Current Aspects of siRNA Bioconjugate for In Vitro and In Vivo Delivery

Dextran-Conjugated Caged siRNA Nanoparticles for Photochemical Regulation of RNAi-Induced Gene Silencing in Cells and Mice

(2019) Changmai Chen et al.   BIOCONJUGATE CHEMISTRY

Spherical Nucleic Acid Nanoparticles: Therapeutic Potential

(2018) Chintan H. Kapadia et al.   BIODRUGS

Advanced siRNA Designs Further Improve In Vivo Performance of GalNAc-siRNA Conjugates

(2018) Donald J. Foster et al.   MOLECULAR THERAPY

A modular platform for targeted RNAi therapeutics

(2018) Ranit Kedmi et al.   Nature Nanotechnology

Comparison of partially and fully chemically-modified siRNA in conjugate-mediated delivery in vivo

(2018) Matthew R Hassler et al.   NUCLEIC ACIDS RESEARCH

Molecular spherical nucleic acids

(2018) Hui Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GalNAc-siRNA Conjugates: Leading the Way for Delivery of RNAi Therapeutics

(2018) Aaron D. Springer et al.   Nucleic Acid Therapeutics

Spherical Nucleic Acid Architecture Can Improve the Efficacy of Polycation-Mediated siRNA Delivery

(2018) Jilian R. Melamed et al.   Molecular Therapy-Nucleic Acids

Defining the Structure of a Protein–Spherical Nucleic Acid Conjugate and Its Counterionic Cloud

(2018) Kurinji Krishnamoorthy et al.   ACS Central Science

A ribonucleoprotein octamer for targeted siRNA delivery

(2018) Wanyi Tai et al.   Nature Biomedical Engineering

An efficient bivalent cyclic RGD-PIK3CB siRNA conjugate for specific targeted therapy against glioblastoma in vitro and in vivo

(2018) Bohong Cen et al.   Molecular Therapy-Nucleic Acids

siRNA Delivery Using Dithiocarbamate-Anchored Oligonucleotides on Gold Nanorods

(2018) Jianxin Wang et al.   BIOCONJUGATE CHEMISTRY

Antitumor effect of palmitic acid-conjugated DsiRNA for colon cancer in a mouse subcutaneous tumor model

(2018) Takanori Kubo et al.   Chemical Biology & Drug Design

RNAi modulation of placental sFLT1 for the treatment of preeclampsia

(2018) Anton A Turanov et al.   NATURE BIOTECHNOLOGY

Hydrophobicity drives the systemic distribution of lipid-conjugated siRNAs via lipid transport pathways

(2018) Maire F Osborn et al.   NUCLEIC ACIDS RESEARCH

Diverse lipid conjugates for functional extra-hepatic siRNA delivery in vivo

(2018) Annabelle Biscans et al.   NUCLEIC ACIDS RESEARCH

Reductive nanocomplex encapsulation of cRGD-siRNA conjugates for enhanced targeting to cancer cells

(2017) Zhaoxiu Zhou et al.   International Journal of Nanomedicine

Using siRNA-based spherical nucleic acid nanoparticle conjugates for gene regulation in psoriasis

(2017) Houshang Nemati et al.   JOURNAL OF CONTROLLED RELEASE

Clinical Proof of Concept for a Novel Hepatocyte-Targeting GalNAc-siRNA Conjugate

(2017) Tracy S. Zimmermann et al.   MOLECULAR THERAPY

The chemical evolution of oligonucleotide therapies of clinical utility

(2017) Anastasia Khvorova et al.   NATURE BIOTECHNOLOGY

Lipophilic siRNA targets albumin in situ and promotes bioavailability, tumor penetration, and carrier-free gene silencing

(2017) Samantha M. Sarett et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Artificial Control of Gene Silencing Activity Based on siRNA Conjugation with Polymeric Molecule Having Coil–Globule Transition Behavior

(2016) Noor Faizah Che Harun et al.   BIOCONJUGATE CHEMISTRY

Development of antibody-siRNA conjugate targeted to cardiac and skeletal muscles

(2016) Tsukasa Sugo et al.   JOURNAL OF CONTROLLED RELEASE

Visualization of self-delivering hydrophobically modified siRNA cellular internalization

(2016) Socheata Ly et al.   NUCLEIC ACIDS RESEARCH

Enzyme-Activatable Cell-Penetrating Peptides through a Minimal Side Chain Modification

(2015) Saskia A. Bode et al.   BIOCONJUGATE CHEMISTRY

siRNA suppression of hTERT using activatable cell-penetrating peptides in hepatoma cells

(2015) Hua Li et al.   BIOSCIENCE REPORTS

Antibody-Mediated Delivery of Anti-KRAS-siRNA In Vivo Overcomes Therapy Resistance in Colon Cancer

(2015) S. Baumer et al.   CLINICAL CANCER RESEARCH

An Aptamer–siRNA Chimera Silences the Eukaryotic Elongation Factor 2 Gene and Induces Apoptosis in Cancers Expressing αvβ3 Integrin

