOURNAL

The provisional matrix: setting the stage for tissue repair outcomes

(2017) Thomas H. Barker et al.   MATRIX BIOLOGY

Wound-induced Ca2+ wave propagates through a simple release and diffusion mechanism

(2017) L. Naomi Handly et al.   MOLECULAR BIOLOGY OF THE CELL

Tracing Information Flow from Erk to Target Gene Induction Reveals Mechanisms of Dynamic and Combinatorial Control

(2017) Maxwell Z. Wilson et al.   MOLECULAR CELL

Live-cell measurements of kinase activity in single cells using translocation reporters

(2017) Takamasa Kudo et al.   Nature Protocols

The role of the endoplasmic reticulum protein calreticulin in mediating TGF-β-stimulated extracellular matrix production in fibrotic disease

(2017) Benjamin Y. Owusu et al.   Journal of Cell Communication and Signaling

Calcium spikes, waves and oscillations in a large, patterned epithelial tissue

(2017) Ramya Balaji et al.   Scientific Reports

Systems Analysis of the Dynamic Inflammatory Response to Tissue Damage Reveals Spatiotemporal Properties of the Wound Attractant Gradient

(2016) Helen Weavers et al.   CURRENT BIOLOGY

Drosophila wing imaginal discs respond to mechanical injury via slow InsP3R-mediated intercellular calcium waves

(2016) Simon Restrepo et al.   Nature Communications

Cellular forces and matrix assembly coordinate fibrous tissue repair

(2016) Mahmut Selman Sakar et al.   Nature Communications

Sensitive red protein calcium indicators for imaging neural activity

(2016) Hod Dana et al.   eLife

Optogenetic Control of Calcium Oscillation Waveform Defines NFAT as an Integrator of Calcium Load

(2016) Pimkhuan Hannanta-anan et al.   Cell Systems

The role of myofibroblasts in wound healing

(2016) B. Hinz   Current Research in Translational Medicine

Calcium Homeostasis and Ionic Mechanisms in Pulmonary Fibroblasts

(2015) Luke J. Janssen et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Collective motion of mammalian cell cohorts in 3D

(2015) Yasha Sharma et al.   Integrative Biology

Mechanics regulates ATP-stimulated collective calcium response in fibroblast cells

(2015) Josephine Lembong et al.   Journal of the Royal Society Interface

From intracellular signaling to population oscillations: bridging size- and time-scales in collective behavior

(2015) A. E. Sgro et al.   Molecular Systems Biology

Optogenetic control of endogenous Ca2+ channels in vivo

(2015) Taeyoon Kyung et al.   NATURE BIOTECHNOLOGY

ERK reinforces actin polymerization to power persistent edge protrusion during motility

(2015) Michelle C. Mendoza et al.   Science Signaling

Paracrine communication maximizes cellular response fidelity in wound signaling

(2015) L Naomi Handly et al.   eLife

Distinct mechanisms regulating mechanical force-induced Ca2+ signals at the plasma membrane and the ER in human MSCs

(2015) Tae-Jin Kim et al.   eLife

Intercellular propagation of extracellular signal-regulated kinase activation revealed by in vivo imaging of mouse skin

(2015) Toru Hiratsuka et al.   eLife

ERK reinforces actin polymerization to power persistent edge protrusion during motility

(2015) Michelle C. Mendoza et al.   Science Signaling

Optical Control of the Ca2+ Concentration in a Live Specimen with a Genetically Encoded Ca2+-Releasing Molecular Tool

(2014) Noritaka Fukuda et al.   ACS Chemical Biology

Human structural proteome-wide characterization of Cyclosporine A targets

(2014) Gang Hu et al.   BIOINFORMATICS

Coherent Motions in Confluent Cell Monolayer Sheets

(2014) Bo Li et al.   BIOPHYSICAL JOURNAL

High-Sensitivity Measurements of Multiple Kinase Activities in Live Single Cells

(2014) Sergi Regot et al.   CELL

NF-kB mediated down-regulation of collagen synthesis upon HEMA (2-hydroxyethyl methacrylate) treatment of primary human gingival fibroblast/Streptococcus mutans co-cultured cells

(2014) R. Grande et al.   Clinical Oral Investigations

Mechanosensitive ATP release from hemichannels and Ca2+ influx through TRPC6 accelerate wound closure in keratinocytes

(2014) H. Takada et al.   JOURNAL OF CELL SCIENCE

Cyclosporin A Promotes Tumor Angiogenesis in a Calcineurin-Independent Manner by Increasing Mitochondrial Reactive Oxygen Species

(2014) Alice Yao Zhou et al.   MOLECULAR CANCER RESEARCH

Imaging Activity in Neurons and Glia with a Polr2a-Based and Cre-Dependent GCaMP5G-IRES-tdTomato Reporter Mouse

(2014) J. Michael Gee et al.   NEURON

Engineering an improved light-induced dimer (iLID) for controlling the localization and activity of signaling proteins

