Insight into the siRNA transmembrane delivery—From cholesterol conjugating to tagging

Bioconjugated oligonucleotides: recent developments and therapeutic applications

(2019) sebastien benizri et al.   BIOCONJUGATE CHEMISTRY

Current Development of siRNA Bioconjugates: From Research to the Clinic

(2019) Ivan V. Chernikov et al.   Frontiers in Pharmacology

Current Aspects of siRNA Bioconjugate for In Vitro and In Vivo Delivery

(2019) Wanyi Tai   MOLECULES

Chemical modulation of siRNA lipophilicity for efficient delivery

(2019) Wanyi Tai   JOURNAL OF CONTROLLED RELEASE

Noncovalent tagging of siRNA with steroids for transmembrane delivery

(2018) Wanyi Tai et al.   BIOMATERIALS

Direct Permeation of Nanoparticles across Cell Membrane: A Review

(2018) Hideya Nakamura et al.   KONA Powder and Particle Journal

Patisiran, an RNAi Therapeutic, for Hereditary Transthyretin Amyloidosis

(2018) David Adams et al.   NEW ENGLAND JOURNAL OF MEDICINE

Efficient siRNA delivery with non-cationic carriers

(2018) Chun Kit K. Choi et al.   Nature Biomedical Engineering

Clustering and separation of hydrophobic nanoparticles in lipid bilayer explained by membrane mechanics

(2018) Matej Daniel et al.   Scientific Reports

Arginine-rich cell-penetrating peptides induce membrane multilamellarity and subsequently enter via formation of a fusion pore

(2018) Christoph Allolio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Role of Hydrophobicity in the Cellular Uptake of Negatively Charged Macromolecules

(2017) Tamara Abou Matar et al.   MACROMOLECULAR BIOSCIENCE

The chemical evolution of oligonucleotide therapies of clinical utility

(2017) Anastasia Khvorova et al.   NATURE BIOTECHNOLOGY

Overcoming cellular barriers for RNA therapeutics

(2017) Steven F Dowdy   NATURE BIOTECHNOLOGY

Mitochondrial DNA depletion by ethidium bromide decreases neuronal mitochondrial creatine kinase: Implications for striatal energy metabolism

(2017) Emily Booth Warren et al.   PLoS One

Cholesterol-Containing Nuclease-Resistant siRNA Accumulates in Tumors in a Carrier-free Mode and Silences MDR1 Gene

(2017) Ivan V. Chernikov et al.   Molecular Therapy-Nucleic Acids

Therapeutic miRNA and siRNA: Moving from Bench to Clinic as Next Generation Medicine

(2017) Chiranjib Chakraborty et al.   Molecular Therapy-Nucleic Acids

siRNA Delivery Strategies: A Comprehensive Review of Recent Developments

(2017) Katyayani Tatiparti et al.   Nanomaterials

Interaction of hydrophobic polymers with model lipid bilayers

(2017) D. Bochicchio et al.   Scientific Reports

Visualization of self-delivering hydrophobically modified siRNA cellular internalization

(2016) Socheata Ly et al.   NUCLEIC ACIDS RESEARCH

Direct proof of spontaneous translocation of lipid-covered hydrophobic nanoparticles through a phospholipid bilayer

(2016) Y. Guo et al.   Science Advances

Pharmacokinetics, biodistribution and cell uptake of antisense oligonucleotides

(2015) Richard S. Geary et al.   ADVANCED DRUG DELIVERY REVIEWS

Update on phase 2 clinical trial results of RXI-109 treatment to reduce the formation of hypertrophic dermal scars

(2015)   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Identification of siRNA delivery enhancers by a chemical library screen

(2015) Jerome Gilleron et al.   NUCLEIC ACIDS RESEARCH

A method for mutagenesis of mouse mtDNA and a resource of mouse mtDNA mutations for modeling human pathological conditions

(2015) Rafik Z. Fayzulin et al.   NUCLEIC ACIDS RESEARCH

Viral membrane fusion

(2015) Stephen C. Harrison   VIROLOGY

Translocation and Induced Permeability of Random Amphiphilic Copolymers Interacting with Lipid Bilayer Membranes

(2014) Marco Werner et al.   BIOMACROMOLECULES

Efficient delivery of RNAi prodrugs containing reversible charge-neutralizing phosphotriester backbone modifications

(2014) Bryan R Meade et al.   NATURE BIOTECHNOLOGY

Study of interactions between polymer nanoparticles and cell membranes at atomistic levels

(2014) C. W. Yong   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Double-stranded RNA under force and torque: Similarities to and striking differences from double-stranded DNA

(2014) J. Lipfert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Mechanisms of RNA Interference

(2013) Ross C. Wilson et al.   Annual Review of Biophysics

Hepatocyte-targeted RNAi Therapeutics for the Treatment of Chronic Hepatitis B Virus Infection

(2013) Christine I Wooddell et al.   MOLECULAR THERAPY

Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling

(2013) Gaurav Sahay et al.   NATURE BIOTECHNOLOGY

Amino-Modified and Lipid-Conjugated Dicer-Substrate siRNA Enhances RNAi Efficacy

(2012) Takanori Kubo et al.   BIOCONJUGATE CHEMISTRY

Homo-polymers with balanced hydrophobicity translocate through lipid bilayers and enhance local solvent permeability

(2012) Marco Werner et al.   Soft Matter

Carrier-free cellular uptake and the gene-silencing activity of the lipophilic siRNAs is strongly affected by the length of the linker between siRNA and lipophilic group

(2011) Natalya S. Petrova et al.   NUCLEIC ACIDS RESEARCH

Elimination Pathways of Systemically Delivered siRNA

(2010) Yuanyu Huang et al.   MOLECULAR THERAPY

The Killing of African Trypanosomes by Ethidium Bromide

(2010) Arnab Roy Chowdhury et al.   PLoS Pathogens

Asymmetric Shorter-duplex siRNA Structures Trigger Efficient Gene Silencing With Reduced Nonspecific Effects

(2009) Chan Il Chang et al.   MOLECULAR THERAPY

siRNA Conjugate Delivery Systems

(2008) Ji Hoon Jeong et al.   BIOCONJUGATE CHEMISTRY

Efficient In Vivo Delivery of siRNA to the Liver by Conjugation of α-Tocopherol

(2008) Kazutaka Nishina et al.   MOLECULAR THERAPY

Asymmetric RNA duplexes mediate RNA interference in mammalian cells

(2008) Xiangao Sun et al.   NATURE BIOTECHNOLOGY

Potent RNAi by short RNA triggers

(2008) C.-y. Chu et al.   RNA