Article
Agronomy
Tingzhen Wang, Mingjia Liu, Yufeng Tian, Yingyan Han, Chaojie Liu, Jinghong Hao, Shuangxi Fan
Summary: This study investigates the important role of mitogen-activated protein kinase 6 (MAPK6) in high temperature bolting of lettuce. The researchers amplified the full-length coding sequence of the LsMAPK6 gene and analyzed its expression using real-time polymerase chain reaction. The results demonstrate that LsMAPK6 is mainly expressed in the stem, stem apex, and taproot, and its expression is significantly promoted by high temperatures.
Article
Biochemistry & Molecular Biology
Hsu-Hsiang Lin, Pen-Hsiu Grace Chao, Wei-Chiu Tai, Po-Chun Chang
Summary: This study successfully developed a biomimetic microfibrous system to assist PDL regeneration and withstand functional load. Collagen-based microfibers were fabricated and PDL cells seeded on waveform microfibers showed enhanced growth and gene expression levels, indicating potential for promoting healing and regeneration under shear stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Gastroenterology & Hepatology
Benno Traub, Aileen Roth, Marko Kornmann, Uwe Knippschild, Joachim Bischof
Summary: Pancreatic cancer is a devastating disease with poor survival rates, prompting the need for new therapeutic approaches. Protein kinases play crucial roles in development and pathogenesis, making them potential targets for precision medicine in patients with deregulated kinase pathways.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Madoka Yasunaga, Hiroyuki Ishikawa, Sachio Tamaoki, Hidefumi Maeda, Jun Ohno
Summary: Culturing HPLSCs as spheroids embedded in collagen gel with rhPAI-1 treatment enhances their cementogenic differentiation. The interaction between HPLSC spheroids and collagenous extracellular matrix is promoted by rhPAI-1, leading to increased cell migration and spread.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Plant Sciences
Xi Zhu, Ning Zhang, Xue Liu, Shigui Li, Jiangwei Yang, Xusheng Hong, Fangfang Wang, Huaijun Si
Summary: The study demonstrates that overexpression of StMAPK11 can promote potato growth, physiological activities, and photosynthesis under drought conditions, indicating its crucial role in enhancing potato drought resistance. The up-regulation of StMAPK11 intensifies drought resistance by elevating antioxidant activities and photosynthesis, providing new insights into its function in drought response.
PLANT CELL REPORTS
(2021)
Article
Microbiology
Wuyun Lv, Yu Xiao, Zhe Xu, Hong Jiang, Qi Tong, Zhengyi Wang
Summary: The role of paxillin in signal pathways in phytopathogenic fungi is not well understood. This study reveals that MoPax1 activates MAP kinase signaling pathways and autophagy through its interaction with MoMka1, and plays an important role in appressorium-mediated plant infection by the rice blast fungus.
Review
Cell Biology
Wei He, Yu Fu, Song Yao, Lan Huang
Summary: The periodontal ligament consists of fibroblasts, cementoblasts, osteoblasts, osteoclasts, periodontal ligament stem cells (PDLSCs), and epithelial cell rests of Malassez. The regulation of programmed cell death is important for immune response but can also lead to the loss of periodontal supporting tissues and root resorption. These findings are relevant for understanding periodontitis and orthodontic root resorption. This comprehensive review focuses on recent studies on mechanisms of periodontal ligament cell death.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Yue-Tong Guo, Yuan-Yuan Lu, Xiao Lu, Shun He, Shi-Jin Li, Shuai Shao, Han-Dan Zhou, Rui-Qi Wang, Xiao-Dong Li, Ping-Jin Gao
Summary: IL-11 plays a crucial role in hypertension-associated vascular remodeling, IL-11 neutralizing antibody can alleviate adventitial fibrosis and inflammatory response, Krüppel-like factor 15 negatively regulates Ang II-induced IL-11 expression in adventitial fibroblasts.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Dentistry, Oral Surgery & Medicine
Yang Yang, Dongping Ren, Duo Zhao, Bo Zhang, Rui Ye
Summary: The overexpression of miR-203 was found to promote PDLC differentiation and suppress inflammatory responses through the AP-1/ICAM-1 axis, potentially inhibiting periodontitis development.
Article
Medicine, General & Internal
Xiaohong Yu, Jing Wang, Qianqian Han, Wen Chu, Shaowen Lu, Yu Liu, Yi Peng, Jie Xu, Yanqing Shui
Summary: The study found that Yunnan Baiyao solution can promote the differentiation of human periodontal ligament fibroblasts and the generation of capillaries on Bio-Oss (R) collagen scaffold in a dose-dependent manner.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2022)
Article
Food Science & Technology
Jeong-Won Kim, Jin-Hwa Kim, Chang-Yeop Kim, Ji-Soo Jeong, Je-Oh Lim, Jong-Choon Kim, Je-Won Ko, Tae-Won Kim
Summary: In this study, the protective effects of DADS against 1,3-DCP-induced hepatotoxicity and oxidative damage were investigated. The results showed that DADS treatment inhibited the increase in serum aminotransferase levels and reduced histopathological alterations in the liver induced by 1,3-DCP. Additionally, DADS treatment reduced 1,3-DCP-induced apoptotic changes in the liver and inhibited phosphorylation of MAPKs. These protective effects may be related to the inhibition of CYP2E1 expression, enhancement of antioxidant enzyme activity, and reduction of apoptotic activity.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Engineering, Biomedical
Chen Zong, Wannes Van Holm, Annelies Bronckaers, Zuodong Zhao, Stevan Cokic, Merve Kubra Aktan, Ana Belen Castro, Bart Van Meerbeek, Annabel Braem, Guy Willems, Maria Cadenas de Llano-Perula
Summary: The study shows that pretreatment of human periodontal ligament stem cells (hPDLSCs) with gold nanocomplexes (AuNCs) and transplantation in a collagen hydrogel scaffold can effectively protect alveolar bone from resorption and promote bone regeneration, suggesting a promising strategy for bone defect treatment.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Pharmacology & Pharmacy
Chaojun Kong, Longfei Jia, Jianping Jia
Summary: This study demonstrated that gamma-mangostin can attenuate oxidative stress and inflammation caused by Aβ42 oligomers, while protecting neurons from toxic medium-induced injury, suggesting its potential protective effect in Alzheimer's disease.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Cell Biology
Andrew C. Tamashunas, Aditya Katiyar, Qiao Zhang, Purboja Purkayastha, Pankaj K. Singh, Sasanka S. Chukkapalli, Tanmay P. Lele
Summary: The study found that in a mouse model of periodontal disease, periodontal ligament fibroblasts (PdLFs) exhibit rounded and disoriented nuclei, indicating reduced actomyosin tension. Inhibiting actomyosin contractility decreased levels of bone regulatory protein osteoprotegerin (OPG). Infection with periodontal bacteria did not replicate the observed nuclear rounding in vivo.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Chiaki Morimoto, Masahide Takedachi, Kohsuke Kawasaki, Junpei Shimomura, Mari Murata, Asae Hirai, Kazuma Kawakami, Keigo Sawada, Tomoaki Iwayama, Shinya Murakami
Summary: The study demonstrated that hypoxia stimulates type I collagen production in HGFs and HPDLs through upregulation of hydroxylases P4HA1 and PLOD2 in an HIF-1 alpha-dependent manner.
JOURNAL OF PERIODONTOLOGY
(2021)