(2014) Gurkan Guntas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Wound repair and regeneration: Mechanisms, signaling, and translation

(2014) S. A. Eming et al.   Science Translational Medicine

Gene Expression Profiling of Lung Myofibroblasts Reveals the Anti-Fibrotic Effects of Cyclosporine

(2014) Nao Hirota et al.   TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE

Wound healing and the role of fibroblasts

(2014) Bainbridge P.   Journal of Wound Care

Ion Selectivity and Competition in Channelrhodopsins

(2013) Franziska Schneider et al.   BIOPHYSICAL JOURNAL

Using Optogenetics to Interrogate the Dynamic Control of Signal Transmission by the Ras/Erk Module

(2013) Jared E. Toettcher et al.   CELL

Ras Activated ERK and PI3K Pathways Differentially Affect Directional Movement of Cultured Fibroblasts

(2013) Leandra Sepe et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Calcium Flashes Orchestrate the Wound Inflammatory Response through DUOX Activation and Hydrogen Peroxide Release

(2013) William Razzell et al.   CURRENT BIOLOGY

Calreticulin Regulates Transforming Growth Factor-β-stimulated Extracellular Matrix Production

(2013) Kurt A. Zimmerman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Coordinated waves of actomyosin flow and apical cell constriction immediately after wounding

(2013) Marco Antunes et al.   JOURNAL OF CELL BIOLOGY

ERK and phosphoinositide 3-kinase temporally coordinate different modes of actin-based motility during embryonic wound healing

(2013) J. Li et al.   JOURNAL OF CELL SCIENCE

Ultrasensitive fluorescent proteins for imaging neuronal activity

(2013) Tsai-Wen Chen et al.   NATURE

Human melanopsin forms a pigment maximally sensitive to blue light ( max   479 nm) supporting activation of Gq/11 and Gi/o signalling cascades

(2013) H. J. Bailes et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Genetically encoded calcium indicators for multi-color neural activity imaging and combination with optogenetics

(2013) Jasper Akerboom et al.   Frontiers in Molecular Neuroscience

Transforming Growth Factor–β Evokes Ca2+Waves and Enhances Gene Expression in Human Pulmonary Fibroblasts

(2012) Subhendu Mukherjee et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

From Mechanical Force to RhoA Activation

(2012) Elizabeth C. Lessey et al.   BIOCHEMISTRY

The spatial and temporal control of cell migration by nanoporous surfaces through the regulation of ERK and integrins in fibroblasts

(2012) Hsu-An Pan et al.   BIOMATERIALS

A TRPC6-Dependent Pathway for Myofibroblast Transdifferentiation and Wound Healing In Vivo

(2012) Jennifer Davis et al.   DEVELOPMENTAL CELL

Individual versus collective fibroblast spreading and migration: Regulation by matrix composition in 3D culture

(2012) Miguel Miron-Mendoza et al.   EXPERIMENTAL EYE RESEARCH

Force-induced fibronectin assembly and matrix remodeling in a 3D microtissue model of tissue morphogenesis

(2012) Wesley R. Legant et al.   Integrative Biology

Irregular Ca2+Oscillations Regulate Transcription via Cumulative Spike Duration and Spike Amplitude

(2012) Shanshan Song et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Early redox, Src family kinase, and calcium signaling integrate wound responses and tissue regeneration in zebrafish

(2012) Sa Kan Yoo et al.   JOURNAL OF CELL BIOLOGY

The p65 subunit of NF-κB and PARP1 assist Snail1 in activating fibronectin transcription

(2012) Jelena Stanisavljevic et al.   JOURNAL OF CELL SCIENCE

Drosophila embryos close epithelial wounds using a combination of cellular protrusions and an actomyosin purse string

(2012) M. T. Abreu-Blanco et al.   JOURNAL OF CELL SCIENCE

NF-κB Accumulation Associated with COL1A1 Trans activators Defects during Chronological Aging Represses Type I Collagen Expression through a –112/–61-bp Region of the COL1A1 Promoter in Human Skin Fibroblasts

(2012) Nicolas Bigot et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Syndecan-4 signaling via NFAT regulates extracellular matrix production and cardiac myofibroblast differentiation in response to mechanical stress

(2012) Kate M. Herum et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Optimization of a GCaMP Calcium Indicator for Neural Activity Imaging

(2012) J. Akerboom et al.   JOURNAL OF NEUROSCIENCE

High-resolution optical control of spatiotemporal neuronal activity patterns in zebrafish using a digital micromirror device

(2012) Peixin Zhu et al.   Nature Protocols

Optogenetic investigation of neural circuits underlying brain disease in animal models

(2012) Kay M. Tye et al.   NATURE REVIEWS NEUROSCIENCE

MAP Kinase Pathways

(2012) D. K. Morrison   Cold Spring Harbor Perspectives in Biology

Calcium signaling is gated by a mechanical threshold in three-dimensional environments