(2015) Ahmad Fawzi Hussain et al.   Nucleic Acid Therapeutics

Spherical nucleic acids for precision medicine

(2015) Chad A. Mirkin et al.   Oncotarget

Novel Endosomolytic Poly(amido amine) Polymer Conjugates for Systemic Delivery of siRNA to Hepatocytes in Rodents and Nonhuman Primates

(2014) Rubina Giare Parmar et al.   BIOCONJUGATE CHEMISTRY

Chemically defined polyethylene glycol siRNA conjugates with enhanced gene silencing effect

(2014) Zuzana Gaziova et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Liposomal Spherical Nucleic Acids

(2014) Resham J. Banga et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Multivalent N-Acetylgalactosamine-Conjugated siRNA Localizes in Hepatocytes and Elicits Robust RNAi-Mediated Gene Silencing

(2014) Jayaprakash K. Nair et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Efficient delivery of RNAi prodrugs containing reversible charge-neutralizing phosphotriester backbone modifications

(2014) Bryan R Meade et al.   NATURE BIOTECHNOLOGY

Systematic evaluation of antibody-mediated siRNA delivery using an industrial platform of THIOMAB–siRNA conjugates

(2014) Trinna L. Cuellar et al.   NUCLEIC ACIDS RESEARCH

Tumor-targeted in vivo gene silencing via systemic delivery of cRGD-conjugated siRNA

(2014) Xiaoxia Liu et al.   NUCLEIC ACIDS RESEARCH

Acidic pH-Responsive siRNA Conjugate for Reversible Carrier Stability and Accelerated Endosomal Escape with Reduced IFNα-Associated Immune Response

(2013) Hiroyasu Takemoto et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

TLR9-mediated siRNA delivery for targeting of normal and malignant human hematopoietic cells in vivo

(2013) Q. Zhang et al.   BLOOD

Influence of diverse chemical modifications on the ADME characteristics and toxicology of antisense oligonucleotides

(2013) Mehrdad Dirin et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Novel Hydrophobically Modified Asymmetric RNAi Compounds (sd-rxRNA) Demonstrate Robust Efficacy in the Eye

(2013) Michael Byrne et al.   JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS

Hepatocyte-targeted RNAi Therapeutics for the Treatment of Chronic Hepatitis B Virus Infection

(2013) Christine I Wooddell et al.   MOLECULAR THERAPY

Molecular basis for improved gene silencing by Dicer substrate interfering RNA compared with other siRNA variants

(2013) Nicholas M. Snead et al.   NUCLEIC ACIDS RESEARCH

Mechanism for the endocytosis of spherical nucleic acid nanoparticle conjugates

(2013) C. H. J. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spherical Nucleic Acid Nanoparticle Conjugates as an RNAi-Based Therapy for Glioblastoma

(2013) S. A. Jensen et al.   Science Translational Medicine

Optimized siRNA-PEG Conjugates for Extended Blood Circulation and Reduced Urine Excretion in Mice

(2013) Frank Iversen et al.   Theranostics

Dimeric DNA Aptamer Complexes for High-capacity–targeted Drug Delivery Using pH-sensitive Covalent Linkages

(2013) Olcay Boyacioglu et al.   Molecular Therapy-Nucleic Acids

Single-Stranded siRNAs Activate RNAi in Animals

(2012) Walt F. Lima et al.   CELL

Self-Assembled Aptamer-Based Drug Carriers for Bispecific Cytotoxicity to Cancer Cells

(2012) Guizhi Zhu et al.   Chemistry-An Asian Journal

Click-Modified Anandamide siRNA Enables Delivery and Gene Silencing in Neuronal and Immune Cells

(2012) Julian Willibald et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Spherical Nucleic Acids

(2012) Joshua I. Cutler et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Hollow Spherical Nucleic Acids for Intracellular Gene Regulation Based upon Biocompatible Silica Shells

(2012) Kaylie L. Young et al.   NANO LETTERS

Topical delivery of siRNA-based spherical nucleic acid nanoparticle conjugates for gene regulation

(2012) Dan Zheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Defined Folate-PEG-siRNA Conjugates for Receptor-specific Gene Silencing

(2012) Christian Dohmen et al.   Molecular Therapy-Nucleic Acids

Multivalent Cyclic RGD Conjugates for Targeted Delivery of Small Interfering RNA

(2011) Md. Rowshon Alam et al.   BIOCONJUGATE CHEMISTRY

Mechanistic Insights into LDL Nanoparticle-Mediated siRNA Delivery

(2011) Honglin Jin et al.   BIOCONJUGATE CHEMISTRY

Prostate-targeted radiosensitization via aptamer-shRNA chimeras in human tumor xenografts