(2012) Warren C. Ruder et al.   Scientific Reports

A Synthetic Photoactivated Protein to Generate Local or Global Ca2+ Signals

(2011) Elizabeth Pham et al.   CHEMISTRY & BIOLOGY

Cumulated Ca2+ spike duration underlies Ca2+ oscillation frequency-regulated NF B transcriptional activity

(2011) L. Zhu et al.   JOURNAL OF CELL SCIENCE

Rho GTPases and their role in organizing the actin cytoskeleton

(2011) S.-T. Sit et al.   JOURNAL OF CELL SCIENCE

Scutellarin-dependent inhibition of collagen biosynthesis in cultured fibroblasts

(2011) Ewa Karna et al.   NATURAL PRODUCT RESEARCH

Protein kinase A governs a RhoA–RhoGDI protrusion–retraction pacemaker in migrating cells

(2011) Eugene Tkachenko et al.   NATURE CELL BIOLOGY

Collective cell guidance by cooperative intercellular forces

(2011) Dhananjay T. Tambe et al.   NATURE MATERIALS

Ultra light-sensitive and fast neuronal activation with the Ca2+-permeable channelrhodopsin CatCh

(2011) Sonja Kleinlogel et al.   NATURE NEUROSCIENCE

Epithelial Barriers in Homeostasis and Disease

(2010) Amanda M. Marchiando et al.   Annual Review of Pathology-Mechanisms of Disease

Intracellular Calreticulin Regulates Multiple Steps in Fibrillar Collagen Expression, Trafficking, and Processing into the Extracellular Matrix

(2010) Lauren Van Duyn Graham et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The extracellular matrix at a glance

(2010) C. Frantz et al.   JOURNAL OF CELL SCIENCE

Rapid blue-light–mediated induction of protein interactions in living cells

(2010) Matthew J Kennedy et al.   NATURE METHODS

Modulation of collagen type I, fibronectin and dermal fibroblast function and activity, in systemic sclerosis by the antioxidant epigallocatechin-3-gallate

(2010) A. Dooley et al.   RHEUMATOLOGY

Optogenetic Control of Cardiac Function

(2010) A. B. Arrenberg et al.   SCIENCE

Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels

(2010) B. Coste et al.   SCIENCE

Basement Membranes: Cell Scaffoldings and Signaling Platforms

(2010) P. D. Yurchenco   Cold Spring Harbor Perspectives in Biology

Wound repair at a glance

(2009) T. J. Shaw et al.   JOURNAL OF CELL SCIENCE

Mechanical force induces type I collagen expression in human periodontal ligament fibroblasts through activation of ERK/JNK and AP-1

(2009) Sung-Ho Kook et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Activation of RhoA and FAK induces ERK-mediated osteopontin expression in mechanical force-subjected periodontal ligament fibroblasts

(2009) So-Yeon Hong et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

RSK Is a Principal Effector of the RAS-ERK Pathway for Eliciting a Coordinate Promotile/Invasive Gene Program and Phenotype in Epithelial Cells

(2009) Ulrik Doehn et al.   MOLECULAR CELL

Spatiotemporal control of cell signalling using a light-switchable protein interaction

(2009) Anselm Levskaya et al.   NATURE

Coordination of Rho GTPase activities during cell protrusion

(2009) Matthias Machacek et al.   NATURE

A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish

(2009) Philipp Niethammer et al.   NATURE

A genetically encoded fluorescent reporter of ATP:ADP ratio

(2009) Jim Berg et al.   NATURE METHODS

Imaging neural activity in worms, flies and mice with improved GCaMP calcium indicators

(2009) Lin Tian et al.   NATURE METHODS

Microfabricated tissue gauges to measure and manipulate forces from 3D microtissues

(2009) W. R. Legant et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulatory Effect of Extracellular Signal-Regulated Kinases (ERK) on Type I Collagen Synthesis in Human Dermal Fibroblasts Stimulated by IL-4 and IL-13

(2008) Rashpal K. Bhogal et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

PyK2 and FAK connections to p190Rho guanine nucleotide exchange factor regulate RhoA activity, focal adhesion formation, and cell motility

(2008) Yangmi Lim et al.   JOURNAL OF CELL BIOLOGY

Substrate rigidity regulates Ca2+oscillation via RhoA pathway in stem cells

(2008) Tae-Jin Kim et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Wound repair and regeneration

(2008) Geoffrey C. Gurtner et al.   NATURE

TGF-β1 targets the GSK-3β/β-catenin pathway via ERK activation in the transition of human lung fibroblasts into myofibroblasts

(2008) F CARACI et al.   PHARMACOLOGICAL RESEARCH

CaMK-II promotes focal adhesion turnover and cell motility by inducing tyrosine dephosphorylation of FAK and paxillin

(2008) Charles A. Easley et al.   CELL MOTILITY AND THE CYTOSKELETON