(2011) Xiaohua Ni et al.   JOURNAL OF CLINICAL INVESTIGATION

Inhibition of HIV transmission in human cervicovaginal explants and humanized mice using CD4 aptamer-siRNA chimeras

(2011) Lee Adam Wheeler et al.   JOURNAL OF CLINICAL INVESTIGATION

Synthesis and in vitro inhibition properties of siRNA conjugates carrying glucose and galactose with different presentations

(2011) Anna Aviñó et al.   MOLECULAR DIVERSITY

Development of a Peptide–Drug Conjugate for Prostate Cancer Therapy

(2011) Wanyi Tai et al.   MOLECULAR PHARMACEUTICS

Assembly of Therapeutic pRNA-siRNA Nanoparticles Using Bipartite Approach

(2011) Yi Shu et al.   MOLECULAR THERAPY

Efficient In Vivo Delivery of siRNA Into Brain Capillary Endothelial Cells Along With Endogenous Lipoprotein

(2011) Hiroya Kuwahara et al.   MOLECULAR THERAPY

Targeting 4-1BB Costimulation to Disseminated Tumor Lesions With Bi-specific Oligonucleotide Aptamers

(2011) Fernando Pastor et al.   MOLECULAR THERAPY

Targeted Delivery of siRNA to Hepatocytes and Hepatic Stellate Cells by Bioconjugation

(2010) Lin Zhu et al.   BIOCONJUGATE CHEMISTRY

Rational Design of Targeted Cancer Therapeutics through the Multiconjugation of Folate and Cleavable siRNA to RAFT-Synthesized (HPMA-s-APMA) Copolymers†

(2010) Adam W. York et al.   BIOMACROMOLECULES

Native albumin for targeted drug delivery

(2010) Elena Neumann et al.   Expert Opinion on Drug Delivery

The role of HER2 in cancer therapy and targeted drug delivery

(2010) Wanyi Tai et al.   JOURNAL OF CONTROLLED RELEASE

Recent Progress in Chemically Modified siRNAs

(2010) M. Gaglione et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

RNAi and small interfering RNAs in human disease therapeutic applications

(2010) Monica R. Lares et al.   TRENDS IN BIOTECHNOLOGY

siRNA vs. shRNA: Similarities and differences

(2009) Donald D. Rao et al.   ADVANCED DRUG DELIVERY REVIEWS

Ligand-Targeted Delivery of Small Interfering RNAs to Malignant Cells and Tissues

(2009) Mini Thomas et al.   Annals of the New York Academy of Sciences

In vivo characterization of activatable cell penetrating peptides for targeting protease activity in cancer

(2009) Emilia S. Olson et al.   Integrative Biology

Gene Regulation with Polyvalent siRNA−Nanoparticle Conjugates

(2009) David A. Giljohann et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis and Biological Evaluation of a Bioresponsive and Endosomolytic siRNA−Polymer Conjugate

(2009) Martin Meyer et al.   MOLECULAR PHARMACEUTICS

In vivo delivery of siRNA to immune cells by conjugation to a TLR9 agonist enhances antitumor immune responses

(2009) Marcin Kortylewski et al.   NATURE BIOTECHNOLOGY

Systemic administration of optimized aptamer-siRNA chimeras promotes regression of PSMA-expressing tumors

(2009) Justin P Dassie et al.   NATURE BIOTECHNOLOGY

Knocking down barriers: advances in siRNA delivery

(2009) Kathryn A. Whitehead et al.   NATURE REVIEWS DRUG DISCOVERY

LHRH Receptor-Mediated Delivery of siRNA Using Polyelectrolyte Complex Micelles Self-Assembled from siRNA-PEG-LHRH Conjugate and PEI

(2008) Sun Hwa Kim et al.   BIOCONJUGATE CHEMISTRY

siRNA Conjugate Delivery Systems

(2008) Ji Hoon Jeong et al.   BIOCONJUGATE CHEMISTRY

Trivalent, Gal/GalNAc-containing ligands designed for the asialoglycoprotein receptor

(2008) Oleg Khorev et al.   BIOORGANIC & MEDICINAL CHEMISTRY

T Cell-Specific siRNA Delivery Suppresses HIV-1 Infection in Humanized Mice

(2008) Priti Kumar et al.   CELL

Reversible siRNA–polymer conjugates by RAFT polymerization

(2008) Karina L. Heredia et al.   CHEMICAL COMMUNICATIONS

Novel Dual Inhibitory Function Aptamer–siRNA Delivery System for HIV-1 Therapy

(2008) Jiehua Zhou et al.   MOLECULAR THERAPY

Efficient In Vivo Delivery of siRNA to the Liver by Conjugation of α-Tocopherol

(2008) Kazutaka Nishina et al.   MOLECULAR THERAPY

Asymmetric RNA duplexes mediate RNA interference in mammalian cells

(2008) Xiangao Sun et al.   NATURE BIOTECHNOLOGY

Potent RNAi by short RNA triggers

(2008) C.-y. Chu et al.   RNA